#=GF ID   Tox-MPTase4
#=GF AC   PF15640.10
#=GF DE   Metallopeptidase toxin 4
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   de Souza RF;0000-0002-5284-4630
#=GF AU   Anantharaman V;0000-0001-8395-0009
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   [1]
#=GF GA   25.00 25.00;
#=GF TC   25.90 27.50;
#=GF NC   24.70 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22731697
#=GF RT   Polymorphic toxin systems: comprehensive characterization of
#=GF RT   trafficking modes, processing, mechanisms of action, immunity
#=GF RT   and ecology using comparative genomics.
#=GF RA   Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL   Biol Direct. 2012;7:18.
#=GF DR   INTERPRO; IPR028912;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A zincin-like metallopeptidase domain found in bacterial
#=GF CC   polymorphic toxin systems [1].
#=GF SQ   37
#=GS A0A0D6TKX0_9FLAO/1-61     AC A0A0D6TKX0.1
#=GS A0A5J6PM35_9BACI/126-267  AC A0A5J6PM35.1
#=GS D1AHH7_SEBTE/326-453      AC D1AHH7.1
#=GS A0A5B1CEX3_9BACT/14-111   AC A0A5B1CEX3.1
#=GS A0A366H4S7_9BACT/525-620  AC A0A366H4S7.1
#=GS A0A517SR58_9BACT/14-111   AC A0A517SR58.1
#=GS H3SCN9_9BACL/325-461      AC H3SCN9.1
#=GS A0A1H3PQF4_9BACL/45-176   AC A0A1H3PQF4.1
#=GS A0A4Z0LAS8_9FLAO/537-679  AC A0A4Z0LAS8.1
#=GS A0A4Y8PS29_9BACL/151-282  AC A0A4Y8PS29.1
#=GS A0A4R6QDX5_9FLAO/46-180   AC A0A4R6QDX5.1
#=GS A0A0D6TJZ2_9FLAO/68-217   AC A0A0D6TJZ2.1
#=GS A0A653X2X9_9FLAO/643-769  AC A0A653X2X9.1
#=GS Q8XCR7_ECO57/309-437      AC Q8XCR7.1
#=GS A0A3G2G8K3_9FLAO/561-703  AC A0A3G2G8K3.1
#=GS A0A430ALF9_9ENTE/13-142   AC A0A430ALF9.1
#=GS L1P1I2_9FLAO/2-67         AC L1P1I2.1
#=GS H1ZEE6_MYROD/1-56         AC H1ZEE6.1
#=GS A0A1E3KYL9_9BACL/116-194  AC A0A1E3KYL9.1
#=GS A0A1Y2Q5J8_9SPHN/15-131   AC A0A1Y2Q5J8.1
#=GS A0A563DJD7_9FLAO/1-63     AC A0A563DJD7.1
#=GS A0A0D1EDW3_9RHOB/506-648  AC A0A0D1EDW3.1
#=GS A0A2S8AEV3_9FLAO/351-482  AC A0A2S8AEV3.1
#=GS A0A7Y8Y024_9FLAO/612-751  AC A0A7Y8Y024.1
#=GS A0A2N1F516_9FLAO/694-817  AC A0A2N1F516.1
#=GS A0A0D6TK82_9FLAO/97-217   AC A0A0D6TK82.1
#=GS A0A345H8U1_9FLAO/625-761  AC A0A345H8U1.1
#=GS A0A653TRD7_9FLAO/52-202   AC A0A653TRD7.1
#=GS A0A243W520_9BACT/16-154   AC A0A243W520.1
#=GS A0A345H8U3_9FLAO/1-63     AC A0A345H8U3.1
#=GS A0A5C6AUN8_9BACT/4-128    AC A0A5C6AUN8.1
#=GS A0A4D6BEX9_9CAUD/319-447  AC A0A4D6BEX9.1
#=GS A0A449BD23_HAPAX/76-198   AC A0A449BD23.1
#=GS A0A345HF37_9FLAO/10-55    AC A0A345HF37.1
#=GS A0A6C2YIL1_9BACT/26-132   AC A0A6C2YIL1.1
#=GS A0A653TMZ5_9FLAO/66-198   AC A0A653TMZ5.1
#=GS A0A1H4SDY0_9FLAO/569-702  AC A0A1H4SDY0.1
A0A0D6TKX0_9FLAO/1-61                ...................................................mvq---------.-------------------------..--..---...-.-.-.-----.....................------.....--..---...-.--------------FHELAH.LKHYEELG-..E..AYL.......L.............L.........S..........KL..................EK....ETYVWKEIFAN..KSK...WTKPELQDALNYIN.KIRV-r...................
A0A5J6PM35_9BACI/126-267             ...........................................kidyvedtgrl---------.-----GGKYYSEKDLKLLGNYLGKR..GV..TLK...V.G.-.-DEFL.....................PPGKGG.....GF..NYN...T.GELVLKSNPTQYEVWHELSH.YIQYKQIGK..E..AYS.......K.............LprtsgsvpiT..........DL..................TRfnapEQFVYDMLSNN..PKRwnyLNEAEQLHANWYIT.Q----ygg.................
D1AHH7_SEBTE/326-453                 ................................................rkkpvv---------.EVNPVGETIATRKEIKNYKTYWGRC..GI..KVK...I.D.K.D-GIL.....................PERMAA.....GF..DYK...D.GIIYVREKPSNISMAHEGYH.TKQWLKLGK..E..EYL.......K.............L.........T..........RL..................QR....EELVYEQIMKN..QYR...FDKASIDNAKIYID.RLRL-e...................
A0A5B1CEX3_9BACT/14-111              ............................................kekipalvky---------.-------------------------..--..---...L.E.R.RGVYL.....................HERING.....SF..DGV...R.GVMTLPRNPTRLNVSHELAH.MLDYKKYGD..D..YYK.......L.............F.........T..........PA..................QR....EQMVLERLKNN..R--...--------------.-----iwdqlndlerdwslny....
A0A366H4S7_9BACT/525-620             .........................................lvrnsdtylkdft---------.-------------------------..--..---...-.-.-.-----.....................---ARA.....GF..NPT...T.CQMHLRSDATYFDYFHELCH.ATMRAQLGS.vE..EYY.......K.............I.........R..........EY..................DR....EMYVFDQIAKN..EHR...FTEEEIDRAIED--.-----alhyynk.............
A0A517SR58_9BACT/14-111              ............................................kekipalvky---------.-------------------------..--..---...L.D.R.RGIYL.....................HEGING.....SF..DGV...R.GVMTLPRNPTRLNVRHELAH.MLDYKKYGD..D..YYK.......L.............F.........T..........PA..................QR....EQMVLERLKNN..R--...--------------.-----iweqlndlerdwslny....
H3SCN9_9BACL/325-461                 ......................................................EGKPVSGQR.KMTPGGQRYASVRDWKTLKKTMQAR..GI..NVS...I.D.S.KGKILid................pltGERKAG.....GF..NPY...T.GEIILKPDATLHEMIHETIH.AEQWFKLGK..E..NYL.......K.............Q.........T..........VL..................ER....EEHVFNELMKP..SYN...LNEEEIFHAKKVIF.KYRNG....................
A0A1H3PQF4_9BACL/45-176              .....................................................i-DKPVSGQL.KYDSQGQRILTTNEFKKFRDEMAKQ..DI..KVV...V.D.T.KEKRL.....................PKNVAA.....GF..DFE...T.KEIILRPDATKVSAIHESYH.VKQYMEIGK..E..KYK.......Q.............L.........P..........AI..................ER....EEYVYNEIMKN..KGQ...FNSAEIHESQRVIF.KYRNG....................
A0A4Z0LAS8_9FLAO/537-679             ......................................slinrgkylgqvleei---------.-------------DIQKIKAFLTTH..NV..DLQ...I.G.K.GDGIIevteyfyp.....sgnivklhPHQAA-.....MFitNGE...T.MKLVLREKATLYEAFHELMH.FRDCQKIGK..K..AFL.......K.............K.........P..........LV..................ER....EKYVYDKMVRY..SEY...LNKKELKHAEDYIN.-----fhyye...............
A0A4Y8PS29_9BACL/151-282             .....................................................a-DMPVSGQV.QTAPNGHRLISIRDLKMFTKEMNEK..NI..RVV...I.D.S.KGKIL.....................PSFADG.....GF..NPT...T.GQIVLKKEPTYLSAKHESYH.AQQWLELGQ..E..QYL.......K.............L.........T..........TL..................ER....EEYVYSQIMKN..KDL...YTSAEILFSQKYIF.KLRT-g...................
A0A4R6QDX5_9FLAO/46-180              .....................nglyggkvlskaelddwakillkkfgtklkkve---------.-------------------------..--..---...-.-.-.--KFD.....................SPDILA.....QF..DPN...T.NTILYKNDVTEYFMVHEHFH.AEEMSKIGF..D..EYV.......K.............D.........A..........ALfgtkfpneytvenllrsyKR....EKYVYEQIEKN..AKR...YN------------.-----lnpfelrhnylnl.......
A0A0D6TJZ2_9FLAO/68-217              kvagrgrqfgqklskadfeeirkflksnkvelefhplnqvkkiegfftasgqpa---------.-------------------------..--..---...-.-.-.---LM.....................PKGAAA.....IFitDGK...K.MKIILREEATVYEFFHEFMH.FRHSKEIGL..E..EFY.......K.............Lggr...dslG..........EL..................IK....EQWVFDILMKN..KQY...LTKSEIDHALYYINnKVRN-k...................
A0A653X2X9_9FLAO/643-769             ................................................eddlll---------.--NKGGKKIQNKATLKKFKSFID-G..GIlfENP...R.D.F.FYFIR.....................KEGYGG.....GF..HPQ...T.KQLFLTENPTEYLAFHEKSH.VKHYLEIG-..D..EYL.......T.............L.........A..........SW..................EK....ETYVFNEIWKE..RNL...WTKEELQHALDYVN.RVRK-i...................
Q8XCR7_ECO57/309-437                 ......................................................DGRRVSGHT.GF-LDGVRL-SRSQINNIAKEMEKL..GI..KV-...I.R.K.ADKYL.....................PPNARA.....AF..DYG...L.RNIYLRKNATLYEVYHEVIH.AKQFAKIGR..E..AYE.......A.............L.........G..........RL..................SR....EEHVLNEILKS..KNL...FNEAEIAHAIKYVE.GLREK....................
A0A3G2G8K3_9FLAO/561-703             ...........................................egksaskrgrf---------.----LGREFMNNRQMKALEKYIAEVlgDV..GVV...M.R.KgEDKFL....................dVSGAQA.....GF..SPT...S.RELFFRKKFTFYEAFHEIQH.ALEFKLLGK..E..AYL.......E.............G.........AagtlveqrirTY..................KR....EKWVYDKIMEK..KHL...FNELELENAE----.-----wvlgqaik............
A0A430ALF9_9ENTE/13-142              ....................................................dy--RRINIQQnDI---GERLATRKEIRSFKKKFGQN..GV..KLT...I.D.K.KGKIL.....................PANVDG.....GF..NFK...T.GKIVLPKNPTQIALHHEGFH.AEQWLNIGQ..D..AYA.......K.............L.........A..........VL..................ER....EEHVFEQIMKN..QHL...FDDQSIIHSIEYIE.RLRLK....................
L1P1I2_9FLAO/2-67                    ...................................................rrm---------.-------------------------..--..---...-.-.-.-----.....................------.....--..---...-.-----------MKMGKRCYH.AKQNYQLGD..Q..KYK.......A.............Q.........S..........RL..................EK....EEYVYDELMKN.hKEQ...LTDYQISGARKYLD.EVRE-e...................
H1ZEE6_MYROD/1-56                    ....................................................ms---------.-------------------------..--..---...-.-.-.-----.....................------.....--..---...-.-------------------H.VKHFEEVGE..V..VYK.......N.............L.........K..........DL..................DK....EMYVWKQILNN..RSK...WTKVELNDALKSIN.RLRV-k...................
A0A1E3KYL9_9BACL/116-194             .............................................dyrnvqrlq---------.--NSRKETLALTKEIRQFKQYWGQY..GI..NVK...V.D.K.KGKVL.....................RGELEA.....GF..DYG...S.GEIWIKKNPSLICIMK----.---------..-..---.......-.............-.........-..........--..................--....-----------..---...--------------.-----dimqsn..............
A0A1Y2Q5J8_9SPHN/15-131              .................................ggvlydttklgrlegylgrrg---------.-------------------------..--..-VT...L.Q.V.GDEFL.....................PLGKAG.....GF..DAV...N.GRLALKSNPTEYEVWHELNH.YIQYRKLGP..E..AYS.......A.............Q.........G..........RI..................AK....EQYVFDALENS..PKRwgaLTPEQRTHAVDYIY.A----vg..................
A0A563DJD7_9FLAO/1-63                ....................................................my---------.-------------------------..--..---...-.-.-.-----.....................------.....--..---...-.------------VAMHEGFH.VKQWGKLGY..E..EYN.......K.............Q.........S..........RL..................QK....EKYVYDELMKN..KGV...LTEWQINHAGAY--.-----nkyleig.............
A0A0D1EDW3_9RHOB/506-648             ................................................elatra-------KR.RMMMLGAGRMTAAQSRRIAQEAAEY..GT..SVRrlsN.S.Q.FDRIY.....................GRDVNA.....AF..NNQ...T.NTILLRENATYYEASHELLH.ARHMHEIGP..D..AYRalgngdrK.............M.........Q..........RY..................LR....ERYVYDNLMRN..GDEi.gMNAAQRGHATNYIR.R----vgrq................
A0A2S8AEV3_9FLAO/351-482             ................................................egdsmk------REA.RYNAEGERMMTSREFKDFRKKMADL..GI..KIE...L.D.T.KGKIL.....................GDKHVA.....GF..DSS...K.KTLYLKKPPKTYDAMHEGFH.AEQWSKLGD..E..AYN.......K.............Q.........T..........RL..................EK....ETYVYEQLMKN..KEI...LTPQQINHAEAYIY.YVEN-g...................
A0A7Y8Y024_9FLAO/612-751             ...............................................dmdwmnr-------KT.TVGNLGGKLLSVQQLRRLRKILSEH..GV..ELI...V.EgA.KTKKFkdmw.............fymrSKGYPG.....GF..NAV...T.KQFFLRSDATEIVAFHELAH.FNHW-KMAK..E..RYS.......D.............L.........T..........DL..................AK....ETYVWEQILKN..RHL...WTKEELIDSLNYIN.S----fmls................
A0A2N1F516_9FLAO/694-817             ................ervlkkrikkllqkyknfnlevrfvdettnvkklkdwn---------.-------------------------..--..---...-.-.-.-----.....................ARKVLG.....SF..KQG..pP.PTLFFRKEVTELTWQHELWH.LEDLKRLGT..K..KFY.......Q.............T.........S..........NW..................KH....EESVWNKIWKT..KNK...WTEEELVDSYFYY-.-----kktarg..............
A0A0D6TK82_9FLAO/97-217              .............lnkfgkitnketlnkfkpfmsdgiqfdtlqdfysymkqegg---------.-------------------------..--..---...-.-.-.-----.....................----LG.....VF..HAK...T.KQLFLTKEPTELMSFHEKMH.VKHYLEIG-..E..KYH.......S.............L.........P..........SW..................ER....ETYVFLEIWKQ..KHL...YTKQELEFSLKYVD.LYRK-e...................
A0A345H8U1_9FLAO/625-761             ...................yggrvlskvdledwavflkkkyrtnlqrvdsfddp---------.-------------------------..--..---...-.-.-.-----.....................--KVLA.....QF..DPN...T.NTIKYKDDVTEYFMAHESFH.AEEMYKLGF..D..EFV.......K.............D.........A..........ALlgvrmedy.tpenwirvyKR....EKYVYDKLIENseKYN...LNQEEMFHAFRYF-.-----dyimyq..............
A0A653TRD7_9FLAO/52-202              ...............................................eidfmvs--------R.KIGNLGGKILTASQIRQLRSFLKQK..GI..HLI...V.E.G.DIKSItklfkpidefknidelfyamrAKGFPG.....GF..NAH...T.KQFYLSKNATEIVQFHELAH.LKHYEELG-..E..AYL.......S.............L.........S..........RL..................EK....ETYVWKEIFAN..KSK...WTKPELQDALNYIN.KIRV-r...................
A0A243W520_9BACT/16-154              ..................pvsfeerrrsgtgylgskrltkrmlgmyrpilaany---------.-------------------------..QV..TLI...V.L.K.KGSPVla................ymdANGMRA.....GF..SAP...Q.QTIYIRRDATYFELAHEMKH.AKHWAQVGA..Q..PYQ.......D.............L.........S..........TL..................EK....ETYVFQELLRE..KHN...LTSAELLDAFRYIN.KIRA-d...................
A0A345H8U3_9FLAO/1-63                ...............................................mkalnke---------.-------------------------..TE..LVI...L.P.K.SHELL.....................E-ENRA.....AF..NAF...T.NKIYVQKGMTEYEIFHEYKH.LEEYTKLGK..E..E--.......-.............-.........-..........--..................--....-----------..---...--------------.-----s...................
A0A5C6AUN8_9BACT/4-128               ...........................................grvtgtrltsa---------.-------------EFDALRSVLSND..DV..WLS...V.G.K.LDA--.....................NGNVVI.....KF..RPNergK.AELHLPTNATSYEKLHELGH.FEHWKSLGK..NynEWI.......K.............L.........S..........QV..................DR....ERWVLDWMRSN..HWN...--------------.-----sissaerknaieqllhalre
A0A4D6BEX9_9CAUD/319-447             ...............................................rmyrnkd---------.---ANKRRTVNITRQNKLTKDFRKR..GG..VIW...QdD.E.SESYL.....................RSRKAS.....AM..NLN...A.DTIVLQKKATVSEILEELFH.AEQWRD-GRlvD..TPI.......S.............K.........I..........KA..................EI....EAQNYLLSVEK..RYN...IPRVEVEQTKRN--.-----lqywree.............
A0A449BD23_HAPAX/76-198              ............................egtrfnfnvntvkqsitlyakwdvdv---------.-------------------------..-F..KVE...Y.D.F.AGGEL.....................PNEEARksyptEF..SFD...S.SIVYFKPSDSSTHPIHESYGrFTGWREIPQ..S..EYI.......K.............L.........S..........SE..................EK....EKYPFIELLRP..KSD...LK------------.-----tlypdliikly.........
A0A345HF37_9FLAO/10-55               ............................................gspeqqlire---------.-------------------------..--..---...-.-.-.-----.....................------.....--..---...-.--------------------.---------..-..---.......-.............-.........-..........-Y..................KR....ENYVYHEIFKN..KNK...FSQKELDNARKYIN.KI---ikd.................
A0A6C2YIL1_9BACT/26-132              ...............kflanadyiiaqlnynaatltiskdvevlikiegkltpt---------.-------------------------..--..---...-.-.-.-----.....................------.....--..TLK...P.GTVLFRSDATRYVVLHEAAH.YRQMAELGL..D..AYR.......S.............Q.........G..........QL..................AR....ETHVHKYLMQR..KHL...LSEREIADA-----.-----k...................
A0A653TMZ5_9FLAO/66-198              .........................lggqklsrqeiklwinkidkisngkaalr---------.-------------------------..--..--I...I.D.E.TDNLL.....................A-GKQA.....GF..NPF...T.QEIFLKKGFTEYEIFHEFSH.LEEFIKLGK..D..NYI.......KgmkvisgnleldlI.........R..........TY..................KR....EMYVYNKILEN..GNK...FNKKELLHAY----.-----eknilpv.............
A0A1H4SDY0_9FLAO/569-702             ............................nkadggvkltrnqllklkndlelkfk---------.-----------------------EL..NL..KVE...I.V.T.KTPKFkarl............kkwngLRNTQG.....SF..NPG...PpPTIYVRQNCTQLTLQHEVWH.MEDLKRFGN..L..EYR.......K.............K.........P..........NW..................KH....EESVWNNIWET..KHR...WTNEELVDSYWY--.-----yvkes...............
#=GC seq_cons                        ..................................................h.hh...............................................h........hh.......................thtu.....uF..s.t...s.tplhl+pssT.hphhHEhhH.hcpatclGp..-..tYh.......p.............h.........s..........ph..................c+....EpaVacplhcs..+ph...hsptEl.cuh.hh.......h...................
//