#=GF ID Tox-REase-3
#=GF AC PF15647.10
#=GF DE Restriction endonuclease fold toxin 3
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 25.00 25.00;
#=GF TC 25.00 28.10;
#=GF NC 23.60 20.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF CL CL0236
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028905;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted toxin of the restriction endonuclease fold present
#=GF CC in bacterial polymorphic toxin systems. In bacterial polymorphic
#=GF CC toxin systems, the toxin is exported by the type 2, type 6, type
#=GF CC 7 or PrsW-peptidase dependent secretion system [1].
#=GF SQ 30
#=GS A0A8A4TJN0_9BACT/3643-3751 AC A0A8A4TJN0.1
#=GS A0A6V8MCF3_9BACL/404-511 AC A0A6V8MCF3.1
#=GS V9G5H8_9BACL/1-56 AC V9G5H8.1
#=GS A0A6G3SGW0_9ACTN/1082-1188 AC A0A6G3SGW0.1
#=GS K0ET12_NOCBR/2-84 AC K0ET12.1
#=GS A0A080KBC9_9GAMM/242-348 AC A0A080KBC9.1
#=GS A0A2D3UA94_STRC0/1448-1556 AC A0A2D3UA94.1
#=GS W7SIA6_9PSEU/3-109 AC W7SIA6.1
#=GS A0A090BVF8_9GAMM/32-107 AC A0A090BVF8.1
#=GS A0A090ZAB0_PAEMA/589-696 AC A0A090ZAB0.1
#=GS A0A0Q6AA06_9FLAO/29-89 AC A0A0Q6AA06.1
#=GS A0A7Y0B441_9ACTN/1449-1557 AC A0A7Y0B441.1
#=GS A7BRQ9_9GAMM/6-110 AC A7BRQ9.1
#=GS A0A1V4SDK6_RUMHU/9-115 AC A0A1V4SDK6.1
#=GS D3EM28_GEOS4/580-688 AC D3EM28.1
#=GS A0A1X7HNX2_9BACL/253-362 AC A0A1X7HNX2.1
#=GS A0A269VMW2_9BACL/78-187 AC A0A269VMW2.1
#=GS A0A8J3CEB3_9PSEU/1214-1322 AC A0A8J3CEB3.1
#=GS A0A098MDE3_9BACL/284-393 AC A0A098MDE3.1
#=GS A0A368KM68_9BACT/359-464 AC A0A368KM68.1
#=GS S5UWF0_STRC3/1459-1567 AC S5UWF0.1
#=GS Q9K120_NEIMB/359-465 AC Q9K120.1
#=GS A0A8J7EC72_9CYAN/116-222 AC A0A8J7EC72.1
#=GS A0A7W7RKH5_9ACTN/1-65 AC A0A7W7RKH5.1
#=GS M3CDP5_STRMB/1481-1589 AC M3CDP5.1
#=GS K9WVQ9_9NOST/737-836 AC K9WVQ9.1
#=GS A0A069DN78_9BACL/272-380 AC A0A069DN78.1
#=GS A0A1H8YNI6_9PSEU/71-178 AC A0A1H8YNI6.1
#=GS A0A7W9US26_9ACTN/1444-1552 AC A0A7W9US26.1
#=GS S0FQT2_RUMCE/653-763 AC S0FQT2.1
A0A8A4TJN0_9BACT/3643-3751 .......kilptg------DID..PAADALAKRLKGEASVkm.egFGN..REFDAISQEYVAQTFGGESFafKPKSFLSKRRRNQIRETLRAARETGREAFFEFVGNrP.AQEV........VDF.........INRN-------adrinak.......
A0A6V8MCF3_9BACL/404-511 ..........glr---QAAKED..AGADLLAKKLGGQSRMifnndPKG..REFDVISDQYIGQTKTSMNS..-----LSSQFREQAKATIEAAIETGRQAYFHFETA.P.ADKVir....qlREY.........-----------ekrynveividis.
V9G5H8_9BACL/1-56 .............---------..----------------.....---..--------------------..-----MNKKVRDQMKATFEAAEQTGKKVYYHFEGE.P.AQSVid....klHEYsqrygidvhID---------tdp...........
A0A6G3SGW0_9ACTN/1082-1188 .............ELQKVPKPD..PAADKLAEKLGGESRMkfendPSG..REFDAISDDYVAQTKPEGMQ..-----MGSAFRNQAKATFERAIESGRTPYFHFEGQ.P.TAEVvs....klQDY.........-----------grrygldpvidi..
K0ET12_NOCBR/2-84 ........kfgnd---------..----------------.....PSG..REFDVVSDEFIGQVKPGGQQ..-----LGSAFRNQGKESFEAARATGRKVYYHFDGE.P.GPGVid....klYEY.........-----------sarygvdvvidtt.
A0A080KBC9_9GAMM/242-348 ............g-LVKVNKPD..AAADALAQRIGGVSRVr..faNDG..REFDCISDMYIAQTKPALQQ..-----LNKSVRVQMKATFEAAKDTNRSVYYHFEGQ.P.SQSVin....klNEYsnrygvkvvI----------dtnp..........
A0A2D3UA94_STRC0/1448-1556 .............ELVKVHKPD..PAADALAERLGGESRVkfendPKG..REIDAISDEYVAQSKPEGMQ..-----MGSALRNQAKATFEYALQSGRTPYFHFDGE.P.GPGVid....klKEYgrrygiepvI----------dttp..........
W7SIA6_9PSEU/3-109 .............NLVKVNKPD..ADADKLAERIGGESRMkfendPAG..KEYDTITDRYVAETKPANFT..-----LNKDWRRQAKAVFDMAVKTGRTPYFHFEGP.P.GPGVle....alKRY.........A----------eryaiepvidl...
A0A090BVF8_9GAMM/32-107 nrkksgkqhgqag--------K..PYEEVVREKTFVKSEV.....ING..REIDSFTNDALIQAKDSESAvnKPHNFLNKKTRTQIKETV-----------------.-.----........---.........-----------vfl...........
A0A090ZAB0_PAEMA/589-696 .........glkq----SAKED..AGADLLAEKLGGQSRMifnndPKG..REFDVVSDQYIGQTKTSMNS..-----LSSQFREQAKATIEAAIETGRKAYFHFETA.P.VDNVir....qlREY.........-----------ekrydveiiidis.
A0A0Q6AA06_9FLAO/29-89 ....gmgtghvgv---------..----------------.....---..--------------------..-----FGKSFRNQAKATFEDAKATNRGVYYKFDSQ.P.AQSIve....klNEY.........-----------slrynvklki....
A0A7Y0B441_9ACTN/1449-1557 ...........dl--IEVTKPD..ADADKLAEKLGGEPRRrfandPDG..REFDAISDEYVAQAKPADFT..-----LNKKFRKQAQATFEAALQSGRTPYFHFDGP.P.GPGVid....klQEYgrrygvepvID---------ttp...........
A7BRQ9_9GAMM/6-110 ....sgkelgeag------K--..QYEMDVREKTGGQSEI.....LEE..KEIDSVTENALIQAKDSQSAihKPKNFLNKKTRNQIKTTIKMAQQQHKSAEFWFKLE.P.HQEV........QQY.........IEQHGGKV---iiw...........
A0A1V4SDK6_RUMHU/9-115 ............d-LKKVDSPD..PAADKLAERINGESRVrfsndTTG..REFDAISDRYIAQSKPADFK..-----LGSSFRNQAKATFEAASQNGKQPYFHFEGS.P.SSSVls....kiAEY.........-----------afrygiepiidi..
D3EM28_GEOS4/580-688 .............ELQKVNKPD..AAADALAERLGGESRMkfdsdPIG..REFDAISDEYVAQTKPALQQ..-----VNKKVRDQMKATFEAAEQTGRKVYYHFEGE.P.AQSVid....klHEYsqrygievhID---------tdp...........
A0A1X7HNX2_9BACL/253-362 .............ELVKVPKGD..EAADMLSKKLGGQSRVkfsndPNR..REFDTISDQYIAQTKPPLNS..-----LDKQFRKQAKATIEAAIETGRKAYFHFEGK.P.DDRVlr....qlKEYaerygveiiID---------tkpl..........
A0A269VMW2_9BACL/78-187 ............n-LEVVNKPD..AAADALAGRIGGQSRVkfsndPAH..REFDAISDQYVAQSKPALQT..-----VNKSIRDQMKATFEAAQETGRKVYYHFEGQ.P.AQSVid....klNEYssrygieviIDTK-------pl............
A0A8J3CEB3_9PSEU/1214-1322 ..........llk---SANKYD..PQAEGLAKRIGGETQMhfandPDG..REFDVVSDRFIGEAKPENFK..-----LGKDFRSKARAMFNICKETGRAPYFQFQGE.P.HRDViraiqryaKEY.........-----------giepvvdtnp....
A0A098MDE3_9BACL/284-393 ............t-LEKVNKPD..AAADALADRIGGQSRVkfsgdSAG..REFDAISDQYVAQSKPALQT..-----VNKSVRDQMKATFEVAQETGRKVYYHFEGQ.P.AQSVid....klNEYssrygidvvIDTK-------pl............
A0A368KM68_9BACT/359-464 ............k-LVKVDSPD..PAADALAKRLGGESRVk...fSNGpdNEFDAVSDLYVAQSKPANFV..-----INKKFRDQAKATFETAIQSGRKPYFHFEGP.P.HRDVlr....klEEY.........-----------gkrygvdpvidi..
S5UWF0_STRC3/1459-1567 .............NLVKVNKPD..PAADALAERLGGESRVkfehdPKG..REIDAISDDYVAQSKPGGMQ..-----MGSALRNQAKATFEYAIQSGRTPYFHFDGE.P.GPGVia....klQEYgrrygiepvIDTK-------p.............
Q9K120_NEIMB/359-465 .............QNAKYREALdiHYEDLIRRKTDGSSKF.....ING..REIDAVTNDALIQAKRTISAidKPKNFLNQKNRKQIKATIEAANQQGKRAEFWFKYG.V.HSQV........KSY.........IESKGGIVKTGl.............
A0A8J7EC72_9CYAN/116-222 ...........gl--VTVNKPD..SAADALATKIGGQPRVrfasdADS..REFDAVSDEFIAQAKPAVGS..-----VSRKFRNQAKATFEAAQQTGRKVYYEFEGQ.P.TGDVin....alKRY.........-----------esrygvevvidv..
A0A7W7RKH5_9ACTN/1-65 ............m---------..----------------.....---..-----------AQAKLSRVQ..-----VNKTFRNQAKAAFEAASQSGRSVYYHFQGG.PlSPEV........RSR.........LE---------eyanrygvdlvidd
M3CDP5_STRMB/1481-1589 ............k-LIKVRKPD..PAADALAERLGGESRVrfehdPKG..REIDAVSDEYVAQSKPGGMQ..-----MGSALRNQVKATFEHAIQSGRKPYFHFEGE.P.GPGVia....klREYgrrynidpvI----------dttp..........
K9WVQ9_9NOST/737-836 ............e-IGKAGK--..DWEEAVQKKTGGKSAI.....IEG..REIDSVTDEALIQAKNINTS..NPKNFLNKKTRTQIKETIRLADERGKRAEFWFKEE.P.HPLI........REY.........IENKRGIVKVG..............
A0A069DN78_9BACL/272-380 ...........gl--KQANKED..VNADLLAKKIGGQSRMifnndPKG..REFDVISEQYIGQTKTSMNS..-----LSSQFREQAKATIEASIETGGKAYFHFETA.P.ADKVir....qlKEY.........-----------ekrynveividiss
A0A1H8YNI6_9PSEU/71-178 ...........al--SQVNKPD..AAADELAAKLGGVSRVkfandPDG..REFDAISDLYVAQTKSTRVK..-----MGSKFRNQARMTFEFAKQSGRIPFFHFEVP.P.DPEVla....kiAEY.........-----------grrygidpvvkig.
A0A7W9US26_9ACTN/1444-1552 ............e-LHEVNKPD..PDADKLAEKLGGEPRRrfandPDG..REFDAISDEYVAQAKPADFT..-----LNKKFRKQAQATFEAAIQSGRTPYFQFDGP.P.GPGVid....klQEYgrrygvepvID---------ttp...........
S0FQT2_RUMCE/653-763 ............k-LVQVNKAD..AAADALASRLGGQSRVkfandSVG..REFDAVSDAYIAQTKPALQT..-----VNQSVRNQMKATFEAAQETGRKVYYHFEGQ.P.AQSVin....klNEYsqrygidviI----------dtnplm........
#=GC seq_cons ................pssKsD..ssADtLAc+lGGpSRh+FtpDssG..REFDulSDpYlAQoKPuh.p.......ls+phRsQuKATFEsAhpoGRpsYFHF-Gp.P.ussVlp....pLpEY.........h..........sp............
//
