#=GF ID Tox-REase-9
#=GF AC PF15650.10
#=GF DE Restriction endonuclease fold toxin 9
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 27.30 27.30;
#=GF TC 27.40 27.40;
#=GF NC 26.70 26.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF CL CL0236
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028902;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted toxin of the restriction endonuclease fold present
#=GF CC in bacterial polymorphic toxin systems. In bacterial polymorphic
#=GF CC toxin systems, the toxin is exported by the type 2 or type 7
#=GF CC secretion system [1].
#=GF SQ 40
#=GS A0A1W1ZJG6_9FLAO/1149-1235 AC A0A1W1ZJG6.1
#=GS B7GLX9_ANOFW/208-295 AC B7GLX9.1
#=GS A0A1H4D5M5_9BACT/62-149 AC A0A1H4D5M5.1
#=GS A0A2T7Q227_9BACT/1044-1130 AC A0A2T7Q227.1
#=GS A0A4R4NF49_9ACTN/372-466 AC A0A4R4NF49.1
#=GS A0A0F0GLE2_LENAE/1010-1084 AC A0A0F0GLE2.1
#=GS E3IWI9_FRAIE/3211-3306 AC E3IWI9.1
#=GS F8KV51_PARAV/1-49 AC F8KV51.1
#=GS A0A5B8VMY5_9BACT/428-515 AC A0A5B8VMY5.1
#=GS A0A8J7WUS9_9ACTN/61-156 AC A0A8J7WUS9.1
#=GS R5G6W7_9FIRM/1512-1589 AC R5G6W7.1
#=GS A0A1T5M3S2_9MICO/1994-2079 AC A0A1T5M3S2.1
#=GS A0A3P1SAY0_9ACTO/2-89 AC A0A3P1SAY0.1
#=GS A0A4U1IXD0_9DELT/160-245 AC A0A4U1IXD0.1
#=GS A0A2U9PAK3_STRAS/3464-3549 AC A0A2U9PAK3.1
#=GS A0A4U0NHW9_9SPHI/1-30 AC A0A4U0NHW9.1
#=GS F8KV49_PARAV/144-193 AC F8KV49.1
#=GS G8M231_ACECE/2887-2974 AC G8M231.1
#=GS A0A3M0I078_9ACTN/29-114 AC A0A3M0I078.1
#=GS C5BI71_TERTT/1669-1752 AC C5BI71.1
#=GS A0A2P8B2N5_9ACTN/1763-1849 AC A0A2P8B2N5.1
#=GS Q5L196_GEOKA/2214-2301 AC Q5L196.1
#=GS A0A1I3P1V1_9PLAN/2373-2457 AC A0A1I3P1V1.1
#=GS A0A2W2B5B1_9HYPH/358-443 AC A0A2W2B5B1.1
#=GS A0A4U1ILA9_9DELT/388-474 AC A0A4U1ILA9.1
#=GS A0A0G3A7N4_9DELT/1-48 AC A0A0G3A7N4.1
#=GS A0A1I5G881_9ACTN/2218-2303 AC A0A1I5G881.1
#=GS A0A4U0NHK2_9SPHI/1237-1322 AC A0A4U0NHK2.1
#=GS A0A1Q2HTR7_9CORY/40-126 AC A0A1Q2HTR7.1
#=GS A0A512RP98_9BACT/1341-1429 AC A0A512RP98.1
#=GS H1Z991_MYROD/1194-1282 AC H1Z991.1
#=GS A0A1H4D3T6_9BACT/31-108 AC A0A1H4D3T6.1
#=GS A0A2T5JGX0_9SPHI/15-70 AC A0A2T5JGX0.1
#=GS H8KTP5_SOLCM/1076-1163 AC H8KTP5.1
#=GS A0A3P1SDP6_9ACTO/2-92 AC A0A3P1SDP6.1
#=GS F9Z4D9_ODOSD/1467-1553 AC F9Z4D9.1
#=GS A0A037ZEC1_9RHOB/379-460 AC A0A037ZEC1.1
#=GS A0A2U2ZK35_9ACTN/1-73 AC A0A2U2ZK35.1
#=GS A0A1I5Z4E8_9BACT/1-81 AC A0A1I5Z4E8.1
#=GS A0A4P7SKM3_9CELL/1-78 AC A0A4P7SKM3.1
A0A1W1ZJG6_9FLAO/1149-1235 ......................................YTKSSLKLGQQMHKSYK..--..--VG.ADG.IKE....FRLPS.G..K...R..ID..FLDINN..RTIY...ELKPFNPRAMQQGQKQLNMYMQELQt......mpQFKG..I...NWKTVLDTY...........
B7GLX9_ANOFW/208-295 ......................................YTKSNLKLGRQMHKSYK..AN..KVLK.GVR.EKE....FRLPS.G..K...R..ID..FIDFEK..KIIY...ELKPNNPRAIKKGLKQLKAYKKEVE.........KIYG..K...GWRTVLEVY...........
A0A1H4D5M5_9BACT/62-149 ..................................gstv----ANRLGQQMHKAYK..AG..DVLD.GVR.IKE....FMLPS.R..K...R..ID..FIDLEK..KIIY...ELKPNNPRAIKQGYKQLEMYKQEVE.........SIYG..K...GFKTILDTY...........
A0A2T7Q227_9BACT/1044-1130 ......................................FTKSSTSLGQQMHRAYK..--..--VG.MDG.IKE....FRLPS.G..K...R..ID..FLDITN..KTVY...ELKPFNPRAMQQGEKQLQTYIQELQs......mpEFKG..I...QWQKVLDTY...........
A0A4R4NF49_9ACTN/372-466 ....................................gn--NSAAATGRSVHRDFSdlLD..SRSQ.VGY.EGE....FTLPS.G..L...R..PDggYTDPATgvRVPI...ELKPDTRAQIRRGRNELREYEQEMGv.......pTGSG..Q...LWVYRI---ga.........
A0A0F0GLE2_LENAE/1010-1084 ............................dqmprgldpe-----------------..--..----.---.-FE....LDLPD.GgtK...R..LD..RVDWDN..RVIY...EIKPNNPVEIAKGQQQVKLYVHYMN.........QQTGlpG...GWSGKVVTY...........
E3IWI9_FRAIE/3211-3306 .....................................g-SNPAARTGQQVHKDFS.tIL..NGYGdVGY.EGE....FKLPS.G..L...R..PDgaFTDPATgvRVPV...ELKPDTRSQIRRGLGELRVYEQEMGv.......pSGSG..Q...LWVYRVNP-q..........
F8KV51_PARAV/1-49 ....................................mi-----------------..--..----.---.---....-----.-..-...-..--..-----N..HIIY...ELKPFNPRSIKLGNKALEIYKQELQt......mpRFEG..I...EWETILETY...........
A0A5B8VMY5_9BACT/428-515 ......................................FTKSSLKLGQQMHKEYK..VE..DVVE.GIA.VKE....YRGIP.G..I...R..PD..FVNFST..KTIY...ELKPNNPRAIKQGYKQLAKYKGIFE.........KQLG..G...TWKTVLDTY...........
A0A8J7WUS9_9ACTN/61-156 ..................................gnna----FAATGRQVHKEFS.dTL..DEYGaIGY.EGE....VTLPS.G..L...R..PDgvYTDPVTgvRVPI...ELKPDNPRQIARGLKELGAYEQEMGv.......aSGSG..Q...LWVYRTN--pq.........
R5G6W7_9FIRM/1512-1589 .....................................s-TISDIKTGREIHNGFM..--..---V.GID.GKE....FPLKKtK..K...R..AD..HLDDNL..KIIR...ELKPRNEKSAIKGIKQISNYNAIMG.........GNY-..-...---------rlili......
A0A1T5M3S2_9MICO/1994-2079 ...................................gen---ADAARGRATHLNYR..--..DALG.GGY.DYE....VRLDS.G..R...R..PD..AVNWAT..REVR...ELKSDAPSSMARGRRQLQGYVSELE.........SMTG..Q...PWTGHLDIY...........
A0A3P1SAY0_9ACTO/2-89 ..................................esle-----AAAGRRAHEMYP..LA..VGQD.QGYlFNR....AIRGS.N..L...R..PD..ALNYRE..RIVR...ELKPDTPSGRSQGKRQLAMYVAELR.........RTTG..E...EWTPQLDLY...........
A0A4U1IXD0_9DELT/160-245 ...................................get---PATKRGREVHKEFKkkVEekEAKG.WRA.EKR....IMGPD.G..K...YvvPD..ALTP-K..RNPI...ELKPNTPTGIEAGKRQIKKYEAAT-.........----..-...---------gkkgrviy...
A0A2U9PAK3_STRAS/3464-3549 ....................................gd--NPAAQVGKEVHHHPA..LT..AAFD.AMG.YQR....GPGQG.A..D...Q..PD..FVTPS-..GDPV...ELKPYTKRGAREGTRQLRRYLTNSG.........SSYG..E...LWGYSF---eg.........
A0A4U0NHW9_9SPHI/1-30 ....................................mq-----------------..--..----.---.---....-----.-..-...-..--..------..----...-----------LGTKQLNNYKSLFE.........QKYD..G...TWNTVLDFY...........
F8KV49_PARAV/144-193 ......................................YTRSNLKHGQEMHRLYK..--..--LGvEGV.KKE....FRLPS.G..K...R..ID..ALDEPI.rKLIY...-------------------------.........----..-...---------ppk........
G8M231_ACECE/2887-2974 ......................................YTKSSLKMGQEMHKAYK..AD..VVDN.ITK.FKE....FRLPS.G..K...R..ID..FIDFET..KTIY...ELKPYNPNGIKTGLKQLEVYLKEVE.........SIYG..G...GWKTILDTY...........
A0A3M0I078_9ACTN/29-114 ...................................gen---ADAARGRQTHLNYR..--..NALG.AGY.DFE....VTLPS.G..L...R..PD..AVDWKN..RVVR...ELKSDAKSSQATGRRQLQNYVAELE.........DMTG..Q...SWTGHLDTY...........
C5BI71_TERTT/1669-1752 ....................................kv--AEAAAKGRQMHKDYD..--..--YG.PGF.EKE....VTLPS.G..K...R..AD..AVNWET..REVV...ELKPNNPNAIRRGEKQVEGYRQELQ.........CTTG..E...CWTSRVETY...........
A0A2P8B2N5_9ACTN/1763-1849 ...................................gdn---PDAAKGREIHNSQE.wQD..HLDS.IGY.SRG....RPVTP.R..D...I..PD.gFTDN--..GFPV...ELKRDGQSGIRKGTRQLRRYMNQMG.........VDYG..E...VWVWKVE--v..........
Q5L196_GEOKA/2214-2301 ......................................YTKSNLKLGRQMHKSYK..AN..KVLK.GVR.EKE....FRLPS.G..K...R..ID..FIDFEK..KIIY...ELKPNNPRAIKKGLKQLKAYKKEVE.........KIYG..K...GWRTVLEVY...........
A0A1I3P1V1_9PLAN/2373-2457 ....................................ge--NSYAQRGRQAHQDWD..--..--PG.DGY.QKG....QLLPS.G..R...K..PD..AVNFDT..CHIK...ELKPNNPKAIRKGEIQLQKYIDEYN........iRYPG..K...NFTGCVETY...........
A0A2W2B5B1_9HYPH/358-443 ...................................get---ASTARGRQAHQNYK..--..DALG.DGY.DDR....LRLPS.G..K...R..PD..AVDLTK..REVR...ELKPDNPKAISRGQKQVETYRKELE.........SLYG..G...SWKSYVDTY...........
A0A4U1ILA9_9DELT/388-474 ....................................ge--NPAAARGREVHKEFKkkVK..EKKG.EGW.RAEeridVEGGT.Y..I...R..PD..AVTPKG..-NPI...ELKPNTPSGRDAGKRQIKKYEEVLK.........KK--..-...---------grviyy.....
A0A0G3A7N4_9DELT/1-48 .....................................m-----------------..--..----.---.---....-----.-..-...-..--..--NAEK..QDVK...ELKPNNPRAIKRGEKQVETYRRELE.........EKRG..G...QWTGQVETY...........
A0A1I5G881_9ACTN/2218-2303 ...................................gen---ADAARGRQTHLNYR..--..SALG.AGY.DFE....VTLPS.G..L...R..PD..AVDWKN..RVVR...ELKSDARSSQATGRRQLQKYVAELE.........DITG..Q...SWTGHLDTY...........
A0A4U0NHK2_9SPHI/1237-1322 ......................................YTRSSLKLGQQKHGAYH..--..---A.GEI.GKE....FRLPS.G..R...R..ID..YLDIEN..GIIY...ELKPFNPRAMKAGQNQLDMYMKELQk......mpRFKG..I...NWKTVLDTY...........
A0A1Q2HTR7_9CORY/40-126 ....................................ga--NSHAAYGNKMHKAYS..AE..K-KA.AGY.VTN....SGLPD.S..RgrlR..PD..AYKMNG..RYIAevrEYKPDSPSGLAHGRKQLRAYVD---.........----..-...---------ysekynraiaa
A0A512RP98_9BACT/1341-1429 ......................................YTKSSLSLGREMHKGYK.lAE..HAPE.LGR.FKE....FTGIK.G..I...R..PD..FVDFGT..KTIY...ELKPFNPRGIQMGTQQLNKYKSLFE.........QNYG..G...SWKTVLEHY...........
H1Z991_MYROD/1194-1282 ......................................YTKSSLAFGREIHAGYK.vAE..HAPA.LGR.FKE....FTGIK.G..I...R..PD..FVDFGT..KTIY...ELKPFNPRGIRSGTKQLNNYKSLFE.........QNYG..G...TWKTVLDHY...........
A0A1H4D3T6_9BACT/31-108 ......................................YTKSSLKLGQQMHKGYK..--..--VG.ADG.IKE....FRLPS.G..K...R..ID..FLDIKN..STIY...ELKPFNPRAMQQGQKQLNMYIRSY-.........----..-...---------rqchslkel..
A0A2T5JGX0_9SPHI/15-70 ............................fhsvysaisl-----------------..--..----.---.---....-----.-..-...-..--..--NHIT..NIIY...ELKPFNPKAVQQGLNQLINYMMELQa......mpRFSG..K...AWETV----...........
H8KTP5_SOLCM/1076-1163 ..................................gstv----ANRLGQLMHKAYK..AA..DVLE.GVR.IKE....FRLPS.G..K...R..ID..FIDFEN..KIIY...ELKPNNPRAIKEGYKQLAMYLQEVE.........SIYG..K...GFKTILDTY...........
A0A3P1SDP6_9ACTO/2-92 ..................................esle-----AAAGRRAHEMYP..LA..VGQD.QGYlFNR....GLLDS.R..L...R..PD..AWSGDL..RIVR...ELKPNTPSGLATGRRQLAGYRQEVA.........NTPG..QnveEWTFILDLY...........
F9Z4D9_ODOSD/1467-1553 ......................................FTKSSLKQGRQMHSLYK..--..--LG.ANG.VKE....YVLPS.K..R...R..ID..FLDIEN..KIIY...ELKPFNPRSIKRGIKQLHDYKRELKlv....pefKEY-..-...TWTMILETY...........
A0A037ZEC1_9RHOB/379-460 ...................wqrygveqhkslggssncd-----------------..--..----.-VT.ERA....IPTDS.S..S...R..PD..CFRVPS..CTVV...EFKPNNDAEIRKGEGQLKRYKASLD.........SYYT..D...LLQD-----llkp.......
A0A2U2ZK35_9ACTN/1-73 ....................................ms---------------YK..--..NALG.AGC.DFE....VTLPS.G..L...R..PD..AVDWKN..RVVR...ELKSDAKSSQATGRRQLKQYVAELE.........EMTG..Q...SWTGHLDTY...........
A0A1I5Z4E8_9BACT/1-81 ......................................-----------MHKAYH..--..---A.GKV.GKE....FRLLS.G..R...R..ID..YLDMQN..GIIY...ELKPNNPRAILQGQKQLQMYLQELQspamlqkypQFKG..I...QWKTVLDTY...........
A0A4P7SKM3_9CELL/1-78 mhqrfvrdmarqvywsgrvgidpgtglrgipdatrlgr-----------------..--..----.---.---....-----.-..-...-..--..------..--PV...ELKPDNPRVIARGVRQLARYERAAN.........K-RG..E...LWAYRVS--st.........
#=GC seq_cons .........................................sshthGpphHptYc.........s.hsh..pE....hpLsS.G..h...R...D..hlDhps..+hlh...ELKPsNPpulppGp+QLptYhpEhp.........phhG..t...tWpshl-hY...........
//