#=GF ID Tox-SHH
#=GF AC PF15652.10
#=GF DE HNH/Endo VII superfamily toxin with a SHH signature
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 22.70 22.70;
#=GF TC 23.00 23.70;
#=GF NC 22.00 22.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR028900;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted toxin of the HNH/Endonuclease VII fold present in
#=GF CC bacterial polymorphic toxin systems with two conserved histidine
#=GF CC residues. In bacterial polymorphic toxin systems, the toxin is
#=GF CC exported by the type 2, type 5, type 6 or type 7 secretion
#=GF CC system [1].
#=GF SQ 46
#=GS A0A5C0B3J6_9BURK/1-94 AC A0A5C0B3J6.1
#=GS A0A432VD78_9SPHN/256-352 AC A0A432VD78.1
#=GS A0A1N7G0X4_9GAMM/67-119 AC A0A1N7G0X4.1
#=GS A0A1I0VU81_9CLOT/698-795 AC A0A1I0VU81.1
#=GS O64023_BPSPB/468-570 AC O64023.1
#=GS G8XAJ2_FLACA/48-140 AC G8XAJ2.1
#=GS A0A140FWK6_PSEPK/1-48 AC A0A140FWK6.1
#=GS A0A0M2KLF8_9GAMM/1-89 AC A0A0M2KLF8.1
#=GS A0A7W8DMV2_9BACT/1526-1629 AC A0A7W8DMV2.1
#=GS A0A3A8ZDE6_9BACT/2431-2523 AC A0A3A8ZDE6.1
#=GS A0A518E005_9BACT/293-389 AC A0A518E005.1
#=GS L8J721_9GAMM/1333-1433 AC L8J721.1
#=GS A0A7G5CHK8_9CAUD/468-570 AC A0A7G5CHK8.1
#=GS A0A0M0KZW2_9BACI/37-137 AC A0A0M0KZW2.1
#=GS A0A1K1LN93_9BACT/961-1061 AC A0A1K1LN93.1
#=GS A0A6M8UFZ4_9GAMM/1363-1456 AC A0A6M8UFZ4.1
#=GS A0A085GP00_9GAMM/1428-1521 AC A0A085GP00.1
#=GS A0A8J4A8V6_9ACTN/1133-1228 AC A0A8J4A8V6.1
#=GS G2Z5N4_FLABF/1428-1521 AC G2Z5N4.1
#=GS A0A8J3Q2Q2_9ACTN/2455-2556 AC A0A8J3Q2Q2.1
#=GS A0A0W7YG86_9BACI/107-201 AC A0A0W7YG86.1
#=GS A0A7X2J080_9BACI/43-91 AC A0A7X2J080.1
#=GS A0A7W8DN23_9BACT/1811-1911 AC A0A7W8DN23.1
#=GS B8I5J4_RUMCH/1231-1327 AC B8I5J4.1
#=GS A0A419SZH3_9FIRM/2297-2393 AC A0A419SZH3.1
#=GS A0A317DK75_9ACTN/2440-2540 AC A0A317DK75.1
#=GS A0A147KCV0_9BACI/1-93 AC A0A147KCV0.1
#=GS A0A1H0QG91_9CLOT/215-311 AC A0A1H0QG91.1
#=GS A0A2N7WGI8_9BURK/68-163 AC A0A2N7WGI8.1
#=GS YOKI_BACSU/468-570 AC O31998.2
#=GS A0A1V4H6I7_9BACL/21-127 AC A0A1V4H6I7.1
#=GS A0A0A5GLR4_9BACI/1-93 AC A0A0A5GLR4.1
#=GS A1TSU8_ACIAC/1484-1581 AC A1TSU8.1
#=GS A0A6L9Y6V8_9BURK/1-47 AC A0A6L9Y6V8.1
#=GS A0A2G3K623_9BURK/5210-5308 AC A0A2G3K623.1
#=GS Q88FK6_PSEPK/1424-1526 AC Q88FK6.1
#=GS S0FSE6_RUMCE/664-762 AC S0FSE6.1
#=GS A0A4S5BE24_9BURK/179-271 AC A0A4S5BE24.1
#=GS Q7N9I4_PHOLL/1-35 AC Q7N9I4.1
#=GS A0A0B6RV08_BURPL/1450-1546 AC A0A0B6RV08.1
#=GS A0A402AVM6_9CHLR/572-674 AC A0A402AVM6.1
#=GS A0A7W8DMK9_9BACT/215-315 AC A0A7W8DMK9.1
#=GS A0A1M6AY88_9CLOT/790-888 AC A0A1M6AY88.1
#=GS A0A2I0QQN4_9BACI/310-398 AC A0A2I0QQN4.1
#=GS A0A4S5BFQ9_9BURK/1298-1398 AC A0A4S5BFQ9.1
#=GS K9GMN9_9PROT/248-344 AC K9GMN9.1
A0A5C0B3J6_9BURK/1-94 ....---MQSHHTIQDAWAKVNVS--..-..GYSRGS.APAILLPV........sSQHSTVTALRNA...RRDER..LANGQPKWGTSMEDEFRNSYRDLGA.AGVSEKCKRKAIKQACKN.F-v.............................
A0A432VD78_9SPHN/256-352 ..ta--LLQAHHGMQNELLTRLFGRF..-..GYNGDA.APTIMLRDsr.....sgSPHGMITAVQNG...ARAAR..SGSGV-TLS----NIREWAIADLRM.SGMPDRDIALYLRTFDTY.F-e.............................
A0A1N7G0X4_9GAMM/67-119 ....DDQIQSHHPIQNAWAKKKIE--..-..SYNEND.AYGVLLPSs......sgMSHAKISVSQRT...RRKK-..-------------------------.------------------.--..............................
A0A1I0VU81_9CLOT/698-795 ....DGLIESHHPIQNEWAEQWAKKN..NisGYKKRN.APGILLKSi......sgESHAKLSSSQRA...RRRK-..-----DGFNTSIVYEFNTGYKELIE.SGVNSKYAKKAIREAYRY.FD..............................
O64023_BPSPB/468-570 ....NSPLENHHGVMDVWAKHNVPNY..-..-VSRGSnTPTVALTK.........EQHNATKKVYREwlfEKTGK..KVGGKVNWKEVSPREIQELTEKMFDaANVPKEARQQYYNAFNQYnF-r.............................
G8XAJ2_FLACA/48-140 ....DDFIQSHHSIQDAWAKKNIN--..-..GYNRDL.APATLLPSs......sgMSHAKISAAQRS...RRAS-..----N-GWNTTLKEEFNTSYKEMLD.AGVPKSQAQKALKDSYKY.FD..............................
A0A140FWK6_PSEPK/1-48 ...m----------------------..-..------.--------.........---------YREwlrEKNGK..PVEGKVDWSQISNREVMQLSERMFDaAGVPATSR----------.--si............................
A0A0M2KLF8_9GAMM/1-89 ..ms----------------KNVPSY..G.gKYPTNS.-PTIALSA.........DNHAATKATYRDwlkQKTGK..PVGGKVDWSTVSNREMKNLSEKMFDaANVPAASRDAYYRAVNQY.L-y.............................
A0A7W8DMV2_9BACT/1526-1629 ..st--PNQNHHGFMNAWLSEHFPTTylG..RMWEED.FPCVELSP.........ENHSKATAVERQ...FRQQKglPPFGNTSWKDVTPQEAIKLMKDSLHaAGAPDELWKVVLNQTN--.--gwlk..........................
A0A3A8ZDE6_9BACT/2431-2523 ...e-GRVQSHHVIQDKWAQKNVP--..-..GYNRND.ATAILLETg......tgKPHTSITNSQRE...RRST-..-----VGYNTSIQDEFNSSYRDLID.AGVDEKTARKAIKDAYKY.FD..............................
A0A518E005_9BACT/293-389 ..gn----ESHHGVMSAWMKRNFA--..-..DYSPNK.APAVLMPK.........ANHNATRGVYNTw.rAEMRQ..QMGGTFDWGKVSQADMRALSDKMFDaAAVPQKIRAEYWTEFEK-.--mln...........................
L8J721_9GAMM/1333-1433 ..gg--RLQSHHGLQQQWAKENISEY..-..DYDASL.APSITIETg......kgFPHTEISKRQNA...RRDAR..IKAGEGKWSSSLQDELQFIVDDMRA.AGFKKKTIEKVLQQQYKM.--ld............................
A0A7G5CHK8_9CAUD/468-570 ....NSPLENHHGVMDVWAKHNVPNY..-..-VSRGSnTPTVALTK.........EQHNATKKVYREwlfEKTGK..KVGGKVNWKEVSPREIQELTEKMFDaANVPKEARQQYYNAFNQYnF-r.............................
A0A0M0KZW2_9BACI/37-137 ..gg--KLQSHHGLQQELAKNNLSQY..-..GYDSKL.APTITIETg......kgLPHTAITNAETA...RRNER..MASGVGKWSTTLQEELQFMVDDLTK.AGFLRNTTSQVLEKQYKM.--ld............................
A0A1K1LN93_9BACT/961-1061 ..rn--FFQSHHGIQDAWARERFDGL..G..VYRRDD.APALLLRTrnfaegsrgTPHGLINDLQGA...RRPT-..-IATR-----TFAEERAFLVSDMNA.VGVPAGVQGPYLAEVDAY.F-g.............................
A0A6M8UFZ4_9GAMM/1363-1456 ....DGFVQSHHPIQDAWAKKRIN--..-..DYQRNS.APATLLKSs......sgSPHAAISTAQRA...RRAA-..----TGGWDTTLKQEFNISYKEMLD.AGVPTNQARKSLGDAFKY.FD..............................
A0A085GP00_9GAMM/1428-1521 ....DGFVQSHHPIQDAWAKKRIN--..-..EYQRNS.APATLLKSa......sgSPHAKISAAQRA...RRAL-..----PGGWDTTLKQEFNVSYREMLN.SGVPAKQARQSLNDAYKY.FE..............................
A0A8J4A8V6_9ACTN/1133-1228 ....NNFFQSHHGIQNEWAKQRFGRL..-..-YDPDA.GRCILLRDrh.....arTPHRIVSARQAT...RMKTT..PF-GK----RTYEMERSWMMEDLTE.AGVSKPVRDRMLRESDQY.FE..............................
G2Z5N4_FLABF/1428-1521 ....DGFVQSHHPIQDAWAQKRVS--..-..GYNRNT.APATLLKSq......sgSPHAKISAAQRT...RRAK-..----QGGWDTNLKEEFNTSYREMID.SGVSPKQAKKAIKDSYKY.FD..............................
A0A8J3Q2Q2_9ACTN/2455-2556 .hag---LENHHGVLDVWAKHNVPGY..T..SRAAG-.STTVALAP.........AEHAATKVVYRDwleGMTGK..RVGGKVDWTTVGPRDAFNLSERMFDaAGVSQTTRNAYYAEFNRY.I-y.............................
A0A0W7YG86_9BACI/107-201 ....DSLVQSHHFIQQEWVRQNLKGA..S..KINRNS.-PAILVRSs......sgQPHAQISRLQNL...RRAN-..-----SGYNNSLKSEFNIAYREMVQ.AGVSKKHIQRLAKEAYKY.FN..............................
A0A7X2J080_9BACI/43-91 ....NSPIENPHSVMDVWGKYRVPNY..-..-VSRGGiTTTVEQTK.........EQHSPTKAVYRQ...-----..-------------------------.------------------.--l.............................
A0A7W8DN23_9BACT/1811-1911 .ggg---MQSHHGLQQEWALQNLKKY..-..GYHPDL.APTVTLETa......kgLPHSIISAEQNR...RQRQR..ENEGKPPWSSSLQEELGYIVADMSK.AGFKPAVIRSVLEQQYRM.--ld............................
B8I5J4_RUMCH/1231-1327 ....DGLVQAHHPIQDEWAKQWAAAN..G.iPYNSGQ.APTILLESi......sgSNHATLSSLQRI...RRRT-..----E-GFNTDIRYEFNTSYREMLQ.AGVDPSMAKKAIKEAYKY.FD..............................
A0A419SZH3_9FIRM/2297-2393 .tgy----EKHHGVLNEWAEHNIP--..-..GYTKKN.APTVLLTP.........ETHGVTKEVYREwlrENYGK..PVGVSPDWTNVPKTDAMKLTNDMFNaAKVPQNVRNEYFE-----.--lfdif.........................
A0A317DK75_9ACTN/2440-2540 ..pg---MEQHHGVMDAWAKHNIPGY..-..KSRAAD.STTIQLSK.........ANHDATKAVYRDwleARTGR..RVGAKVDWSSVSSREIFDLSERMFDaASVPQKARDAYYTAFDRY.I-h.............................
A0A147KCV0_9BACI/1-93 ....----------MDVWAKHNVPNY..-..-VSRGGnTPTVALTK.........EQHDATKAVYRQwlyEKTGK..KVGGKIDWQSVSPREIQELTERMFAaANVPISARKEYYNSFNKYnF-r.............................
A0A1H0QG91_9CLOT/215-311 ....DGLIEAHHPIQDEWAKQWEKAT..G.kKYSSYK.APTILLRTg......kgEIHSKISALQSE...RWSI-..----E-GFNTDIVHEFNMGYKELIQ.AGAKCKYAKKAIREAYRY.FD..............................
A0A2N7WGI8_9BURK/68-163 .tgy----QSHHVIQDRWAKANEI--..A..GYSYGA.APAILIPQ........nPIHKAISDSQNA...RRDAA..VAAGKDPWSSSIQGPFNYSSQDMRA.AGISDETGLHYNRHRY--.--yaa...........................
YOKI_BACSU/468-570 ....NSPLENHHGVMDVWAKHNVPNY..-..-VSRGSnTPTVALTK.........EQHNATKKVYREwlfEKTGK..KVGGKVNWKEVSPREIQELTEKMFDaANVPKEARQQYYNAFNQYnF-r.............................
A0A1V4H6I7_9BACL/21-127 ..gg--RLESHHGLQGEWAKENLAKY..-..GYDYKE.APTVTLETgkipgankdHPHTELNNRQSE...RRDDR..IAEGKGKWSSTLQEELTFIVEDFKA.LGFTRETIEKIMEQQYKM.--ld............................
A0A0A5GLR4_9BACI/1-93 ....----------MDVWAKHNVPNY..-..-ISRGGnTPTVALTK.........EQHDATKAVYRQwlyETTGK..KVGGKVDWQSVSPKEIQELTQKMFNaAKVPNSARQEYYYAFNRY.--nyr...........................
A1TSU8_ACIAC/1484-1581 ..sd---TESHHIIQDAWAKSQIGKQ..G..GYSTYG.APAILLQN.........GPHDIANAAQNA...RRDAR..LATGRGKWESPLRDEFDNASRDLRA.AGVSERCRKRALKKAYQY.FY..............................
A0A6L9Y6V8_9BURK/1-47 ...m----------------------..-..------.--------.........------------...-----..-VGGKVDWKKITPREISTLTEKMFDsAKVPLESRNNYYRALNQY.L-yr............................
A0A2G3K623_9BURK/5210-5308 ....DNYVQSHHPIQDKWAQENIV--..-..GYDRNA.APAILLESs......sgSPHAKISAAQRS...LRREM..KTNEMNPWGNTINQEFNIGYKQMID.AGVPANQAKKAIKDSYKY.FD..............................
Q88FK6_PSEPK/1424-1526 ....NSPLENHHGILDIWAAQNVPSY..G.gKYPKGS.-PTIVLSS.........KNHAATKAVYREwlrEKTGK..PVGGKVDWSQISNREVMQLSERMFDvAGVPATSRTSYYRALNRY.L-h.............................
S0FSE6_RUMCE/664-762 ..pg---IQNHHGVMDMWAQKNIPGY..K..PRPADS.-TAMALTP.........EQHNATRSVFGK..wKYENY..GFKGQVDWKSISPQQIQKLSEDMFDaAKVPQAARRDYYQEFHRY.I-y.............................
A0A4S5BE24_9BURK/179-271 ....DNRVQSHHAIQQEWAKRNVP--..-..GYDPNA.APAILLPSs......sgMSHAQISAAQRA...FRRN-..----N-GFGTDIRTEFNEAARKMRA.AGVPEAQVRRVINQSYKY.FD..............................
Q7N9I4_PHOLL/1-35 ..mr----------------------..-..------.--------.........------------...-----..------------KEEFHTSYREMID.AGVPKAQARKALGDAYKY.FD..............................
A0A0B6RV08_BURPL/1450-1546 .sgy----QSHHIIQDRWAKANDI--..E..GYNYRQ.APAILIPQ........nPTHKAISDSQNT...RRDAM..VAAGQDPWSTSIQDQFNYSSQDMRV.AGVSDDCRKRALKKAYKY.FD..............................
A0A402AVM6_9CHLR/572-674 ...n-PPLENHHGIMDAWAVENIPSY..V..GRNKEN.-PTVALTK.........SQHAATQAAFREwlfNRTGK..PVGGKTDWQNVSPREIFDLSERMFDaAGVPHDVRYEYYMSFYRY.I-yr............................
A0A7W8DMK9_9BACT/215-315 ...g-GLMQSHHGLQKRWAMHNLAKF..-..GYNHDL.APTVTLETg......tdLQHTIISNLQNA...RRDDR..IASGKGAWSSTLQEELGYIVSDLTA.AGFSRQHISKVLEQQY--.--gmld..........................
A0A1M6AY88_9CLOT/790-888 ..pg---LENHHGVMDMWAQKNIPGY..K..PRPADS.-TAIALTK.........EQHNATRSVFGK..wKYENY..GFKGKVDWENVSPREIQGLSERMFDaAKVPQDARAEYYREFNKY.I-y.............................
A0A2I0QQN4_9BACI/310-398 qkvk----DSHHIIQDA-AVRDLP--..-..LYKRNE.APAIHLQGpn....ikgTEHNIAGQVQRQ...P--G-..--GGT------YAAERRIGYKAMRR.AGVSEGQARREIGSVDQY.F-s.............................
A0A4S5BFQ9_9BURK/1298-1398 ..pg---LENHHGVMDVWATHNIEGY..-..KSRASH.NPTMALEP.........DLHDATKGIYRDwleEKTGR..RVGGKIDWTTISLEEATALSEKMFDaADVPKEARDNYYDAFEKY.--qa............................
K9GMN9_9PROT/248-344 ..ta--LMQCHHGLQNSLMTKLFKTY..-..NYDGGA.APTIWLRNsr.....rgSPHGSITAVQNG...QKSTR..NAAGI-TFEDI--------------.------------------.--rewaiadlritqmpehkiaeylavfdayfe
#=GC seq_cons .......hpsHHsl.ctWAccNlst......tYspss.uPslhLps.........p.Hsthpss.pp...c+ssh...htGpssWsss.tcEhphhhccMhs.AGVsppstpphhpph.+Y.h...............................
//
