#=GF ID ToxB_N
#=GF AC PF18224.5
#=GF DE ToxB N-terminal domain
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF04211
#=GF GA 25.00 25.00;
#=GF TC 26.30 27.20;
#=GF NC 24.80 21.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 25063993
#=GF RT Solution NMR structures of Pyrenophora tritici-repentis ToxB and
#=GF RT its inactive homolog reveal potential determinants of toxin
#=GF RT activity.
#=GF RA Nyarko A, Singarapu KK, Figueroa M, Manning VA, Pandelova I,
#=GF RA Wolpert TJ, Ciuffetti LM, Barbar E;
#=GF RL J Biol Chem. 2014;289:25946-25956.
#=GF DR INTERPRO; IPR041450;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is the N-terminal domain of ToxB found in Pyrenophora
#=GF CC tritici-repentis. This domain is crucial for toxin activity.
#=GF CC There are only two amino acid differences between ToxB and toxb,
#=GF CC an inactive homolog of ToxB. These two differences are a Val at
#=GF CC position 3 in ToxB compared to a Thr in toxb, and an Ala at
#=GF CC position 12 in ToxB compared to a Val in toxb. AvrPiz-t, a
#=GF CC secreted avirulence protein produced by the rice blast fungus,
#=GF CC is a structural homolog to ToxB [1].
#=GF SQ 44
#=GS A0A8H6K491_9PEZI/22-80 AC A0A8H6K491.1
#=GS A0A8H3W4W0_9PEZI/24-87 AC A0A8H3W4W0.1
#=GS A0A8H3ZLY8_9PEZI/24-86 AC A0A8H3ZLY8.1
#=GS K2S1D3_MACPH/97-157 AC K2S1D3.1
#=GS H1W0C4_COLHI/23-83 AC H1W0C4.1
#=GS A0A2J6T063_9HELO/20-81 AC A0A2J6T063.1
#=GS A0A8H6U844_9PEZI/23-83 AC A0A8H6U844.1
#=GS A0A8H3W047_9PEZI/570-628 AC A0A8H3W047.1
#=GS T0LTU1_COLGC/276-334 AC T0LTU1.1
#=GS A0A7J6IF65_COLFN/35-93 AC A0A7J6IF65.1
#=GS A0A7J6IKX4_COLFN/24-87 AC A0A7J6IKX4.1
#=GS A0A484FG33_COLOR/35-95 AC A0A484FG33.1
#=GS A0A135V4Q0_9PEZI/22-82 AC A0A135V4Q0.1
#=GS A0A7J6JH07_COLFN/38-96 AC A0A7J6JH07.1
#=GS A0A1J9QW02_9PEZI/23-82 AC A0A1J9QW02.1
#=GS A0A8H4FE58_COLGL/24-86 AC A0A8H4FE58.1
#=GS T0M3E4_COLGC/24-79 AC T0M3E4.1
#=GS A0A484FKL7_COLOR/86-144 AC A0A484FKL7.1
#=GS A0A6P8AQM4_MAGGR/24-81 AC A0A6P8AQM4.1
#=GS T0M181_COLGC/22-82 AC T0M181.1
#=GS A0A8H4FI93_COLGL/24-87 AC A0A8H4FI93.1
#=GS A0A8H3ZS90_9PEZI/503-561 AC A0A8H3ZS90.1
#=GS A0A1Q8S9N0_9PEZI/241-299 AC A0A1Q8S9N0.1
#=GS A0A8H4N7S9_9PEZI/23-84 AC A0A8H4N7S9.1
#=GS A0A8H4FI15_COLGL/20-78 AC A0A8H4FI15.1
#=GS A0A2V1BZA5_9HELO/23-77 AC A0A2V1BZA5.1
#=GS A0A7J6IS19_COLFN/65-125 AC A0A7J6IS19.1
#=GS A0A8H3W5H3_9PEZI/312-372 AC A0A8H3W5H3.1
#=GS A0A4R8QK08_COLTR/24-91 AC A0A4R8QK08.1
#=GS A0A484FD83_COLOR/24-91 AC A0A484FD83.1
#=GS K7N7F2_9PEZI/23-83 AC K7N7F2.1
#=GS A0A3M7M1U4_9PLEO/25-85 AC A0A3M7M1U4.1
#=GS A0A010RED5_9PEZI/22-82 AC A0A010RED5.1
#=GS A0A4V6DH92_9PEZI/23-83 AC A0A4V6DH92.1
#=GS T0LBR9_COLGC/24-87 AC T0LBR9.1
#=GS A0A4R8QP41_COLTR/215-273 AC A0A4R8QP41.1
#=GS A0A8H6N919_9PEZI/23-83 AC A0A8H6N919.1
#=GS A0A010RU27_9PEZI/20-78 AC A0A010RU27.1
#=GS A0A8H4CQX9_COLGL/406-460 AC A0A8H4CQX9.1
#=GS A0A8H3WII6_9PEZI/418-465 AC A0A8H3WII6.1
#=GS T0KB65_COLGC/429-487 AC T0KB65.1
#=GS A0A8H6MLW4_9PEZI/22-80 AC A0A8H6MLW4.1
#=GS A0A8H4CF96_COLGL/15-78 AC A0A8H4CF96.1
#=GS A0A8H4C9R2_COLGL/47-107 AC A0A8H4C9R2.1
A0A8H6K491_9PEZI/22-80 CNIQVRNDVGRVVGSTCVNAGATGSVTS...SQ.TGAN........ISFKTSNTCGVDSTGG--IGPNESLSN.....
A0A8H3W4W0_9PEZI/24-87 CSIELLNINQAVVDTKCIPFDTTIAMKD...PT.GPGGg.....qlYKVHVNNLCGIRLDDGQELSNGASLRK.....
A0A8H3ZLY8_9PEZI/24-86 CQIELLNINQQVVDSVCIPYDSIRAMRD...AT.APHGa.....vnYPVHVNSNCGVGLDRG-NLVNGATFR-n....
K2S1D3_MACPH/97-157 CSVDVININQASMGNGCIPEGGEGGVRV...PS.RNQQ........YFVEASDTCGVSLNSNQVLPDGWSLRY.....
H1W0C4_COLHI/23-83 CKVELLNFNSVAVGTGCVPFNYYASIYD...PN.TRAG........YTIHATNDCGLSVQAGQRLPENYSLRK.....
A0A2J6T063_9HELO/20-81 CNINVLNVNNAVIGNGCVPPGSQGNIPY...MG.GTAS.......sIDVATTSSCGVSPIQGRQLRPGLSL--qv...
A0A8H6U844_9PEZI/23-83 CQVEILNVSQASVGSGCVPFDSFANILN...TA.NNAK........YAISATRDCGFKVQNGQRLPDGFSLRK.....
A0A8H3W047_9PEZI/570-628 CRVEILDGNSFQLGTACIPKGDQGPVAV...NG.RN--........YFVTATTSCGLGFLGTQTHPSDWQLK-l....
T0LTU1_COLGC/276-334 CRVEILDGNSFQLGTACIPKGGQGPVAV...NG.RN--........YFVTATTSCGLGFLGTQTHPSDWQLK-l....
A0A7J6IF65_COLFN/35-93 CNIQVRNSVGGVVGSSCVDAGATGSVKS...SQ.SGAT........INFKTSTSCGVDATGG--LGPNESLSN.....
A0A7J6IKX4_COLFN/24-87 CSIELLNVNQAVVDTKCIPFDTTIAMKD...PT.GPGGg.....qlYKVHVNNLCGIGLDDGQELSNGASLRK.....
A0A484FG33_COLOR/35-95 CQVELLNINQAVVGSGCVPFNYYANIYD...SI.TRAG........YTVEANINCGLKFQAGRRIPDGYSLR-r....
A0A135V4Q0_9PEZI/22-82 CQVELLNINQAVVGTGCVEMNYYANIYD...ST.KRAG........YTVNANSNCGLSFGNIQVIPDGYSLRQ.....
A0A7J6JH07_COLFN/38-96 CRVEILDGNSFQLGTACIPKGGQGPVAV...NG.RN--........YFVTATTSCGLGFLGTQTHPSDWQLK-l....
A0A1J9QW02_9PEZI/23-82 CSVDIINFNQVAVGHACIPANGEGDIVV...AS.TKKT........YTVLTSESCGLSLRA-QALPANWSLQ-y....
A0A8H4FE58_COLGL/24-86 CQIELLNINQEVVDSVCIPCDSTRAMRD...AT.APHGa.....vnYQVHVDSNCGVGLDRG-NLVNGAT---frs..
T0M3E4_COLGC/24-79 CNVALKNDFDVQVGSGCISKTDGGYILA...SG.KN--........FFVQVTESCGIDVLYL---PNTWS---aqs..
A0A484FKL7_COLOR/86-144 CTIEIRNSVGAVVGSTCITAGQPGSVQS...IQ.SGAT........YTFKTSEFCGVGATNE--LIKDESLSK.....
A0A6P8AQM4_MAGGR/24-81 CNVEILNQNQVSVGSGCARINSVTNISD...NQ.GR-R........WGVNANSSCGLSTT--QTLPSGWSL--th...
T0M181_COLGC/22-82 CQVELLNINQAVVGSGCVQMNYYANIYD...SI.TRAG........YTVNANNNCGLSFSGSQRIPDGYSLR-r....
A0A8H4FI93_COLGL/24-87 CSIELLNVNQAVVDTKCIPFDTTTAMKD...PT.GPGGg.....qlYKVHVNNLCGIGLDDGQELANGASLRK.....
A0A8H3ZS90_9PEZI/503-561 CNIQVRNSVGGVVGSSCVDAGATGSVKS...SQ.SGAT........INFKTSTSCGVDATGG--LGPNESLSN.....
A0A1Q8S9N0_9PEZI/241-299 CNIQVRNGSNSITTSACVLAGSSGVITN...PQ.SGSV........ISYRTSEFCGISITGG--ATPDESLSN.....
A0A8H4N7S9_9PEZI/23-84 CAVDILNINQASVASGCVPEGGEAMVAAtvpPG.KSVN........YLVLASDSCGVSVSSNQVLPDGW----tw...
A0A8H4FI15_COLGL/20-78 CRVEILDGNSFQLGTACIPKGGQGPVAV...NG.RN--........YFVTATTSCGLGFLGTQTHPSDWQLK-l....
A0A2V1BZA5_9HELO/23-77 CGFSIRNINNAVMGSGCARDGGEGSVTI...PGfGPAT........FTVSNSGNCGLRIVS------------rnadf
A0A7J6IS19_COLFN/65-125 CQVELLNINQAVVGSGCVQMNYYANIYD...SI.TRAG........YTVNANNNCGLSFSGSQRIPDGYSLR-r....
A0A8H3W5H3_9PEZI/312-372 CQVELLNINQAVVGTGCVQMNYYANIYD...SI.TRAG........YTVNANNNCGLSFSGSQRIPDGYSLR-r....
A0A4R8QK08_COLTR/24-91 CQIEILNVSQAVVATACIPFGGTQYVLQ...PE.HNAGpglprginYHITVNENCGIGLVDQ-EWAHGDSAR-k....
A0A484FD83_COLOR/24-91 CQIEILNVNQAVVATACIPFGGMQYVLQ...PE.HNAGpglprginYQITVNENCGIGLVDQ-EWAHGDSAR-k....
K7N7F2_9PEZI/23-83 CKVELLNFNSVAVGTGCVPFNYYASIYD...PN.TRAG........YTIHATNDCGLSVQAGQRLPENYSLRK.....
A0A3M7M1U4_9PLEO/25-85 CVANILNINGAVIGTGCVPAGGSLTIPV...SG.GDHS........YLIQASTSCGLGLTSTQRFINGESV--as...
A0A010RED5_9PEZI/22-82 CQAELLNINQAVVGTGCVQMNYYANIYD...ST.RRAG........YTVNANSNCGLSFGNIQVIPDGYSLRQ.....
A0A4V6DH92_9PEZI/23-83 CKVEILNFSSAVVGSGCVPFNSDASIYD...PN.TRAG........YRVRATNDCGLSLEAGQSLPANYSLRK.....
T0LBR9_COLGC/24-87 CSIELLNVNQAVVDTKCIPFDTTTAMKD...PT.GPGGg.....qlYKVHVNNLCGIGLDDGQELANGASLRK.....
A0A4R8QP41_COLTR/215-273 CTIEIRNSVGAVVGSTCITAGQSGSVKS...IQ.SGAT........YNFNTSEFCGVGATNE--LIKNESLSK.....
A0A8H6N919_9PEZI/23-83 CQVEILNVSQASVGSGCVPFDSFANILN...TA.NNAK........YAISATRDCGFKVQNGQRLPDGFSLRK.....
A0A010RU27_9PEZI/20-78 CSVQVLDANNFQIGTACIPKGGQGSVRY...NG.GS--........YFITATSSCGLGFVSTQTHPAGWQLK-l....
A0A8H4CQX9_COLGL/406-460 CNVALKNDFDVQVGSGCISKTDGGYILA...SG.KN--........FFVQVTESCGIDVLYL---PNTW----saq..
A0A8H3WII6_9PEZI/418-465 CNVALKDDFDKQVGSGCISKTDGGYILA...SG.KN--........FFVQVTSSCGIDV--------------lyl..
T0KB65_COLGC/429-487 CNIQVRNSVGGVVGSSCVDAGATGSVQS...SQ.SGAT........INFKTSTSCGVDATGG--LGPNESLSN.....
A0A8H6MLW4_9PEZI/22-80 CNIQVRNDVGRVVGSTCVNAGATGSVTS...SQ.TGAN........ISFKTSNTCGVDPTGG--IGPNESLSN.....
A0A8H4CF96_COLGL/15-78 CNIELLNINQAVADSACIPIDSTQVMTD...RS.ACGSp.....ltYKVHVNGNCGVGLDDDQQLDPSNSLRK.....
A0A8H4C9R2_COLGL/47-107 CQVELLNINQAVVGSGCVQMNYYANIYD...ST.TRAG........YTVNANNNCGLSFSGSQRIPDGYSLR-r....
#=GC seq_cons CplElLNhNpuVVGouClshsstuslhs...ss.ssus........YpVpsossCGluhssspplssshSLp......
//
