#=GF ID   Toxin_R_bind_C
#=GF AC   PF07951.16
#=GF DE   Clostridium neurotoxin, C-terminal receptor binding
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_3087 (release 15.0)
#=GF GA   25.00 25.00;
#=GF TC   31.50 31.50;
#=GF NC   21.40 20.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0066
#=GF RN   [1]
#=GF RM   9783750
#=GF RT   Crystal structure of botulinum neurotoxin type A and
#=GF RT   implications for toxicity. 
#=GF RA   Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC; 
#=GF RL   Nat Struct Biol 1998;5:898-902.
#=GF DR   INTERPRO; IPR013104;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The Clostridium neurotoxin family is composed of tetanus
#=GF CC   neurotoxins and seven serotypes of botulinum neurotoxin. The
#=GF CC   structure of the botulinum neurotoxin reveals a four domain
#=GF CC   protein.  The N-terminal catalytic domain (Pfam:PF01742), the
#=GF CC   central translocation domains and two receptor binding domains
#=GF CC   [1].  This domains is the C-terminal receptor binding domain,
#=GF CC   which adopts a modified beta-trefoil fold with a six stranded
#=GF CC   beta-barrel and a beta-hairpin triplet capping the domain [1].
#=GF CC   The first step in the intoxication process is a binding event
#=GF CC   between this domains and the pre-synaptic nerve ending [1].
#=GF SQ   6
#=GS A0A0A7FZS7_9CLOT/1072-1268  AC A0A0A7FZS7.1
#=GS BXA1_CLOBH/1088-1293        AC P0DPI1.1
#=GS Q332E0_CBCP/1089-1291       AC Q332E0.1
#=GS A0A0C1TVZ1_9CLOT/1083-1297  AC A0A0C1TVZ1.1
#=GS TETX_CLOTE/1105-1314        AC P04958.2
#=GS C4IHM1_CLOBU/1063-1251      AC C4IHM1.1
A0A0A7FZS7_9CLOT/1072-1268             .....YHSEPDSTILKDFWGNYLLYNKKYYLLNLLKPNMSVTKN--SD-I---LNINRQRGIYSKTNIFSNAR-LYTGVEVIIRKVgsTDTS..NTDNFVRKNDTVYINVV.DGNSEYQLY.ADV----STSAVEKTIKLRRISNSNYNSNQMIIMDSI-----GDNCTMNFKTNN-GND...IGLLGFHL..----NN-----.-LVAS...SWYYKNIRNNTR..NNGCFWSFISKEHGWQE.
BXA1_CLOBH/1088-1293                   .....YDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVN--NVGIRGYMYLKGPRGSVMTTNIYLNSS-LYRGTKFIIKKY..A-SG..NKDNIVRNNDRVYINVV.VKNKEYRLA.TNA----SQAGVEKILSALEIPD-VGNLSQVVVMKSKNDQGITNKCKMNLQDNN-GND...IGFIGFHQ..------FNNIA.KLVAS...NWYNRQIERSSR..TLGCSWEFIPVDDGWGE.
Q332E0_CBCP/1089-1291                  fnslq-----YTNVVKDYWGNDLRYNKEYYMVNID-------------YLNRYMYANSRQIV---FNTRRNNNDFNEGYKIIIKRI..R-GN..TNDTRVRGGDILYFDMT.INNKAYNLFmKNETMYADNHSTEDIYAI-GLREQTKDINDNIIFQIQPMNNTYYYASQIFKSNFNGENisgICSIGTYR..FRLGGDWYRHN.YLVPTvkqGNYASLLES---..-TSTHWGFVPVS-----e
A0A0C1TVZ1_9CLOT/1083-1297             ...yw--IQSSTNTLKDFWGNPLRYDTQYYLFNQGMQNIYIKYF--S---KASMGETAPRTNFNNAAI--NYQNLYLGLRFIIKKA..SNSRniNNDNIVREGDYIYLNIDnISDESYRVY.VLV----NSKEIQTQLFLAPIND---DPTFYDVLQIKKYYEKTTYNCQILCEKD-TKT...FGLFGIGKfvKDYGYVWDTYDnYFCIS...QWYLRRISENINklRLGCNWQFIPVDEGWTE.
TETX_CLOTE/1105-1314                   .....YTSYLSITFLRDFWGNPLRYDTEYYLIPVASSSKDVQLKNITDYM---YLTNAPSYTNGKLNIY--YRRLYNGLKFIIKRY..TPNN..EIDSFVKSGDFIKLYVS.YNNNEHIV-.---GYPKDGNAFNNLDRILRVGYNAPGIPLYKKMEAVKLRDLKTYSVQLKLYDDKNAS...LGLVGTHN..GQIGND-PNRD.ILIAS...NWYFNHLKD--K..ILGCDWYFVPTDEGWTN.
C4IHM1_CLOBU/1063-1251                 .....YNNEPNANILKDFWGNYLLYDKEYYLLNVLKPNNFINRR--TDST--------LSINNIRSTILLANR-LYSGIKVKIQRV..NNSS..TNDNLVRKNDQVYINFV.A-SKTHLLP.LYA----DTATTN-KEKTIKISSSGNRFNQVVVMNSV-----GNNCTMNFKNNN-GNN...IGLLGFKA..----------D.TVVAS...TWYYTHMRDNTN..SNGFFWNFISEEHGWQE.
#=GC seq_cons                          .....YpspssoslLKDFWGN.LpYDKcYYLlNlhpsNh.lphp..os.h...hhhsu.phs..psNIh.Nsp.LYpGlKhIIK+h..ssos..ssDNhVRpsDhlYlNls.hsNcpYpLh.h.s....sssuspphhplhcIssps.shsphllMpuh...thsshss..hpsNs.Gss...IGLlGh+p.......s..phs.hLVAS...sWYhpplccs.p..phGCpWpFIPs-cGWpE.
//