#=GF ID   Toxin_R_bind_N
#=GF AC   PF07953.16
#=GF DE   Clostridium neurotoxin, N-terminal receptor binding
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_1058 (release 15.0)
#=GF GA   22.00 22.00;
#=GF TC   22.00 22.00;
#=GF NC   21.90 21.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0004
#=GF RN   [1]
#=GF RM   9783750
#=GF RT   Crystal structure of botulinum neurotoxin type A and
#=GF RT   implications for toxicity. 
#=GF RA   Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC; 
#=GF RL   Nat Struct Biol 1998;5:898-902.
#=GF DR   INTERPRO; IPR012928;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The Clostridium neurotoxin family is composed of tetanus
#=GF CC   neurotoxin and seven serotypes of botulinum neurotoxin. The
#=GF CC   structure of the botulinum neurotoxin reveals a four domain
#=GF CC   protein.  The N-terminal catalytic domain (Pfam:PF01742), the
#=GF CC   central translocation domains and two receptor binding domains
#=GF CC   [1]. This domains is the N-terminal receptor binding
#=GF CC   domain,which is  comprised of two seven-stranded beta-sheets
#=GF CC   sandwiched together to form a jelly role motif [1]. The role of
#=GF CC   this domain in receptor binding appears to be indirect.
#=GF SQ   20
#=GS C4IHM1_CLOBU/859-1054      AC C4IHM1.1
#=GS T1K852_TETUR/130-270       AC T1K852.2
#=GS Q332E0_CBCP/880-1080       AC Q332E0.1
#=GS A5HZZ8_CLOBH/848-1024      AC A5HZZ8.1
#=GS A0A0C1TUH0_9CLOT/848-1024  AC A0A0C1TUH0.1
#=GS A0A0A7G0U0_9CLOT/813-988   AC A0A0A7G0U0.1
#=GS A0A2G9PMF5_LITCT/35-145    AC A0A2G9PMF5.1
#=GS TETX_CLOTE/893-1096        AC P04958.2
#=GS A0A0C1TVZ1_9CLOT/877-1074  AC A0A0C1TVZ1.1
#=GS A0A7R9M017_9ACAR/278-419   AC A0A7R9M017.1
#=GS A0A8B7YB91_ACAPL/335-500   AC A0A8B7YB91.1
#=GS A0A7R9KH06_9ACAR/224-366   AC A0A7R9KH06.1
#=GS A0A443SUR0_9ACAR/304-449   AC A0A443SUR0.1
#=GS A0A0A7FZS7_9CLOT/869-1063  AC A0A0A7FZS7.1
#=GS A0A6P6XZE1_DERPT/370-512   AC A0A6P6XZE1.1
#=GS A0A834R896_SARSC/340-482   AC A0A834R896.1
#=GS C4IHM0_CLOBU/813-989       AC C4IHM0.1
#=GS Q332E1_CBCP/847-1023       AC Q332E1.1
#=GS A0A8B7YD54_ACAPL/335-500   AC A0A8B7YD54.1
#=GS BXA1_CLOBH/885-1079        AC P0DPI1.1
C4IHM1_CLOBU/859-1054                 .....................................................................................................NDKYVDTS.GYDSNINI.....NGDVYKYP...TN........KNQF.GIYN..D.KL..SE..VNISQ.NDYII.....YD.N...K.......Y...KNF.SISFW.VRIPNYDNKiVN..VNNEYTII.NCM...rD....N..N......S..G....W....KV....S......L.N....H...N.E.I....IWT..LQ.D......NS.GINQ.KLA...FN.Y.GN.ANGI.S.DYI...NKWIFVTITNDRLGDS...KLYINGNLIDK.K.SIL.N..L..G..N..IHV..SD..N.ILFKI..VN........C.S.Y-...TRYI....GIRYFNIFDKEL........................................
T1K852_TETUR/130-270                  .........................................................................................hesdkifefdga--------.--------.....--------...--........----.----..-.--..-S..VAAMI.PETVL.....DH.N...L.......T...NKF.SISFW.MKHEPPADH.TN..KHIKEHII.CNAddhkK....N..R......H..H....Y....AL....F......V.R....N...C.R.L....ILL..LR.R......EF.NQEK.RTI...FRpA.EW.RWKL.A.EVC..dNKWHHYAISVSF-PEV...SLYLDGQLYKN.T.S--.-..-..-..-..---..--..-.-----..--........-.-.--...----....------------tnpeiv..................................
Q332E0_CBCP/880-1080                  .....................................................................................................KNTLVDTS.GYNAEVSE.....EGDVQLNP...IF........PFDF.KLGS..S.GEdrGK..VIVTQ.NENIV.....YN.S...M.......Y...ESF.SISFW.IRINKWVSN.--..-LPGYTII.DSV....K....N..N......S..G....W....SI....G......I.I....S...N.F.L....VFT..LK.Q......NE.DSEQ.SIN...FS.Y.DI.SNNA.P.GY-...NKWFFVTVTNNMMGNM...KIYINGKLIDT.I.KVK.E..L..T..G..INF..SK..T.ITFEI..NKipdtglitS.D.SD...NINM....WIRDFYIFAKEL........................................
A5HZZ8_CLOBH/848-1024                 .....................................................................................................NNVIGDAS.GKNTSIEY.....SKDIGLVY..gIN........SDAL.YLNG..S.NQ..--..-SISF.SNDFF.....EN.G...L.......T...NSF.SIYFW.LRNLGKDTI.--..---KSKLI.GSK....E....D..N......C..G....W....EI....Y......F.Q....D...T.G.L....VFN..MI.D......SN.GNEK.NIY...L-.-.--.----.S.DVS..nNSWHYITISVDRLKEQ..lLIFIDDNLVAN.E.SIK.E..I..L..N..IYS..SN..I.ISL--..--........-.L.SE...NNPS....YIEGLTILNK--pt......................................
A0A0C1TUH0_9CLOT/848-1024             ....................................................................................................k-KVIKDIS.GKDTLVQY.....SDTIDLSY..gVN........GDAL.YLKE..P.NQ..--..-SVNF.SNNIF.....EN.G...L.......T...NSF.SICFW.LRNLGQDNL.--..---SSNLI.GNI....V....N..N......C..G....W....QI....Y......F.E....N...N.G.L....VFS..MV.D......CN.GNEK.NIY...L-.-.--.----.S.DVL..sKYWYYISVSVDRLRNK..lLIFINDKLIVN.E.SIE.Q..I..L..N..IYS..SN..I.ISL--..--........-.V.NE...NNPI....CIEELSILNKAL........................................
A0A0A7G0U0_9CLOT/813-988              .....................................................................................................KNVIGDGS.GKNTLVEY.....TNDIGLIY..gIN........NNAL.YLNQ..S.NQ..--..-SVSF.TNDYF.....EN.G...L.......T...NSF.SIYFW.LRNLGKDII.--..---KSKLI.SSK....L....D..N......C..G....W....EI....Y......L.E....D...N.G.L....VFN..II.D......SN.GSYK.KIY...I-.-.--.----.S.DMN...NSWNYIAISVDRLKEQ..lLIFVNDVLVAN.E.DIK.D..I..L..N..IYS..SN..T.ISL--..--........-.V.SE...NNQI....CIEGLSILNTNI........................................
A0A2G9PMF5_LITCT/35-145               ......................................................................................skagevqaavtldgt--------.--------.....--------...--........----.----..-.--..--..-----.-----.....--.-...-.......-...---.-----.---------.--..--------.---....-....-..-......-..-....-....--....-......-.-....D...N.S.V....IFT..VT.Q......LN.ANSQ.VIK...FK.-.--.DPKL.K.VLF..dEKWHQLKILVKN-KSA...NLFLDNTLIEN.R.ALE.E..I..G..P..IFI..NG..K.TQVLK..RQ........T.S.DE...ALTM....EIQKLRLYC---dp......................................
TETX_CLOTE/893-1096                   .....................................................................................................NDIISDIS.GFNSSVIT.....YPDAQLVP..gIN........GKAI.HLVN..N.ES..SE..VIVHK.AMDIE.....YN.D...M.......F...NNF.TVSFW.LRVPKVSAShLEqyGTNEYSII.SSM....K....K..Hsl.sigS..G....W....SV....S......L.K....G...N.N.L....IWT..LK.D......SA.GEVR.QIT...FR.-.DL.PDKF.N.AYL..aNKWVFITITNDRLSSA...NLYINGVLMGS.A.EIT.G..L..G..A..IRE..DN..N.ITLKL..DR........C.N.NN...NQYV....SIDKFRIFCKAL........................................
A0A0C1TVZ1_9CLOT/877-1074             ...................................................................................................gg--RLIDSS.GYGATMNV.....GSDVIFND...IG........NGQF.KLNN..S.EN..SN..ITAHQ.SKFVV.....YD.S...M.......F...DNF.SINFW.VRTPKYNNNdIQtyLQNEYTII.SCI....K....N..D......S..G....W....KV....S......I.K....G...N.R.I....IWT..LI.D......VN.AKSK.SIF...FE.Y.SI.KDNI.S.DYI...NKWFSITITNDRLGNA...NIYINGSLKKS.E.KIL.N..L..D..R..INS..SN..D.IDFKL..IN........C.T.DT...TKFV....WIKDFNIFGREL........................................
A0A7R9M017_9ACAR/278-419              ....................................................................................dgresdqiyefdgatna--------.--------.....--------...--........----.----..-.--..--..--VVI.PEATL.....SH.N...L.......T...NKF.TVSFW.MKHEPPLDP.TN..KHIKEHII.CNAddhkK....N..R......H..H....Y....SL....F......V.R....N...C.R.L....ILL..LR.R......EF.NEEK.HTI...FKpA.EY.RWKL.S.EVC..dNEWHHYSVSLNF-PDA...ILFVDGLKFRN.T.---.-..-..-..-..---..--..-.-----..--........-.-.--...----....------------stnpei..................................
A0A8B7YB91_ACAPL/335-500              ........................................................................................wtedlltdeghds--------.--------.....--------...--........-EQI.YEFD..G.EE..SA..--VII.PEKYA.....PS.N...L.......T...YRF.SISYW.MKHGETEGL.--..--NKEHIL.CSS....D....S..Egl..nrH..H....Y....AV....F......I.H....N...C.R.L....VLL..LR.H......QD.EGKS.DAF...FP.T.EF.RWKV.D.EVC..dKQWHRYTFNVDF-PSV...MLYIDGELHQT.K.MIS.D..D..W..P..LHH..SN..-.-----..--........-.-.--...----....------------ypvaltigacydggk.........................
A0A7R9KH06_9ACAR/224-366              ....................................................................................dgresdqiyefdgatna--------.--------.....--------...--........----.----..-.--..--..--VVI.PEATL.....NH.N...L.......T...NKF.TVSFW.MKHETPLDQ.TN..KHIKEHII.CNAddhkK....N..R......H..H....Y....SL....F......V.R....N...C.R.L....ILL..LR.R......EF.NEEK.HTV...FK.PaEY.RWKL.S.EVC..dNEWHHYSVGLNF-PDA...ILYVDGQKFRN.T.S--.-..-..-..-..---..--..-.-----..--........-.-.--...----....------------tnpeiv..................................
A0A443SUR0_9ACAR/304-449              ....................................................................................tdeghesdqiyefdgat--------.--------.....--------...--........----.----..-.--..--..NSVVI.QESTL.....HH.N...L.......T...DNF.TIAFW.MKHEPPADH.NN..KHIKEHII.CNAddhkK....N..R......H..H....Y....AL....F......V.R....N...C.R.L....ILL..LR.R......EY.NQEK.HTV...FK.P.AEwRWKL.A.EVC..dNEWHHYAVIVNF-PDV...ILFVDGQRFKN.S.S--.-..-..-..-..---..--..-.-----..--........-.-.--...----....------------nnpeivd.................................
A0A0A7FZS7_9CLOT/869-1063             .....................................................................................................NNRFIDSS.GYGSNISI.....NGDIYIYS...TN........RNQF.GIYS..S.RL..SE..VNITQ.NNTII.....YN.S...R.......Y...QNF.SVSFW.VRIPKYNNL.KN..LNNEYTII.NCM...rN....N..N......S..G....W....KI....S......L.N....Y...N.N.I....IWT..LQ.D......TT.GNNQ.KLV...FN.Y.TQ.MIDI.S.DYI...NKWTFVTITNNRLGHS...KLYINGNLTDQ.K.SIL.N..L..G..N..IHV..DD..N.ILFKI..VG........C.N.D-...TRYV....GIRYFKIFNMEL........................................
A0A6P6XZE1_DERPT/370-512              .......................................................................................egresdqiyefdgt--------.--------.....--------...--........----.----..-.--..-N..NAVIV.PENVF.....DH.N...L.......T...SKF.TISFW.MKHEPPLDQ.SN..KHIKEHII.CNAddhkK....N..R......H..H....Y....SL....F......V.R....N...C.R.L....ILL..LR.R......EF.DEEK.HTV...FK.P.AEyRWKL.A.QAC..dNEWHHFAVSMDF-PDA...TLFVDGIRFHN.S.---.-..-..-..-..---..--..-.-----..--........-.-.--...----....------------ssnpeiv.................................
A0A834R896_SARSC/340-482              .....................................................................................egkesdqiyefdgasn--------.--------.....--------...--........----.----..-.--..--..-AVIV.PETIF.....DH.N...L.......T...NKF.TISFW.MKHEPPLDQ.SN..KHIKEHII.CNAddhkK....N..R......H..H....Y....SL....F......V.R....N...C.R.L....ILL..LR.R......EY.NKEK.HTV...FK.P.AEyRWKL.A.QTC..dNEWHHYSVSMDF-PDA...SLWVDGIRFHN.T.---.-..-..-..-..---..--..-.-----..--........-.-.--...----....------------ssnpeiv.................................
C4IHM0_CLOBU/813-989                  .....................................................................................................NNVIGDTS.GKNTLVEY.....PKDIGLVY..gIN........NNAI.HLTG..A.NQ..--..-NIKF.TNDYF.....EN.G...L.......T...NNF.SIYFW.LRNLNQNTI.--..---KSKLI.GSK....E....D..N......C..G....W....EI....Y......F.E....N...N.G.L....VFN..II.D......SN.GNEK.NIY...L-.-.--.----.S.NIS..nKSWHYIVISINRLKDQ..lLIFIDNILVAN.E.DIK.E..I..L..N..IYS..SD..I.ISL--..--........-.L.SD...NNNV....YIEGLSVLNKTI........................................
Q332E1_CBCP/847-1023                  ....................................................................................................s-NIIEDIS.GKNTLIQY.....TESIELVY..gVN........GESL.YLKS..P.NE..--..-TIKF.SNKFF.....TN.G...L.......T...NNF.TICFW.LRFTGKNDD.--..---KTRLI.GNK....V....N..N......C..G....W....EI....Y......F.E....D...N.G.L....VFE..II.D......SN.GNQE.SVY...L-.-.--.----.S.NII..nDNWYYISISVDRLKDQ..lLIFINDKNVAN.V.SID.Q..I..L..S..IYS..TN..I.ISL--..--........-.V.NK...NNSI....YVEELSVLDN--pi......................................
A0A8B7YD54_ACAPL/335-500              ........................................................................................wtedlltdeghds--------.--------.....--------...--........-EQI.YEFD..G.EE..SA..--VII.PEKYA.....PS.N...L.......T...YRF.SISYW.MKHGETEGL.--..--NKEHIL.CSS....D....S..Egl..nrH..H....Y....AV....F......I.H....N...C.R.L....VLL..LR.H......QD.EGKS.DAF...FP.T.EF.RWKV.D.EVC..dKQWHRYTFNVDF-PSV...MLYIDGELHQT.K.MIS.D..D..W..P..LHH..SN..YpVALTI..GA........C.-.--...----....------------yddfd...................................
BXA1_CLOBH/885-1079                   ....................................................................................................s-NHLIDLS.RYASKINI.....GSKVNFDP...ID........KNQI.QLFN..L.ES..SK..IEVIL.KNAIV.....YN.S...M.......Y...ENF.STSFW.IRIPKYFNS.IS..LNNEYTII.NCM....E....N..N......S..G....W....KV....S......L.N....Y...G.E.I....IWT..LQ.D......TQ.EIKQ.RVV...FK.Y.SQ.MINI.S.DYI...NRWIFVTITNNRLNNS...KIYINGRLIDQ.K.PIS.N..L..G..N..IHA..SN..N.IMFKL..DG........C.R.DT...HRYI....WIKYFNLFDKEL........................................
#=GC seq_cons                         ....................................................................................................s............................................tth.h..t..s.p........sVhh.spshh......s.s...L.......T...ssF.SISFW.h+p.s.ss.........Kp+II.sst....c....N..p......p..t....a....pl....a......l.c....s...s.p.L....Iap..Lp.c......ps.spc+.clh...Fp...t..t.pl.u.-hh..sNcWaalololch.scs...hLaIsGpLhcN.p.sI..p..l..h..s..Ih...ss....l.h.......................t........lp.h.lhs...........................................
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