#=GF ID   Toxin_ToxA
#=GF AC   PF11584.12
#=GF DE   Proteinaceous host-selective toxin ToxA
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_1zld
#=GF GA   25.00 25.00;
#=GF TC   28.70 28.60;
#=GF NC   24.50 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0389
#=GF RN   [1]
#=GF RM   16214901
#=GF RT   Structure of Ptr ToxA: an RGD-containing host-selective toxin
#=GF RT   from Pyrenophora tritici-repentis. 
#=GF RA   Sarma GN, Manning VA, Ciuffetti LM, Karplus PA; 
#=GF RL   Plant Cell. 2005;17:3190-3202.
#=GF DR   INTERPRO; IPR021635;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   ToxA is produced by particular Pyrenophora tritici-repentis
#=GF CC   races and is a proteinaceous host-selective toxin. It is
#=GF CC   necessary and sufficient to cause cell death in sensitive wheat
#=GF CC   cultivars [1].ToxA adopts a single-domain, beta-sandwich fold
#=GF CC   which has novel topology. The protein is directly involved in
#=GF CC   recognition events required for ToxA action. It is thought to be
#=GF CC   distantly related to FnIII proteins, gaining entry to the host
#=GF CC   via an integrin-like receptor [1].
#=GF SQ   4
#=GS M2URZ2_COCH5/46-160  AC M2URZ2.1
#=GS K2RRC6_MACPH/34-158  AC K2RRC6.1
#=GS B2W5I9_PYRTR/1-113   AC B2W5I9.1
#=GS Q0TVA4_PHANO/61-177  AC Q0TVA4.2
M2URZ2_COCH5/46-160             QGSCVSISRPANNPSINNIGQIDITSVVNGGPGM--TWDLNNLVRVHV....SREVDGSLSFDWTNTG.SANRLIVTEWNSSSSTSGNGYVLLGSYGLPTGTGNICFPVGSGQGR-TWKMQLE...........................................
K2RRC6_MACPH/34-158             QGGCLSALPRP-NP-VNNVGRISFQAAIDARERR--TWWPNNLIDVHIevpeNVESTNHVTVEITNRSwSANAIVLTNFQDTRSTT-------------------------------------qprqqvrvtvpaqtrqagaviagttiecvrlprldgtwyfqve
B2W5I9_PYRTR/1-113              ----MSITINPSRPSVNNIGQVDIDSVILGRPGAIGSWELNNFITIGL....NRVNADTVRVNIRNTG.RTNRLIITQWD-NTVTRGDVYELFGDYALIQGRGSFCLNIRSDTGRENWRMQLE...........................................
Q0TVA4_PHANO/61-177             QGSCMSITINPSRPSVNNIGQVDIDSVILGRPGAIGSWELNNFVTIGL....NRVNANTVRVNINNTG.RTNRLIITQWD-NTLTRGDVYELFGDYALIQGRGSFCLNIRSDSGRENWRMQLE...........................................
#=GC seq_cons                   QGuChSIohsPspPSVNNIGQlDIsSVI.GRPGt..oW-LNNhlsltl....NR.sssoVpVsIsNTG.psNRLIlTpWs.sosTpGssY.LhGsYuL.pGpGshChsltSspGR.sW+MQLE...........................................
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