#=GF ID Trp_ring
#=GF AC PF18669.5
#=GF DE Trimeric autotransporter adhesin Trp ring domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF07867
#=GF GA 27.10 27.10;
#=GF TC 27.60 27.60;
#=GF NC 26.50 24.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 18948113
#=GF RT Repetitive architecture of the Haemophilus influenzae Hia
#=GF RT trimeric autotransporter.
#=GF RA Meng G, St Geme JW 3rd, Waksman G;
#=GF RL J Mol Biol. 2008;384:824-836.
#=GF RN [2]
#=GF RM 15029242
#=GF RT Structural basis for host recognition by the Haemophilus
#=GF RT influenzae Hia autotransporter.
#=GF RA Yeo HJ, Cotter SE, Laarmann S, Juehne T, St Geme JW 3rd, Waksman
#=GF RA G;
#=GF RL EMBO J. 2004;23:1245-1256.
#=GF DR INTERPRO; IPR040482;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Autotransporters are synthesized as precursor proteins with
#=GF CC three functional domains, namely, an N-terminal signal peptide,
#=GF CC an internal passenger domain, and a C-terminal pore-forming
#=GF CC translocator domain. The C-terminal translocator domain is
#=GF CC embedded in the outer membrane and facilitates delivery of the
#=GF CC internal passenger domain to the bacterial surface. In
#=GF CC conventional autotransporters, the C-terminal translocator
#=GF CC domain contains approximately 300 amino acids and is monomeric.
#=GF CC In contrast, in trimeric autotransporters, the translocator
#=GF CC domain contains 60 to 70 amino acids and forms trimers in the
#=GF CC outer membrane [1]. This entry represents a Trp-ring domain
#=GF CC which is found in the translocator region of H. influenzae Hia
#=GF CC autotransporter, an adhesive protein that promotes adherence to
#=GF CC respiratory epithelial cells [2]. Trp-ring domains appear to be
#=GF CC crucial repeated modular units in Hia, both in the general
#=GF CC architecture of the passenger domain and in the structure of the
#=GF CC binding domains [1].
#=GF SQ 76
#=GS A0A377R308_9NEIS/2437-2491 AC A0A377R308.1
#=GS A0A134CB45_9FIRM/298-348 AC A0A134CB45.1
#=GS F9MQG4_9FIRM/2627-2673 AC F9MQG4.1
#=GS A0A3S4ZMD5_9NEIS/2595-2643 AC A0A3S4ZMD5.1
#=GS A0A1T0AZ81_9PAST/4157-4211 AC A0A1T0AZ81.1
#=GS F9MQG4_9FIRM/963-1013 AC F9MQG4.1
#=GS M4R6R0_BIBTR/1112-1160 AC M4R6R0.1
#=GS F9MQG4_9FIRM/2081-2135 AC F9MQG4.1
#=GS A0A377I3T4_HAEPH/1733-1779 AC A0A377I3T4.1
#=GS A0A1T0CG27_9GAMM/971-1020 AC A0A1T0CG27.1
#=GS F9MQG4_9FIRM/1592-1643 AC F9MQG4.1
#=GS F2BGV3_9NEIS/120-173 AC F2BGV3.1
#=GS A0A2M8RZB5_9PAST/1113-1161 AC A0A2M8RZB5.1
#=GS A0A1S9ZUS9_9GAMM/310-357 AC A0A1S9ZUS9.1
#=GS A0A134CB04_9FIRM/473-519 AC A0A134CB04.1
#=GS A0A134CB45_9FIRM/773-823 AC A0A134CB45.1
#=GS F9N6N5_9FIRM/990-1044 AC F9N6N5.1
#=GS A0A263HFJ5_9PAST/1343-1390 AC A0A263HFJ5.1
#=GS F9MQG4_9FIRM/802-850 AC F9MQG4.1
#=GS F9MQG4_9FIRM/1435-1481 AC F9MQG4.1
#=GS A0A263HB69_9PAST/826-873 AC A0A263HB69.1
#=GS A0A1T0CKU9_9GAMM/1466-1515 AC A0A1T0CKU9.1
#=GS A0A377I3T4_HAEPH/1346-1392 AC A0A377I3T4.1
#=GS F9N556_9FIRM/79-133 AC F9N556.1
#=GS A0A286ECR5_9NEIS/430-476 AC A0A286ECR5.1
#=GS A0A134CB04_9FIRM/295-346 AC A0A134CB04.1
#=GS A0A1V3J3Y5_9PAST/1086-1133 AC A0A1V3J3Y5.1
#=GS M4RGP3_BIBTR/1207-1255 AC M4RGP3.1
#=GS A0A377I3T4_HAEPH/2-42 AC A0A377I3T4.1
#=GS A0A263HFJ5_9PAST/1005-1052 AC A0A263HFJ5.1
#=GS A0A1V4AZP0_9PAST/1177-1225 AC A0A1V4AZP0.1
#=GS A0A134CBF2_9FIRM/541-589 AC A0A134CBF2.1
#=GS F9N555_9FIRM/1-59 AC F9N555.1
#=GS F9MQG4_9FIRM/2285-2336 AC F9MQG4.1
#=GS A0A286EWP4_9NEIS/243-297 AC A0A286EWP4.1
#=GS A0A286EX56_9NEIS/100-148 AC A0A286EX56.1
#=GS F9N6N5_9FIRM/1394-1442 AC F9N6N5.1
#=GS A0A377R308_9NEIS/2029-2083 AC A0A377R308.1
#=GS A0A377I3T4_HAEPH/383-429 AC A0A377I3T4.1
#=GS A0A134CB45_9FIRM/457-503 AC A0A134CB45.1
#=GS M4RGP3_BIBTR/1536-1584 AC M4RGP3.1
#=GS A0A377R308_9NEIS/1621-1675 AC A0A377R308.1
#=GS F5S9C5_KINKI/1082-1130 AC F5S9C5.1
#=GS F9MQG4_9FIRM/1910-1961 AC F9MQG4.1
#=GS A0A377I3H9_HAEPH/54-107 AC A0A377I3H9.1
#=GS L1NSC4_9NEIS/54-107 AC L1NSC4.1
#=GS M4R6R0_BIBTR/1771-1819 AC M4R6R0.1
#=GS A0A134CB04_9FIRM/91-145 AC A0A134CB04.1
#=GS A0A3N4VQH3_9PAST/2032-2083 AC A0A3N4VQH3.1
#=GS A0A134CB45_9FIRM/1-34 AC A0A134CB45.1
#=GS M4RGP3_BIBTR/877-925 AC M4RGP3.1
#=GS A0A1V3J3Y5_9PAST/1573-1622 AC A0A1V3J3Y5.1
#=GS A0A448TVH7_9PAST/845-897 AC A0A448TVH7.1
#=GS M4RGP3_BIBTR/1872-1920 AC M4RGP3.1
#=GS F9MQG4_9FIRM/1275-1326 AC F9MQG4.1
#=GS A0A1T0B713_9PAST/6913-6969 AC A0A1T0B713.1
#=GS F9MQG4_9FIRM/1752-1798 AC F9MQG4.1
#=GS F9N6N6_9FIRM/644-692 AC F9N6N6.1
#=GS A0A263HB69_9PAST/1461-1508 AC A0A263HB69.1
#=GS A0A377I3T4_HAEPH/770-816 AC A0A377I3T4.1
#=GS F9N6N5_9FIRM/426-479 AC F9N6N5.1
#=GS A0A377I3H9_HAEPH/733-780 AC A0A377I3H9.1
#=GS F9MQG4_9FIRM/1120-1166 AC F9MQG4.1
#=GS F9MQG4_9FIRM/2447-2498 AC F9MQG4.1
#=GS F9N557_9FIRM/389-438 AC F9N557.1
#=GS A0A377R308_9NEIS/2845-2899 AC A0A377R308.1
#=GS F9MQG4_9FIRM/2784-2834 AC F9MQG4.1
#=GS A0A1T0AZ81_9PAST/4775-4829 AC A0A1T0AZ81.1
#=GS A0A286EWM3_9NEIS/97-144 AC A0A286EWM3.1
#=GS M4RGP3_BIBTR/2182-2230 AC M4RGP3.1
#=GS A0A134CB45_9FIRM/616-662 AC A0A134CB45.1
#=GS M4R6R0_BIBTR/1442-1490 AC M4R6R0.1
#=GS F9N6N6_9FIRM/240-288 AC F9N6N6.1
#=GS A0A134CB45_9FIRM/143-189 AC A0A134CB45.1
#=GS A0A4V3D9G1_9PAST/517-564 AC A0A4V3D9G1.1
#=GS F9N396_9FIRM/2045-2103 AC F9N396.1
A0A377R308_9NEIS/2437-2491 ...MGWVVSSDkt....tgnLTKTFNGQVKNAGEVEFVGT..GA..AEVSAQT.T.TGGKHTITVNVD...
A0A134CB45_9FIRM/298-348 ...LGFIIKGTd.......tAGKPVSGQVKHTNTVEFAGE..DL..AKVITES.-.KDGVSKVTVKVN...
F9MQG4_9FIRM/2627-2673 ...MGWILSV-.........-GDTYADKVQNAQEVNFKGA..GL..AEVSGQT.-.EGQKRVITVTVD...
A0A3S4ZMD5_9NEIS/2595-2643 ..q-GWVVSA-.........DGNNYADDVRHANEVRFSGK..DA..VTVTGST.D.SDGIRNITVSVD...
A0A1T0AZ81_9PAST/4157-4211 ...LGFVLSTTn......kdGAETYKDQVRHGNQLNVTGSkdGL..VSVKGNT.D.ENGKRELVVNVK...
F9MQG4_9FIRM/963-1013 ...LGFVIKGKa.......dNDSDVTGQVKHANTVEFAGE..DL..AKVITES.-.KDGKHKVTVKVD...
M4R6R0_BIBTR/1112-1160 ...YGWVVST-.........PDNQFTQAVKNANEVKFTGS..DG..IKVAGAV.D.STGVYNITFEVN...
F9MQG4_9FIRM/2081-2135 ...MGFVLGASvn....adgGNKAYQDVVKNGNKVKFVGL..GG..AWISGKT.A.DDGTRIITIDVN...
A0A377I3T4_HAEPH/1733-1779 ...LGWVVSA-.........--GDYAANVTNANEVRFNGS..NG..ISVTGET.D.EHGVRNINVSI-a..
A0A1T0CG27_9GAMM/971-1020 ...YGWVVAT-.........PDNGYDAAVKSANTVNFIGD..NH..ISVTGANnA.TTGTYDVKIE--la.
F9MQG4_9FIRM/1592-1643 ...LGFVIKGKa......adGTTDVTGQVKHANTVEFAGE..DL..AKVITES.-.ANGASKVTVKVN...
F2BGV3_9NEIS/120-173 ...MGWVVSSDkt....tgnESQAFSGQVKNAGEVEFVGT..GA..ANVSAKT.-.VNGKHTVTVGVD...
A0A2M8RZB5_9PAST/1113-1161 ...LGWVVSA-.........NGNNYADDVRNANQVNFTGI..HG..AKVTGST.D.ANGVRQITIS--as.
A0A1S9ZUS9_9GAMM/310-357 ...MGWVVAA-.........EGNDYQDTVKNANKVNFVGE..GM..ATVTGET.-.KDGVRTITVNVD...
A0A134CB04_9FIRM/473-519 ...MGWVLST-.........-GDDYAEKVQNANEINFKGV..DG..ITITGKT.-.DGGKRIVSVGVD...
A0A134CB45_9FIRM/773-823 ...LGFVIKGKa.......aDGSDVSAQVKHANTVEFAAE..DL..AKVITES.-.ANGVSKVTVKVN...
F9N6N5_9FIRM/990-1044 ...MGWIVSSDkt....tgnLGNPYSEAVKNANEVKFVGE..GT..ATVSGKT.D.EKGVRTITVKVD...
A0A263HFJ5_9PAST/1343-1390 ...MGWVVSA-.........SGNGYIDTVKNANKVDFVGS..GL..ATVTGET.-.QGDVRTITVNVD...
F9MQG4_9FIRM/802-850 ..i-GWILSV-.........PGDKYSAAVTHNRKVSFFGK..DL..AKVTAAG.K.GEEPRMITVTVD...
F9MQG4_9FIRM/1435-1481 ..v-GFVVA--.........DGGNYHATVTNAQTVKFVGE..GL..AEVSGET.-.KDNVRTFTVKVD...
A0A263HB69_9PAST/826-873 ...MGWIVSA-.........SGNGYLNTVKNANQVNFVGI..DG..ISVTGED.-.VGDIRTITAKVN...
A0A1T0CKU9_9GAMM/1466-1515 ...YGWVVAT-.........PDNGYDAAVKNANTVNFIGD..NH..ISVTGANnA.TTGTYDVKIE--la.
A0A377I3T4_HAEPH/1346-1392 ...LGWVVSA-.........--GDYAANVTNANEVRFNGS..NG..ISVTGET.D.EHGVRNINVSI-a..
F9N556_9FIRM/79-133 ...MGWIVSSDkt....tgeTDKAYTDTVKNANEVKFVGE..GT..AIVSGKT.D.DKGVRTITVKVD...
A0A286ECR5_9NEIS/430-476 ...LGWVVSA-.........KGNNYSDAVKSSNEVEFVGE..NG..VSVTGMT.-.KDGKRIITIQ--g..
A0A134CB04_9FIRM/295-346 ...LGWVISTG........kDGKGFAEKVKTADEVNFQGE..ENgpITVTGSA.-.NGSKRIVTIGVD...
A0A1V3J3Y5_9PAST/1086-1133 ...MGWIVSA-.........EGNNYTDTVKNANEVKFKGK..NG..ISVTGET.-.KDGVREITVAI-e..
M4RGP3_BIBTR/1207-1255 ...YGWVVST-.........SDNAFKQAVKNANQVNFVGS..EG..VNVEGSA.S.EEGVYNVTFGVK...
A0A377I3T4_HAEPH/2-42 sag--------.........---DHSAAVTNTDEVVFEGT..NG..VDVSAKS.-.ENGVHTITVSI-a..
A0A263HFJ5_9PAST/1005-1052 ...LGWVVSA-.........SGNEYKNTVKNANEVNFVGA..NG..ISVTGET.-.KENVREIKISVD...
A0A1V4AZP0_9PAST/1177-1225 ...LGWIVST-.........SDNGYADQVRNANKVNFKGK..DG..ISVTGET.N.ADGVREITIAL-k..
A0A134CBF2_9FIRM/541-589 ..i-GWILSV-.........PDDSYSEAVVHNRKVSFFGK..DL..AKVTAAG.K.GEDPRMITVTVD...
F9N555_9FIRM/1-59 ...MGWIVSSNkttgengavTTDEYSATVKNANEVKFVGE..GT..AVVSGKT.D.DQGVRTITVKVD...
F9MQG4_9FIRM/2285-2336 ...LGFVIKGKa......adGTTDVTGQVKHANTVEFAGE..DL..AKVITES.-.ANGVSKVTVKVN...
A0A286EWP4_9NEIS/243-297 ...MGWVVQSDkt....tgdTSKEFSNQVKNADVVKFVGT..GA..ATVSANT.T.ADGTNVITIDV-a..
A0A286EX56_9NEIS/100-148 ...MGWVVST-.........TTGEYKDVVKNANEVKFIGT..GG..ATVTGKT.N.AEGVREITIDVQ...
F9N6N5_9FIRM/1394-1442 ...LGWIVSA-.........EGNSYSDQVRNANEVKFVGE..GT..ATVTGKT.D.DKGVRTITVKVD...
A0A377R308_9NEIS/2029-2083 ...MGWVVSSDkt....tgnLTKTFNGQVKNAGEVEFVGT..GA..AEVSAQT.T.TGGKHTITVNVD...
A0A377I3T4_HAEPH/383-429 ...LGWVVSA-.........--GDYAANVTNANEVRFNGS..NG..ISVTGET.D.EHGVRNINVSI-a..
A0A134CB45_9FIRM/457-503 ...LGFVVSA-.........-GDSYSEKVQHAQEVNFKGE..GL..AEVSGKT.-.EGQKRIITVKVD...
M4RGP3_BIBTR/1536-1584 ...YGWVVAT-.........PDNQFQQAVRNANHVNFVAG..TG..VSVEGAV.S.SDGVYNITIATN...
A0A377R308_9NEIS/1621-1675 ...MGWVVSSDkt....tgnLTKTFNGQVKNAGEVEFVGT..GA..AEVSAQT.T.TGGKHTITVNVD...
F5S9C5_KINKI/1082-1130 ...MGWVVSTK.........DSNGYTDVVKNSNQVDFKGT..GL..ATVKGET.-.VNGVRTITVDVN...
F9MQG4_9FIRM/1910-1961 ...LGFVIKGKa......edGTTDVVAQVKHADTVEFAGE..DL..AKVITES.-.ANGVSKVTVKVN...
A0A377I3H9_HAEPH/54-107 ...MGWVVSSNki....tgnLGTEYTAQVKNANEVKFVGT..GA..AVVSGKT.-.DDNTRTITVDV-a..
L1NSC4_9NEIS/54-107 ...MGWVVSSDkt....tgnESQAFSGQVKNAGEVEFVGT..GA..AKVTAKT.-.ENGKHTVTVGVD...
M4R6R0_BIBTR/1771-1819 ...YGWVVAT-.........PDNQFQQAVRNANHVNFVAG..TG..VSVEGAV.S.SDGVYNVTIATN...
A0A134CB04_9FIRM/91-145 ...MGFVLGASvn....aagGDKAYQDVVKNGNRVKFVGL..GG..AWISGKT.A.DDGTRIITIDVN...
A0A3N4VQH3_9PAST/2032-2083 ...MGWVVGAP........qTEGGYTDQVRNANKVDFIGE..GL..AKVTGKT.NaTTGVREITVSVN...
A0A134CB45_9FIRM/1-34 ...--------.........-------QVKHANTVEFAGE..DL..AHVVVTS.-.ADGKHKVTVKVN...
M4RGP3_BIBTR/877-925 ...YGWVVST-.........PDNQFTQAVKNANEVKFTGS..DG..IKVAGAV.D.STGVYNITFEVN...
A0A1V3J3Y5_9PAST/1573-1622 ...MGWIVSA-.........EGNKYTDTVKNSNEVKFIGD..NG..ISVKGAT.NaTTGVREITIAM-e..
A0A448TVH7_9PAST/845-897 ...LGWIVSAGk......tdSSSTYKDVVKNANEVHFVGS..DG..IIVDGQT.N.SDGVREIKITL-d..
M4RGP3_BIBTR/1872-1920 ...FGWVVST-.........PDNQFTQAVRNANHVNFVAG..NG..VVVEGAV.A.SEGVYNVTIAA-q..
F9MQG4_9FIRM/1275-1326 ...LGFVIKGKa......adGTTDVTGQVKHANTVEFAGE..DL..AKVITES.-.ANGVSKVTVKVN...
A0A1T0B713_9PAST/6913-6969 ...LGFVVATRtedpqsdeaKNNNYSAKVQHANKLEVVGG..NN..IEVIGVT.-.KGNTREIKV---sm.
F9MQG4_9FIRM/1752-1798 ..v-GFVVA--.........DGANYHATVTNAQTVKFVGE..GL..AEVSGKT.-.EDNVRTFTVKVD...
F9N6N6_9FIRM/644-692 ...MGFVVSA-.........KDNGYTEQMRNANKVEFKGD..NG..VQVTGKT.L.ADGTREITVAL-k..
A0A263HB69_9PAST/1461-1508 ...MGWVISA-.........-EDSYKDTVKNANEVKFLGT..GL..ATVSGKT.D.EAGVRTITVNVD...
A0A377I3T4_HAEPH/770-816 ...LGWVVSA-.........--GDYAANVTNANEVRFNGS..NG..ISVTGET.D.EHGVRNINVSI-a..
F9N6N5_9FIRM/426-479 ...MGWVVSSDkt....tgeLTKAYTDQVKNADEVKFVGE..GG..VTVSGKT.-.ENGIRTITVKA-e..
A0A377I3H9_HAEPH/733-780 ...MGWIVST-.........SANDYSANVTNTKEVNFVGL..GA..VDVSGSN.-.VDEIRNINVSVD...
F9MQG4_9FIRM/1120-1166 ...MGFVVA--.........DGANYHATVANAQTVKFVGD..GL..ATVTGET.-.KGDVRTFTVKVD...
F9MQG4_9FIRM/2447-2498 ...LGFVIKGKa......ldGTTDVVAQVKHADTVEFAGE..DL..AKVITES.-.KDGVSKVTVKVN...
F9N557_9FIRM/389-438 ...MGWVVSAK.........DGNGYKDVVKNANVVDFKGG..KG..IEITGKT.L.TDGTREITVGIK...
A0A377R308_9NEIS/2845-2899 ...MGWVVSSDkt....tgnLTKTFNGQVKNAGEVEFVGT..GA..AEVSAQT.T.TGGKHTITVNVD...
F9MQG4_9FIRM/2784-2834 ...LGFVIKGTd.......eNGKAVSGQVRHANTVEFAGD..GL..AKVITES.-.KDGVSKVTVKVN...
A0A1T0AZ81_9PAST/4775-4829 ...MGFVVATRned...pesKAGTYADKVQNANKLEVVGG..DN..IEVTGST.-.KGNTREIKV---sma
A0A286EWM3_9NEIS/97-144 ...MGWVVST-.........ATGEYKDVVKNANEVQFIGD..GL..ATVTGVT.-.EGNIRKIKIDVK...
M4RGP3_BIBTR/2182-2230 ...YGWLVST-.........PDNNFTQAVRNANQVNFVGT..EG..ASVEGSV.S.ADGVYNVTVGVK...
A0A134CB45_9FIRM/616-662 ..v-GFVVA--.........DGGNYHATVTNAQTVKFVGE..GL..AEVSGKT.-.ENDVRTFTVKVD...
M4R6R0_BIBTR/1442-1490 ...YGWVVST-.........SDNAFKQAVKNANQVNFVGS..EG..VNVEGSA.S.EEGVYNVTFGVK...
F9N6N6_9FIRM/240-288 ...LGWIVSA-.........EGNKYSDQVRNANEVKFVGE..GT..ASVTGKT.D.ENGVRTITVKVD...
A0A134CB45_9FIRM/143-189 ...MGFVVA--.........DGANYHATVANAQTVKFVGE..GL..ATVTGET.-.KGDIRTFTVKVD...
A0A4V3D9G1_9PAST/517-564 ...MGWLVSA-.........KGNDYLDTVKNANEVKFIGT..GL..ANVTGET.-.KDNVREITIDVK...
F9N396_9FIRM/2045-2103 ...MGWIVSSDkttgangttTATEYSEAVKNANEVRFVGE..GS..AIVSGKT.D.DKGVRTITVKVD...
#=GC seq_cons ...hGWVVSu..........ssssYsspV+NANcVcFsGp..ss..spVoGcT...psGlRpITVpVs...
//
