#=GF ID   Tsi1
#=GF AC   PF21565.1
#=GF DE   Immune protein Tsi1
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF SE   ECOD:EF20321
#=GF GA   27.00 27.00;
#=GF TC   27.30 28.30;
#=GF NC   26.80 22.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RC   Paper describing PDB structure 3vpj
#=GF RN   [1]
#=GF RM   22700987
#=GF RT   Structural insights into the Pseudomonas aeruginosa type VI
#=GF RT   virulence effector Tse1 bacteriolysis and self-protection
#=GF RT   mechanisms.
#=GF RA   Ding J, Wang W, Feng H, Zhang Y, Wang DC;
#=GF RL   J Biol Chem. 2012;287:26911-26920.
#=GF RC   Paper describing PDB structure 4eqa
#=GF RN   [2]
#=GF RM   22931054
#=GF RT   Structural insight into how Pseudomonas aeruginosa
#=GF RT   peptidoglycanhydrolase Tse1 and its immunity protein Tsi1
#=GF RT   function.
#=GF RA   Shang G, Liu X, Lu D, Zhang J, Li N, Zhu C, Liu S, Yu Q, Zhao Y,
#=GF RA   Zhang H, Hu J, Cang H, Xu S, Gu L;
#=GF RL   Biochem J. 2012;448:201-211.
#=GF RC   Paper describing PDB structure 4fgi
#=GF RN   [3]
#=GF RM   22792331
#=GF RT   Structural insights into the effector-immunity system Tse1/Tsi1
#=GF RT   from Pseudomonas  aeruginosa.
#=GF RA   Benz J, Sendlmeier C, Barends TR, Meinhart A;
#=GF RL   PLoS One. 2012;7:e40453.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This protein family includes Immune protein Tsi1 from
#=GF CC   Pseudomonas aeruginosa and similar proteins predominantly from
#=GF CC   bacteria. Tsi1 plays a role in preventing early activation of
#=GF CC   toxin Tse1. Tsi1 binds to a large surface of Tse1 and thereby
#=GF CC   occludes the active site to specifically inhibits enzyme
#=GF CC   activity by forming a hydrogen bond with the catalytic diad. It
#=GF CC   adopts an all-beta fold consisting of 14 beta-strands, which
#=GF CC   constitute three antiparallel blade-shaped beta-sheets [1-3].
#=GF SQ   7
#=GS A0A7Y9Y0Q0_9SPHN/28-166  AC A0A7Y9Y0Q0.1
#=GS U2ZTB1_PSEA4/20-161      AC U2ZTB1.1
#=GS TSI1_PSEAE/22-167        AC Q9I2Q0.1
#=GS A0A2R7T001_9BURK/1-135   AC A0A2R7T001.1
#=GS A0A432M842_9GAMM/12-133  AC A0A432M842.1
#=GS A0A0D6T0R4_9PSED/22-167  AC A0A0D6T0R4.1
#=GS A0A2T5P7R2_9PSED/22-167  AC A0A2T5P7R2.1
A0A7Y9Y0Q0_9SPHN/28-166             anpsri------SLQADAPGYA.YYYGGHDAVTVRIENPQPG-SPADVLAEPPARVT-YGGGTACEIG-GGNWKRDSFWSYDAGRALAVAEFSGSNDWLTFYDSRTCAKLGD.IDVSGRRWRFEDGAVVLCED---------------------lpdgkdrcfthsrlplp..
U2ZTB1_PSEA4/20-161                 ......CAYRALAIEPE--TPA.LYVGIGERVRVEFDNYK-LDGEVDSFPEPPLRIRAVQGGKACEVE-GGIWLRNAVLLDASEQRLLVQSFSGAGGELTFYDTSSCAQLAR.VELPEASWALQGEQLVIGRTCSAAGLAHCAEREVHTLNQQC...................
TSI1_PSEAE/22-167                   ......CTFTQLEIVPQFGSPN.MFGGEDEHVRVMFSNEDPNDDNPDAFPEPPVYLADRDSGNDCRIEDGGIWSRGGVFLSQDGRRVLMHEFSGSSAELVSYDSATCKVVHR.EDISGQRWAVDKDGLRLGQKCSGESVDSCAKIVKRSLAPFC...................
A0A2R7T001_9BURK/1-135              ....lq----PVAIEPAATEPTdNYIGRTSMLEIRFHNNK-TSGPVDAFPEPPLTVKRLDTQTECTIQDGGIWVRRHVWASRTGGTLVTHEYSGSNDELVFYDTRNCARTAV.IDVSDARWAIEGG----------------------------vvtkspaqagkrpsrvgld
A0A432M842_9GAMM/12-133             cdftpv------PIVGS-----.--VGKVGQVSVSFGEAD-DVKHPAAWQ-GPLQI-SVDGAPQCSVSEDVSIVEEPVMLAGD--VLYVPTYSGSNNRLYAVDVKTCKVIWRsVNFSGKT-VLKQGRLVAGK----------------------sgiavdkrcr.........
A0A0D6T0R4_9PSED/22-167             ......CGFAPLPLSASAAAPN.VFVGKGQHLEVSFTNENPEIKEPDAFPEPPVVLRDTASGKGCNIEDGGIWAREPLYLSRDEKRLVTFEYSGSNSELVAYDTATCKAVHR.LDVSGKRAAVVGEQLVLGSQCDGDSLGSCKKQARQPVQPFC...................
A0A2T5P7R2_9PSED/22-167             ......CSFTSLELSADPAAPS.NFVGEGRQLQVRFVNENPDISAPDAFPEPPLVLLNKATGVSCSIEDGGIWARSPLLLSSDESRLLTYEFSGSNAELVAYDTATCAVVQR.QDISGQRAGLRDGQLTLGQQCDGDGLDSCKQLAPLPTQTFC...................
#=GC seq_cons                       ...........lslpss.ssPs..alGcspplpVpFsNtp.s.stsDAFPEPPlhltshsuGssCpIp-GGIWsRpslhLupstppLlshEaSGSNsELshYDotTCthltR.lDlSGpRhulcsstLslGpp........................................
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