#=GF ID Tsi6
#=GF AC PF18660.5
#=GF DE Tsi6
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF08152
#=GF GA 26.90 26.90;
#=GF TC 27.10 27.60;
#=GF NC 26.40 26.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 29237732
#=GF RT Diverse NADase effector families mediate interbacterial
#=GF RT antagonism via the type VI secretion system.
#=GF RA Tang JY, Bullen NP, Ahmad S, Whitney JC;
#=GF RL J Biol Chem. 2018;293:1504-1514.
#=GF DR INTERPRO; IPR040818;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Tsi6 inhibits the NADase activity of Tse6, an integral membrane
#=GF CC toxin from Pseudomonas aeruginosa. The Tsi6 immunity protein
#=GF CC adopts an all-alpha-helical fold that binds to a surface of Tse6
#=GF CC [1].
#=GF SQ 37
#=GS M5DP83_9GAMM/4-88 AC M5DP83.1
#=GS A0A523Q4L7_9BURK/1-58 AC A0A523Q4L7.1
#=GS A0A1T5LW87_9GAMM/2-85 AC A0A1T5LW87.1
#=GS A0A839UQ42_9GAMM/2-88 AC A0A839UQ42.1
#=GS B2JFU0_PARP8/5-83 AC B2JFU0.1
#=GS Q88I97_PSEPK/5-87 AC Q88I97.1
#=GS Q2SFS3_HAHCH/4-83 AC Q2SFS3.1
#=GS A0A1I3K1B5_9PSED/1-59 AC A0A1I3K1B5.1
#=GS TSI6_PSEAE/2-84 AC Q9I740.1
#=GS G7Z743_AZOL4/10-89 AC G7Z743.1
#=GS A0A248JNA0_9PROT/59-139 AC A0A248JNA0.1
#=GS A0A090VWM0_PSEVU/7-89 AC A0A090VWM0.1
#=GS D3IMR9_9BACT/12-91 AC D3IMR9.1
#=GS A0A4U1HIJ8_9DELT/10-93 AC A0A4U1HIJ8.1
#=GS A0A6M8UJR6_9GAMM/13-95 AC A0A6M8UJR6.1
#=GS A0A248JLL4_9PROT/13-93 AC A0A248JLL4.1
#=GS A0A090UZA0_PSEVU/5-95 AC A0A090UZA0.1
#=GS A9BU08_DELAS/2-84 AC A9BU08.1
#=GS A0A1N7SFE0_9BURK/5-83 AC A0A1N7SFE0.1
#=GS A0A0J1GL55_9GAMM/6-87 AC A0A0J1GL55.1
#=GS A5G1B6_ACICJ/8-86 AC A5G1B6.1
#=GS A0A0D6SLL5_9PSED/2-84 AC A0A0D6SLL5.1
#=GS A0A4U1JIA1_9DELT/10-92 AC A0A4U1JIA1.1
#=GS A0A2U2GYD2_YERPE/10-100 AC A0A2U2GYD2.1
#=GS A0A4V2WEC1_9SPIR/54-136 AC A0A4V2WEC1.1
#=GS A0A014MH20_9GAMM/9-91 AC A0A014MH20.1
#=GS W0P9E0_ADVMD/8-100 AC W0P9E0.1
#=GS A0A1H4FNW7_ALKAM/2-84 AC A0A1H4FNW7.1
#=GS A0A1I1UAD5_9DELT/11-93 AC A0A1I1UAD5.1
#=GS F9D911_9BACT/15-93 AC F9D911.1
#=GS A0A5C0AXJ4_9BURK/44-126 AC A0A5C0AXJ4.1
#=GS D4E4Q0_SEROD/4-86 AC D4E4Q0.1
#=GS A0A523Q1V8_9BURK/5-83 AC A0A523Q1V8.1
#=GS A0A4U1HSX1_9DELT/12-92 AC A0A4U1HSX1.1
#=GS A0A433SD84_9BURK/4-84 AC A0A433SD84.1
#=GS F8F4A3_GRAC1/9-90 AC F8F4A3.1
#=GS J8UT44_PSEPU/8-90 AC J8UT44.1
M5DP83_9GAMM/4-88 ..................k-IVDMIDEVLPEIQLKEKTS..EDSN..........IYASIARQLEFLKNCYENG.....L.DYRVKLNg.kKLNFGIIASRNFA..G.PEEELEEKISRINSYIIH.............
A0A523Q4L7_9BURK/1-58 ..................m--------------------..----..........--QSCKTQLEYLQELVDGR.....R.QDAQRLY...EIILGVYAAREFE..A.LDMRFAEMLYAV------edvvkt.......
A0A1T5LW87_9GAMM/2-85 ..................k-SIDAVQRALALARTRAGKT..PGFP..........LYASCVAQLEYLLSNLDGS.....VpVDRPKLR...TFTIGHYAVREFE..E.SDEELARALKDAYLIASK.............
A0A839UQ42_9GAMM/2-88 ................stf---NKIENAKRQIDSLLLKN..PNYQ..........LLQSIHNQLLFIIGDFDENgkilkK.NKKNDVE...KLILGVQAIRELD..T.SFPELSDLLCDIDF----eyk..........
B2JFU0_PARP8/5-83 .................nl--LSKIDQALTGIELNSSGA..S--A..........NIESIHRQLTWCRAQLTGQ.....P.SEHKQ-G...PLTMGLIATREFDmwG.DNPELASLINEI------qra..........
Q88I97_PSEPK/5-87 ...................TPLGYVQKAIDITAQRNKAC..PAYP..........IYGMLLNQLDYVKAVFEGR.....E.QDKSKLH...QLSIGAIASKDFE..E.NDPELARALKDAYYVAIQ.............
Q2SFS3_HAHCH/4-83 ...............ketl------CEAIAINEERLKLT..PDFE..........IYHSIARQLNYLLAIVDGK.....E.KDESKLD...KIILGHFAVREFE..E.SDPELSQILKKCQNIA--f............
A0A1I3K1B5_9PSED/1-59 ...................--------------------..----..........MYSSLLNQLQYVKHCIEDA.....G.IDRSRLH...DISVGHIAIREFE..E.SDPEFAATLNRAYFIC--yy...........
TSI6_PSEAE/2-84 ...................TPIEYIDRALALVVDRLARY..PGYE..........VLLSAEKQLQYIRSVLLDR.....S.LDRSALH...RLTLGSIAVKEFD..E.TDPELSRALKDAYYVGI-r............
G7Z743_AZOL4/10-89 ..............lrrri------ARASAGIAALAGRE..PDNS..........WLTSIQRQLDYVDGAARDG.....A.KRLDRAA...DLNFGLLASHYVD..D.IDPALAAELHAI------saat.........
A0A248JNA0_9PROT/59-139 ..................t-SIQVSERALALAEARLAAA..PEFS..........TYASLVAQLRYVLMALKGG.....E.--RARLK...EIIVGHYAVREFA..E.SDPELAEALMAAQAIAT-r............
A0A090VWM0_PSEVU/7-89 ...................TALDYINDAIHAVSKRISSN..SEFP..........LYTLAKEQLEYIKSILIGT.....E.SDKSKLH...TLNLGALASKEFE..T.TDEELAGHLSNANYIASQ.............
D3IMR9_9BACT/12-91 .................dq----LCDETMAYFKKIMNDY..PQIT..........MYKSIYVQIWMIKKDLSEN....vR.LDRVKDF..qKYSLGAIAAKNFD..E.GD----------------vygdaigtidama
A0A4U1HIJ8_9DELT/10-93 ............efdrrlg-------DAMKGIDALAAQY..PEER..........AIQSIKLQLEALHGWTRGG.....R.KPEQVEK..dRLNFGLLASRFVD..E.IDSKLAGELYQLASY---viy..........
A0A6M8UJR6_9GAMM/13-95 ...................TAIDYVNDAIDVLQSRLVKK..PTFA..........LYIMAFEQVKCVKNILLEV.....E.KDKSKLH...TMNLGVLASKEFD..T.TDPELAQSLSNVNYIASQ.............
A0A248JLL4_9PROT/13-93 .................vp---DLIRDALARCRRLREQW..PDIA..........TFASVHRQLDYLLKVATDP.....V.ADRSRLT...DIVIGVQAAREVE..T.IDPDLADLLHTIN-----awan.........
A0A090UZA0_PSEVU/5-95 ...................TALDYVDRALRLAKKRHHHI..K-YNvigg.dtlepMYNSIVQQLIFLHNIITGQ.....E.TDKAKLW...KLTFGMYATKEFE..V.TDPIFEDRLGDAFYIASQ.............
A9BU08_DELAS/2-84 ...................TPLEYIDRALALVAQRALAL..PGHV..........FFQHLAQQLQYVRAVLLDR.....G.LDRSRLH...QITIGSVAVKEFD..E.TDPELARALKDAHYVAVQ.............
A0A1N7SFE0_9BURK/5-83 ...............elly----KIDEALSVVEPML--A..PTWP..........NVQSIHRQLMWCRAQISGE.....T.SE-SKQG...PLTMGLIATREFEmwG.DNPELAALINQI------qra..........
A0A0J1GL55_9GAMM/6-87 ..................l-KLAVCERALLLLQAQPNAF..I-VP..........IYTSVEAQLHWLIDYFSGK.....E.TDMKRLH...TLTFGHYAVRELS..P.RYGELYAGLNAAFYVAEK.............
A5G1B6_ACICJ/8-86 .................pf-----LNEALRKVETLLAAR..PGLP..........PLVSIRNQLIYLKQVCAGT.....-.VGSERLP...ETILGIHAVRDIE..S.WDIKLAYQIHRID-----tvvdr........
A0A0D6SLL5_9PSED/2-84 ..................s-VLEPLDHALVLVRERKQRL..PGFA..........PYAQAEAELVYLRRAVQDP.....T.LDRTPLH...QGSLGALAVKEFE..E.TDPELARALKDAHWIAAQ.............
A0A4U1JIA1_9DELT/10-92 .................ef--LEVLEQTRIEAEARFQRA..PRSA..........LYESIARQLAAMQSMTESG.....R.TPTEDER..eSITIGLLAARELE.pA.QDPDLVDFIER-------lheln........
A0A2U2GYD2_YERPE/10-100 ...................TALDYVDRALRLAQKRHHHI..K-YNvigg.etlepMYNSIVQQLIYLHNVITGE.....E.KDKTKLW...KLTFGMYATKEFE..A.TDPIFEDRLGDAFYIASQ.............
A0A4V2WEC1_9SPIR/54-136 ................ltq----LVREALNMTNERLRKS..PEWQ..........TLQVIQKQLIAIEEDLKNQ.....G.ASKDELK..kRINIGLISVREFE..A.DDPDFTDLLQKIDYRYK-k............
A0A014MH20_9GAMM/9-91 ..................a-TLNYVTDAISIVELRLKKN..PDFN..........LYVMALNQLRYVQAVLTGA.....E.KDKSKLH...TMNLGVLASKEFD..T.SDPDLAKNLSNVNYIASQ.............
W0P9E0_ADVMD/8-100 ...................TAIEYVDRALIMANRRYEAN..RSKQelesisslevMYDSIVQQLTFVRRILTGE.....E.KDKARLW...ELTFGTYSAKEFD..A.SDPVFFDRLGDAFFIASQ.............
A0A1H4FNW7_ALKAM/2-84 ...................TPIEIVRKGISLTEKRLKDI..PDFD..........IYQSIIKQLQYLLSIIDGS.....E.LDRSKLD...KIIVGHFAVREFE..E.SDPELAEILKNCQSIAF-k............
A0A1I1UAD5_9DELT/11-93 ...............dafa-------QVLAEARARTQALdpSQWP..........LLRRIADQLELMARATARG.....R.VPHEEDR..aRVDVGLIAAREFE..Q.TDPEYADQLQELEYT---frr..........
F9D911_9BACT/15-93 ..................k---EIVDLAIEETKNLMEMS..PKVA..........IYASIYNQLVDIKQNIIGE.....N.KVFSRFElykRYSLGAVAVKNFD..E.NADEYAQKLID-------sy...........
A0A5C0AXJ4_9BURK/44-126 ..................q-PVDYLDEALALCRQRRRRF..PGAQ..........LYSAIENQLNYLRGVVVGK.....Q.TDRSRLR...DIALDRFARGGMD..G.VDAVFARALKNAAHIG--hr...........
D4E4Q0_SEROD/4-86 ...................TAIDYVNAALAVVKERQNTL..PSFP..........LYQSALNQIQYIKDILEGN.....N.NDKSKLH...TITLGAYASKEFA..T.TDPELAQHLSNVNYIASQ.............
A0A523Q1V8_9BURK/5-83 ...............spip-------QALTRCLELLQTH..PHSQ..........PLQSCKAQLEYLQELVDGR.....R.QDAQRLN...EIILGVYAAREFE..A.LDMGFAEMLYAV------edvvk........
A0A4U1HSX1_9DELT/12-92 .................ff---EVLDETRREAEALAQQA..RGFQ..........PLRSVADQLAAMQTMTAGG.....R.TPTEDER..dSISIGLIAVRELE..PaTDA---------------qmasftarlhel.
A0A433SD84_9BURK/4-84 rielllraqnqcgklmvmy--------------------..PENI..........TLQSIDSQIQYLIDLENGV.....T.NDRSKLS...QIIIGVQTAREIE..G.LDENAADIFYKVA-----seak.........
F8F4A3_GRAC1/9-90 ................sgl-----LDSASKMVNDRLAHA..PGWQ..........VLQVIQTQLQAMQDDVNHE.....R.VPTAEAK..kRINIGVLAVREFE..A.NDPEFADILIKAAYLYKK.............
J8UT44_PSEPU/8-90 ...................TPLEYVDKALALAIDRQNRI..PGFP..........VYATVIDQLKYIRAVFDGT.....E.KDKSKLH...RLTIGAIAAKEFE..P.TDEALAEALLHVYYIAEQ.............
#=GC seq_cons ......................thlpcAlthsppphpph..Pths..........hapSltpQLpalpshlpGp.....p.pD+s+Lc...clslGhhAs+EF-..s.sDP-LActLpps..h................
//
