#=GF ID TsiV3
#=GF AC PF20889.1
#=GF DE Antitoxin TsiV3
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE ECOD:632.20.1
#=GF GA 28.40 28.40;
#=GF TC 28.90 101.60;
#=GF NC 28.00 27.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RC Paper describing PDB structure 4noo
#=GF RN [1]
#=GF RM 24699653
#=GF RT Molecular mechanism for self-protection against the type VI
#=GF RT secretion system in Vibrio cholerae.
#=GF RA Yang X, Xu M, Wang Y, Xia P, Wang S, Ye B, Tong L, Jiang T, Fan
#=GF RA Z;
#=GF RL Acta Crystallogr D Biol Crystallogr. 2014;70:1094-1103.
#=GF RC Paper describing PDB structure 4nso
#=GF RN [2]
#=GF RM 24751834
#=GF RT Structural basis for recognition of the type VI spike protein
#=GF RT VgrG3 by a cognate immunity protein.
#=GF RA Zhang J, Zhang H, Gao Z, Hu H, Dong C, Dong YH;
#=GF RL FEBS Lett. 2014;588:1891-1898.
#=GF RN [3]
#=GF RM 24348240
#=GF RT Dual expression profile of type VI secretion system immunity
#=GF RT genes protects pandemic Vibrio cholerae.
#=GF RA Miyata ST, Unterweger D, Rudko SP, Pukatzki S;
#=GF RL PLoS Pathog. 2013;9:e1003752.
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Antitoxin TsiV3, also known as TsaB, is a immmunity protein from
#=GF CC Vibrio cholerae that inhibits the activity of toxin VgrG3, a
#=GF CC protein found in the spike of the type VI secretion system
#=GF CC (T6SS) syringe- like complex. TsiV3 folds into a three-helix
#=GF CC bundle and adopts a dimeric assembly to bind the deep
#=GF CC active-site groove of the catalytic domain in the C-terminal
#=GF CC region of VgrG3, modifying the conformation and preventing
#=GF CC substrate binding [1-3].
#=GF SQ 6
#=GS A0A023PSF3_VIBCL/32-121 AC A0A023PSF3.1
#=GS A9MJU9_SALAR/40-133 AC A9MJU9.1
#=GS A0A2X4SVP4_SALER/40-133 AC A0A2X4SVP4.1
#=GS A0A0Q2N7S0_VIBFU/32-121 AC A0A0Q2N7S0.1
#=GS I2BAU5_SHIBC/40-133 AC I2BAU5.1
#=GS TSIV3_VIBCH/32-121 AC Q9KN41.1
A0A023PSF3_VIBCL/32-121 .SGVHQKILVCIQNEIAKSETQIRNNISSKSIDYGFP.......DDFYSKQRLAIHEKCMLYINVGGQRGELLMNQCELSMLQGLDIYIQQYIEDVDN
A9MJU9_SALAR/40-133 n-PMSTE---CIDAEINAQNKSIDSFIGKHGDITSPEdgnivelKLFTDNQRKYIDGKCDLWLKTGGQNGMLLNKQCVLDETISLKKLLSDFVSSVDG
A0A2X4SVP4_SALER/40-133 n-PMSTE---CIDAEINAQNKSIDSFIGKHGDITSPEdgnivelKLFTDNQRKYIDGKCDLWLKTGGQNGMLLNKQCVLDETISLKKLLSDFVSSVDG
A0A0Q2N7S0_VIBFU/32-121 .SGDHQEMILCIQNETASVESQVKKIVSESGEYYGIY.......KDFYTKQRLAIHEKCSLYINLGGQRGELFMAQCELDGVISLELFVKQYTDDLDN
I2BAU5_SHIBC/40-133 .DPMSTT---CIDSELNTQDGLINSFIGKHRDITSPEdgnpidlKSFAGSQRKLIDEKCDLWLKAGGQNGVLLSKQCILDETISLKNMLTDFVRSVDG
TSIV3_VIBCH/32-121 .SGVHQKILVCIQNEIAKSETQIRNNISSKSIDYGFP.......DDFYSKQRLAIHEKCMLYINVGGQRGELLMNQCELSMLQGLDIYIQQYIEDVDN
#=GC seq_cons .sshppc...CIpsEIssp-spIcshIuc+u-hhu.........KsFhspQRhhIcEKCsLalpsGGQpG.LL.pQC.LDtsISLchhlppalcsVDs
//
