#=GF ID   UL42
#=GF AC   PF17638.6
#=GF DE   HCMV UL42
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   PRODOM:PD028077
#=GF GA   25.00 25.00;
#=GF TC   25.20 25.20;
#=GF NC   23.80 24.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   26555021
#=GF RT   Degradation of host ubiquitin E3 ligase Itch by human
#=GF RT   cytomegalovirus UL42.
#=GF RA   Koshizuka T, Tanaka K, Suzutani T;
#=GF RL   J Gen Virol. 2016;97:196-208.
#=GF DR   INTERPRO; IPR035110;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Family members include UL42 proteins found in Human
#=GF CC   cytomegalovirus (HCMV). UL42 has two Pro-Pro-X-Tyr (PPxY)
#=GF CC   sequences, a hydrophobic region at the C terminus and no
#=GF CC   N-terminal signal peptide. These features are shared with herpes
#=GF CC   simplex virus (HSV) UL56. UL42 has a putative C-terminal
#=GF CC   trans-membrane region. HCMV UL42 interacts with Itch, a member
#=GF CC   of the Nedd4 family of ubiquitin E3 ligases, through its PY
#=GF CC   motifs as observed in HSV UL56, suggestive of a regulatory
#=GF CC   function [1].
#=GF SQ   13
#=GS UL42_HCMVA/1-125         AC P16815.2
#=GS A0A0F7GA40_SCMVC/20-135  AC A0A0F7GA40.1
#=GS A0A2J6RHL0_9HELO/10-120  AC A0A2J6RHL0.1
#=GS Q7TFR3_RHCM6/1-130       AC Q7TFR3.1
#=GS A0A0G2UM21_9BETA/13-133  AC A0A0G2UM21.1
#=GS G8XSV6_9BETA/5-119       AC G8XSV6.1
#=GS UL42_HCMVM/1-125         AC F5HHZ3.1
#=GS G8XTU7_SCMVC/3-118       AC G8XTU7.1
#=GS G8XUB7_9BETA/46-163      AC G8XUB7.1
#=GS A0A0K1H030_9BETA/5-127   AC A0A0K1H030.1
#=GS I3WFA0_9BETA/1-130       AC I3WFA0.1
#=GS Q8QS47_9BETA/1-146       AC Q8QS47.1
#=GS A0A1L6Z022_9BETA/5-127   AC A0A1L6Z022.1
UL42_HCMVA/1-125                    .............MEPTPMLRD...RD..HDDAPPTYEQAMGL....CP.............T.T.V..STP...........PP......P............PPDCSPPPYRPPYCLVSSP..SP.R.HTFDMDMMEMPAT.MH..P.TTGA........YFDN...GWKWTFALLVVAILGI..IFLAVVFTVVINRDSANITTGTQASSG......
A0A0F7GA40_SCMVC/20-135             ......qqlpqhq--------Q...PT..NDDAPPSYEEALGM....AT.............V.S.F..TAM...........GH......G............APTFSDDSAPPPYCLVVGE..VPpRpDNFQMDMSDFPPT.SH..P.PIEA........YYED...GWKWTVGVFIIAILGI..ILLAVLVSVLMQMKSR-----------n.....
A0A2J6RHL0_9HELO/10-120             ..........pyp---------...-E..YDGAHPPQERLLGQ....PP.............V.ApL..SQP...........PP......A............QSAAAPAPYRAPFQ-TDTP..FH.E.HSYDSPVANQYAA.SH..P.NDPD........VQEGrrlSKKWQRRLYWIVPLGIlaIVLAVLFEV------------------yksdfe
Q7TFR3_RHCM6/1-130                  msatnessprnds---------...--..EDVRPPAYDEIVGS....PP.............R.P.R..DLPtqsrrnrrgltTD......A............PPDSPPPPYHAV---VGEV..PP.RpDNFRMDMTEFPAN.MH..P.PVEA........YYDD...GWKCTIVVFVVSLLGI..ILMTVLVSVILVLNKS-----------nnkgt.
A0A0G2UM21_9BETA/13-133             ......qpqpqrp------QRQ...QS..NDDAPPSYEEALGMetfvLP.............IdA.LgtRAP...........AS......P............SDDSSPPPY---YMVVGGA..PP.RpDNFRMDMSEFPAT.SH..P.PIEA........YYED...GWKWTVGVFIVSILGI..ILLAVLVSVLMT---------------lkntg.
G8XSV6_9BETA/5-119                  ....lqcpvlvgm---------...ED..PDLPPPSYEEAMCS....GN.............V.T.L..TAL...........-P......M............SAMALPPPYEE-QCLSTSLemDP.I.SERDSNCPGRPTSnME..NlLLSD........NFYS...GLKWTLALFIMAVVGL..IFIAIIFAVVISR--------------rh....
UL42_HCMVM/1-125                    .............MEPTPMLRD...RD..HDDAPPTYEQAMGL....CP.............T.T.V..STP...........PP......P............PPDCSPPPYRPPYCLVSSP..SP.R.HTFDMDMMEMPAT.MH..P.TTGA........YFDN...GWKWTFALLVVAILGI..IFLAVVFTVVINRDSANITTGTQASSG......
G8XTU7_SCMVC/3-118                  ......atnehps---------...--..EDELPPSYEESLGM....AT.............I.V.I..PVT...........ELg....gR............VSRPSPDEQPPPYHLVTGE..APpRpDNFRMDMSDFPAT.MQ..P.PVEA........YYDD...GWKWTICVFLVSILGI..VLLAILVSVLLTIQS------------ssr...
G8XUB7_9BETA/46-163                 .....rdpwvprr--------P...RD..-PDSPPSYEEAMSM....PR.............VdG.I..PLP...........PP......P............STTGFPPPYEEP-------..CQ.P.TVLEMELIAGPAG.SSrsS.TNSAadslllsdEFYS...GVRWTIVLFVVAVIGL..IFIAVVLGVVISRG-------------kgs...
A0A0K1H030_9BETA/5-127              ...nessprndse---------...--..-DVRPPAYDEIVGS....PP.............R.P.R..DLP...........TQ......PrrdrigltttaaPPDSPPPPYHA---VVGEV..PP.RpDNFRMDMTEFPAN.MH..P.PVEA........YYDD...GWKCTIVVFVVSLLGI..ILLTVLVSVIL----------------vlnknk
I3WFA0_9BETA/1-130                  msatnessprnds---------...--..EDVRPPAYDEIVGS....PP.............R.P.R..DLPtqsrrnrrgltTD......A............PPDSPPPPYHAV---VGEV..PP.RpDNFRMDMTEFPAN.MH..P.PVEA........YYDD...GWKCTIVVFVVSLLGI..ILMTVLVSVILVLNKS-----------nnkgt.
Q8QS47_9BETA/1-146                  .............MDPTPILRDeegRDggQDDAPPSYEQAVGL....GPppryeeaggphvaI.T.M..NAA...........PDhnnnrlP............LPNCSPPPYRPPYCLMSSP..PR.R.HTFDMDMMDIPAT.MH..P.PTTA........YLDQ...SWKWSAALMVVAVLGI..IFLAVVFTVVLNRRNGNTVTGTS----g.....
A0A1L6Z022_9BETA/5-127              ...nessprndse---------...--..-DVRPPAYDEIVGS....PP.............R.P.R..DLP...........TQ......PrrdrigltttaaPPDSPPPPYHA---VVGEV..PP.RpDNFRMDMTEFPAN.MH..P.PVEA........YYDD...GWKCTIVVFVVSLLGI..ILLTVLVSVIL----------------vlnknk
#=GC seq_cons                       ......ps...t..............p..pDssPPoYEEulG.....sP.............h.s.h..shP...........ss......s............sPcusPPPY+ss..lVuss..sP.R.csFcMDMs-hPAs.MH..P.PlpA........YaDs...GWKWTlslFVVulLGI..IlLAVLloVllsht...............p...
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