#=GF ID   VMAP-M1
#=GF AC   PF19963.3
#=GF DE   vWA-MoxR associated protein middle region (VMAP-M) 1
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF SE   Aravind L
#=GF GA   25.00 25.00;
#=GF TC   25.10 25.10;
#=GF NC   24.30 24.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   32101166
#=GF RT   Highly regulated, diversifying NTP-dependent biological conflict
#=GF RT   systems with implications for the emergence of multicellularity.
#=GF RA   Kaur G, Burroughs AM, Iyer LM, Aravind L;
#=GF RL   Elife. 2020; [Epub ahead of print]
#=GF DR   INTERPRO; IPR045440;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Highly variable central region of the vWA-MoxR associated
#=GF CC   protein (VMAP) of the classical ternary system (vWA-MoxR-VMAP)
#=GF CC   in NTP-dependent conflict systems. VMAP-Ms may be involved in
#=GF CC   sensing of invasive entities.
#=GF SQ   49
#=GS F4XUA0_9CYAN/99-202       AC F4XUA0.1
#=GS A0A251W8M5_9CYAN/212-333  AC A0A251W8M5.1
#=GS A0A139WVR5_9CYAN/78-187   AC A0A139WVR5.1
#=GS B2JBD2_NOSP7/31-143       AC B2JBD2.1
#=GS A0A1Z4UTL4_9CYAN/216-337  AC A0A1Z4UTL4.1
#=GS A0A2T1EMF9_9CYAN/76-189   AC A0A2T1EMF9.1
#=GS A0A1Q8ZE13_9CYAN/47-162   AC A0A1Q8ZE13.1
#=GS K9V226_9CYAN/117-219      AC K9V226.1
#=GS A0A844MZN4_9CYAN/152-270  AC A0A844MZN4.1
#=GS A0A5P8WAF8_9NOSO/125-234  AC A0A5P8WAF8.1
#=GS A0A367QVZ2_9NOSO/125-234  AC A0A367QVZ2.1
#=GS A0A0V7ZLG3_9CYAN/92-205   AC A0A0V7ZLG3.1
#=GS A0A2K8SKH0_9NOSO/238-352  AC A0A2K8SKH0.1
#=GS A0YZ46_LYNSP/243-361      AC A0YZ46.1
#=GS B4VQ76_9CYAN/80-189       AC B4VQ76.1
#=GS K7W0Z5_9NOST/110-236      AC K7W0Z5.1
#=GS A0A2T1DQW3_9CYAN/509-641  AC A0A2T1DQW3.1
#=GS K9RLQ4_9CYAN/122-228      AC K9RLQ4.1
#=GS A0A8J7F7A9_9CYAN/1-93     AC A0A8J7F7A9.1
#=GS F4XXB1_9CYAN/100-205      AC F4XXB1.1
#=GS A0A856MLJ8_9CYAN/129-233  AC A0A856MLJ8.1
#=GS A0A0G2ZBA6_9DELT/113-218  AC A0A0G2ZBA6.1
#=GS A0A2T1C0D5_9CYAN/75-184   AC A0A2T1C0D5.1
#=GS A0A1U7IF50_9CYAN/196-305  AC A0A1U7IF50.1
#=GS A0A1Z4JPM2_LEPBY/82-174   AC A0A1Z4JPM2.1
#=GS A8ZQB3_ACAM1/235-341      AC A8ZQB3.1
#=GS A0A2T1C3C7_9CYAN/133-236  AC A0A2T1C3C7.1
#=GS A0A1Z4NC26_9CYAN/115-227  AC A0A1Z4NC26.1
#=GS F4Y2C9_9CYAN/125-230      AC F4Y2C9.1
#=GS A0A0V7ZK94_9CYAN/133-239  AC A0A0V7ZK94.1
#=GS A0A8J6XD23_9CYAN/485-601  AC A0A8J6XD23.1
#=GS B0JTN4_MICAN/232-360      AC B0JTN4.1
#=GS A0A367QI21_9NOSO/19-134   AC A0A367QI21.1
#=GS E0UD37_GLOV7/132-239      AC E0UD37.1
#=GS A0A1Z4RAS2_9CYAN/118-226  AC A0A1Z4RAS2.1
#=GS A0A3N6R8N5_9CYAN/211-323  AC A0A3N6R8N5.1
#=GS A0A2T1C0E1_9CYAN/102-229  AC A0A2T1C0E1.1
#=GS A0A2T1CA00_9CYAN/118-232  AC A0A2T1CA00.1
#=GS A0A1Z4IZZ1_9CYAN/77-186   AC A0A1Z4IZZ1.1
#=GS K9REE0_9CYAN/99-213       AC K9REE0.1
#=GS A0A8J7FWN3_9CYAN/220-324  AC A0A8J7FWN3.1
#=GS A0A251WI26_9CYAN/210-325  AC A0A251WI26.1
#=GS A0A3N6RZ59_9CYAN/233-356  AC A0A3N6RZ59.1
#=GS A0A4V2E2S2_9CYAN/204-317  AC A0A4V2E2S2.1
#=GS A0A139XF36_9CYAN/96-212   AC A0A139XF36.1
#=GS F4XXB0_9CYAN/100-216      AC F4XXB0.1
#=GS A0A8J7E1N5_9CYAN/233-351  AC A0A8J7E1N5.1
#=GS A0A2K8TAT6_9NOSO/42-145   AC A0A2K8TAT6.1
#=GS A0A0F5YJV4_9CYAN/1-75     AC A0A0F5YJV4.1
F4XUA0_9CYAN/99-202                  ....................................ILRPLQRNFIK..QMQQAYIACCPDRKD---K...........tPGSFYDIIEYLDDIHQ.......-PTDDEKLIVKFVDN..L...LVNGN..ITK...SKAEQLEQWLEKNAKN.......VYNLLF------YQQN---..........---------inlqpdiivkp..........
A0A251W8M5_9CYAN/212-333             ...........................mlhcgldvt-----QTATKK..IIEPAYRYAMPENWIRSEG............DWSFDRLLLELGDTVD.......----SEIALSKFSAY..L...LALSE..FSD..dVLREQFQNWCNQHLENfh...giYQQAVKDVAQQSEQRRSQEq.......geIEAHLLVLI.....................
A0A139WVR5_9CYAN/78-187              ....................................ILQLYQKSDIS..PIKRAYQVCCPQGFLQQSD............--TVKDILATLQDLPS.......-NNQKFTPIDFFVAH..L...VLDSK..ISQ...ELAENIKKWGENNIAQ.......FTQLLHDCKQDLINKNQPS..........-DSYLLINI.....................
B2JBD2_NOSP7/31-143                  ........................qqniknqinllf---LNISDD-D..AINKAFSKIAPDGWFDWRD...........kPKDVNDVLEQLEEIPY.......-SNPNNSALLKFICL..L...TQDNN..IPQ...TIRQKLKQILTNESFE.......---------ASSKTTSVQS..........LHSYLLIQL.....................
A0A1Z4UTL4_9CYAN/216-337             ....................................ILTTNPNTSIT.sAIQTAYQTCCLENPPQKI-............PTTIEAIVQDLYDLDKinldskvKFN-PNGHTAKFIKS..L...ITLIT..NDHilqTTLKDLRKWGSNNIEN.......FDKLIQDVNQQDRNTDING..........-ESYILIKI.....................
A0A2T1EMF9_9CYAN/76-189              ....................................ILQSSSSQRQL.dTMRAAYLNVLKHRAGKIQH...........nPTLPDEMITQLLRLPK.......-GHFDYGALEEFVAH..L...VLKLQ..EV-...DVIAALQRWGEEQLDK......rWADLLQHVEQQQTQQSQQT..........-QPALLVVI.....................
A0A1Q8ZE13_9CYAN/47-162              ..........................acgsddekhr----------LeiAINAALRHCNPNGGD-LSP............QKQLRDLSTDRAPTPG.......--WESEGRLVHFAMV..L...ARMDD..TPL...HAYENLKTWIEKQCRL......dFPRLLDRATIEMKQQKVPFi........nECQYLMVD-v....................
K9V226_9CYAN/117-219                 ...................................l-LVNNLDDG--..TINKAFSATVPDDWYIWRN...........tYKTVNEALKQLEEIPY.......-QNPSDTPLLKFASL..L...TQDNN..IPE...SIREKLKQLLTNQAFK.......-----T----NKKSPSTQS..........LHSYLLIQL.....................
A0A844MZN4_9CYAN/152-270             ....................................ILTPLEKKFMH..EMTQAYRACRNKGYEDWED...........sTDTLEQILTYLMEMPE.......-ANAPFSPIVQFVAQflL...LLEDK..LPQ...KATDELRNWGANKEDN.......FQIFLNQLNNKNRVSRTAKd.......tpSPTYLLIR-l....................
A0A5P8WAF8_9NOSO/125-234             ..........................lkdldfsdip---------QE..SIRQAYRDALPPDASVWNL...........eGNNITQILQELNEFRR.......--------LFEFFNC..L...SQDES..LPE...EIRNKLSNTAKNIVSK.......--------KHPDENTNKSSadffsdkeglLESYLI---atl..................
A0A367QVZ2_9NOSO/125-234             .........................flnksdfsgip---------QE..IIQQAYQDALPPDASVWNL...........eGNDITQILQVIEEFRK.......--------SFEFVKR..L...SQDEN..IPQ...EIRDKLSALAEELAAK.......-KHSGDKTKPSTDFLSNPKg........qLESYLI---ati..................
A0A0V7ZLG3_9CYAN/92-205              ....................................ILKPYFDKHKD..KVIVAYKLSLPDILTDKDK...........tPKNAAELIYDSLRFPP.......QEKDKYSPLEKFVIN..L...LLDES..L--...SCNTDLEIWAKENIGEd.....rYKQRITGLREEKKQERREV..........-YPGLFVAI.....................
A0A2K8SKH0_9NOSO/238-352             ..............................rcgsne----KQDQFRK..AIDKALLDCNPQGSGRTWQ............----QQLVDLSIDRPP......pTGWETEGRLVYFVMM..L...ALING..RPT...SALEELKAWVERCGHKys...dlFVRFNDEMKQKNFLASNEC..........--ECLMVAV.....................
A0YZ46_LYNSP/243-361                 iellkkvkikilistatnvlreaidhhleihgyqeg-----------..-------------------............--EQSKLMNILLDTPP.......HQDQNLPRIIEFVRQ..L...SLDDR..IEL...SIRQELESWLQTEAEN.......LKIKLPSLSESKPSNLSNQ.........vTQSYLMVTL.....................
B4VQ76_9CYAN/80-189                  ....................................ILASVDPPTTQ..RIKAAYLASSPSSWSDFRPt..........iPPTIEQLLADLEDMPS.......-GDSGYKRMDQFVAH..L...IADDQ..IPQ...SLRQQLHDWLKQNVDD.......IAQLLTQIKPETDPE----..........-QFYLMVWI.....................
K7W0Z5_9NOST/110-236                 .........iqllssdsnssnlsqeslkdldfsrip---------QE..SIQQAYQKALPPDADVW-Gl..........eGNNITQILQQLEQFRR.......--------LVEFFNK..L...SQDKN..VPQ...EIRNQLSGVAEELALK.......KYPDENKNKTPADFVSSQEg........qLQFYL----iatl.................
A0A2T1DQW3_9CYAN/509-641             .................irerdiqqssarlrleelk-----------..RILDIHLNLFPEVLRACQQlfairkyspgqtLQNAQELIAELLRIPP......gRSQ-PYDAIEQFVAC..L...VSSSQ..NT-...ALLTALQGWVEQYVQE......gWQELLERVEDYQKQTAQEA..........-QPVVLVAI.....................
K9RLQ4_9CYAN/122-228                 ...................................v-CKETLENS--..SQPQDVLGSFPQLIN----............PKSLGIFKTIFLENNY.......TSYKDVPSILEFAER..L...SQETK..VSK...HIRDKLNYWVKTVAQS.......-----LNIKLPTYEKNKLFtf......taLNSYLLVTV.....................
A0A8J7F7A9_9CYAN/1-93                ....................................-----------..-MSKAYLATVPDGWFDFRE...........kVTQIDDILKQLEDIPH.......QSY-NNSPLLKFINL..L...TQDEH..IPQ...AICEKLKQLLTNNSFE.......---------TNNKTKSLQP..........LHSYLLIQL.....................
F4XXB1_9CYAN/100-205                 ....................................ILLPLENNLMK..QMQQAYRGCCADNLLDDSAe.........eiPESLEEILESLDKIPQ.......YYNDQEIPIIQFGAR..L...LETED..IPN...PIGVQLKQWLYENAKH.......-------------------..........---------dlspgtgrtgkkscqtt....
A0A856MLJ8_9CYAN/129-233             .................................vcr---ITLENF--..TKTQDVLGNYPELAD----............LESLGVLKTILLNKCP.......RNDKGIPSIVEFAER..L...SKEKE..VGE...SHQNKLNQWVGKIAQE.......-----LNLTLPTYFEDQSSa........tLQSYLLITV.....................
A0A0G2ZBA6_9DELT/113-218             .........................lleqhfwpsil-----------..------PSTWPGSFTQLQE...........eRECVEELVDVLAEFPD......rDPRGRASPLFEFVLR..L...CKGLD..AG-...SVAERLMQWLESTALA.......LGKDLNRIKEQGHQLLGEL..........---YLMVKL.....................
A0A2T1C0D5_9CYAN/75-184              ....................................ILRGYFEQEKL..IFQKAYRLSLPDRLIDKEL............PSSLEALISNL-QLPQ.......-QQESYSFQEKFIGN..L...FIEQN..LTS...KLKRKLKEWAEENIKD.......CHQLLIQLNQERAQRSLYY..........--PALLVAI.....................
A0A1U7IF50_9CYAN/196-305             ..........................lltplnlell-----------..LIKKAYQACSPPDWPYPI-............PDTLEEILTQLNTMPP.......-GKSKYTKTEQFLAY..L...VADST..LSQ...SVSQNLKIWGEQNIQD.......FPQLLNEVQQTLGIKSSSD..........-EPYLMVVI.....................
A0A1Z4JPM2_LEPBY/82-174              ...........................tlidllspi---------QF.eVVIKIYRNCLAEGRARSI-............PDTLEALVQQLTDLPK.......------DLLVRFVGL..L...IREP-..---...IEQNALKAWAIQQGMT.......---------LPEAEVRTA-..........-EICLMIK-v....................
A8ZQB3_ACAM1/235-341                 ....................................LLKPHQKAVED..HLQEAYGIYHPISEDP---............PSALADKLRAAMKAKK.......--------LPHLMAC..L..lLPEAQ..APE...TLNQSLRQWFSDRGYDie...qyKFQADQDYKAHSPEDHEDK..........-QPHLLFWV.....................
A0A2T1C3C7_9CYAN/133-236             ............vgdcysqevkslansnlsnwfkcf-----------..-------------------............-----ILLKLFLEAYP.......-GSSDYPNILALVQN..L...LQKSA..LSN...EIKRELREWLQEVNPN.......FTSQAT-LSSSTNESQQPTg.......geLKAHLMITV.....................
A0A1Z4NC26_9CYAN/115-227             ....................................ILKTLELDYFT..QIQQSYSICVPRYSSDWL-............PENIEDIYQALQDIYH.......-QEDSLDSITKFVAL..L...LNNSE..LCEn.tAIAKLLKQWGQHNNPQ.......FYHLLKQTKQDSQHKQKHI..........-DIYLIILI.....................
F4Y2C9_9CYAN/125-230                 .................................lly---PLKKNNK-..PKQEVYRDYFQKVNFSEDK...........iVANLNDIIDNLDTILD.......ENFYSEKPIIDFADF..L...LKNRDidISQ...ENACQLNQWLKIE---.......-------------------..........---------skrskasyiisyiirlvsnnr
A0A0V7ZK94_9CYAN/133-239             ....................................ICRITLENN--..SKFQDILGNLPELIK----............PENLGIFKTIFLDKYP.......KNNRDIPTIIEFVER..L...TKEQE..IST...NIREQLNCWLNLIAKE.......-----FDISLPCYEVQKLSqg......trINSYLLVTV.....................
A0A8J6XD23_9CYAN/485-601             .........................lklildkidfk-----------..LVKDAYLKTLPKGAAIDNRev........snPKDIESIIQILLKDYP......kTNSDIPTSIIELAQR..L...ANQKQ..GDD...RKYQDLENWLEQVIAK.......LDIKLPDISKEEYDYKQLQ..........--SYLLIIV.....................
B0JTN4_MICAN/232-360                 ................................cife-----NKSYQD..QLNTAYENLKIEVRDHLVDlp.......rviPSSWSDFIEIIYQLDEry..ltyASQSKFSWLEIFIGY..L...IIQLT..STD...ALAKLLKEWLKKYQTK.......WEVLINTLENNLNHRSQNIaqk....stdKNPCLFVTL.....................
A0A367QI21_9NOSO/19-134              ....................................ILLPWEKHFID..QIKQAYLACIPDELRKVWKdk.......tptPNSLEEILAELQDIPQ.......----GETYIIRFIGY..L...LVDTE..ISK...NIGSDLNQLGKQNANN.......FSVLLDKLKHEKRELEKDQ.........dIPTYLMIS-l....................
E0UD37_GLOV7/132-239                 ............................dldfssip---------QE..SIQQAYQDALPPDAGVWDL...........kGNNLTQILQNLEEFRR.......--------LSNFLNR..L...SQDEN..VPQ...EIRSTLIALAEGLASK.......KPQNDNNAKLNANFSSHKEg........qLESYLIVTI.....................
A0A1Z4RAS2_9CYAN/118-226             ...........................ilqavcret---------LR..NITQNIEENVPQIIN----............ISNLRTLKEIFLEKYP.......LRKDNIPTILDFAER..L...TNNKQ..ITD..vNTKNKIQLWLKEIAHN.......-----KNIKLPIYQEVKPSs.......stVNSHLLIVV.....................
A0A3N6R8N5_9CYAN/211-323             ..............................lvfsae------EKDWK..IFQKVYGNCCPEDWPYTD-............PQNIKEMINYLLDMPP.......-RKNSYSSLIEFIAR..L...LIEPE..IKK..sEYYQQLKNWGENNYTD.......LDKLLEKLKNVREEQQTSY..........LKSCLMIYV.....................
A0A2T1C0E1_9CYAN/102-229             .........................lvdelrkiidq----KDESFGQ..CLKQVYQDFLLDVNDEPELd.........reINNLDDIVWELEDRTE.......-QSIFLEFLPRLIAY..L..sIYQPR..ISQ...AISNNLQQWTRENMVRfkvdkseFNNALKQFKQTYKQRSGKV..........---YLIIAI.....................
A0A2T1CA00_9CYAN/118-232             ...................frqeslpdldwgkiple-----------..SIQQAYQDSLPPDAGVWNL............--AENDIAQRLQTIEQ.......-----FRRLPEFFER..L...SQDKN..VPL...EIRHQLKEISNELASK.......--KHPENIKNKSSTDLFSTqs......rkLESYLIVTL.....................
A0A1Z4IZZ1_9CYAN/77-186              ....................................ILEPYVDSTIT..YINRAYQACCPEGFSQ--Q............PDTVEGILEILQDIRG.......-NNPQFAPIARFVAH..L...VLDFN..IPK...ALRDELQKWGENNIKD.......FNQLREDIQKDNNSDIQDA..........-NSYLVIRV.....................
K9REE0_9CYAN/99-213                  ....................................ILKPLEGTYIE..TMQQAYQACADDSSFHDWEe.........eiPETPETLIEIFEGIEE......tSSQNYNEKLSQFAVN..L...LNDGD..IPE...KKASQLNKWGEKYVGK.......FYKQLSHRENDVQDKDTTS..........---HLII--if...................
A0A8J7FWN3_9CYAN/220-324             .............................lllpfyr-------TVDR..SIKAAFNACCPKNWSGSK-............PKALPAMIAELQDMPQ.......-GDAPFSRILQFVAR..L...ATAV-..-P-...DINQQLQDWAISQGHD.......WQALLEQIQPAQAVS--QI..........--SYLFI--rv...................
A0A251WI26_9CYAN/210-325             ....................................LLEPEQNSLTE..QIQIAYEVCRREGTTQSYK............-AELSARLDDLAGMAD.......-GEIEEPMLVQFAAC..L...LNQSG..LSD...NVRTQLEQWAQRYTQN.......LNTLRTKLQDQQNQKLNHQsi......ksKHPGLLISV.....................
A0A3N6RZ59_9CYAN/233-356             ....................................ILENYFLSD--..EIRYAYYQSLPENSIPLSSgks.....lhefPESLREMIQNLDNWMK.......---ENYSLLERFICF..L...LLHLQ..DLEtlpKLCQELEKWLESYLQN.......HQNLMGALRKEKAIKNQQPfq.....vgeQETCLLV--ga...................
A0A4V2E2S2_9CYAN/204-317             ..................................ll--EGAAVPSE-..SVEGAYRVCRPEGALQPV-............PEDLPSKVKALARMKD.......--QGGYSALVRFAVC..L..tLAEFP..VAL...PLKQQLRAWLKQREIDte...avEQAIAPQIQLEQAITANTA..........-SPHLLIWL.....................
A0A139XF36_9CYAN/96-212              ....................................ILIPLEKSFFH..EMTQAYRSCRNIGYEDWED...........sVDTFEKILTNLIDMPE.......-ANTYPSHIVKFVAQ.fL..iLKKNN..FPS...ETADKLRDWGKSNNPD.......FLNLLTSLENKVNTTAENA.........lIPTYLLVQI.....................
F4XXB0_9CYAN/100-216                 ....................................ILFPLPNNIIE..AMQQAYQACCPNNLWDDWEd.........elPDSFYEILKNLDDIPQ......aTND--EKRIVKFVAR..L...LETGD..IPK...PIGDQLKQWLEKNAKS.......YSDLLSQTSSHSQNDQQQN.........vAQPYLLVKL.....................
A0A8J7E1N5_9CYAN/233-351             ....................................LLRPCKKSLKQ..QIQRAYNACRPPAWNGEQ-............PTTLVEIVSALNDLDEr.....dSANREYSPLVEFAVR..L...ANCAE..ITN...VLRQDLQMWVELTFELdg...keFARLRDRLANRQTNPQEPD..........PKSSLLIS-l....................
A0A2K8TAT6_9NOSO/42-145              .................................llf---LNISDD-D..AINKAFSKIAPDGWFDWRD...........kPKDVNDVLEQLEEIPY.......-SNPNNSALLKFVCL..L...TQDNN..IPQ...TIRQKLKQLLTNESFE.......---------ASSKTTSVQS..........LHSYLLIQL.....................
A0A0F5YJV4_9CYAN/1-75                ...................................m-----------..-------------------............----------------.......---ENYGLLDRFIGY..LflhLEDLN..RSP...ELRPQLENFLNFYFKD......eAQNFLNYLKKERAIKEQQKte.....ageKEPCLLVGI.....................
#=GC seq_cons                        ...........................................t.....tlppAYpsshPpsht................spslppllptLt-hsp........tp.t.s.lhcFlsp..L...hpcpp..lsp...slpppLcpWhcppspc.......h.thhpphppppppppppt...........psaLlltl.....................
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