#=GF ID VMR2
#=GF AC PF17055.9
#=GF DE Viral matrix protein M2
#=GF AU Llagostera M;0000-0001-8177-8321
#=GF SE Manual
#=GF GA 27.00 27.00;
#=GF TC 28.60 212.80;
#=GF NC 24.00 20.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 1989386
#=GF RT Structural characteristics of the M2 protein of influenza A
#=GF RT viruses: evidence that it forms a tetrameric channel.
#=GF RA Sugrue RJ, Hay AJ;
#=GF RL Virology. 1991;180:617-624.
#=GF RN [2]
#=GF RM 8579000
#=GF RT Influenza virus M2 protein and haemagglutinin conformation
#=GF RT changes during intracellular transport.
#=GF RA Ciampor F, Cmarko D, Cmarkova J, Zavodska E;
#=GF RL Acta Virol. 1995;39:171-181.
#=GF RN [3]
#=GF RM 7507186
#=GF RT Influenza virus M2 protein ion channel activity stabilizes the
#=GF RT native form of fowl plague virus hemagglutinin during
#=GF RT intracellular transport.
#=GF RA Takeuchi K, Lamb RA;
#=GF RL J Virol. 1994;68:911-919.
#=GF DR INTERPRO; IPR031454;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Is a viral transmembrane protein which forms a proton-selective
#=GF CC ion channel that is needed for the efficient release of the
#=GF CC viral genome during virus entry. Once is attached to the cell
#=GF CC surface, the virion enters the cells by endocytosis.
#=GF CC Acidification of the endosome triggers M2 ion channel activity.
#=GF CC Also plays a role in viral proteins secretory pathways. Elevates
#=GF CC the intravesicular pH of normally acidic compartments, such as
#=GF CC trans-Golgi network [1, 2]. It seems that M2 protein ion channel
#=GF CC activity can affect the status of the conformational form of
#=GF CC cleaved HA during intracellular transport [3].
#=GF SQ 4
#=GS MATRX_MMVR/1-235 AC Q6E0W8.1
#=GS B5FX44_9RHAB/17-233 AC B5FX44.1
#=GS A0A3Q9D1F5_9RHAB/1-234 AC A0A3Q9D1F5.1
#=GS MATRX_TAVCV/1-235 AC Q5GA87.1
MATRX_MMVR/1-235 ......................MDAPINPSSPTRSSYETALERQWLIKDEPSHHVDLGCHFTLEIKAFSPKMIELLETGSLTLGSVYQGLYNLIKDKDCKGLELDRDTTHGNKLHVLAAAFLCVLRKYENQVRFYNVKTKDSLTGEIQYMSRVHIGDDNLGLFDPDTYRMIGGSFPEGIYRLNLRTQLTPRGEDDGLEIIMGTILTVPVRGPADRQPLGVLMDRQLRQFPVGTNPWSSLGEAKPKGRSLSLLRGILM.
B5FX44_9RHAB/17-233 ......spslstvnqtclddti----------------------------------VGCHFTLELRAHTPGIRKMLEDGEITIGSVYKGIYSMMKNDIVSGLTLGRDATSENKLHILAASFLCVLRKYEGDIKIFQSEEKDQFSGRVELLARVHIGDDHLGVYDPECYQLVGVKIPDGMYHLTLKTTLTAPESSETLSLILGIIITSPARVPPTMKPMGVDTKALLPTFPPGTNPWKDIGEVKEQRKAISRLRSIL-f
A0A3Q9D1F5_9RHAB/1-234 metpitavgtesekkpspfsvs-----------------------LIQKDDTQDPIVGCHFTLEIRAYHPDMMKLLEDGDITLGSLYQGIHHIMKQRECQGLTLGFDANHDNKLHVLALAFLCVIRKYEGKVATYIERSKDAFSGSEQLLARIHIGDDHLGTFDPEVYQICGVPVPHGMYHITLNTRLTPPHQDDGLSVTLGVVLNSPARGLAGRSPMGVDAKRLISSFPKGTDPWASLGDIKEKRTAVAKLRSIL-f
MATRX_TAVCV/1-235 ......................METPIIPSSSSLDRSGNSSNLLSVIPFQERTDSIIGCHFTLEIKAYHPDMMKSSEEGDVTLGSLYQGIHHIIRNKECQGLILGMDATHENKLHILALAFLCVIRKYEGKVSTYIERSKDTFSGVEQLLARIHIGDDHLGTYDPEVYQICGVEVPQGTYQLTLRTVLTPHNHTDGLSITLGIIVNSPARGMQGRSPMGVDVKRLILSFPKGTDPWTSYGEIKDKKGAVSKLKSIL-f
#=GC seq_cons .............................................lI..p.ppcs.lGCHFTLEI+AapPcMhKhLE-G-lTLGSlYQGIaplhKs+-CpGLpLGhDATH-NKLHlLAhAFLCVlRKYEGcVphY.p+oKDsFSGp.QLLARlHIGDDHLGsaDPEsYQlsGVplPcGhY+LTL+TpLTP.ppsDGLSlhLGlIlsSPARG.ssRpPMGVDsKRLl.oFPhGTsPWsSlGElK-K+pAlS+LRSIL.F
//
