#=GF ID VP3-like
#=GF AC PF18965.4
#=GF DE Outer capsid protein VP3-like
#=GF PI DUF5705;
#=GF AU Hirsh L;0000-0002-8215-6716
#=GF SE Jackhmmer
#=GF GA 25.00 25.00;
#=GF TC 171.70 81.70;
#=GF NC 22.40 20.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 14694120
#=GF RT A reovirus of the fungus Cryphonectria parasitica that is
#=GF RT infectious as particles and related to the coltivirus genus of
#=GF RT animal pathogens.
#=GF RA Hillman BI, Supyani S, Kondo H, Suzuki N;
#=GF RL J Virol. 2004;78:892-898.
#=GF RN [2]
#=GF RM 17170467
#=GF RT Baculovirus expression of the 11 mycoreovirus-1 genome segments
#=GF RT and identification of the guanylyltransferase-encoding segment.
#=GF RA Supyani S, Hillman BI, Suzuki N;
#=GF RL J Gen Virol. 2007;88:342-350.
#=GF DR INTERPRO; IPR045917;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This entry represents a group of Reoviridae proteins, including
#=GF CC outer capsid protein VP3 from Cryphonectria parasitica
#=GF CC mycoreovirus 1 [1,2].
#=GF SQ 9
#=GS A0A291ID07_9VIRU/66-1155 AC A0A291ID07.1
#=GS Q76H86_MYRVW/1-1085 AC Q76H86.1
#=GS A0A292FWR1_9VIRU/794-1164 AC A0A292FWR1.1
#=GS A0A499RIH4_9VIRU/70-315 AC A0A499RIH4.1
#=GS A0A292FWR1_9VIRU/134-421 AC A0A292FWR1.1
#=GS VP3_CTFVL/14-1181 AC Q9ENL3.1
#=GS A0A168MTE8_9VIRU/1-1084 AC A0A168MTE8.1
#=GS A0A499RIH4_9VIRU/632-1028 AC A0A499RIH4.1
#=GS VP3_MYRV9/1-1065 AC Q7TDB4.1
A0A291ID07_9VIRU/66-1155 .................tevythtlsellkleknvdedvlrrvqraactevayqyiarisslyrvilenyptdfvwaqagelvydevfllpalyeiardraanvlmyed---------.---------------...-----------------..........-----.....--..--------.....-----.--------...----..--....---------------------...----------------..-------------......-------------....--------.....------------------------------------------YhgciggrvaidgdrnegmrrlfvtwlhgmgqiqapeyesvmdpeykvvlerdykvfflgdslprdgdlgwlhGK-MP.............YRTVWMPNASYSRMVRRMLLSRMPSGAHGVLNIPIPHYFEFDCAADLELRCWHGVRATWLKL..FDANVN....GEVDDCRLNEALMVNCPRDL..sSAVRESMFSCS.--...-LARGVPPHVVSTLKSVKMIAGAQH--YHVVQ-.GDGDW--WRREDIFPQGRY...SIRWGEI.......IAIRG--------.IDEGiPDR...---FA....SWIEVMNP---.....-IY........--....YTDIGLkANQLM......ITVPTDPEPGWIEVHENDLKF.KVYQLDR--VNYSVDpVSSCATIFFSQVQfdlpfpppyeldqqrdavvnrelynamtlgsnrqigefhgkiastTKKLRDLYTF............EKDRTVP-VNTALNRKDAKEN............PLEY..LCVEA..................WIEALRTVsdqmdydPRWAHD.DQEQDDPRYrlVDVMIRVSKHL..........WSK.PYRLSMIANATLLIHAIAr.....hLLSFNLAHYDGLRLE.DLTIAWYGEGAEEMTRLMKEC....GFKRYIPip....nsMGGADHME..QHVLRG-QNKKVNVTiMNYpLE......WVDGVDRaFIADACVL.....LRIGEIGVLRARSGVENYFVGLSA......VLRdgfl.difrIGMGGLPSDF-----YFMW.....IKRGPDNFQARDaVFRGT.IPF......GL------.GRRFLPNTYDH......QKVGLREWISDALLGDFHApICV.EMDLSEGDLERGFYLIGAITKSFRVRCFSR-GALRIYRATGTLDIDATLRNVRmDGDRI.SVAr......gSIRHPLdLVRTLTPGSLSP.lPYTFKVVNSL........NALQsvTFMLIKEWLRRELNMMD...EGRVILFDVGGRRGELSGWVSDhqnLRYICIDPAA....GERIPKGEVLMNEdrtaphrWDFrGQVDEQVD.IALRLCGE...PNMQKERVFLVFSNVASNVFER...YEGADEPLNNFMRQLVNSDtrafVRDMST...LHGNRNG..ANCVILRSKFCRDFVF.............DARRGYIPAIYPEv............gtAMHYAPLQEHRNQ..IVN-...WTPTCRE..IMDA..MY---..--ARGLQ..LDSFSEMILPIMAKH-------tffls...................................................
Q76H86_MYRVW/1-1085 .............................................................................................................MELFSLNAPsTLQSQFLPLSTFISH...INQPLQPHHIRIRSLVK..........DVLINvdqdhPPaeVSFSHPPLddllfLGVLSvRTFVPLEEvltPKRArdDPaapeNRIISAAFEAGNSVLDGYRQL...FSDLATTIDVAEQRISdwFVFLPCVKMCMQ-......---FRMLKYNIDSlrdlICVKMSRDemqdiFLRHALQFISSWHKYVPRSHHLLRPQRYLLVNIDLHSLSWSLQ........................................................................GKYVA.............YNVHFLESRDIRSLDLAIRRQSRPCGYHPRQNFGLLHYFSFQDVSDMD------KRQTFLSL..RTASNTqrgiAMTRETRVVECLRTNVSCSRfvnVLASASLVGYC.GV...DVHIKVEKDLESVVTYVDSICQRELLREHYVELfHRNLWGPFKYYEMISTGAS...TLPVGEMlnivprrVALSDVAGGTNCR.LLRG.PLRdplPVSMYrryvTRLNVVDTGVE.....SRYdncglvcaLPpaanGTFMGD.ADEVIstaissTRYPSTSRPPVLSVP------.--LGDSPHANAQNVG.FKGPAAEYMSSVV.............................................TSRRNVLPQI............SFD-WIG--GDSDDVRNARQI............----..-----..................VMRLMTSV.......DGWLLD.EDRNSATDV..PFI----NAAI..........FSI.LVTAQLTSQGLAQTASG-.......--SVRLTCVNTPFSV.QRSMAWIGDVVLLNHAYVSPT....DADGFNE........LGGSVI--..CYVDGMESDEDETLL.---.--......WLEGILR.CISGELSLvflvrRPTYRVLEMFFDSLSTTYTMGVFTeplldnELG.........VSIACQILEAPIALTMFSAtalgrASSVLYSVQAHL.VHDSTlDPF......SSWLAHGD.-----------......-------------AVQFRS.AGW.KMERPESLFDDVIAYVGAIAHVGRIWKWLDHNGHMRYSAHGRVGYCRWTESSR.LGDEL.AIR........TVDAPV.LKVSRTAPDMPN..EVRPRVCDAL........AYLS..----AWTATWMVGLTRAdwyVNVRCVVDIGGRDGRMSGPWVD...KRYVIVDPGNvvgeARQYQARGRTGDP.......LDF.DFVNPDITiRHLIDAGIfsqAEFDAGTVMFLFSHVIINACRT...PTAQLAAITAIRQRLVGPK....VVVHNC...GEIERGQ..TL-SHLTDWRRYREIS.............WGQNKWISPKYPS...............P---PQSIAVSQF..IVDGwtvMHPSLHD..VRNA..NF---..----GFAhvPSYEARLILPAVILS-TVWAVS........................................................
A0A292FWR1_9VIRU/794-1164 ..........................................................................faterrvisrafiheevdldtwirrtlggeyllpy---------.---------------...-----------------..........-----.....--..--------.....-----.--------...----..--....---------------------...----------------..-------------......-------------....--------.....-------------------------------------------........................................................................-----.............--------------------------------------------------------------..------....--------------------...-----------.--...---------------------------------.-------------------...-------.......-------------.----.---...-----....-----------.....---........--....------.-----......---------------------.---------------.-------------.............................................----------............---------------------............----..-----..................--------.......------.---------..-----------..........---.------------------.......---------------.---------------------....-------........--------..---------------.---.--......-------.--------.....------------------------......---.........-------------------.....------------.-----.---......--------.-----------......-------------------.-GI.EVDVSVYDCDAALRVMTAICRNVKARCFKQ-GNINAYRLFGYLDIDMVLRNARiQGNDI.EIArmdvdvgmN-----.LIR-ALSPSLVSasEAVPKLVNVL........NALQaaTNFVIRSWVNHYLLNYE...YERYYILDVGGRRGELSGWFDLgprLSYFCIDPNA....REMIPKGRIVRGRrgv.perWNFnAPVADEAH.RILETCGV...QLQHDGQVICIFSNVLSNAYETlvdPRGSFQRLINQIDRWEGAV....FIRDMCtfhGQINREG..TC--PLPAKLCESFVF.............DAGLGFIPSAYPR...............V----RAGIVYEA..ISR-...-SQRLHS..LSPCcrEIYDV..LHARGLY..LDQLGEFLLPILLAH-VVY---vgt.....................................................
A0A499RIH4_9VIRU/70-315 .....................................................................................kvilsrdykvlflgegtsvdgnlq---------.---------------...-----------------..........-----.....--..--------.....-----.--------...----..--....---------------------...----------------..-------------......-------------....--------.....-----------------------------------------ML........................................................................NNKIS.............YDTVWLPNASYSKMIDIMLEDSKPSGCHNILNIPIPHYFRFKSQNDLHLRLWKGVRDTWRKL..YEANIN....GAVNDCRLNEGMIVNVSLP-...SILSRSLFCCS.--...-LAKGINGKLISNLKDVQGLALAQN--TNVIR-.GWNVWWRVLNNERNRIQNP..fNIVEGEC.......VSIIG--------.----.---...-----....-----------.....---........--....------.-----......---------------------.---------------.-------------.............................................----------............---------------------............----..-----..................--------.......------.---------..-----------..........---.------------------.......---------------.---------------------....-------........--------..---------------.---.--......-------.--------.....------------------------......---.........-------------------.....------------.-----.---......--------.-----------......-------------------.---.-----------------------------------------------------.-----.---........------.------------..----------........----..-----------------...----------------------...----------....-------------.......---.--------.--------...----------------------...-------------------....------...-------..----------------.............-------------...............-------------..----...-------..----..-----..-------..----------------------vddntpknvaveieitdevsffdiggkqdqvtlslktreitnwiefqqddyqlril
A0A292FWR1_9VIRU/134-421 fiwvrsteaaaeemyllpalyecarasmsnvlcygagrgviggtipigprrgqqmelvfrrwlyhlealsnvdsreylepqfrvilprdyktlfigesvnedgnlswls---------.---------------...-----------------..........-----.....--..--------.....-----.--------...----..--....---------------------...----------------..-------------......-------------....--------.....-------------------------------------------........................................................................-GSIS.............YSTVWLPNMPYDRMVEQMLQDPYPCGCHNILNIPVAHYFQFKSKEDLIIRLWKGVRDTWKKL..YQANLY....GALDDSRLNEVMIVNR-VD-...-FLPDALVNCMfSA...TISKGVSKQSIENLRDVRSMASAQ----HMVAMqGWGNW---WNY--------...-------.......-------------.----.---...-----....-----------.....---........--....------.-----......---------------------.---------------.-------------.............................................----------............---------------------............----..-----..................--------.......------.---------..-----------..........---.------------------.......---------------.---------------------....-------........--------..---------------.---.--......-------.--------.....------------------------......---.........-------------------.....------------.-----.---......--------.-----------......-------------------.---.-----------------------------------------------------.-----.---........------.------------..----------........----..-----------------...----------------------...----------....-------------.......---.--------.--------...----------------------...-------------------....------...-------..----------------.............-------------...............-------------..----...-------..----..-----..-------..----------------------edpgrhdyrvargectaiigvddntplsvavrveirdp..................
VP3_CTFVL/14-1181 ............................................................................................................r-DCFGLKHE.ILASIYNEKSTFSSEngsIQILEEAEVNALGELVR..........DGTVA.....--..ISF--GP-.....-GIYS.RMFSHLRD...----..DS....--------DYRSALTDCVAHG...WKQTRDARDVREWQRS..AAIMCAERYMYKV......RQAYKRVVENLDH....--------.....--MYAWHYLTE----GPSEHVFILPAMYESVRHETTSEAYGMQcggiiggnvslmlprdeqyttlfkawlms.............lakmslselrephwngvrvqlsrdhrilyyGDLLPsdgditylvnkleYHTIWFPEGDFETMMGAMLRDSFPAGCHAHLNIPVPHYFVFDTDDDLILRCWKGVRDTWIKL..RLGYEE....GGVNDSRMSEALIVNRDLP-...ADLSESLFCCC.--...-LARGVSRDQVRTLKDVRNVAQAQI--RHVVS-.GQGVW-----WEHMVRGQPlacSIRPGKV.......VLVVD--------.YEDG.PLH...-VS--....IRVRLLNV---.....-HY........--....ARELGMkASDVV......VRIPTSNRPRWVETKEYERSL.RFYEFRP--------.--GPITTEFHHVFafycy...................................wgcgrVEKRRHLYQIrevrrgnlysrsRFLRRIAEDGEKVKVQGRTHVtatravqhekcnPNEDiiYSREFarelaltgkikeagalavIYTCMQTLgvdidppAGWVREgRPKQRTAKL..CHLLTRILTAF..........FSYrGGSSSLVCSVMVVIFSII.......LYYLRLKHVDQEVRYdELTLIWYGDGGVELQRILREV....SMTRFVA........VAGDPATPeyIAQAKLWANKKSNIVvFNY.ARpyergpVFENLIR.---DTVSL.....REAAEVFILRTDDSWSQYGNTVVA......MLGegdfcdlvhFGASCDPMEH-----YFVH.....ISQPPGTNPGYE.PANQE.EPF......EEWLYETQaMERVIPTTWES......EIVDARGMLVSILTFHFRF.AGWfELDVPGDDIGRGLQLMGSINKVVHVSCFVQ-NGRRYFRLSVDLDVDRVLRNMRhEGDAL.MAAe.....lfVTDAVL.VCEGLVVGEMHR.lQRTYRSVNAM........VYHQgmTNFIVYEWMRRVLLTNL...LDEMLVFDIGGRNGELSGWVVQdvkVHYFCVDPAG....EEAIPKGQRVRLPgg..raiWDIaETVEQNVA.RYLEVVGK...PQTPAEGIILIFSNSIVAA---...-------------------....--YEAA...GRNNRNQvaNLYQQLQAWGGRVFIRdqlvptranpgdyWIQAAFPGNVYPPglcedfnidpdagilPLRYPDTGQGATD..VVL-...ANGRLGH..LTSS..WFQSLycGAARGFI..LNGFGRLIWPIYCRHVVVLATR........................................................
A0A168MTE8_9VIRU/1-1084 .............................................................................................................MELFSLNAPsTLQSQFLPLSTFISH...ITQPLQSNHVRVRSLLK..........DVLVNidpehPPaeVSFTHPLLddlsyLGVLSvRTSVPIEEamnSKRIreDPlaseNRILAVALEYGNAVLDGYRQL...FSDLATTINVVEQRNHdwFVFLPCVKMCMQ-......---FRMFRYNVDGlrhlICARVPRQsiqdaFFPHALQFISSWHKYVPGSHHLLRPQRYLLVNVDLHSISWSLQ........................................................................GKYVP.............YNVHFLDARDIRSLDFAIRRQSKPCGYHPRQNFGLLHYFSFSSISDLE------RRQVFLSL..RTASNTqrgvAMIRETRVVECLRTNQSCSRfvnMLASASLVGFC.GV...DVHIKLENDIESVVTYVDSICQRELLRENYVELfHRNQWTSFKYYEMISTGAS...TIPVGEIlhiiprrVALSDVAGGTNCR.LLRG.ALRdplPVSVYrryvTRLNAVDTGVE.....SRFdncglacaIPnaadTTLMGH.AHEDIatvissTRYPSTSRAPVMSVP------.--LGESTHANAQLVG.FKGPAAEYMSSVL.............................................MSRRVAFPQV............TFD-WIG--GNGDDIRNARQI............----..-----..................VMHLMSSV.......DAWLLS.EDRSSAFDV..PFV----NAAI..........FSI.LTTAHLTSQGRAQTASG-.......--SVRLTCVNTPFVV.QRAMAWISDVVLLNHVYVSPT....DADGFNE........LGGSVI--..CYVDGMEADENETII.---.--......WLDGILQ.CIAGELSLvflirRPTYRVIETLFNRLSTNYEMGVFTeplldnGLG.........VSVACRVLHASIALTNFDAtplgaAVSVLYSVQPHL.VHDSVlDPF......SSWLSHGE.-----------......-------------DVQFRS.AGW.KMECPESMFGDIIAYVGAIAHVGRIWKWLDHNGHMRYSAHGRVGYCRWTESSR.LGDEL.AIR........DVDAPI.LKVSRNAPDMPN..EVRPRVCDAF........AYLS..----AWTATWMVDLTRAdwyVNVRCVVDVGGRDGRMSGPWVD...KRYVIVDPGNvvgeARQYQARSRTGEP.......LEF.SFVNPGITvRHLIDVGLftqAEFDAGHVMFLFSHVIINACTT...RESQLAAITAIEHELVGPK....VVVHNC...GEIQQGH..TL-ADLTDWRRYREVS.............WGLNKWISPKYPS...............P---PPSIAVSQFggAWNV...MHPSLHD..VRNA..NF---..--GFSHV..PSYEARLILPAVILS-TVWAVS........................................................
A0A499RIH4_9VIRU/632-1028 ........................................................................................wqartpndshrnrliefvkpy---------.---------------...-----------------..........-----.....--..--------.....-----.--------...----..--....---------------------...----------------..-------------......-------------....--------.....-------------------------------------------........................................................................-----.............--------------------------------------------------------------..------....--------------------...-----------.--...---------------------------------.-------------------...-------.......-------------.----.---...-----....-----------.....---........--....------.-----......---------------------.---------------.-------------.............................................----------............---------------------............----..-----..................--------.......------.---------..-----------..........---.------------------.......---------------.---------------------....-------........--------..---------------.---.--......-------.--------.....------------------------......---.........-------------------.....------------.-----.---......------SQ.SRRVITRAFFS......EIKDIYTWIRRALLGEYLSpAGI.EIDSTERDLVRTLNVAGCICRSFKVRSFSQ-GPHRAFRLSGSLDLDMILRNCRlKGERIeMISm......dINYGLD.LVRSLSPGLIFQ.sEFFAKEVNPM........HALQatTNFIIKSWVDMYLNIMP...DERFYLIDVGGRRGELSGWVTSsprITYISVDPES....LENIPKGSITLENgr..pasWNFlRNPKEEAA.RILTLHGL...VADRDQQIILIFSNVLSNVLER...NAAAGRIMQQLV----RHI....DDWTAM...VFIRDMS..TF--HGESFRPRSAIRnd........ylpMVKSKFMKDFVFDrvr.........gyiPSAYPNVQDGLES..QMLN...GIKRMRNwaPCYK..EILDV..LYARGMK..LDSFGEFILPMLLKH-VVY---lgt.....................................................
VP3_MYRV9/1-1065 .............................................................................................................--MFDRQYP.TVHDLYIPFPVFQSR...LEQPFDTTVTSIRELRTissqstvygyDLTVN.....DP..LYYDLEPL.....LG---.NSISLTLD...PKLT..DS....ERLDAVYLDINNRLANCHGDLlrkFSATSYSIDTSVIP--..YVFLPMYRYLLHImtgsafNSLFRQMIVNVDA....NCANADES.....LLTSAQHLFALLNKINPSRQ-LPAPLRHILINATIADVPYDMQ........................................................................GKFVP.............YNVVFLPTSNESLRDATIARIREPAGYHPRPSIVVPHYFVFRSTTDALCRFMYLAKRTFLHVndKTATHT....----SVRRCELLRLNFPLDQ...SFAQLSLLVQL.QLplsTLSIQRLPHLSTTVNQLITLASSSYSEQAIINL.LRVNWNVIGYIELSTLGEP...SLPA---.......IRVYDFTSSMNTRsVTQG.P--...NVQIR....TRSNAIDVHVRefirfGRY........LP....------.-----......LEIPKCRVPRLVSLQVINYSLnHLLSVTPWPDQYDVT.RHRPERIIENSV-.............................................--KRTIQYQ-............EYDPSVGTWATSSDMTNYTHI............PSDS..YYHQF..................IVTCLRSF.......CG-LRD.LPRENSARY..PYVVLLYGLALgheiapsrmgLTY.AMTSHMISYVLSTITTGIdvapseiISRFKLFLIDVPFA-.--------DTIIHDLRKVTPNvnvhSTSIFTSnergdariLTGWVVIR..IAVSRFEQQKRS---.FEY.MS......YFNDILR.FCDGGI--.....--------IHFDIPDATFLMHVVT......---.........-SLQCTPNRRVKVLSYF--.....ASQSPFSLTLHF.YRDTT.DPLlpvaniGHWVTRHQ.MKRYAYTDRDStiplrhEVIPALSTVMSRMTAEYSF.VCQ.KSDLPV-----CLSALSTISNYARVATWTDYRGIAHWSGSAVIDPLRLLDSSR.TG-VL.ATN........VPIEPL.IAPSHGVPRLER..-STYRVVDAFhlcsligpIFIQ..REFNIWTASRTSERTRH...-----VIDVGGRDGAFRGLFPH...AMYTVIDPAP....APQHMISNYISEP.......WDF.NDFQGSLD.RIMDTLGI...--IDPQDVFLVFSHVFISALNR...PAAHVNALEQLGALQCSSV....VSTQTS...GSSAS--..TLYSSYVNHNPFLEIR.............MENAAYLTRTYPS...............PYPLPTRAEMNEA..ILNN...ARSRLHQ..TSAA..EILDL..AMRFGYA..PSYEAIVTLPALCDQHVVYAIQ........................................................
#=GC seq_cons ..........................................................................................................................................................................................................................................................................................................................................................................................................................................sp.ls.............Ypshahsstshpph..thhppphPsGhHsh.Nhsl.HYF.Fps.sDh.......hRpTahpL..hpAs.p....u.hp-sRhsEshhsNhshs.....hhptSLhsh........lthtl..c..pslp.Vpslsttp....phlp..t.s.W...h..-h...tt....sl............l.l.s................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hpa...hsh.ch-hs...h.tslthhusIs+sh+lhpa.p.sshhhaphpu.lshshhhcssR..Gptl..ht........s..t...lh.shsssph.p...hh.+.sssh.........hlp......hhphh.h...hh.....t.hhlhDlGGRcGchSG.hsp...hpYhhlDPss....tcth.ttphhht........hsF.t.sp.phs.RhL..hGh......pstplhhlFSpVh.sshpp....tut.t.h.t......t........hpss...sp.pp.t..sh...h.shh.h..l...............htttahsshYPp...............s...s...th.p...hh.....hp.ph+p..hpss...h.......thGhh...s..uchlLPhhhhp.sVh...........................................................
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