#=GF ID   VP40
#=GF AC   PF07447.16
#=GF DE   Matrix protein VP40
#=GF AU   Vella Briffa B;0000-0003-4380-1783
#=GF SE   Pfam-B_22295 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   25.50 271.90;
#=GF NC   23.40 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   VP40
#=GF RN   [1]
#=GF RM   12919741
#=GF RT   Oligomerization and polymerization of the filovirus matrix
#=GF RT   protein VP40. 
#=GF RA   Timmins J, Schoehn G, Kohlhaas C, Klenk HD, Ruigrok RW,
#=GF RA   Weissenhorn W; 
#=GF RL   Virology 2003;312:359-368.
#=GF DR   INTERPRO; IPR008986;
#=GF DR   SCOP; 1h2c; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family contains viral VP40 matrix proteins that seem to be
#=GF CC   restricted to the Filoviridae. These play an important role in
#=GF CC   the assembly process of virus particles by interacting with
#=GF CC   cellular factors, cellular membranes, and the ribonuclearprotein
#=GF CC   particle complex. It has been shown that the N-terminal region
#=GF CC   of VP40 folds into a mixture of hexameric and octameric states -
#=GF CC   these may have distinct roles [1].
#=GF SQ   8
#=GS A0A3Q8U6Q5_9MONO/2-283  AC A0A3Q8U6Q5.1
#=GS C7B285_9MONO/2-283      AC C7B285.1
#=GS X5H596_9MONO/27-295     AC X5H596.1
#=GS G8EFI3_LLOVA/16-295     AC G8EFI3.1
#=GS VP40_EBOSU/37-295       AC Q5XX06.1
#=GS B0LPL6_9MONO/37-295     AC B0LPL6.1
#=GS VP40_MABVM/2-283        AC P35260.3
#=GS VP40_EBOZM/27-295       AC Q05128.1
A0A3Q8U6Q5_9MONO/2-283             .......ASSQGSSSYNQFLSPPPYPIDQSFGHYQLEA--ESQPNQIMPYYVGDIDFA..EQHKTDVIHAFLLEATIDLIGPTEKGRKAVPAWLPLGIISNYEYPLAQTVALLLTGSYTITSFSERGQKFVRVNRNGFGISSHPLQIIRNGNQAFPQAMVIPRNFLNGNFTFQLSNIAVNIQRLPDDAWRPSKDKVVGT.--SMHPAIVVNPYLPPIVLPPVKKHAQKQAKTPQAGSLL------AISNLLHQLIVKKVPEKVGLFKIELPSNIFSQREGMLRRGAAIAPTVYFQAPENMPL..
C7B285_9MONO/2-283                 .......ASSSNYNTYMQYLNPPPY-ADHGANQLIP-ADQLSNQHGITPNYVGDLNLD..DQFKGNVCHAFTLEAIIDISAYNERTVKGVPAWLPLGIMSNFEYPLAHTVAALLTGSYTITQFTHNGQKFVRVNRLGTGIPAHPLRMLREGNQAFIQNMVIPRNFSTNQFTYNLTNLVLSVQKLPDDAWRPSKDKLIGN.--TMHPAISIHPNLPPIVLPTVKKQAYRQHKNPNNGPLL------AISGILHQLRVEKVPEKTSLFRISLPADMFSVKEGMMKKRGESSPVVYFQAPENFPL..
X5H596_9MONO/27-295                .......ARGGNSNT--GFLTPESVNGDTPSNPLRPIADDTIDHASHTP---------..----GSVSSAFILEAMVNVISGPKVLMKQIPIWLPLGVADQKTYSFDSTTAAIMLASYTITHFGKATNPLVRVNRLGPGIPDHPLRLLRIGNQAFLQEFVLPPVQLPQYFTFDLTALKLITQPLPAATW--TDDTPTGS.NGALRPGISFHPKLRPILLPN------KSGKKGNSADLTSPEKIQAIMTSLQDFKIVPIDPTKNIMGIEVPETLVHKLTGKKVTSKNGQPIIPVLLPKYIGL..
G8EFI3_LLOVA/16-295                .sspegl-----------YYNPDAG-KKHGNPHSHPVPHTEHSRASNTIRPTADFSLDydSSSASGAISAFMLEAYVNVISNNKVLLKLVPLWLPLGVAGQDLYSFDSTASALLIASYTITHFGMTTRPLVRVNRLGPGIPDHPLHLLRLGNQAFLQELVLPPLQLPQFFTFELTELRLYTHLMPQTIW---IDSAHGDrHELLRPGLSVNPRLRPILLPC------KTGKKVSQHEIASPDKIKSVANYIKELKLVTLDATKGVYALEIPEPLFEKLTGKKSPQKGSSTLIPILVPRLM--sk
VP40_EBOSU/37-295                  kqevlpg-------------------MDTPSNSMRPVADDNIDHTSHTP---------..----NGVASAFILEATVNVISGPKVLMKQIPIWLPLGIADQKTYSFDSTTAAIMLASYTITHFGKANNPLVRVNRLGQGIPDHPLRLLRMGNQAFLQEFVLPPVQLPQYFTFDLTALKLVTQPLPAATW--TDETPSNL.SGALRPGLSFHPKLRPVLLPG------KTGKKGHVSDLTAPDKIQTIVNLMQDFKIVPIDPAKSIIGIEVPELLVHKLTGKKMSQKNGQPIIPVLLPKYIGL..
B0LPL6_9MONO/37-295                kqevlpg-------------------MDTPSNSMRPVADDNIDHTSHTP---------..----NGVASAFILEATVNVISGPKVLMKQIPIWLPLGIADQKTYSFDSTTAAIMLASYTITHFGKANNPLVRVNRLGQGIPDHPLRLLRMGNQAFLQEFVLPPVQLPQYFTFDLTALKLVTQPLPAATW--TDETPSNL.SGALRPGLSFHPKLRPVLLPG------KTGKKGHVSDLTAPDKIQTIVNLMQDFKIVPIDPAKSIIGIEVPELLVHKLTGKKMSQKNGQPIIPVLLPKYIGL..
VP40_MABVM/2-283                   .......ASSSNYNTYMQYLNPPPY-ADHGANQLIP-ADQLSNQQGITPNYVGDLNLD..DQFKGNVCHAFTLEAIIDISAYNERTVKGVPAWLPLGIMSNFEYPLAHTVAALLTGSYTITQFTHNGQKFVRVNRLGTGIPAHPLRMLREGNQAFIQNMVIPRNFSTNQFTYNLTNLVLSVQKLPDDAWRPSKDKLIGN.--TMHPAVSIHPNLPPIVLPTVKKQAYRQHKNPNNGPLL------AISGILHQLRVEKVPEKTSLFRISLPADMFSVKEGMMKKRGENSPVVYFQAPENFPL..
VP40_EBOZM/27-295                  .......ARGGNSNT--GFLTPESVNGDTPSNPLRPIADDTIDHASHTP---------..----GSVSSAFILEAMVNVISGPKVLMKQIPIWLPLGVADQKTYSFDSTTAAIMLASYTITHFGKATNPLVRVNRLGPGIPDHPLRLLRIGNQAFLQEFVLPPVQLPQYFTFDLTALKLITQPLPAATW--TDDTPTGS.NGALRPGISFHPKLRPILLPN------KSGKKGNSADLTSPEKIQAIMTSLQDFKIVPIDPTKNIMGIEVPETLVHKLTGKKVTSKNGQPIIPVLLPKYIGL..
#=GC seq_cons                      .......Aputs.so..taLsP.sh.tDpsuNph+PlADsphs+sSpTP...............uuVsSAFlLEAhVNVISssKVLhKtlPlWLPLGIAsQcpYSFDSTsAAlhlASYTITHFG+sspPLVRVNRLGsGIPDHPLRLLRhGNQAFLQEhVLPPlQLPQaFTF-LTsL+LsTQ.LPsssW..ocDossGs.ptuLRPGlShHP+LRPILLPs......KoGKKsssu-LsuP-KIpAIsslLp-hKlVslDssKulhuIElPEsLhcKLTGKKhspKsupPlIPlLlP+hhsL..
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