#=GF ID VP4_helical
#=GF AC PF17478.6
#=GF DE Rotavirus VP4 helical domain
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_161 (release 1.0)
#=GF GA 27.00 27.00;
#=GF TC 65.30 59.20;
#=GF NC 23.00 20.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 21157433
#=GF RT Atomic model of an infectious rotavirus particle.
#=GF RA Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC;
#=GF RL EMBO J. 2011;30:408-416.
#=GF DR INTERPRO; IPR035329;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF SQ 13
#=GS VP4_ROTHC/497-744 AC Q82040.1
#=GS E2EBU1_9VIRU/524-614 AC E2EBU1.1
#=GS A0A0K0LAS3_9VIRU/597-759 AC A0A0K0LAS3.1
#=GS A0A125RLH1_9VIRU/483-763 AC A0A125RLH1.1
#=GS D7NN57_9VIRU/485-776 AC D7NN57.1
#=GS VP4_ROTSH/485-776 AC A2T3T2.1
#=GS L0CQJ3_9VIRU/483-763 AC L0CQJ3.1
#=GS D0VZZ4_9VIRU/497-744 AC D0VZZ4.2
#=GS A0A0K0LAS3_9VIRU/521-610 AC A0A0K0LAS3.1
#=GS VP4_ROTS1/485-776 AC P12976.1
#=GS E2EBU1_9VIRU/601-777 AC E2EBU1.1
#=GS A0A1B4XK08_9VIRU/485-776 AC A0A1B4XK08.1
#=GS M4H2P4_9VIRU/472-738 AC M4H2P4.1
VP4_ROTHC/497-744 ..............ASSSTVRMDLERKINDLRDDFNALASSVALSDILSLAMSPLTFSNLLESVPAITSSVKDVAASVMKKFRS----------TKMFKKAAKQNYR.-----------------EFVIGDLLEDVTNV----------.------ARNNNSLNYSDITSAMMVSTT.NRLQITDVDTFSEIVSRSADNFISNRSYRMIE..N..N..TVHEI-TPTRRFSYDIKTLQQRNFDIDKFSKLASQSPVISAIVDFATIKAIRDTYG.ISDDIIY.KLVASDAPTILSFINQNNPLIRNRITNLINQCKL............
E2EBU1_9VIRU/524-614 .............q-SSVTVRQDLDKDIAKLREEFNALSQEIAVNQLIETAMLPLDVMSTSGAVASGASTISTSIKNVSKQFSKSKASIT-LTSFKNLS--------.-----------------------------------------.---------------------------.--------------------------------..-..-..--------------------------------------------------------.-------.----------------------------------divdsvp.....
A0A0K0LAS3_9VIRU/597-759 ltsfknlsdvidtv---------------------------------------------------------------------------------------------.---------------------------------PTNQIA--.KSLNHVSKRSIGTQFEDITAAVVKKTM.DKG--IGTDDMAELITDIADSAIPIRAYRVID..K..SesAVYEISSTGKAIKYNTE-LTQLPFDEVKFKKLISESPVISAIIDFQTLKLYNQTFGkISTDMLD.NFLASNPELLLKMVNEKNP---------------............
A0A125RLH1_9VIRU/483-763 .............q-NSTTVRTDLERQLSDLREEFNALSQEIAMSQLIDLALLPLDLFSAFSGITGTIDAVKNMATNIMKKFKVSNIAKAVTNVTEELSDAATNTIKqTSTIKK-------LRNLATQ-TDAVSKRNAV----TTMSQK.FRVREMTTQTDNLTFDDISAAVLKAKF.DKSTQISSSTLPEIISEAADKYIPNRTYRILD..Q..D..IAFEVDTSGRFFAYRVDTFEEVLFDMEKFVDLASDSPVISAIIDFKTIKNLNDNFG.ITKQQAF.NLLRSDPRVLKDFINQNNPIIRNRINQLLLQCKL............
D7NN57_9VIRU/485-776 .............m-NSVTVRQDLERRLNELREEFNNLSQEIAVSQLIDLAMLPLDMFSMFSGIESTVNAAKSMATNVMRKFKSSKLASSVSMLTDSLSDAASSIAR.STSVRSIGSTASAWANISEQTQDAVSEVATISSQVSQISGR.LRLKEITTQTEGMNFDDISAAVLKAKI.DRSIQVDQNALPDVITEASEKFIRNRAYRVID..G..D..EAFEAGTDGRFFAYKVETLEEMPFNMEKFADLVTNSPVISAIIDFKTLKNLNDNYG.ITREQAF.NLLRSDPKVLRGFIDQNNPIIKNRIEQLIMQCRL............
VP4_ROTSH/485-776 ..............ANSVTVRQDLERQLGELREEFNALSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSMATNVMKKFKKSGLANSVSTLTDSLSDAASSISR.GSSIRSIGSSASAWTDVSTQITDISSSVSSVSTQTSTISRR.LRLKEMATQTEGMNFDDISAAVLKTKI.DKSTQISPNTIPDIVTEASEKFIPNRAYRVIN..N..D..DVFEAGIDGKFFAYKVDTFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYG.ITKQQAF.NLLRSDPRVLREFINQDNPIIRNRIEQLIMQCRL............
L0CQJ3_9VIRU/483-763 .............q-NSTTVRTDLERQLSDLREEFNALSQEIAMSQLIDLALLPLDLFSAFSGIAGTIDAVKNMATNIMKKFKVSNIAKAVTNVTEELSDAAANTIKqTSTIKKVQ-------NLATQT-DAVS-KRNV---ATTMSQK.FRVREMTTQTDNLTFDDISAAVLKAKF.DKSTQISSSTLPEIVSEAADKYIPNRTYRILD..Q..D..IAFEVDTSGRFFAYRVDTFEEVLFDMEKFVDLASDSPVISAIIDFKTIKNLNDNFG.ITKQQAF.NLLRSDPRVLKDFINQNNPIIRNRINQLLLQCKL............
D0VZZ4_9VIRU/497-744 ..............ASSSTVRMDLERKINDLRDDFNALASSVALSDILSLAMSPLTFSNLLESVPAITSSVKDVAANVMKKFRS----------TKMFKKAAKQNYR.-----------------EFVIGDLLEDVTNV----------.------ARNNNSLNYSDITSAMMVSTT.NRLQITDVDTFSEIVSRSADNFISNRSYRMIE..N..N..TVHEI-TPTRSFSYDIKTLQQRNFDVDKFYKLASQSPVISAIVDFATIKAIRDTYG.ISNDIIY.KLVASDAPTILSFINQDNPLIRNRITNLINQCKL............
A0A0K0LAS3_9VIRU/521-610 .............q-SSVTVRQDLDKDIAKLREEFNSLSQEIAVNQLIETAMLPLDVMSTFGAISSGASTISTSIKKVSKQFSKSKASI---TLT------------.-----------------------------------------.---------------------------.--------------------------------..-..-..--------------------------------------------------------.-------.----------------------------------sfknlsdvidtv
VP4_ROTS1/485-776 ..............ANSVTVRQDLERQLGELREEFNALSQEIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSMATNVMKKFKKSGLANSVSTLTDSLSDAASSISR.GSSIRSIGSSASAWTDVSTQITDISSSVSSVSTQTSTISRR.LRLKEMATQTEGMNFDDISAAVLKTKI.DKSTQISPNTIPDIVTEASEKFIPNRAYRVIN..N..D..DVFEAGIDGKFFAYKVDTFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYG.ITKQQAF.NLLRSDPRVLREFINQDNPIIRNRIEQLIMQCRL............
E2EBU1_9VIRU/601-777 ........tsfknl---------------------------------------------------------------------------------------------.------------------------SDIVDSV--PTDQLA--.KNLNHVSKRSIGTQFEDITAAVVKKTM.DKG--IGTDDMAELITDIADSAIPVRAYRVIDksE..N..AVYEVSSIGKAIKYDTE-LTQLPFDEIKFKKLISESPVISAIIDFQTLKLYNQTFGkIDANVLD.NFLASNPEILLKMVNEKNPIITDRIKTLIEQCRI............
A0A1B4XK08_9VIRU/485-776 .............m-NSVTVRQDLERQLGELRDEFNNLSQQIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSMATNVMKKFKKSNLANSVSTLTDSLSDAASSVSR.SSSVRSLGSTASAWTEVSEVATEVNELTNSISTQTSTISKR.LRLKEMATQTDGMNFDDISAAVLKTKI.DKSTQINANTLPDIVTEASEKFIPNRTYRVIA..D..D..EVLEASTDGRFFAYKVETFEEVPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYG.INKQQAL.NLLRSDPKVLREFINQNNPIIRNRIENLIMQCRL............
M4H2P4_9VIRU/472-738 ..............AASVTVRQDLDIKLSQLRQEFNQVAENLAVSQAIGLATMPFDMLSMFSGTFDVVQNIGDFTSTLFSKFSK------TTTGVQLLK-YTKYT--.-----------DELVDVATSTDDVLE----V----ATIANKaKIMKSVETMTDSLDFEDISTAVLNKAMrEIGTQTDYNSIAQIAAESID-MIPTKAYRVID..NasD..TVYEVSKD-ANIAYKLTDLSQIQFDIDKFKKLSSESPVLSAIIDFKTIKMMNQANG.KLDRITLdNLLASNPQILKTMIAQNNPIIVRRVQELIDQCRL............
#=GC seq_cons ...............sSsTVRpDLERplu-LR-EFNuLSQpIAhSQLI-LAhLPLDhhShFuultushsusKshAsNVMKKF+pSthu....shTc.LpcAApp..+..................t..htDh.p.hssV....sphu...hplpchsppopuhsF-DIoAAVlKsph.D+up.lsssohs-Ilo-uu-paIPNRuYRlI-..p..s..tVaEssosG+hFuYcl-ThpplsFDhpKFtcLso-SPVISAIIDFpTlKslNDsaG.Iocp.hh.NLLtSDPclLhpFINQsNPII+NRIppLI.QC+L............
//
