#=GF ID VPg
#=GF AC PF20915.1
#=GF DE Viral genome-linked protein
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE ECOD:3639.1.1
#=GF GA 27.00 27.00;
#=GF TC 32.90 98.50;
#=GF NC 24.00 18.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 23487472
#=GF RT Structures of the compact helical core domains of feline
#=GF RT calicivirus and murine norovirus VPg proteins.
#=GF RA Leen EN, Kwok KY, Birtley JR, Simpson PJ, Subba-Reddy CV,
#=GF RA Chaudhry Y, Sosnovtsev SV, Green KY, Prater SN, Tong M, Young
#=GF RA JC, Chung LM, Marchant J, Roberts LO, Kao CC, Matthews S,
#=GF RA Goodfellow IG, Curry S;
#=GF RL J Virol. 2013;87:5318-5330.
#=GF RN [2]
#=GF RM 9152420
#=GF RT Identification of a protein linked to the genomic and subgenomic
#=GF RT mRNAs of feline calicivirus and its role in translation.
#=GF RA Herbert TP, Brierley I, Brown TD;
#=GF RL J Gen Virol. 1997;78:1033-1040.
#=GF RN [3]
#=GF RM 16835235
#=GF RT Caliciviruses differ in their functional requirements for eIF4F
#=GF RT components.
#=GF RA Chaudhry Y, Nayak A, Bordeleau ME, Tanaka J, Pelletier J,
#=GF RA Belsham GJ, Roberts LO, Goodfellow IG;
#=GF RL J Biol Chem. 2006;281:25315-25325.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This family represents Viral genome-linked protein (VPg) from
#=GF CC Caliciviruses such as Feline calicivirus (FCV). VPg plays a key
#=GF CC role in translation initiation from genomic and subgenomic RNAs
#=GF CC and is thought to function as a cap substitute for ribosomal
#=GF CC recruitment. It interacts with the initiation factor eIF4E. This
#=GF CC protein shows a compact helical structure flanked by flexible N
#=GF CC and C terminal ends [1-3].
#=GF SQ 4
#=GS POLG_RHDVF/998-1062 AC P27410.1
#=GS POLG_VESVA/1079-1139 AC Q9DUN3.1
#=GS POLG_FCVUR/970-1030 AC Q66914.1
#=GS POLG_BECN1/926-986 AC Q288N7.1
POLG_RHDVF/998-1062 kt--KRGRGarVNLGNDEYDEWQAARREfvNAHDMTAEEYLAMKNKAAMGSDDQDSIMFRSWWTRRQ
POLG_VESVA/1079-1139 ..GPRKNTG..VALTDDEYNDWKQSKAE..KNLDLTVKDFLQLRHRAAMGADNTDAVKFRYWYSKKQ
POLG_FCVUR/970-1030 ..GPYRGRG..VALTDDEYDEWREHNAT..RKLDLSVEDFLMLRHRAALGADDADAVKFRSWWNSRS
POLG_BECN1/926-986 ..GWLSGSG..VALSDEEYDEWMKYSKK..KGKKINADEFLQLRHRAAMGNDDDDARDYRSFYTAYQ
#=GC seq_cons ..G.h+GpG..VALoDDEYDEWpptptc..+shDlos--FLtLRHRAAMGuDDsDAlcFRSWaop+Q
//
