#=GF ID   VioE
#=GF AC   PF18234.5
#=GF DE   Violacein biosynthetic enzyme VioE
#=GF AU   Smart A;0000-0002-6965-5633
#=GF SE   ECOD:EUF04563
#=GF GA   25.00 25.00;
#=GF TC   27.40 105.30;
#=GF NC   20.90 17.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0048
#=GF RN   [1]
#=GF RM   18171675
#=GF RT   The violacein biosynthetic enzyme VioE shares a fold with
#=GF RT   lipoprotein transporter proteins.
#=GF RA   Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL;
#=GF RL   J Biol Chem. 2008;283:6467-6475.
#=GF DR   INTERPRO; IPR040857;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is VioE present in Chromobacterium violaceum. VioE
#=GF CC   plays a key role in the biosynthesis of violacein. Violacein has
#=GF CC   potential medical applications as an antibacterial,
#=GF CC   anti-tryptanocidal, anti-ulcerogenic and as an anti-cancer drug.
#=GF CC   VioE forms a homodimer with a chiefly hydrophobic interface
#=GF CC   between the two VioE monomers.The fact that VioE adopts a fold
#=GF CC   normally associated with lipoprotein carrier proteins may be due
#=GF CC   to VioE for binding the hydrophobic polyethylene glycol [1].
#=GF SQ   16
#=GS W0UYU6_9BURK/7-188       AC W0UYU6.1
#=GS A0A0X8GQQ8_9BURK/8-189   AC A0A0X8GQQ8.1
#=GS A0A2D2DPB8_9BURK/7-188   AC A0A2D2DPB8.1
#=GS Q7NSZ5_CHRVO/6-187       AC Q7NSZ5.1
#=GS A0A1Z4RDE9_9CYAN/10-191  AC A0A1Z4RDE9.1
#=GS A0A4P9VKA7_9GAMM/9-195   AC A0A4P9VKA7.1
#=GS A0A5B1BHU6_9FLAO/3-172   AC A0A5B1BHU6.1
#=GS K9RH59_9CYAN/383-563     AC K9RH59.1
#=GS A0A166XV66_9GAMM/9-191   AC A0A166XV66.1
#=GS A0A0M2WT33_9BURK/7-188   AC A0A0M2WT33.1
#=GS A0A244CR76_PSEDV/10-192  AC A0A244CR76.1
#=GS A0A845GYQ1_9BURK/7-187   AC A0A845GYQ1.1
#=GS A0A0K1K273_9BURK/7-188   AC A0A0K1K273.1
#=GS A0A1S1MS82_9GAMM/10-192  AC A0A1S1MS82.1
#=GS A0A4V3DVK8_9NEIS/5-182   AC A0A4V3DVK8.1
#=GS A0A2G3K9N9_9BURK/10-190  AC A0A2G3K9N9.1
W0UYU6_9BURK/7-188                  .PPLLPMQWSSAYLSYWSPMREEDQLTSGYCWFDYARNICRIDGLFNPWPEKETGHRLWMSEIGDARQGQSRRQKVAYARETAAAGST.....LRETALEDELTPFHALFLPQAILLEGNALHGGRHTVLGQPVDAWVVQRP.ARVPSVFYLQAGGNRLLRMVTGNDPRHLSVRDFPNFCAGAIPDSVF
A0A0X8GQQ8_9BURK/8-189              .PPRLPEQWSSSYISYWQPMQKEDQITSGICWFDYEQNRCRIDGLFNPWSEEKTGHRLWMSEIVTAGEGKTKKSKIAYCRESPLGEGE.....YEAVVLDDDLESCHEVLLTQDVLLQYQASYVGSQHLLGRETEAWTFTKP.GKGPSTYYFVKGTNQLLRMVTGDPAVHASIRDFPNFTTHTIPAEIF
A0A2D2DPB8_9BURK/7-188              .PPLLPMQWSSAYISYWSPMREDDEVTSGYCWFDYARDICRIDGLFNPWSEKETGHRLWMSEIGDARRGQSRKQKVAYAREAEPAGVK.....LYERALADEVTPFHELFLPQAILIDGEARHDGRHTVLGQAADAWVVERP.GKAASVFYLQAGGNHLLRMVTGNDAQHQSVRDFPNFLAGDIAASVF
Q7NSZ5_CHRVO/6-187                  .PPLLPARWSSAYVSYWSPMLPDDQLTSGYCWFDYERDICRIDGLFNPWSERDTGYRLWMSEVGNAASGRTWKQKVAYGRERTALGEQ.....LCERPLDDETGPFAELFLPRDVLRRLGARHIGRRVVLGREADGWRYQRP.GKGPSTLYLDAASGTPLRMVTGDEASRASLRDFPNVSEAEIPDAVF
A0A1Z4RDE9_9CYAN/10-191             .PPMLPIQWSTSYVSYWQPMLEEDRMTSGYCWFDYRRNVCRIDGLFNPWAEEETGYNLWMSEIFTPGEGQTRKAKIAYTKSEGREQTI.....YQAIPLSDDVDACHELLLTQDILIRNNATYAGSHTILAMRTDAWTFSRP.LKGQSTYYFQQGTNHLVRMVTGDPNTHASVRDFPNFDTHIIPDHIF
A0A4P9VKA7_9GAMM/9-195              .PPLLPDQWSSSYISYWTPMFDEDQITSGYCWFNYIDNKCRIDGLFNPWSEKETGHRLWMSELVNASNGVTHKKKIAYTKTKQHTEEKkikliYNAIPSPHEINDSHELLLAKDVLIKHKATYAGKHKILNIQADSWEFYIP.NKGPATYFFKAGTNCLIRMVTGDPKLHASVRDFPTFNTEKISEFIF
A0A5B1BHU6_9FLAO/3-172              l-PQLPDTWQAAYISLWKPMMPENFISNGMAWFDYDKGLYRIDGLSNPWDVKTTGYKLWLSEIGVQAEKKKQKKTINIYPDKLV--E-.....----NLENHVYEGK-HPLPQNVLSLWNASHIGQTEIEEQSVDIWESESQ.DKK---LYISSVTHVPLKMELK-KNEQTHVKKFISPLIGEIQETIF
K9RH59_9CYAN/383-563                .PPLLPKQWSTSYVSYWQPMLDEDQITSGYCWFDYSNNLGRIDGLFNPWSEKETGHRLWMSQIFTPGKGETRMSKVAYARKENEQ-TA.....YKAVNLEDDVDSCHELLLTQDILIRHNATYAGSHTILGIKTDAWKFKRP.GKAVSTYYFKQGTNHLIRMVTGDPNKHASVRDFPNLNTEVISGNIF
A0A166XV66_9GAMM/9-191              .PPILPLQWNSSYISYWSPMQPEEHITSGYCWFDYGKNVCRIDGLFNPWSEEKTGHRLWMSEIMYPGTNESFKSKVAYSREHMDKQSE.....FSEEVLNDEIDPCHELILMQDVLQKCDAQYQGTCEVLGFTADIWHFQRPnSKGPATYYLKAGTNELLRMVTGDPNVLASVRDFPNFNTREIDPDIF
A0A0M2WT33_9BURK/7-188              .PPLLPMQWSSAYVSYWTPMQEDDQVTSGYCWFDYARNICRIDGLFNPWPEKEHGHLLWMSEIGDARREQSRKQKVAYARQAQATGEQ.....LQGTALADEVTPFQALFLPQAVLLDGGARHDGRHSVLGREADAWVVEPA.GKPPSVFYLEADGNRLLRMVTGNDPQHRSVRDFPNLSVSDIPDSVF
A0A244CR76_PSEDV/10-192             .PPLLPEQWSSSYISYWMPMQPDDDITSGYCWFDYTKNVCRIDGIFNPWSEIKMGNRLWMSEIMHPNTDESFKSKVAYTRDDMKSTSE.....FSAQVLTDEIDPCHELILTQDVLITCNAQYMGIETVLGHQAEKWCFQRPdNKGPATYYFIKETNHLVRMITGDPNICASVRDFPNFNTFKIDKEIF
A0A845GYQ1_9BURK/7-187              .PPLLPTQWSSAYVSYWSPMQPEDQLTSGYCWFDYARNICRIDGLFNPWPEKEKGHRLWMSELGDAGHRQSRKRKVAYAREGTAAGEQ.....LLETVLDDELSSFPELFLPQAILRDGGALHNGRHTVLGQAADAWVVERP.G-ASSVFYLQAGGNRLLRMVTGNDPQHQSVRDFPNFCTGDIADSIF
A0A0K1K273_9BURK/7-188              .PPLLPLQWSSAYVSYWTPMQEDDQITSGYCWFDYGRNICRIDGLFNPWSEKETGHRLWMSEIGDARREQSRKQKVAYAREAAAAGVE.....LYDTALPDEVTPFHELFLPQAILVDGEARHDGRHTVLGQEADAWVVERP.GKAPSVFYLQAGGNHLLRMVTGSDAQHQSVRDFPNFFAGEIADSIF
A0A1S1MS82_9GAMM/10-192             .PPRLPNKWSSSYISYWQPMLPEDDITSGYCWFDYTKNVCRIDGLFNPWSEAQKGHRLWMSEIMYPSSNESFKAKVAYTRAHTNMPSE.....FIESVLNDEVDACHELILTQDVLIQCNAQFIGLHDVLGQSAEAWTFERPhGKGPATYYFATGTNQLLRMITGDPNVHASVRDFPNFNTLDIPASTF
A0A4V3DVK8_9NEIS/5-182              .PPLLPQQWSSAYISYWSPMMPEDQISSGYCWFDYTRNLCRIDGLFNPWSERTTGYRLWMSETGNASARRTHKQKVAYGRD----GVE.....LSAQPLAEESALFEQLYLPQGVLREHRARHDGRHEVLGLVADAWTYQRP.GKGPATLFLKADTDLLLRMVTGDADGHASVRDFPNLCTRSIPAWIF
A0A2G3K9N9_9BURK/10-190             .PPLLPAQWSGAYISYWSPMQPDDQITSGYCWFDYTRNICRIDGLFNPWSEKETGHRLWMSEIGNAERKLSHKQKIAYSREMMDFGVA.....LFEMP-EREVTPFEQLYLPRALLQENHAVYAGNESILGQTADAWTFTKQ.GKDPSTYYFKAGTDLLLRMVTGDPKQHASVRDFPCIATHPIPDWIF
#=GC seq_cons                       .PPLLPtQWSSuYlSYWoPM.sEDQITSGYCWFDYs+NlCRIDGLFNPWSE+-TGHRLWMSEIssAupspo+KpKVAYuR-ptstssp.....hptpsLsDElsshHELhLsQslLlcssApasGpHsVLGppADAWsapRP.GKuPSTaYhpAGTNpLLRMVTGDsspHASVRDFPNFsTtcIscsIF
//