#=GF ID VirDNA-topo-I_N
#=GF AC PF09266.14
#=GF DE Viral DNA topoisomerase I, N-terminal
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF SE pdb_1vcc
#=GF GA 25.00 25.00;
#=GF TC 30.10 29.60;
#=GF NC 24.40 21.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF WK Type_I_Topoisomerase
#=GF RN [1]
#=GF RM 7994576
#=GF RT Crystal structure of the amino-terminal fragment of vaccinia
#=GF RT virus DNA topoisomerase I at 1.6 A resolution.
#=GF RA Sharma A, Hanai R, Mondragon A;
#=GF RL Structure. 1994;2:767-777.
#=GF DR INTERPRO; IPR015346;
#=GF DR SCOP; 1vcc; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Members of this family are predominantly found in viral DNA
#=GF CC topoisomerase, and assume a beta(2)-alpha-beta-alpha-beta(2)
#=GF CC fold, with a left-handed crossover between strands beta2 and
#=GF CC beta3 [1].
#=GF SQ 45
#=GS A0A7R5WJE9_9POXV/17-72 AC A0A7R5WJE9.1
#=GS W6JIX1_9POXV/9-63 AC W6JIX1.1
#=GS Q9J587_FOWPN/7-64 AC Q9J587.1
#=GS Q6TVQ8_ORFSA/4-61 AC Q6TVQ8.1
#=GS A0A220T6F1_9POXV/4-61 AC A0A220T6F1.1
#=GS P87507_AMEPV/16-63 AC P87507.1
#=GS Q9YVW2_MSEPV/9-63 AC Q9YVW2.1
#=GS A0A223FNE3_9POXV/4-61 AC A0A223FNE3.1
#=GS H6TA67_9POXV/4-61 AC H6TA67.1
#=GS Q6TUT8_YMTV5/4-61 AC Q6TUT8.1
#=GS A0A385HB85_FOWPV/7-64 AC A0A385HB85.1
#=GS A0A2U9QHN8_9POXV/4-61 AC A0A2U9QHN8.1
#=GS Q9DHN6_YLDV/4-61 AC Q9DHN6.1
#=GS Q8V3M1_SWPV1/4-61 AC Q8V3M1.1
#=GS Q9JFB0_VACCT/4-61 AC Q9JFB0.1
#=GS Q9Q8M6_MYXVL/4-61 AC Q9Q8M6.1
#=GS A0A1B1MRF7_9POXV/4-61 AC A0A1B1MRF7.1
#=GS A0A6B9R4L0_9POXV/4-61 AC A0A6B9R4L0.1
#=GS A0A2C9DT52_9POXV/5-62 AC A0A2C9DT52.1
#=GS TOP1_VACCW/4-61 AC P68698.1
#=GS Q6VZF8_CNPV/7-64 AC Q6VZF8.1
#=GS A0A7H0DN83_MONPV/4-61 AC A0A7H0DN83.1
#=GS Q0NPA5_9POXV/4-61 AC Q0NPA5.1
#=GS A0A097IVT5_9POXV/4-61 AC A0A097IVT5.1
#=GS TOP1_VACCC/4-61 AC P68697.1
#=GS E2CZW9_9POXV/4-61 AC E2CZW9.1
#=GS Q98254_MCV1/5-62 AC Q98254.1
#=GS A0A0M3ZEN1_9POXV/7-64 AC A0A0M3ZEN1.1
#=GS A0A3F2YKN1_SHEVT/4-61 AC A0A3F2YKN1.1
#=GS Q0GNY0_HSPV/4-61 AC Q0GNY0.1
#=GS F1AX55_ORFV/4-61 AC F1AX55.1
#=GS U3UBD1_9POXV/4-61 AC U3UBD1.1
#=GS Q775U1_CAMPS/4-61 AC Q775U1.1
#=GS Q070E5_CPRVZ/5-62 AC Q070E5.1
#=GS TOP1_VAR67/4-61 AC P32989.1
#=GS Q08FR6_DPV83/4-61 AC Q08FR6.1
#=GS A0A1C9HHU7_LSDV/4-61 AC A0A1C9HHU7.1
#=GS A0A223FMS8_9POXV/4-61 AC A0A223FMS8.1
#=GS TOP1_RFVKA/4-61 AC P16472.1
#=GS A0A1V0QGY7_CNPV/7-64 AC A0A1V0QGY7.1
#=GS A0A1L3IZJ5_9POXV/4-61 AC A0A1L3IZJ5.1
#=GS D3IZK9_9POXV/4-61 AC D3IZK9.1
#=GS Q08F96_DPV84/4-61 AC Q08F96.1
#=GS G3EIG2_9POXV/4-61 AC G3EIG2.1
#=GS A0A0H4Y1C1_9POXV/6-62 AC A0A0H4Y1C1.1
A0A7R5WJE9_9POXV/17-72 ydkssgivfdng---------------QKLPTDHLVYQIIQKYRLPLHLENIQITRvSTMEEADNGIVYIG
W6JIX1_9POXV/9-63 ..........yk--YIAGKLYDSNDKLV---TKKELYNIINKYKVPSHLHDVTLVA.NNISEADNGIIYIG
Q9J587_FOWPN/7-64 ............FHYKDDKLYYDAAYKNLVPASNKTYEIIKAYRVPPHLKEVIVYE.QSLEEASNSLIFIG
Q6TVQ8_ORFSA/4-61 ............LHLSDGKLFFDKELTQPVPDDNPAYAVLAKIRIPPHLSDVVVYE.QDLESAQQGLIFVG
A0A220T6F1_9POXV/4-61 ............FYYKDGKLFLDSTYKQEVSKKNPTYEILKHIKIPSHLSNVIIYE.QTYEQSLSRLVFIG
P87507_AMEPV/16-63 ............IYNTDGQEIVDDNLLN----------IIKKYKPPKHLNNIELIA.KNIEEADNGIIYIG
Q9YVW2_MSEPV/9-63 ......ynvinn------KIYDDKNNEIINEELN---KIIIKYKPPSHLHDIKLIA.KNIKEADNGIVYIG
A0A223FNE3_9POXV/4-61 ............LFYKEGKLFFDSKFLNPVPDNNPAYDVLQHIKIPAHLTDVIIYE.QTWEDALTRLIFVG
H6TA67_9POXV/4-61 ............LYYKLGKLFLDKDLTIHVKGDNPAYEILEHIKIPEHLTDVIIYE.QTYEQSLTGLIFVG
Q6TUT8_YMTV5/4-61 ............LYYNDGKLFEDKELTMSVSSDNPAYEILKKIKIPSYLTDVVVYE.QTYDESLNRLIFVG
A0A385HB85_FOWPV/7-64 ............FHYKDDKLYYDAAYKNLVPASNKTYEIIKAYRVPPHLKEVIVYE.QSLEEASNSLIFIG
A0A2U9QHN8_9POXV/4-61 ............LFLKSGKLFFDKEHTKIVPISNPAYEVIKAIRIPQNLHDIVVYE.QTLENASNGLMFVG
Q9DHN6_YLDV/4-61 ............LYYNNGKLFEDKEFTIFVSFDNPTYEILKKVKIPSYLTDVIVYE.QTYEESLTKLVFVG
Q8V3M1_SWPV1/4-61 ............FLYYDGKLFFDTDLTKQVPYDNPTYDILKYIKIPNHLTNVMVYE.QTYEQSLHRLIFVG
Q9JFB0_VACCT/4-61 ............LFYKDGKLFTDNNFLNPVSDDNPAYEVLQHVKIPTHLTDVVVYE.QTWEEALTRLIFVG
Q9Q8M6_MYXVL/4-61 ............FVYKDGKLYEDKELTMPVPSSNPTYEILKHVKIPSHLTNVIVYE.QTYEQSLSRLIFVG
A0A1B1MRF7_9POXV/4-61 ............LYYKDNKLFFDKELTQNVPNSNPAYSVLKSIKIPAHLTDVVVYE.QTLEEAVNGLMFVG
A0A6B9R4L0_9POXV/4-61 ............FYYKDNKLFIDSNFKNAVPLDNPTYIILKRIKIPQHLTNVIIYE.QTYEQAITRLIFVG
A0A2C9DT52_9POXV/5-62 ............FYYSDGVLYYDRTCTRQVPADNVTYDVLRRVRVPAHLSDVIVYE.QTYEEALEGLVFVG
TOP1_VACCW/4-61 ............LFYKDGKLFTDNNFLNPVSDDNPAYEVLQHVKIPTHLTDVVVYE.QTWEEALTRLIFVG
Q6VZF8_CNPV/7-64 ............LYYKEGKLYYDNAYKKRVPISNPTYEILKRYKIPTYLKDIIIYE.QTYEEALNSLIFVG
A0A7H0DN83_MONPV/4-61 ............LFYKDGKLFTDNNFLNPVSDDNPAYEVLQHVKIPTHLTDVVVYE.QTWEEALTRLIFVG
Q0NPA5_9POXV/4-61 ............LFYKDGKLFTDNNFLNPVSNDNPAYEVLQHVKIPTHLTDVVVYE.QTWEEALTRLIFVG
A0A097IVT5_9POXV/4-61 ............LYYKLGKLFLDKDLTIHVKGDNPAYEILEHIKIPEHLTDVIIYE.QTYEQSLTGLIFVG
TOP1_VACCC/4-61 ............LFYKDGKLFTDNNFLNPVSDDNPAYEVLQHVKIPTHLTDVVVYE.QTWEEALTRLIFVG
E2CZW9_9POXV/4-61 ............FVYKDGKLYEDKELTMPVPSSNPTYEILKHVKIPSHLTNVIVYE.QTYEQSLSRLIFVG
Q98254_MCV1/5-62 ............FFYKDGELFHDRKCTRRVSRSNATYEVLRHVRIPAHLHDVRVLE.QTYEQAQRGLVFVG
A0A0M3ZEN1_9POXV/7-64 ............FYYNDGRLYYDSEYKKLVPKSNIAYQIIKMYKIPSHLKDIIIYE.QTYEQALNSLILVG
A0A3F2YKN1_SHEVT/4-61 ............LFYNDGKLFTDKNLTTLVSFDNPTYEIIKKIRIPPHLTDVIVYE.QTYEQSLTRLIFVG
Q0GNY0_HSPV/4-61 ............LFYKDGKLFTDNNFLNPVSDDNPAYEVLQHVKIPTHLTDVVVYE.QTWEEALTRLIFVG
F1AX55_ORFV/4-61 ............LHLSNGKLFFDKELTQPVPDDNPAYAVLAKIRIPPHLSDVVVYE.QDLESAQQGLIFVG
U3UBD1_9POXV/4-61 ............LFLRNGKLFFDKECTRAVPNSNPAYEVLKNVRIPPHLTDVVVYE.QTYEQALGGLIFVG
Q775U1_CAMPS/4-61 ............LFYKDGKLFTDNNFLNPVSDDNPAYEVLQHVKIPTHLTDVVVYE.QTWEEALTRLIFVG
Q070E5_CPRVZ/5-62 ............LFYLEGVLYYDADRTRRVEDSNPTYDVVARVKIPAHLTDVAFVE.QTLEESARGLIFIG
TOP1_VAR67/4-61 ............LFYKDGKLFTDNNFLNPVSDNNPAYEVLQHVKIPTHLTDVVVYG.QTWEEALTRLIFVG
Q08FR6_DPV83/4-61 ............FSYKDGKLFFDKEFKHIVPYDNKTYEILRHVKIPPHLTDVIIYE.QSYEQSLTGLIFVG
A0A1C9HHU7_LSDV/4-61 ............LFYNDGKLFTDKNLTTLVSFDNPTYEIIKRIRIPPHLTDVIVYE.QTYEQSLTRLIFVG
A0A223FMS8_9POXV/4-61 ............LFYKEGKLFFDSKFLNPVPDNNPAYDVLQHIKIPAHLTDVIIYE.QTWEDALTRLIFVG
TOP1_RFVKA/4-61 ............FTYKDGKLYEDKELTIPVHCSNPTYEILKHVKIPSHLTDVIVYE.QTYEQSLSRLIFVG
A0A1V0QGY7_CNPV/7-64 ............LYYKEGKLYYDNDYKKLVPMSNPTYEILKMYKIPSYLKDIIIYE.QTYEESLNNLIFVG
A0A1L3IZJ5_9POXV/4-61 ............LYYNLGKLYLDKELTIHAKGDNPAYEILEHIKIPTHLTDVIIYE.QTYEQSLSGLIFVG
D3IZK9_9POXV/4-61 ............LHLADGKLFFDKELTQPVPDDNPAYAVLAKIRIPPHLSDVVVYE.QDLESAQQGLIFVG
Q08F96_DPV84/4-61 ............FSYKDGKLFFDKEFKHIVPYDNKTYEILRHVKIPPHLTDVVIYE.QSYEQSLTGLIFVG
G3EIG2_9POXV/4-61 ............LFYKEGKLFFDNKFLNPVPDNNLAYDVLKHIKIPAYLTDVIVYE.QTWDDALSGLIFVG
A0A0H4Y1C1_9POXV/6-62 ......ifiklk------RIFVDDSGKI-IDESDDLYKILENVNIPGHLKNVKFKL.QSFSDHESGLIFTG
#=GC seq_cons ............LaYKDGKLFhDpphpp.VsssNPsYElLc+lKIPsHLTDVlVYE.QTaEpALstLIFVG
//
