#=GF ID WYL_3
#=GF AC PF18488.5
#=GF DE WYL domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF05081
#=GF GA 25.30 25.30;
#=GF TC 25.60 27.30;
#=GF NC 22.70 25.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0654
#=GF RN [1]
#=GF RM 21813644
#=GF RT Structures of Phytophthora RXLR effector proteins: a conserved
#=GF RT but adaptable fold underpins functional diversity.
#=GF RA Boutemy LS, King SR, Win J, Hughes RK, Clarke TA, Blumenschein
#=GF RA TM, Kamoun S, Banfield MJ;
#=GF RL J Biol Chem. 2011;286:35834-35842.
#=GF DR INTERPRO; IPR040691;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Many phytopathogens secrete and/or inject 'effector' proteins
#=GF CC inside host cells to modulate cellular processes. Phytopathogens
#=GF CC deliver effector proteins inside host plant cells to promote
#=GF CC infection. Crystal structures of the effector domains from two
#=GF CC oomycete RXLR proteins, Phytophthora capsici AVR3a11 and
#=GF CC Phytophthora infestans PexRD2 reveal a core alpha-helical fold
#=GF CC (termed the 'WY-domain') which enables functional adaptation of
#=GF CC these fast evolving effectors through (i) insertion/deletions in
#=GF CC loop regions between alpha-helices, (ii) extensions to the N and
#=GF CC C termini, (iii) amino acid replacements in surface residues,
#=GF CC (iv) tandem domain duplications, and (v) oligomerization. It is
#=GF CC proposed that the core fold provides both a degree of molecular
#=GF CC stability and plasticity that enables development/maintenance of
#=GF CC effector virulence activities while allowing evasion of
#=GF CC recognition by the plant innate immune system during rapid 'arms
#=GF CC race' co-evolution [1].
#=GF SQ 71
#=GS A0A0W8CDS4_PHYNI/68-131 AC A0A0W8CDS4.1
#=GS D0NME1_PHYIT/59-122 AC D0NME1.1
#=GS A0A833RUA4_PHYIN/58-120 AC A0A833RUA4.1
#=GS A0A0W8C141_PHYNI/60-132 AC A0A0W8C141.1
#=GS G5A4Z2_PHYSP/74-137 AC G5A4Z2.1
#=GS A0A329SDB2_9STRA/67-130 AC A0A329SDB2.1
#=GS D0NIL2_PHYIT/56-118 AC D0NIL2.1
#=GS G5A4Y5_PHYSP/62-125 AC G5A4Y5.1
#=GS W2ZFM1_PHYPR/143-200 AC W2ZFM1.1
#=GS SFI5_PHYIT/67-130 AC D0NMF6.1
#=GS V9ERH1_PHYPR/56-119 AC V9ERH1.1
#=GS A0A8J5MG43_9STRA/63-123 AC A0A8J5MG43.1
#=GS D0P4F6_PHYIT/59-122 AC D0P4F6.1
#=GS W2XYL2_PHYPR/74-135 AC W2XYL2.1
#=GS G4YJ04_PHYSP/38-104 AC G4YJ04.1
#=GS A0A3R7KM62_9STRA/64-95 AC A0A3R7KM62.1
#=GS W2R5W4_PHYPN/56-119 AC W2R5W4.1
#=GS G4YP53_PHYSP/57-119 AC G4YP53.1
#=GS A0A833S8X0_PHYIN/73-134 AC A0A833S8X0.1
#=GS A0A329S5Z2_9STRA/38-99 AC A0A329S5Z2.1
#=GS A0A3R7GSD5_9STRA/85-147 AC A0A3R7GSD5.1
#=GS A0A833WP37_PHYIN/1-56 AC A0A833WP37.1
#=GS RXLRO_PHYIT/56-118 AC D0NP16.1
#=GS W2QCY2_PHYPN/59-99 AC W2QCY2.1
#=GS A0A833WFU5_PHYIN/1-56 AC A0A833WFU5.1
#=GS A0A329RX06_9STRA/59-121 AC A0A329RX06.1
#=GS D0NPH2_PHYIT/58-120 AC D0NPH2.1
#=GS A0A833SXR6_PHYIN/59-122 AC A0A833SXR6.1
#=GS W2QB56_PHYPN/68-131 AC W2QB56.1
#=GS W2ZG01_PHYPR/68-131 AC W2ZG01.1
#=GS D0MUF9_PHYIT/53-116 AC D0MUF9.1
#=GS D0NCP7_PHYIT/60-121 AC D0NCP7.1
#=GS W2Y085_PHYPR/60-121 AC W2Y085.1
#=GS W2P990_PHYPN/59-121 AC W2P990.1
#=GS V9FAE6_PHYPR/74-135 AC V9FAE6.1
#=GS A0A6A3ZL09_9STRA/48-111 AC A0A6A3ZL09.1
#=GS A0A0W8DM65_PHYNI/60-121 AC A0A0W8DM65.1
#=GS A0A8J5IBX5_9STRA/38-96 AC A0A8J5IBX5.1
#=GS A0A3R7JBX1_9STRA/81-143 AC A0A3R7JBX1.1
#=GS A0A3R7K4B9_9STRA/69-124 AC A0A3R7K4B9.1
#=GS V9FAE8_PHYPR/68-131 AC V9FAE8.1
#=GS A0A8J5IIA8_9STRA/67-118 AC A0A8J5IIA8.1
#=GS D0NPH0_PHYIT/58-120 AC D0NPH0.1
#=GS A0A8J5I409_9STRA/60-88 AC A0A8J5I409.1
#=GS A0A833W6I7_PHYIN/1-55 AC A0A833W6I7.1
#=GS V9F6C4_PHYPR/59-121 AC V9F6C4.1
#=GS A0A833WWR7_PHYIN/1-57 AC A0A833WWR7.1
#=GS A0A8J5J392_9STRA/45-93 AC A0A8J5J392.1
#=GS W2YX95_PHYPR/49-112 AC W2YX95.1
#=GS D0NIN6_PHYIT/56-118 AC D0NIN6.1
#=GS W2QDR8_PHYPN/38-99 AC W2QDR8.1
#=GS D0NPH3_PHYIT/58-120 AC D0NPH3.1
#=GS W2ZJ39_PHYPR/59-96 AC W2ZJ39.1
#=GS RD2_PHYIT/56-118 AC D0NIN5.1
#=GS A0A0W8DBT6_PHYNI/59-121 AC A0A0W8DBT6.1
#=GS D0NP19_PHYIT/56-118 AC D0NP19.1
#=GS H3GPY3_PHYRM/63-124 AC H3GPY3.1
#=GS V9FAF9_PHYPR/59-99 AC V9FAF9.1
#=GS A0A833SXE5_PHYIN/58-120 AC A0A833SXE5.1
#=GS A0A6A4C610_9STRA/48-111 AC A0A6A4C610.1
#=GS A0A225WDP2_9STRA/60-123 AC A0A225WDP2.1
#=GS W2ZE82_PHYPR/59-121 AC W2ZE82.1
#=GS A0A225UWH8_9STRA/60-118 AC A0A225UWH8.1
#=GS A0A833SX01_PHYIN/56-118 AC A0A833SX01.1
#=GS A0A0W8CLV6_PHYNI/56-119 AC A0A0W8CLV6.1
#=GS A0A8J5ITJ4_9STRA/57-120 AC A0A8J5ITJ4.1
#=GS G4YP50_PHYSP/57-119 AC G4YP50.1
#=GS D0NIN3_PHYIT/56-118 AC D0NIN3.1
#=GS W2QB65_PHYPN/60-101 AC W2QB65.1
#=GS A0A0W8C2V8_PHYNI/49-112 AC A0A0W8C2V8.1
#=GS A0A833WMA4_PHYIN/1-56 AC A0A833WMA4.1
A0A0W8CDS4_PHYNI/68-131 ....PPLSMDDMKAMMKEGISREMYARKLGIAEQMAQ.fITSGLPGIE..EFKG...........TSEFKKYEFYMNFLNDM...........
D0NME1_PHYIT/59-122 ....RSLNKKTMMDMMESLTTKEKLASDLRIADKIDD.fTRHNKPDMN..EFMR...........TPEYVKYIGYVNFLNDM...........
A0A833RUA4_PHYIN/58-120 ....RGLDNAKMKSMWKDGWSADNYATKLGIADDIAH..AETSTGALQ..QLMQ...........THKYEKYKTYLNYLITK...........
A0A0W8C141_PHYNI/60-132 ....RSLTTREMKNMMKNLTTKEEFASTLGISQLIN-..SDLNGGALM..RFMQitliivfarpwSSEYLKYRAYMDFLNDM...........
G5A4Z2_PHYSP/74-137 ....RALSLEEMKRMMKAGMNEEAFAEELGVSEKMKL.vSSQPNTGLA..TFLT...........SPEYAKIAAYQNFLI--ga.........
A0A329SDB2_9STRA/67-130 ....RSLTFEDMMGMMTAMKSKEAYASELGIATKMDD.fINKHAPDIE..IFKG...........SEDFKKYQAYMNFLNVM...........
D0NIL2_PHYIT/56-118 ....RALNTEKMKTMLKAGMTVDDYAAKLKLTDKIAA..AANSARAME..KLGE...........TLKMKKLLRYLNYVAEH...........
G5A4Y5_PHYSP/62-125 ....PALTIAEMQKLMLEGVNEVDYAKRLGITEPMEK.aINEGQKAVL..KLTM...........TDEHKKYMTYRYHLIAK...........
W2ZFM1_PHYPR/143-200 ....RSLTTREMKKMMKNLTTKEEFASTLGISQLIN-..SDLNGGALM..RFMQ...........SHMHAGYT---------seyae......
SFI5_PHYIT/67-130 ....PPLTTDEMMAMMKAGKSKNAYAFELGIAGQMAD.fINSGLPDIE..TFKK...........TPEFQKYEFYMNFLNDM...........
V9ERH1_PHYPR/56-119 ....RTLDNKTMMEMMTKLITKEEHAADLGILDDIMK.lTTTNGGGLT..QFMK...........TVAYKKHIAYVDFLNTM...........
A0A8J5MG43_9STRA/63-123 .rgl-----EKMKRMWEAGTSADQYAMKLGIADDIVS..AQHSATALG..NLMR...........TREYKKYAAYLSFLAQK...........
D0P4F6_PHYIT/59-122 ....RSLSKKTMMDMMTNLTTKEKLASDLRIADKIDD.fTRHNKPGMN..EFMR...........TPEYVKYIGYVNFLNDM...........
W2XYL2_PHYPR/74-135 ....RSLTTREMKKMMKNLTTKEEFASTLGISQLIN-..SDLNGGALM..RFMQ...........SSEYLKYRAYMDFLNDM...........
G4YJ04_PHYSP/38-104 ...r-ILEIGELKSLKARKASLEGYAKQLGIEKELKIfkTHVFYNDLShvDFAQ...........TAAFKKYQAYQDFLRD-l..........
A0A3R7KM62_9STRA/64-95 lrfk---------------------------------..--TSLNGYD..AFLQ...........TPEYMKYRAYLNYLRSK...........
W2R5W4_PHYPN/56-119 ....RTLDNKTMMEMMTKLITKEEHAADLGILDDIMK.lTTTNGGGLT..QFMK...........TVAYKKHIAYVDFLNTM...........
G4YP53_PHYSP/57-119 ....RALDPATLQRMFKDGVKVDDFAATLGITDDIAN..AMRSATALN..NLLG...........TPNYEKYRSYLNYVTKK...........
A0A833S8X0_PHYIN/73-134 ....RALSTREMKKMKKKLTTKEDFAATLGIADKIS-..DNLNGGALM..RFMQ...........TTEYQKDRAYMDFLNDM...........
A0A329S5Z2_9STRA/38-99 ....RSLAPKEMNEMMKKLTTKEAYASELGILDKIN-..SNLNGGALM..RFMQ...........THEYQKYRAYMNYLNAM...........
A0A3R7GSD5_9STRA/85-147 ....RALTKKKMKKKMKNKMTVDGYANKLSIAEQMEG..FKTSLRGYS..AFLE...........THKYGKLRTYINFLRDN...........
A0A833WP37_PHYIN/1-56 ....-------MKELLSAGYSVDDFAKKLDIADDLVG..AQTSSGALQ..KFMH...........TDKYLQYATYLIFVSK-a..........
RXLRO_PHYIT/56-118 ....RSLSKAEMKRLFEAGNSLDDFAKHLGIADDVVR..AQSSNTVLQ..RLMQ...........TDEYMKYSTYLNFLSKQ...........
W2QCY2_PHYPN/59-99 ....RSLPVKEMKKLMKKLTTKEDFADMLGISKQMGR..F--------..----...........-----------------hqgcsry....
A0A833WFU5_PHYIN/1-56 ....-------MKQLLDAGNSVDDFAKKLGIADDLVR..AQTLSGALQ..KLMH...........TDKYRQYVTYLKFLSK-p..........
A0A329RX06_9STRA/59-121 ....RTLDAEKMKQMWEAGTTVDAYASKLKITNDIAT..AANSAKAMG..KLAE...........THKFKKLMLYLNYVAEK...........
D0NPH2_PHYIT/58-120 ....RGLDNAKMKSMWKDGWGADSYAPKLDIADDIAH..AETSAGALQ..QLMQ...........THKYEKYKTYLNYLITK...........
A0A833SXR6_PHYIN/59-122 ....RSLSKKTMMDMMTNLTTKEKLASDLRIADKIDD.fTRHNKPGMN..EFMR...........TPEYVKYIGYVNFLNDM...........
W2QB56_PHYPN/68-131 ....PPLSMDDMKAMMKEGISREMYARKLGIAEQMAQ.fITSGLPGIE..EFKG...........TSEFKKYEFYMNFLNDM...........
W2ZG01_PHYPR/68-131 ....PPLSMDDMKAMMKEGISREMYARKLGIAEQMAQ.fITSGLPGIE..EFKG...........TSEFKKYEFYMNFLNDM...........
D0MUF9_PHYIT/53-116 ....RSLTPQKMMSMMKDKMTTGKYATKLGISTQLKT.mTTQETEGLT..QYMQ...........STKYIKLQAYSNFLNEM...........
D0NCP7_PHYIT/60-121 ....RALSTREMKKMKKKLTTKEDFAATLGIADKIS-..DNLNGGALM..RFMQ...........TTEYQKDRAYMDFLNDM...........
W2Y085_PHYPR/60-121 ....RALTPEKMMKMMLNKMTKEEYAAKLGILEKIN-..SGLNGGALM..QFMR...........TYKYNKYRGYMDFLNGM...........
W2P990_PHYPN/59-121 ....RALNLEKMKTMLDAGMSVDDYAFKLKLTDKIAA..AANSAKEMA..KLAE...........THKFKKLLLYLNYVAEH...........
V9FAE6_PHYPR/74-135 ....RSLTTREMKKMMKNLTTKEEFASTLGISQLIN-..SDLNGGALM..RFMQ...........SSEYLKYRAYMDFLNDM...........
A0A6A3ZL09_9STRA/48-111 ...v-ALTIDQMKALMAEGVNEEAYAKRLGVHDRMVK.lSEAGGTGLH..DFMM...........TDEYKKINAYQDFLRE-a..........
A0A0W8DM65_PHYNI/60-121 ....RSLTTREMKKIMKNLTTKEEFASTLGISQLIN-..SDLNGGALM..RFMQ...........SSEYLKYRAYMDFLNDM...........
A0A8J5IBX5_9STRA/38-96 ....RALSTSEVEKMMKNMMSKEKYAAQLGIHEKINH.fFNVNAGNLA..RFIR...........TAEYQKYRD--------dme........
A0A3R7JBX1_9STRA/81-143 ....RGLSSLKMKFMRSQGMSADDYAEKLGIAAKMKG..FESNPRGFQ..AFLE...........TDKYEKYKTYLNYLKSK...........
A0A3R7K4B9_9STRA/69-124 verl------KFSQMNKKRMTANDYAKKLDIAERMAE..VESTGRHVL..EFQM...........TTGYAKYLT--------mvd........
V9FAE8_PHYPR/68-131 ....PPLSMDDMKAMMKEGISREMYARKLGIAEQMAQ.fITSGLPGIE..EFKG...........TSEFKKYEFYMNFLNDM...........
A0A8J5IIA8_9STRA/67-118 ....RSLTIEDMMGMMKAMKSKDAYASELGITTKMDD.fVNKHAPA--..----...........-----------------tsitllaatna
D0NPH0_PHYIT/58-120 ....RGLDNAKMKSMWKDGWSADNYATKLGIADDIAH..AETSTGALQ..QLMQ...........THKYEKYKTYLNYLITK...........
A0A8J5I409_9STRA/60-88 ....KALTPEKMKKMMKKLMTKEEYAAKLEV------..---------..----...........-----------------re.........
A0A833W6I7_PHYIN/1-55 ....-------MKKMMKKLTTKEDFAATLGIADKIN-..GNLSRGALM..RFMQ...........TTEYEKYRAYMDFLNDM...........
V9F6C4_PHYPR/59-121 ....RALNLEKMKTMLDAGMSVDDYAFKLKLTDKIAA..AADSAKEMA..KLAE...........THKFKKLLLYLNYVAEH...........
A0A833WWR7_PHYIN/1-57 ....-------MMSMMKDKMTTGKYATKLGISTQLKT.mTTQETEGLT..QYMQ...........STKYIKLQAYSNFLNEM...........
A0A8J5J392_9STRA/45-93 ....KALTPEKMKKMMKKLMTKEEYAAKLGISGQIRA.sLKGNSQALL..RLM-...........-----------------fap........
W2YX95_PHYPR/49-112 ....RTLDNKTMMEMMTKLITKEEHAADLGILDDIMK.lTTTNGGGLT..QFMK...........TVAYKKHIAYVDFLNTM...........
D0NIN6_PHYIT/56-118 ....RALNTEKMKTMLKAGMTVDDYAAKLKLTDKIAA..AANSARAME..KLGE...........TLKMKKLLRYLNYVAEH...........
W2QDR8_PHYPN/38-99 ....RSLTTREMKKMMKNLTTKEEFASTLGISQLIN-..SDLNGGALM..RFMQ...........SSEYLKYRAYMDFLNDM...........
D0NPH3_PHYIT/58-120 ....RGLDKAAMKTMWEDGMSAAGYAKKLGITDKIAL..AEKSAGVLQ..QLMQ...........TRRYEKYQQYLNYLAKK...........
W2ZJ39_PHYPR/59-96 ....RSLPVKEMKKLMKKLTTKEDFADMLGISKQMGR..---------..----...........-----------------fhqgc......
RD2_PHYIT/56-118 ....RALNTEKMKTMLKAGMTVDDYAAKLKLTDKIAA..AANSARAME..KLGE...........TLKMKKLLRYLNYVAEH...........
A0A0W8DBT6_PHYNI/59-121 ....RALNLEKMKTMLDAGMSVDDYAFKLKLTDKIAA..AANSAKEMA..KLAE...........THKFKKLLLYLNYVAEH...........
D0NP19_PHYIT/56-118 ....RSLSKAEMKRLFEAGNSLDDFAKHLGIADDVVR..AQSSNTVLQ..RLMQ...........TDEYMKYSTYLNFLSKQ...........
H3GPY3_PHYRM/63-124 ..ka---EKALFKAMRGNGKTADDYAEELGIAAAMRE..VERTGRGVH..KLQL...........TQAYGDYVKYYNYLRS-n..........
V9FAF9_PHYPR/59-99 ....RSLPVKEMKKLMKKLTTKEDFADVLGISKQMGR..F--------..----...........-----------------hqgcsry....
A0A833SXE5_PHYIN/58-120 ....RGLDNAKMKSMWKDGWSADSYAPKLDIADDIAH..AETSAGALQ..QLMQ...........THKYEKYKTYLNYLITK...........
A0A6A4C610_9STRA/48-111 ...v-ALTIDQMKALMAEGVNEEAYAQRLGVHDRMKK.lTEAGGTGLY..DFMM...........TDEYKKINAYQDFLRE-a..........
A0A225WDP2_9STRA/60-123 ....RKLDAAKMARMSKSGMTAKGYAKKLNIDEILDA.aLKMSAETRA..RFMG...........THKYQKYIKYFNYLQDK...........
W2ZE82_PHYPR/59-121 ....RALNLEKMKTMLDAGMSVDDYAFKLKLTDKIAA..AADSAKEMA..KLAE...........THKFKKLLLYLNYVAEH...........
A0A225UWH8_9STRA/60-118 ....RALDTAKMARMRKDGMTAKDYAKKLNIDETLDA.aLRMSAEARA..RFMG...........THKYHKYKEYFN-----...........
A0A833SX01_PHYIN/56-118 ....RSLSKAEMKRLFEAGNSLDDFAKHLGIADDVVR..AQSSNTVLQ..RLMQ...........TDEYMKYSTYLNFLSKQ...........
A0A0W8CLV6_PHYNI/56-119 ....RTLDNKTMMEMMTKLITKEEHAADLGILDDIMK.lTTTNGGGLT..QFMK...........TVAYKKHIAYVDFLNTM...........
A0A8J5ITJ4_9STRA/57-120 ....RVLSPEKMMAMMKGTMTKEKYAEKLGITKQLEG.fTKKNIEGML..QFMQ...........THKYQKYQNYANFLEDK...........
G4YP50_PHYSP/57-119 ....RALDPATLQRMFKDGVKVDDFAATLGITDDIAN..AMRSATALN..NLLR...........TPKYEKYRSYLNYVTKK...........
D0NIN3_PHYIT/56-118 ....RALNTEKMKTMLKAGMTVDDYAAKLKLTDKIAA..AANSARAME..KLGE...........TLKMKKLLRYLNYVAEH...........
W2QB65_PHYPN/60-101 ....RSLTTREMKNMMKNLTTKEEFASTLGISQLIN-..SDLNGGALM..R---...........-----------------...........
A0A0W8C2V8_PHYNI/49-112 ....RTLDNKTMMEMMTKLITKEEHAADLGILDDIMK.lTTTNGGGLT..QFMK...........TVAYKKHIAYVDFLNTM...........
A0A833WMA4_PHYIN/1-56 ....-------MRQSFKAGYSVDDFAKYLGIADDVVG..ARTSSTVLQ..QLMR...........TDEYMKYATYLNFVSQ-q..........
#=GC seq_cons ....RuLshccMKpMhcsthot-caApcLGIs-clst..sppsusult..phhp...........TpcYpKahsYhsaLsph...........
//