#=GF ID   WipA_N
#=GF AC   PF21662.1
#=GF DE   WipA, alpha-helical hairpin
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   PDB:5n6xA
#=GF GA   27.00 27.00;
#=GF TC   142.50 141.30;
#=GF NC   25.10 22.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Coiled-coil
#=GF RN   [1]
#=GF RM   28389563
#=GF RT   Structure of the WipA protein reveals a novel tyrosine protein
#=GF RT   phosphatase effector from Legionella pneumophila.
#=GF RA   Pinotsis N, Waksman G;
#=GF RL   J Biol Chem. 2017;292:9240-9251.
#=GF DR   SO; 0001080; coiled_coil;
#=GF CC   This entry represents the alpha-helical hairpin of WipA protien
#=GF CC   from Legionella pneumophila [1] which adopts a coiled-coil
#=GF CC   structure. WipA is one of the effector proteins that is involved
#=GF CC   in its pathogenicity. This domain interacts with the phosphatase
#=GF CC   domain of another WipA molecule to form a dimer. It has been
#=GF CC   suggested that it mediates protein-protein interactions with a
#=GF CC   tyrosine- phosphorylated host target [1].
#=GF SQ   6
#=GS A0A378LXA9_9GAMM/59-163  AC A0A378LXA9.1
#=GS A0A222P2C2_9GAMM/59-162  AC A0A222P2C2.1
#=GS A0A0W0YWB7_LEGSP/59-163  AC A0A0W0YWB7.1
#=GS Q5ZS02_LEGPH/59-163      AC Q5ZS02.1
#=GS A0A0W0YLA9_9GAMM/59-163  AC A0A0W0YLA9.1
#=GS A0A0W0ZP74_9GAMM/59-162  AC A0A0W0ZP74.1
A0A378LXA9_9GAMM/59-163             .DAYQHFVNIYGQYGEMIQDYLENRTLLQFSQIKIDNAKERITNLEKQLSLITNSELEQYKNLMQWQQQTLEKLKTAEEEQKRLKQKIKEPKEKLILCIKQFNQYM
A0A222P2C2_9GAMM/59-162             s-VYEQFVKIYDQFGEILQICLENKTLQHFQKVKIENCLAQIAHINQKLML-LDSQSDQYQLLKQDKQQWFDKLSSTTSSNKLIEERFKEIKDQVVHLIGQFNSLM
A0A0W0YWB7_LEGSP/59-163             .DAYQRFVFIYEQYGDIIEQYQENRTLLQFAQIKKANIKEKLAGIEKQLSLGVTPDRPQYQSLIHRYQQATADLQTALENEKNLQGKLLEPKDKLLHLVAQFHQFM
Q5ZS02_LEGPH/59-163                 .EAYQQFVTIYEQYDDMVQEYLEIRTLLQLIQIKITNAQQRILDIEQKLSLATDHQKEFSQSLLQLKKPIEANLQMAEKSKAGLEEKLSGLKTRLPSCIERFNKFM
A0A0W0YLA9_9GAMM/59-163             k-TYEEFVTLYESYGEILEEYLENSTLLQLERTKITNAKERIENIKTQLSLEENKDSPQYQSLFLLQQQIESRLETSQECKKRLKQLRSEIIKKVPPVLEQLNQFI
A0A0W0ZP74_9GAMM/59-162             .EAYQQFVTLYEQYGEILQEYLENRVLLQFTQVKIDNAKERIANLDKQL-IETNKETQQYQTLAQLRQQTLEKLHAAEEEQRKLKQKLSAPQNKLVDCIAQFNHFM
#=GC seq_cons                       .-AYQpFVsIYEQYGEIlQ-YLENRTLLQFpQlKIsNAKERIssI-pQLSLtssp-ppQYQoLhQhpQQhhs+LpoApEspKpLcpKlpE.KcKLlpsItQFNpFM
//