#=GF ID YNR034W-A-like
#=GF AC PF11503.12
#=GF DE YNR034W-A-like
#=GF PI DUF3215;
#=GF AU Pollington J;0000-0002-8158-8998
#=GF SE pdb_2grg
#=GF GA 25.00 25.00;
#=GF TC 25.40 27.10;
#=GF NC 24.60 24.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 31579828
#=GF RT Structural insights into the EGO-TC-mediated membrane tethering
#=GF RT of the TORC1-regulatory Rag GTPases.
#=GF RA Zhang T, Peli-Gulli MP, Zhang Z, Tang X, Ye J, De Virgilio C,
#=GF RA Ding J;
#=GF RL Sci Adv. 2019;5:eaax8164.
#=GF RN [2]
#=GF RM 26206314
#=GF RT Crystal structure of the Ego1-Ego2-Ego3 complex and its role in
#=GF RT promoting Rag GTPase-dependent TORC1 signaling.
#=GF RA Powis K, Zhang T, Panchaud N, Wang R, De Virgilio C, Ding J;
#=GF RL Cell Res. 2015;25:1043-1059.
#=GF DR INTERPRO; IPR021591;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family of proteins is predominantly found in
#=GF CC Saccharomycetales, including YNR034W-A (also known as Ego4) and
#=GF CC YCR075W-A (Ego2) from Saccharomyces cerevisiae. Ego2 is a
#=GF CC component of the yeast EGO complex (EGOC), which is responsible
#=GF CC for the amino acid-dependent activation of the target of
#=GF CC rapamycin complex 1 (TORC1). Ego2 adopts a Roadblock domain fold
#=GF CC that consists of a central core beta-sheet of five anti-parallel
#=GF CC beta-strands flanked by a long alpha-helix on the bottom side.
#=GF CC Ego4 shows a similar configuration. It interacts with the GTPase
#=GF CC Gtr2, but its specific function remains unknown [1,2].
#=GF SQ 37
#=GS G8ZNA1_TORDC/7-78 AC G8ZNA1.1
#=GS G0WFP0_NAUDC/4-73 AC G0WFP0.1
#=GS A7TG05_VANPO/9-80 AC A7TG05.1
#=GS G0V6K6_NAUCC/20-97 AC G0V6K6.1
#=GS B5FV93_KLULA/5-76 AC B5FV93.1
#=GS A0A7H9HXX3_9SACH/7-78 AC A0A7H9HXX3.1
#=GS A0A1G4KB08_9SACH/11-82 AC A0A1G4KB08.1
#=GS A0A1B7TFC2_9ASCO/10-83 AC A0A1B7TFC2.1
#=GS A0A1E4RUA3_CYBJN/4-79 AC A0A1E4RUA3.1
#=GS A0A1S7HL09_9SACH/7-78 AC A0A1S7HL09.1
#=GS J7S9E9_KAZNA/1-71 AC J7S9E9.1
#=GS A0A1E5RYM5_HANUV/10-83 AC A0A1E5RYM5.1
#=GS YN034_YEAST/7-82 AC Q3E841.1
#=GS J8QA58_SACAR/3-73 AC J8QA58.1
#=GS G0VEQ4_NAUCC/5-76 AC G0VEQ4.1
#=GS A0A1X7R7E5_9SACH/17-97 AC A0A1X7R7E5.1
#=GS I2H6E7_TETBL/19-104 AC I2H6E7.1
#=GS J8PXQ1_SACAR/7-82 AC J8PXQ1.1
#=GS G8JPX0_ERECY/7-78 AC G8JPX0.1
#=GS H2ASV6_KAZAF/17-94 AC H2ASV6.1
#=GS A0A0C7MUF4_9SACH/11-82 AC A0A0C7MUF4.1
#=GS A0A7H9AX10_ZYGMR/7-78 AC A0A7H9AX10.1
#=GS A0A1G4JNF4_9SACH/3-74 AC A0A1G4JNF4.1
#=GS B4UN63_CANGA/10-86 AC B4UN63.1
#=GS G8C0P8_TETPH/8-78 AC G8C0P8.1
#=GS A0A1X7R4Q8_9SACH/6-78 AC A0A1X7R4Q8.1
#=GS A0A1G4M8V4_LACFM/11-82 AC A0A1G4M8V4.1
#=GS H2AXC6_KAZAF/12-85 AC H2AXC6.1
#=GS J6EIT3_SACK1/7-82 AC J6EIT3.1
#=GS A0A4C2E1U4_9SACH/15-86 AC A0A4C2E1U4.1
#=GS G0WI07_NAUDC/12-88 AC G0WI07.1
#=GS C5DC10_LACTC/11-82 AC C5DC10.1
#=GS EGO2_YEAST/3-73 AC Q3E830.1
#=GS A0A1S7HYV3_9SACH/7-78 AC A0A1S7HYV3.1
#=GS A0A1E5R144_9ASCO/9-79 AC A0A1E5R144.1
#=GS Q756J0_ASHGO/7-78 AC Q756J0.1
#=GS B4UN59_CANGA/6-77 AC B4UN59.1
G8ZNA1_TORDC/7-78 .......................LQEAIPKAIGTLSFDENNQLIESTGIGK..............DRINDIVEIGQMELDKNGY.GV..VSD...KD..VLVNVFKQA.GK.TVVVYT-p.
G0WFP0_NAUDC/4-73 ...................sesr----IPNCIGTLIFDNNNNIIDATGIGE..............TKLKEISELSIAQLDSNGF.GL..LREe.nEN..LIIQLWRED.DK.K------lp
A7TG05_VANPO/9-80 .......................LKEALPNVLGTIVIDENNNIVASTGIGL..............ERVEDVVELSRVKLDDSGY.GL..FQD...HD..VNCNVYRQD.GK.TVVVYT-a.
G0V6K6_NAUCC/20-97 .......................LHEIIPRVKGTVILDDKLNVVKASGIGKgl..........kkTHIQDVLHACHDELGRVGY.SV..YSD...TL..GPIHLWLNPmDRqTTLVFT-a.
B5FV93_KLULA/5-76 .......................LAEMVPNAIGMIAFDDAGQIIEAVGIGK..............ERKEDVLQLQQVELDQDGF.GI..LEH...DN..VQVLIYKRE.DK.TLAVYTH..
A0A7H9HXX3_9SACH/7-78 .......................LEEAIPNAIGTLSFDEDNQLIESTGIGK..............DRVNDIVEIGQMELDKDGY.GV..VSD...KD..VLVNVFKQA.GK.TVVVYT-p.
A0A1G4KB08_9SACH/11-82 .......................LSQLVPNAIGMLAFDEKKNVIEASGIAK..............DRLSDVEQISQVKLDSEGF.GL..LQE...DS..VQVIIYKQE.DK.TLAVYT-y.
A0A1B7TFC2_9ASCO/10-83 .......................LTKLIPNAIGHIAFDENKKIINCSGIGIe...........rsKNLEEIDQLNDVEVVDN-F.AM..IEQ...GP..VKICIYKME.GK.SIVVYS-y.
A0A1E4RUA3_CYBJN/4-79 nelrrlveesgilspegallfsk-----------------DGVLGSYGVAK..............--LEDFDDLRDLKLTKEGF.GL..YEL...HS..YKILILAKG.NE.TLAVYT-k.
A0A1S7HL09_9SACH/7-78 ......................i-KQNMPKALGTLSFDENNKLVESTGIGK..............DRVDDITDISQMELDQDGY.GV..MQD...GQ..LLINVFKDH.GK.SVVVYT-p.
J7S9E9_KAZNA/1-71 .....................mt-----STLLGTLLFDGNDNLVECSGVGQ..............ARVADIKQLSVVPLDKEGY.GAvkVNG...TD..MTAYLYKRG.EM.TLVSYQ-n.
A0A1E5RYM5_HANUV/10-83 .......................LTKVIPHAIGHIAFDENKKIVNCSGIGIe...........rsKNLEEIDQLNDIEVEDN-F.AL..IEQ...GP..VRIYVYRNE.GQ.TIAVYS-y.
YN034_YEAST/7-82 .......................ITEVLPRAVGSLTFDENYNLLDTSGVAKvi..........ekSPIAEIIRKSNAELGRLGY.SV..YED...AQ..YIGHAFKKA.GH.FIVYFT-p.
J8QA58_SACAR/3-73 .....................ae---QNSNIKGTIAFDSHGNVIESTGVGS..............TRIEDICELSRVALDAEGF.AQ..VQG...DS..LLVHLYKRD.DV.TLAVYT-g.
G0VEQ4_NAUCC/5-76 .....................ds---VIPEVEGTLIFDDKKNIIDATDIGE..............QRLKEITDLLDAKLNADGY.GF..LED...DH.gYQVQLWGED.DK.RIALF--ik
A0A1X7R7E5_9SACH/17-97 ......................w-KELLPHSIGRQSVDKNLHTTYAEGVAEkfpk......efqkTHIEDLLHFTANELGKTGY.AI..KDD...GD..KIAHLFSGKnGA.VHVLFT-p.
I2H6E7_TETBL/19-104 ....................adf----YDGAIAVVTLDKNNNIVKSTGEAInmmggkkieemaknEKFRNYRQKSADELGSFGI.QM..WNN...TK..VISHIFKKPdGT.SDVVYT-k.
J8PXQ1_SACAR/7-82 .......................LSEVLPRAVGTLTFDENYNLLDTSGVAKmi..........ekSPIAEMVKKSNTELGRLGY.SI..YED...AE..YIGHAFKKA.GH.FIVYLT-p.
G8JPX0_ERECY/7-78 .......................LSQLVPNAIGLLAFDENNQVVDAFGIGK..............ERKGDIRQLSQVEVDDEGF.AL..LQE...ND..IEVILLKQH.DK.TIAVYR-y.
H2ASV6_KAZAF/17-94 .......................LFELIPKTVGTLTFDENEHLIDTSGVGRel..........kkTHIQDIFKKANEGLGKVGYfTF..YDD...HH..GLTHVFKRHdGK.TTVIYT-d.
A0A0C7MUF4_9SACH/11-82 .......................LTRLAPNAAGLLVFDENCNVLEASGVGK..............DRLEDIITINRSELDSDGF.GS..LEG...PN..LNLAVYKRD.GH.TVVIYS-r.
A0A7H9AX10_ZYGMR/7-78 .......................LDEAIPKAIGTLSFDENNQLIESTGCGK..............DRVDDIIEISQMELDKEGY.GV..ISE...SD..VIINVFKKA.GK.TVVVYT-p.
A0A1G4JNF4_9SACH/3-74 .......................LTDIIPKAAGMLVLDENYNLIEASGVGQ..............QHLADIPVIRQTELDGEGF.AV..LES...SE..NRVIIYRQD.KA.TMAVYT-s.
B4UN63_CANGA/10-86 .......................LTALGQDTLGTLTFDEKHHLIDTSGIGEki..........nkSFVADAVRKSNDELGKLGY.QV..YED...SK..VVGHAFKDGaGK.TTVYFH-d.
G8C0P8_TETPH/8-78 .....................lq---QLPHVVGTLTFDENNNVVTVTGIAS..............DRILDIDSISKVELDSEGF.GL..VQI...NN..LICNIYRQD.NN.TVVIYQ-d.
A0A1X7R4Q8_9SACH/6-78 ...................tdkg-----NKPLGTLIFDENNNILLCSGIGK..............SRKQDIIQLATLHVDDEGF.AM..VED...KQagLTVSLFRDE.DM.TTVVYT-k.
A0A1G4M8V4_LACFM/11-82 .......................LAQVVPNAVGMLAFDENDNVIEASGLGK..............DRVTDIAQLKLVELDSEGF.GL..LQV...EN..VQIIILKQE.GK.MIAVYT-y.
H2AXC6_KAZAF/12-85 .....................lt---TIPNTIGTILFDENNNLIQYSGIGE..............AKFQDIQKLCKVPLDKEGY.AV..VKDpdnDE..IKIFIYKND.EK.TLVTYT-r.
J6EIT3_SACK1/7-82 .......................ITEVLPRAVGSLTFDENYNLLDTSGVAKvi..........ekSPIAELIKKSNAELGRLGY.SV..YED...AE..YIGHVFKKA.GH.FIVYFT-p.
A0A4C2E1U4_9SACH/15-86 .......................LQQSIPKALGTLSFDQNNRLVESTGIGK..............SRVEDIIDISQMELDDDGY.GV..TQD...GE..ILVNVFKDA.GR.SVIIYT-s.
G0WI07_NAUDC/12-88 ......................y-EQLLPRALGTLTFDEKKNLVDTSGFGKel.........sktTHIPEILRKCDKELGRIGY.TV..FDD...SR..HVGRAFQKG.GK.TVVLFTE..
C5DC10_LACTC/11-82 .......................LAQLVPNAIGLLAFDGNCNVIEASGVAK..............NRLEDIVQINQAKVDSEGF.AL..LRD...GD..IQVMVYKHD.GE.TLAVYTQ..
EGO2_YEAST/3-73 ......................a--EKQSDIKGTIAFDTHGNVIESTGVGS..............QRIEDIGDLSKVTLDAEGF.AQ..VQG...DS..LLVHLYKRN.DI.TLAVYT-s.
A0A1S7HYV3_9SACH/7-78 ......................i-KQNMPKALGTLSFDENNKLVESTGIGK..............DRVDDITDISQMELDQDGY.GV..MQD...GQ..LLINVFKDH.GK.SVVVYT-p.
A0A1E5R144_9ASCO/9-79 .......................LTSLIPNAIGHIAFDESNNVIDTSGVGK..............DRRADVENLSQVEL-QDGF.AL..LEE...KD..VKIYIYKQM.GK.TIAVYA-y.
Q756J0_ASHGO/7-78 .......................LSKLVDGAIGVLAFDENHQVVDWAGIGK..............DRVSDIPQLSAAEVDQEGF.AV..LRD...GG..LEVMLLRED.DK.TVAVYR-e.
B4UN59_CANGA/6-77 .......................LQELLPGSVGVMTFDSNNNLVLADGVAK..............DKVNDIPELSEVQCNAEGV.AV..LEN...GD..YIVHVCKKD.GN.TLVVYT-g.
#=GC seq_cons .......................lpphlPpulGsLsFDENssll-uoGlG+..............s+lpDIhplupsEL-p-Ga.ul..lp-...sp..lhlplaKcs.s+.TllVYT...
//
