#=GF ID   Yos9_DD
#=GF AC   PF17880.5
#=GF DE   Yos9 dimerzation domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00609
#=GF GA   30.50 30.50;
#=GF TC   32.10 39.00;
#=GF NC   28.40 25.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   22262864
#=GF RT   Structural and biochemical basis of Yos9 protein dimerization
#=GF RT   and possible contribution to self-association of
#=GF RT   3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation
#=GF RT   ubiquitin-ligase complex.
#=GF RA   Hanna J, Schutz A, Zimmermann F, Behlke J, Sommer T, Heinemann
#=GF RA   U;
#=GF RL   J Biol Chem. 2012;287:8633-8640.
#=GF DR   INTERPRO; IPR041039;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the dimerization domain (DD) found in Yos9 proteins in
#=GF CC   yeast. Structural analysis revealed that this domain contributes
#=GF CC   to self association of Yos9. The overall fold of the domain can
#=GF CC   be classified as an alpha-beta-roll architecture, comprising two
#=GF CC   alpha-helices and seven beta-strands [1].
#=GF SQ   25
#=GS A0A1G4J517_9SACH/248-383  AC A0A1G4J517.1
#=GS OS9_CANGA/254-382         AC Q6FV52.1
#=GS A7TL63_VANPO/290-386      AC A7TL63.1
#=GS G0V839_NAUCC/253-380      AC G0V839.1
#=GS I2H917_TETBL/286-414      AC I2H917.1
#=GS J7R9I5_KAZNA/256-380      AC J7R9I5.1
#=GS A0A1X7R538_9SACH/261-382  AC A0A1X7R538.1
#=GS A0A1S7HLP9_9SACH/253-381  AC A0A1S7HLP9.1
#=GS G8ZWM9_TORDC/248-373      AC G8ZWM9.1
#=GS A0A7H9HRK1_9SACH/251-378  AC A0A7H9HRK1.1
#=GS OS9_KLULA/250-383         AC Q6CNH1.1
#=GS A0A4C2E2X5_9SACH/266-394  AC A0A4C2E2X5.1
#=GS OS9_YEAST/271-395         AC Q99220.1
#=GS A7TM15_VANPO/267-399      AC A7TM15.1
#=GS H2AYX8_KAZAF/262-386      AC H2AYX8.1
#=GS A0A7H9AVY8_ZYGMR/252-381  AC A0A7H9AVY8.1
#=GS A0A1S7HYI9_9SACH/253-381  AC A0A1S7HYI9.1
#=GS G0W4G8_NAUDC/258-385      AC G0W4G8.1
#=GS OS9_ASHGO/248-380         AC Q756T2.1
#=GS A0A0C7N0Z5_9SACH/251-388  AC A0A0C7N0Z5.1
#=GS G8BNI5_TETPH/270-401      AC G8BNI5.1
#=GS A0A1G4JNJ9_9SACH/258-393  AC A0A1G4JNJ9.1
#=GS C5DIQ0_LACTC/248-381      AC C5DIQ0.1
#=GS A0A1G4MIG3_LACFM/249-388  AC A0A1G4MIG3.1
#=GS G8C0J1_TETPH/302-429      AC G8C0J1.1
A0A1G4J517_9SACH/248-383             ..lt---TSRFQPFFLGQGFYFLQNry...gsGVLDGQNVSKLLYIDDVi.fSEDD..sGLHPSE....DLFLERAVKAFQELTTKGLLAVPGTQAFSPGD.TLSWVSEVVDNKGNSICILKVKVGEDAV.AQLTFDR..------.-------mssgsshitenviqy......
OS9_CANGA/254-382                    ....VDIVSNYDVSFVANQVYFLLP.......MNNSNVDRALLMYTGNA...TEDG..lEMDPFP....MEIYKKFIDVMNKMLGLGLLSPPDGKPFDVHD.SYQWIGDIVDMHGNYLNRLRLDVDVNME.ATLIIDK..SINFTG.PNNFQWY.....................
A7TL63_VANPO/290-386                 ...l-DVIEDSKPIFLGYGFYFLTD.......--KNENSNNRLIYTGSS...EN--...------....--LQKNLGFAVDYLVTEKYIKISNDD----ND.EFTWNCDIINIKHELIDKISLVLNDDA-.-------..------.-------ligfkn...............
G0V839_NAUCC/253-380                 ....VDLTTLYDPIFLGRSIYLLRP.......NALGNNKKYKLMYSGPL...PSGE...SWELPS....EHLYKTFNTIFGRMMDLHLLKDSDGSIAEIGD.AFEWIADIVDTDGKFLSRFKVKESPNDT.LELLLFK..SLHSGV.DGNFISF.....................
I2H917_TETBL/286-414                 ...s-DVLPKYSPYFLGHGLYLLNP......hENIPELNTSVILYTGDV...DLLY...DEQTTL....SDLYAHLSKAIPVMLFHQALTLPNGARFQEGD.AFQWIAEIVDMNFNHIKNVFVDIGSDGM.ANFVIDD..KTEFPD.EGNFIY-v....................
J7R9I5_KAZNA/256-380                 ....IALLAEFDPTFIGYGTYLLRH.......--VDPNRNDVVLYTGPL...HKND...--EHAV....QLLYQQLTSSLNQLFTQQLLRSPGNANINVGD.TFEWVADIISPEGDVLYTLKLEMLPTGK.VDIFLLE..TFGTIGnGGNFQWY.....................
A0A1X7R538_9SACH/261-382             ....IDLLAEYDPTFLGYGIYFLQS.......--LDENKRDTLMYTSDD...LS--...--GEIP....KETFDRFGKAFNRMINQKMLVSPNGSPVVNGD.IFTWMSEIFDITGTVISKLSIHVSEIGK.AELHLDN..DLLFPE.PSNFVAY.....................
A0A1S7HLP9_9SACH/253-381             ....VSLMAKYEPIFVGSDFYLLKP......hGNTTMDTRNVLLYSGKH...TIKD...GFVESN....AELYENIGSAFSRMLFQQLLMSPSESPYKPGD.EFSWVSDILDLQGNFLTRLQFNLSSSSL.ADITLDS..NVQFPE.KGNLVYH.....................
G8ZWM9_TORDC/248-373                 ....VDIISSYKPTFLGNEVYLLEP......yDKISSHNRTALMFTGNM...SSHG...--SLLE....QKLDIKLANAISRMVFQHLLLLPDGLPYNVDD.KFAWMSEVLDSKGNFVTMVQFNLSST-L.ADIDINS..SIEFKG.PGNFVFF.....................
A0A7H9HRK1_9SACH/251-378             ....IETIGYYKPIFIGNELYLLEP......hHKGTLQNRTALLYTGNL...PITD...SLYEES....YGINEKFANAIGRMLFQHLLLSPDQSPYEPGD.KFAWISEVLDAKGQFLTMVSFNLTSS-L.AEIAIDD..SLHFTG.PGNFLFY.....................
OS9_KLULA/250-383                    ...l-DIFNRYSATVLDHGIYLLKP.......-KNSAKDRRQLMYHAAE...PLDS...QTTLFEltveERFIGDFISSLKKLIGSDFIQSPTGKSIKPGD.LFLWRAPVVDETGNLLFLIDLELNSASE.AI-----..------.-------gkvnndasllnelpihnmvyf
A0A4C2E2X5_9SACH/266-394             ....VDLLGKYEPIFAGSDFYLLVP......rIGSTVDRRKVLLYSGKH...KVKD...GFIESN....ANLYDNIGSAFSRMLYQQLLIPPDESDYKPGD.EISWISDVVDLHGNYLTRLQFNLSSNSV.ADISLSS..LIEFPE.SGNLLYH.....................
OS9_YEAST/271-395                    ....IDLITKYEPIFLGSGIYFLRP.......--FNTDERDKLMVTDNA...MS--...NWDEIT....ETYYQKFGNAINKMLSLRLVSLPNGHILQPGD.SCVWLAEVVDMKDRFQTTLSLNILNSQR.AEIFFNK..TFTFNEdNGNFLSY.....................
A7TM15_VANPO/267-399                 ...l-NVISEYNPLFLGYGFYLLNPki..ssySHDQFPSRSVLMYSGIS...NIEQ...NVDAIY....RELYQRAGKAMTRMMYLKFLTLPDGNPYMHGD.RFTWISDVVDLNGKFITRMIFTIDEKDV.AEIKLDY..TLEFKN.FGNFVSY.....................
H2AYX8_KAZAF/262-386                 ....IDMITAYSPKFLGHGVYLLEP.......--ARENEMWALMYSDDI...NNED...-NGKVS....RHVYENFGNAINKLIAQGLLKAPDGSPMQSGD.QYAWISDIFDLEGNRVQKLRFAIADSRQ.GELVIRN..NLTSPL.DSNFEYY.....................
A0A7H9AVY8_ZYGMR/252-381             ..lh--TIAEFEPTFMGNELYFLRP......cNPINQTERTSLVYSGQL...IIEG..kPSEKET....EIVRMRFKKAIGRMLIQELILLPDGSPLQNGD.EISWFSEVVDLKGNFLTTVHFTINSSSI.PHITFDP..YFDTKG.KGNVLSY.....................
A0A1S7HYI9_9SACH/253-381             ....VSLMAKYEPIFVGSDFYLLKP......hGNTTMDMRNILLYSGKH...TIKD...GFVDSN....AELYENIGSAFSRMLFQQLLMSPSESPYKPGD.EFSWVSDILDLQGNFLTRLQFNLSSSSL.ADITLDS..TIQFPE.TGNLVYH.....................
G0W4G8_NAUDC/258-385                 ...a-DLVTYFDPIFLGQSIYLLAP.......NGKNHEKKANLMYTEQL...NDPS...IWDSPT....EVLYKAFTIAFSRVITLGLLHFPDGSKLENGD.TFSWIAEIVDITGKPLSKIKVSTKHDGS.MELLIYK..DLPLLD.VGNFEYY.....................
OS9_ASHGO/248-380                    ..at--LVEAYKPTFLGHGFYHLAPh.....aNLTHKETTAMLMYHQQP...IPGNe.eDDGTMD....SAFIKHSTMAYMQLLEMGLLNGPDGLPFSEEG.NFTVYAKVIGFDGGLITVTRFQISHGEViIDHVVPE..VLEDME.QGN----sedy.................
A0A0C7N0Z5_9SACH/251-388             ...s--LLRSFVSHFLGHNFYHLQYhl..pyhAASQSIAPSKLLFTGELvlsNENS...ELHPTE....TVFLEKAIKAFQNINAKDLFETPDGSHFTIGDyELKWESEVIDKKGRTLCVLEIDIDATSR.ANVSFYKpdSMSEPV.LNNIIHY.....................
G8BNI5_TETPH/270-401                 ....INVLSAYDPTFLGYSFYLLTPks...avINSEIKNRNLLMYTGAV...SKYA...SLDELY....AVLYQKASNAVSRMMFMKYLLLPDNKPFKEGD.EFTWVADLVNMEGNRVYTLTFHINERLL.VDIQKTE..GVQFPE.IGNFISY.....................
A0A1G4JNJ9_9SACH/258-393             ...i-TLTELYRPIFVGHGFFLLTEtv..pddVFVRPLRPQILVFTGSA...QESFslqMSEAAR....SNFLSKAWNAFETILSRELLQGPDGTLCKFGD.EFIWVGEVRNLNGDHIVDLRFEIDHQLA.ASVSLED..QASAGE.SKSFK--lf...................
C5DIQ0_LACTC/248-381                 irsl----LEYSPTFLGSGFYFLQErsn.pkfTGMRNNAASKLLYIEEL...KLSGedaELDPSE....KLFFDRAANAFQEIILKNLFPKSQNLPLTIED.AFVWFVEVVDKRGDHLCILRVGVESG-I.ASISFD-..------.-------qsgesglnfrgn.........
A0A1G4MIG3_LACFM/249-388             .vla---VENYDFYFAGNAFYLLQPsfvdlgnSYGISNNMTVLLYMDDL...VISPdelSIDKTK....TTFLQRIMIAFHKMLAQKKITSPNGKPYEFGD.QFIWLSKVIDYKGNVLCVVKVSMDGKAQ.AAFEFDSigAIDDLT.DSNFVSY.....................
G8C0J1_TETPH/302-429                 ....IDLFYNFKPFFIGSGVYFLKHkt...ieANMGSRKPDKLLFSGDI...SK--...------....--LDSKLETMLPSLIKLDSFFESELFNYEDHD.SFKWIGDIVNLQNKVTDTVLISVTYN-T.FNNRIER..TIQ---.-------rsynstishytsnfief....
#=GC seq_cons                        .....sllspYcPhFLGpuhYLLpP.......tthsppppshLhYoGsh...s.ps...thpt.p....ptlhp+hssAhs+hltppLLtsPsGsshpsGD.pFsWlu-llDhcGshlsplphslssssh.Acltlsp..slph.t..uNhh.a.....................
//