#=GF ID Zincin_1
#=GF AC PF06262.15
#=GF DE Zincin-like metallopeptidase
#=GF PI DUF1025; Zinicin_1;
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Eberhardt R;0000-0001-6152-1369
#=GF SE Pfam-B_9726 (release 9.0)
#=GF GA 22.40 22.40;
#=GF TC 22.40 22.40;
#=GF NC 22.30 22.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0126
#=GF RN [1]
#=GF RM 23671590
#=GF RT CLCAs - A Family of Metalloproteases of Intriguing Phylogenetic
#=GF RT Distribution and with Cases of Substituted Catalytic Sites.
#=GF RA Lenart A, Dudkiewicz M, Grynberg M, Pawlowski K;
#=GF RL PLoS One. 2013;8:e62272.
#=GF DR INTERPRO; IPR010428;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This family of proteins has a conserved HEXXH motif, suggesting
#=GF CC they are putative peptidases of zincin fold [1]. The structure
#=GF CC of this family is a minimal version of the metalloprotease fold
#=GF CC (PDB:3E11).
#=GF SQ 4295
#=GS A0A6G6Y0J9_9SPHN/32-130 AC A0A6G6Y0J9.1
#=GS A7IEJ3_XANP2/45-144 AC A7IEJ3.1
#=GS A0A171DN49_9ACTN/31-116 AC A0A171DN49.1
#=GS A0A327YB99_9RHOB/28-128 AC A0A327YB99.1
#=GS A0A7Y0KIE7_9PSEU/25-111 AC A0A7Y0KIE7.1
#=GS A0A3D9BSI9_9RHOB/29-129 AC A0A3D9BSI9.1
#=GS A0A0D6TD75_9RHOB/34-134 AC A0A0D6TD75.1
#=GS A0A2U1FBR1_9PSEU/25-111 AC A0A2U1FBR1.1
#=GS A0A3M0GRA1_9ACTN/27-114 AC A0A3M0GRA1.1
#=GS A0A660CI18_9PSEU/48-151 AC A0A660CI18.1
#=GS A0A5B2X1M0_9PSEU/29-115 AC A0A5B2X1M0.1
#=GS Q89X28_BRADU/67-165 AC Q89X28.1
#=GS A0A7Y9US39_9ACTN/49-144 AC A0A7Y9US39.1
#=GS A0A6L9SGA1_9ACTN/51-134 AC A0A6L9SGA1.1
#=GS A0A3L9YCM5_9RHOB/35-135 AC A0A3L9YCM5.1
#=GS A0A0Q7KE90_9ACTN/80-160 AC A0A0Q7KE90.1
#=GS A0A164KM32_9NOCA/35-133 AC A0A164KM32.1
#=GS A0A2C7AFG6_9PROT/31-129 AC A0A2C7AFG6.1
#=GS A0A1W6CVI7_9RHOB/34-134 AC A0A1W6CVI7.1
#=GS A0A846N5I1_9PROT/35-131 AC A0A846N5I1.1
#=GS A0A2Z3I811_9HYPH/36-135 AC A0A2Z3I811.1
#=GS A0A6B3GMD2_9ACTN/25-101 AC A0A6B3GMD2.1
#=GS Q745J0_MYCPA/29-115 AC Q745J0.1
#=GS A0A1T4Z2Y2_9ACTN/42-119 AC A0A1T4Z2Y2.1
#=GS A0A5N8VPS5_9ACTN/61-148 AC A0A5N8VPS5.1
#=GS A0A1I0I107_9ACTN/31-116 AC A0A1I0I107.1
#=GS A0A4S5JA96_9HYPH/40-138 AC A0A4S5JA96.1
#=GS D1A3L6_THECD/31-116 AC D1A3L6.1
#=GS S4M8S2_9ACTN/39-125 AC S4M8S2.1
#=GS A0A239PYM9_9RHOB/34-134 AC A0A239PYM9.1
#=GS A0A1W2FIE3_9PSEU/29-115 AC A0A1W2FIE3.1
#=GS A0A1I7DDN0_9HYPH/40-138 AC A0A1I7DDN0.1
#=GS A0A2T5BBA9_MYCDI/40-138 AC A0A2T5BBA9.1
#=GS A0A3G8ZI22_9ACTN/26-114 AC A0A3G8ZI22.1
#=GS D1BEK8_SANKS/31-119 AC D1BEK8.1
#=GS A0A1A1YGI1_9MYCO/39-138 AC A0A1A1YGI1.1
#=GS A0A4R4SI60_9ACTN/28-113 AC A0A4R4SI60.1
#=GS A0A7W9AEY4_9SPHN/36-132 AC A0A7W9AEY4.1
#=GS A0A4R6RE80_9HYPH/43-142 AC A0A4R6RE80.1
#=GS S5Y2L5_PARAH/34-134 AC S5Y2L5.1
#=GS A0A1B9YZV7_9BRAD/32-130 AC A0A1B9YZV7.1
#=GS A0A192ILW3_9HYPH/33-131 AC A0A192ILW3.1
#=GS A0A6B2RY81_9ACTN/50-137 AC A0A6B2RY81.1
#=GS A0A3G6IXY1_9CORY/15-112 AC A0A3G6IXY1.1
#=GS A0A7H8J167_9ACTN/34-121 AC A0A7H8J167.1
#=GS A0A3M8KA26_9CORY/29-115 AC A0A3M8KA26.1
#=GS A0A7J9YQX5_9ACTN/2-50 AC A0A7J9YQX5.1
#=GS I4F366_9ACTN/55-152 AC I4F366.1
#=GS A0A0Q5L3B1_9MICO/17-104 AC A0A0Q5L3B1.1
#=GS A0A1A0M118_9MYCO/29-115 AC A0A1A0M118.1
#=GS A0A370ASN9_9ACTN/28-115 AC A0A370ASN9.1
#=GS A0A853BPJ5_9ACTN/25-113 AC A0A853BPJ5.1
#=GS A0A7W6WM98_9PROT/36-134 AC A0A7W6WM98.1
#=GS A0A0Q7SXU9_9CAUL/34-133 AC A0A0Q7SXU9.1
#=GS A0A2S1Z8M7_9ACTN/28-115 AC A0A2S1Z8M7.1
#=GS A0A2P8AWH9_9ACTN/62-149 AC A0A2P8AWH9.1
#=GS Q82DD7_STRAW/119-189 AC Q82DD7.1
#=GS A0A1M5MTX3_9RHOB/29-129 AC A0A1M5MTX3.1
#=GS A0A7K0DR28_9NOCA/35-132 AC A0A7K0DR28.1
#=GS A0A5Q0LPD0_9ACTN/25-112 AC A0A5Q0LPD0.1
#=GS A0A1V9A5H2_SACPI/58-152 AC A0A1V9A5H2.1
#=GS A0A2T7TII6_9MICC/77-163 AC A0A2T7TII6.1
#=GS A0A848KYW0_9ACTN/70-169 AC A0A848KYW0.1
#=GS H6MVL7_GORPV/39-137 AC H6MVL7.1
#=GS A0A159YYG0_9RHOB/34-134 AC A0A159YYG0.1
#=GS A0A1W0AV66_9NOCA/29-115 AC A0A1W0AV66.1
#=GS A0A1P8XVI0_9ACTN/67-138 AC A0A1P8XVI0.1
#=GS A0A2U2Z5Q4_9ACTN/62-148 AC A0A2U2Z5Q4.1
#=GS H0QH76_ARTGO/82-168 AC H0QH76.1
#=GS A0A0S9C6B6_9MICC/54-147 AC A0A0S9C6B6.1
#=GS A0A0J6XP37_9ACTN/69-158 AC A0A0J6XP37.1
#=GS Q3SNU8_NITWN/32-130 AC Q3SNU8.1
#=GS A0A1X6WSP6_9MICO/30-116 AC A0A1X6WSP6.1
#=GS A0A419R4D7_9SPHN/33-132 AC A0A419R4D7.1
#=GS A0A5R9LXM7_9ACTN/34-121 AC A0A5R9LXM7.1
#=GS A0A1G7BZV2_9PROT/35-133 AC A0A1G7BZV2.1
#=GS A0A5M3XYI2_9ACTN/51-139 AC A0A5M3XYI2.1
#=GS A0A0A0CY59_9PROT/27-124 AC A0A0A0CY59.1
#=GS A0A5B9DMQ9_9HYPH/38-139 AC A0A5B9DMQ9.1
#=GS A0A1G6XVG7_9ACTN/25-113 AC A0A1G6XVG7.1
#=GS A0A4Y8KLJ5_9MICO/28-115 AC A0A4Y8KLJ5.1
#=GS A0A2K8PJV1_STRLA/38-126 AC A0A2K8PJV1.1
#=GS A0A841DET0_PLAVE/28-113 AC A0A841DET0.1
#=GS A0A2L0WG29_9HYPH/40-138 AC A0A2L0WG29.1
#=GS A0A4P9JDU1_9MICC/25-116 AC A0A4P9JDU1.1
#=GS A0A1C5H5Q4_9ACTN/70-157 AC A0A1C5H5Q4.1
#=GS W5TPB6_9NOCA/35-134 AC W5TPB6.1
#=GS A0A5C8ZEJ3_9ACTN/25-113 AC A0A5C8ZEJ3.1
#=GS A0A0K2ASM7_STRA7/38-125 AC A0A0K2ASM7.1
#=GS A0A1M6FRB4_9RHOB/36-136 AC A0A1M6FRB4.1
#=GS A0A0N9Y8Q0_MYCFO/29-115 AC A0A0N9Y8Q0.1
#=GS A0A1A3BU66_9MYCO/29-115 AC A0A1A3BU66.1
#=GS A0A1R3USB5_9ACTN/16-100 AC A0A1R3USB5.1
#=GS A0A0M8WW45_9ACTN/25-112 AC A0A0M8WW45.1
#=GS W0IZH2_9BACT/29-123 AC W0IZH2.1
#=GS A0A810NF57_9ACTN/39-126 AC A0A810NF57.1
#=GS A0A6G8FK77_9MICO/28-114 AC A0A6G8FK77.1
#=GS A7HAD2_ANADF/257-354 AC A7HAD2.1
#=GS D5ZY06_STRV1/64-149 AC D5ZY06.1
#=GS F9EEB2_9ACTO/36-134 AC F9EEB2.1
#=GS A0A6F8YJ62_9ACTN/29-116 AC A0A6F8YJ62.1
#=GS A0A086MTK3_9ACTN/28-115 AC A0A086MTK3.1
#=GS A0A1M6YQY5_9RHOB/17-117 AC A0A1M6YQY5.1
#=GS A0A0F4JLL9_9ACTN/38-126 AC A0A0F4JLL9.1
#=GS A0A1A9GGX6_9ACTN/35-123 AC A0A1A9GGX6.1
#=GS A0A2T4JI48_9RHOB/34-134 AC A0A2T4JI48.1
#=GS A0A8J3JAK4_9ACTN/27-114 AC A0A8J3JAK4.1
#=GS A0A2S6GXA6_9PSEU/60-150 AC A0A2S6GXA6.1
#=GS A0A1I3L3M1_9RHOB/37-134 AC A0A1I3L3M1.1
#=GS A0A845A9U3_9SPHN/28-126 AC A0A845A9U3.1
#=GS E2PXV0_STRCL/37-124 AC E2PXV0.1
#=GS A0A6M1RQC6_9BACT/31-122 AC A0A6M1RQC6.1
#=GS A0A364JXE5_9HYPH/40-137 AC A0A364JXE5.1
#=GS B2HMM3_MYCMM/29-115 AC B2HMM3.1
#=GS A0A1L2ZPD1_9MICC/29-129 AC A0A1L2ZPD1.1
#=GS A0A4R4NBU4_9ACTN/26-134 AC A0A4R4NBU4.1
#=GS A0A3S5ESN1_9ACTN/27-113 AC A0A3S5ESN1.1
#=GS A0A511CWK2_9PSEU/60-157 AC A0A511CWK2.1
#=GS L8TTI8_9MICC/48-141 AC L8TTI8.1
#=GS A0A178IDK0_9BACT/29-122 AC A0A178IDK0.1
#=GS A0A239K952_9MICO/39-122 AC A0A239K952.1
#=GS A0A2I1JBB8_9MICC/29-121 AC A0A2I1JBB8.1
#=GS K2JRX1_9PROT/60-158 AC K2JRX1.1
#=GS A0A1G6WAX7_9ACTN/25-112 AC A0A1G6WAX7.1
#=GS A0A8J3QHW9_9ACTN/29-116 AC A0A8J3QHW9.1
#=GS A0A318TR96_9BRAD/32-130 AC A0A318TR96.1
#=GS A0A2N3PY38_9PROT/33-130 AC A0A2N3PY38.1
#=GS A0A495RPF5_SPHMI/37-134 AC A0A495RPF5.1
#=GS A0A1G9UB10_9ACTN/34-121 AC A0A1G9UB10.1
#=GS B0TE39_HELMI/35-117 AC B0TE39.1
#=GS A0A1C5D073_9ACTN/53-140 AC A0A1C5D073.1
#=GS A0A0N1GMN5_9ACTN/38-125 AC A0A0N1GMN5.1
#=GS F6EFX9_HOYSD/39-135 AC F6EFX9.1
#=GS A0A0Q5RPZ1_9MICO/27-113 AC A0A0Q5RPZ1.1
#=GS A0A5C5GED5_9RHOB/30-129 AC A0A5C5GED5.1
#=GS A0A7W9MHQ9_9ACTN/28-113 AC A0A7W9MHQ9.1
#=GS A0A248YXH6_9ACTN/25-112 AC A0A248YXH6.1
#=GS A0A2P7B2E6_9HYPH/40-138 AC A0A2P7B2E6.1
#=GS A0A2G4JSP1_9CAUL/33-132 AC A0A2G4JSP1.1
#=GS N6X9J6_9ACTO/29-116 AC N6X9J6.1
#=GS A0A550HG08_9ACTN/25-112 AC A0A550HG08.1
#=GS A0A101QRN2_9ACTN/28-115 AC A0A101QRN2.1
#=GS A0A2S6GL46_9PSEU/25-111 AC A0A2S6GL46.1
#=GS A0A1H7YTE7_STRJI/38-130 AC A0A1H7YTE7.1
#=GS Q1YF12_AURMS/88-186 AC Q1YF12.1
#=GS A0A2P8EFH7_9ACTN/30-117 AC A0A2P8EFH7.1
#=GS A0A1G5DR50_9HYPH/34-133 AC A0A1G5DR50.1
#=GS A0A838XLM8_9HYPH/33-132 AC A0A838XLM8.1
#=GS A0A101UH70_9ACTN/38-125 AC A0A101UH70.1
#=GS A0A8J8HSX1_9BACT/27-122 AC A0A8J8HSX1.1
#=GS A0A4Q9V1X0_9ACTO/61-142 AC A0A4Q9V1X0.1
#=GS A0A0A0HGD3_9RHOB/33-133 AC A0A0A0HGD3.1
#=GS W6WCQ8_RHIS8/40-138 AC W6WCQ8.1
#=GS A0A7T0KDZ0_9CORY/28-114 AC A0A7T0KDZ0.1
#=GS A0A8A4ZL02_9MICO/62-146 AC A0A8A4ZL02.1
#=GS A0A8J3GQT8_9MICO/29-116 AC A0A8J3GQT8.1
#=GS A0A4P6KCX6_9MICO/28-114 AC A0A4P6KCX6.1
#=GS A0A1R3URS2_9ACTN/34-116 AC A0A1R3URS2.1
#=GS A0A2U9P508_STRAS/28-115 AC A0A2U9P508.1
#=GS A0A2S8B644_9SPHN/44-142 AC A0A2S8B644.1
#=GS A0A7T1AM44_9BACT/25-119 AC A0A7T1AM44.1
#=GS A0A1E7JXQ5_9ACTN/25-116 AC A0A1E7JXQ5.1
#=GS A0A2S4Y9Z9_9ACTN/65-148 AC A0A2S4Y9Z9.1
#=GS A0A5N8YVQ3_9CHLR/28-123 AC A0A5N8YVQ3.1
#=GS A0A2S2BPP4_9NOCA/29-115 AC A0A2S2BPP4.1
#=GS A0A2S0UNN2_9RHOB/40-140 AC A0A2S0UNN2.1
#=GS H6RLA4_BLASD/28-114 AC H6RLA4.1
#=GS A0A073ATX4_9PSEU/28-125 AC A0A073ATX4.1
#=GS A0A086Y9D5_9RHOB/34-133 AC A0A086Y9D5.1
#=GS A0A4S8PW01_9ACTN/55-143 AC A0A4S8PW01.1
#=GS A0A1N6GN80_9RHOB/27-127 AC A0A1N6GN80.1
#=GS A0A7I7XD30_9MYCO/54-152 AC A0A7I7XD30.1
#=GS A0A852R189_9ACTN/62-147 AC A0A852R189.1
#=GS A0A101TTH3_9ACTN/38-123 AC A0A101TTH3.1
#=GS A0A852VT11_9MICO/50-131 AC A0A852VT11.1
#=GS A0A1Q4V1S1_9ACTN/38-124 AC A0A1Q4V1S1.1
#=GS A0A132MWX6_9ACTN/73-159 AC A0A132MWX6.1
#=GS A0A0Q7YYM0_9ACTN/28-115 AC A0A0Q7YYM0.1
#=GS A0A255H2J5_9ACTN/43-140 AC A0A255H2J5.1
#=GS D2B9E0_STRRD/31-116 AC D2B9E0.1
#=GS D3Q2P3_STANL/25-112 AC D3Q2P3.1
#=GS V6KZU9_9ACTN/28-119 AC V6KZU9.1
#=GS A0A0P0SC77_9PSEU/29-115 AC A0A0P0SC77.1
#=GS A0A0M7A3R1_9HYPH/42-141 AC A0A0M7A3R1.1
#=GS F9Y9Y1_KETVW/38-137 AC F9Y9Y1.1
#=GS A0A7U7B2H6_9PROT/29-127 AC A0A7U7B2H6.1
#=GS A0A101UZM1_9ACTN/28-115 AC A0A101UZM1.1
#=GS A0A1I2ILU1_9ACTN/30-117 AC A0A1I2ILU1.1
#=GS A0A6G2W023_9ACTN/53-140 AC A0A6G2W023.1
#=GS A0A6N7KPL0_9ACTN/63-148 AC A0A6N7KPL0.1
#=GS H6RKX5_BLASD/58-155 AC H6RKX5.1
#=GS A0A5D0RVP6_9RHOB/32-132 AC A0A5D0RVP6.1
#=GS D3DBY2_9ACTN/28-114 AC D3DBY2.1
#=GS A0A418KRV8_9ACTN/30-120 AC A0A418KRV8.1
#=GS A0A1I7NT32_9HYPH/35-133 AC A0A1I7NT32.1
#=GS A0A840SRA4_9RHOB/34-133 AC A0A840SRA4.1
#=GS A0A6N7I8Y5_9ACTN/28-113 AC A0A6N7I8Y5.1
#=GS B9JET1_AGRRK/40-138 AC B9JET1.1
#=GS A0A2R8AHR7_9RHOB/31-131 AC A0A2R8AHR7.1
#=GS A0A376GWC0_CORST/28-114 AC A0A376GWC0.1
#=GS A0A6B3I3N7_9ACTN/25-73 AC A0A6B3I3N7.1
#=GS A0A2Y9ALY8_9MICO/28-118 AC A0A2Y9ALY8.1
#=GS A0A2M9IG13_9ACTN/51-138 AC A0A2M9IG13.1
#=GS A0A437P9J8_9HYPH/39-138 AC A0A437P9J8.1
#=GS A0JU69_ARTS2/34-120 AC A0JU69.1
#=GS A0A7J9WCG9_9ACTN/28-113 AC A0A7J9WCG9.1
#=GS A0A4S2SK03_9ACTN/101-189 AC A0A4S2SK03.1
#=GS A0A6L7EZ65_9ACTN/42-125 AC A0A6L7EZ65.1
#=GS A0A345HN98_9ACTN/55-141 AC A0A345HN98.1
#=GS A0A4Y9MWF4_9ACTN/54-151 AC A0A4Y9MWF4.1
#=GS A0A2V3DT14_9MICC/25-118 AC A0A2V3DT14.1
#=GS A0A059FG34_9PROT/31-130 AC A0A059FG34.1
#=GS K2GMF1_9RHOB/31-131 AC K2GMF1.1
#=GS A0A5E7YHN3_9SPHN/39-137 AC A0A5E7YHN3.1
#=GS A0A0H1RA66_9HYPH/34-133 AC A0A0H1RA66.1
#=GS A0A0N0JXY1_9HYPH/33-132 AC A0A0N0JXY1.1
#=GS A0A2P8PZC2_9ACTN/25-112 AC A0A2P8PZC2.1
#=GS A0A7T0KGF5_9CORY/53-152 AC A0A7T0KGF5.1
#=GS A0A1M6D2T2_9ACTN/30-120 AC A0A1M6D2T2.1
#=GS V6JVX9_STRNV/61-141 AC V6JVX9.1
#=GS A0A429R2B3_9ACTN/25-112 AC A0A429R2B3.1
#=GS A0A7X3LTT6_9HYPH/38-137 AC A0A7X3LTT6.1
#=GS A0A4R2K6U5_9PSEU/60-155 AC A0A4R2K6U5.1
#=GS A0A1S2QKL7_9ACTN/28-115 AC A0A1S2QKL7.1
#=GS A0A1I1V1Z2_9DELT/145-238 AC A0A1I1V1Z2.1
#=GS A0A0Q8EBJ3_9ACTN/29-117 AC A0A0Q8EBJ3.1
#=GS A0A1X9YFX6_9SPHN/31-129 AC A0A1X9YFX6.1
#=GS A0A5D0VFU1_9RHOB/42-141 AC A0A5D0VFU1.1
#=GS A0A7Y0BCK7_9ACTN/25-112 AC A0A7Y0BCK7.1
#=GS A0A3Q9FWB3_STRLT/69-163 AC A0A3Q9FWB3.1
#=GS F2J300_POLGS/51-150 AC F2J300.1
#=GS A0A2M9CDG8_9CELL/76-160 AC A0A2M9CDG8.1
#=GS A0A371RFY8_9PROT/28-127 AC A0A371RFY8.1
#=GS A0A1I3LDU7_9ACTN/42-124 AC A0A1I3LDU7.1
#=GS R7WJC5_9NOCA/59-158 AC R7WJC5.1
#=GS A0A5B2TGI6_9PROT/31-129 AC A0A5B2TGI6.1
#=GS A0A4R7I2C9_9ACTN/28-111 AC A0A4R7I2C9.1
#=GS A0A1Y4DH54_9ACTN/28-129 AC A0A1Y4DH54.1
#=GS A0A366IE42_9MICO/28-114 AC A0A366IE42.1
#=GS A0A5J6V459_9MICO/50-128 AC A0A5J6V459.1
#=GS A0A6I3KT94_9NOCA/35-133 AC A0A6I3KT94.1
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#=GC seq_cons ......................................................tsVslhV-DhP........................................................s.......s.............c.............L..hG..L..a...c..G..l.P.Lsc....cssh.........sushP......sRIslYRcPlhp..hsc.........s.c..--...lsc....VppslVHElAHaa.......G..l..s-...-clctl.......................
//
