#=GF ID   bDLD1
#=GF AC   PF20689.1
#=GF DE   Bacterial Death-like domain 1
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Aravind L
#=GF GA   25.00 25.00;
#=GF TC   25.20 26.10;
#=GF NC   20.70 19.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0041
#=GF RN   [1]
#=GF RM   32101166
#=GF RT   Highly regulated, diversifying NTP-dependent biological conflict
#=GF RT   systems with implications for the emergence of multicellularity.
#=GF RA   Kaur G, Burroughs AM, Iyer LM, Aravind L;
#=GF RL   Elife. 2020; [Epub ahead of print]
#=GF RN   [2]
#=GF RM   34061031
#=GF RT   Bacterial death and TRADD-N domains help define novel apoptosis
#=GF RT   and immunity mechanisms shared by prokaryotes and metazoans.
#=GF RA   Kaur G, Iyer LM, Burroughs AM, Aravind L;
#=GF RL   Elife. 2021; [Epub ahead of print]
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This bacterial adaptor domain of the Death-domain fold is
#=GF CC   involved in protein-protein interactions in biological conflict
#=GF CC   systems. bDLDs show a characteristic architectural pattern. One
#=GF CC   copy is always fused, typically to the N- or C-terminus, of a
#=GF CC   core component of a biological conflict system; examples include
#=GF CC   VMAP and iSTAND. Further copies of the same bDLD are fused to
#=GF CC   either effector or signal-transducing domains, or additional
#=GF CC   Effector-associated domains (EADs). bDLD pairs are frequently
#=GF CC   observed together on the genome in conserved gene neighborhoods,
#=GF CC   but can also be severed from such neighborhoods and located in
#=GF CC   distant regions, indicating the bDLD-bDLD coupling approximates
#=GF CC   the advantages of collinear transcription [1,2].
#=GF SQ   8
#=GS A0A8J7F146_9CYAN/1-71     AC A0A8J7F146.1
#=GS A0A8J7F2T0_9CYAN/3-104    AC A0A8J7F2T0.1
#=GS A0A139WX65_9CYAN/20-124   AC A0A139WX65.1
#=GS A0A8J7JSQ3_9CYAN/1-103    AC A0A8J7JSQ3.1
#=GS A0A8J7FEJ2_9CYAN/405-509  AC A0A8J7FEJ2.1
#=GS A0A844MDS8_9CYAN/1-105    AC A0A844MDS8.1
#=GS A0A8J3IUL4_9CHLR/1-108    AC A0A8J3IUL4.1
#=GS A0A139WX44_9CYAN/1-52     AC A0A139WX44.1
A0A8J7F146_9CYAN/1-71                .m-AGIPPQLLNKLRQALLLCEQFESDRKLRPIF.T.YEPLRPWRFSLPQADSLTSRVDNLIGFLV-----.-.-.-.-----------------------------------pnpppnalv........
A0A8J7F2T0_9CYAN/3-104               .g--GLPKELNHRCRQVFLQCDEFKHYDALIAVF.V.TDELLPFKSEIRNANNRKQLVDFCLEDLLQKRIK.S.G.K.PVLEIFLATLKDKYEVGNALHDELAA---------lyrdvhl..........
A0A139WX65_9CYAN/20-124              ..IIGIPNHFYTRCRNVLLQCEEFDTNAKLRAIF.I.TEKLNPFSLGLPEATNITERVDLCLNYLLQKRHS.S.G.E.PVFPIFLEVLRDRYLEGNALREELTQCMEEAKQIW.................
A0A8J7JSQ3_9CYAN/1-103               .m-AGIPPQLHKRLRNVLLECEQFESDRNLKTIF.T.NESLRPWRSSLPQADSLNSRVDYLIAFLVNKRRS.DtK.E.NALVLFVRLLSELIDEADNRHQ-------------qlkhlaaele.......
A0A8J7FEJ2_9CYAN/405-509             ts--GIPPKIYSKLRNALLDCEQFDSVQQLRNFFkL.NTPLKPWRS-CWKAGSPSEMVEDAIGYLHDKFRSdT.K.E.NALIILVRLLADSIDPGDSRNQIL-----------adlaqelsvv.......
A0A844MDS8_9CYAN/1-105               .m-AGIPSQLLNRLRQALLQCEQFASDRNLRSVF.FnNEPLRPWRSNLPQADSLTSRVDNVIGFLVDKRRS.D.TqE.NALVLLLRSLSNLIDE-------------------ederhqqlanlasevei
A0A8J3IUL4_9CHLR/1-108               mp--GIPGPLLASLRDTLSDCDEFENYNTLKAVF.V.HELLVPWRKRLRSAGNPLGLADETINLLWQESRS.D.T.KtNALVLLLIVLRDRYKPDTDLYERLD----------glacdleqalqa.....
A0A139WX44_9CYAN/1-52                ..--------------------------------.-.--------------------MDLCLNYLLQNRHR.S.G.E.SILLIFLEVLRDRYPEENALHEELNECIRKAE---lyl..............
#=GC seq_cons                        ....GIPspLhs+LRpsLLpCEpF-osppL+slF.h.sE.LpPWRppL.pAsshsphVD.sIsaLlpKR+S.s.s.E.ssLllhLclLpDphc.ssshpp.L.............ht.t..h........
//