#=GF ID   bPH_7
#=GF AC   PF20794.1
#=GF DE   Bacterial PH domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Max Bileschi
#=GF GA   25.00 25.00;
#=GF TC   25.30 25.10;
#=GF NC   24.60 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0266
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents a group of bacterial PH domains that
#=GF CC   contain two transmembrane helices. The function of this family
#=GF CC   is uncertain, but they may act as antitoxins or as chaperones
#=GF CC   for membrane bound complexes.
#=GF SQ   43
#=GS R9M6E9_9FIRM/2-134       AC R9M6E9.1
#=GS A0A4R2KC04_9CLOT/1-132   AC A0A4R2KC04.1
#=GS R5SPA1_9FIRM/14-153      AC R5SPA1.1
#=GS E3CVG7_9BACT/1-130       AC E3CVG7.1
#=GS G7V6K5_THELD/7-135       AC G7V6K5.1
#=GS A0A415E4I4_9FIRM/3-135   AC A0A415E4I4.1
#=GS A0A1B2I321_9BACT/14-150  AC A0A1B2I321.1
#=GS I0I351_CALAS/28-134      AC I0I351.1
#=GS A0A1M6LW63_9CLOT/21-146  AC A0A1M6LW63.1
#=GS A0A1G9DTV4_9CLOT/4-133   AC A0A1G9DTV4.1
#=GS A0A1I0HEP4_9FIRM/22-158  AC A0A1I0HEP4.1
#=GS W2BWH1_9FIRM/1-53        AC W2BWH1.1
#=GS C6JLC7_FUSVA/2-134       AC C6JLC7.1
#=GS I4BXX9_ACEMN/4-135       AC I4BXX9.1
#=GS E4KZ68_9FIRM/14-148      AC E4KZ68.1
#=GS A0A1M4NEU1_9CLOT/46-174  AC A0A1M4NEU1.1
#=GS D7N8Q8_9FIRM/21-155      AC D7N8Q8.1
#=GS A0A415E106_9FIRM/2-134   AC A0A415E106.1
#=GS R6E2N7_9FIRM/2-135       AC R6E2N7.1
#=GS A0A239LIY7_9BACT/25-158  AC A0A239LIY7.1
#=GS A0A401UH83_9CLOT/22-150  AC A0A401UH83.1
#=GS A0A010ZN57_9BACT/13-150  AC A0A010ZN57.1
#=GS W2C0J7_9FIRM/2-141       AC W2C0J7.1
#=GS A0A4Y8I221_9BACT/1-129   AC A0A4Y8I221.1
#=GS A0A1I1XQX1_9FIRM/2-134   AC A0A1I1XQX1.1
#=GS A0A1H0VJG1_9CLOT/22-145  AC A0A1H0VJG1.1
#=GS U2NL43_9CLOT/22-150      AC U2NL43.1
#=GS A0A8H2R0P4_9FIRM/2-134   AC A0A8H2R0P4.1
#=GS A0A6G7WHD4_9LACT/45-170  AC A0A6G7WHD4.1
#=GS R6E0D4_9FIRM/14-153      AC R6E0D4.1
#=GS A0A1M6QLS6_9CLOT/1-126   AC A0A1M6QLS6.1
#=GS A0A2Z4WG45_9CLOT/22-149  AC A0A2Z4WG45.1
#=GS D1VUJ8_9FIRM/14-148      AC D1VUJ8.1
#=GS A0A073J6U8_9BACT/14-150  AC A0A073J6U8.1
#=GS A0A1C7IFL5_9FIRM/15-148  AC A0A1C7IFL5.1
#=GS F4XEL4_9FIRM/15-148      AC F4XEL4.1
#=GS A0A095XIU3_9FIRM/2-134   AC A0A095XIU3.1
#=GS A0A371IPA2_9FIRM/15-149  AC A0A371IPA2.1
#=GS R6E2I9_9FIRM/2-136       AC R6E2I9.1
#=GS R6DRV5_9FIRM/3-136       AC R6DRV5.1
#=GS A0A1Y4GLU7_9BACT/12-148  AC A0A1Y4GLU7.1
#=GS E7GKL2_CLOSY/17-150      AC E7GKL2.1
#=GS A0A416RD26_9FIRM/14-147  AC A0A416RD26.1
R9M6E9_9FIRM/2-134                  ..............................r-YYGL-LHERRLWVKVSVLLLAL.CMLF........LEA...ARG.QW.........LYVPVVLFVVL..ACF....FQK.EHIVSQEGVDIH.Y.RLFGSSL.HSCWTWSEIT..TLHQDTRKAAPN-VMLHF...GKGVNTRVFVM...KPEDSQAVLALAKRANPQIHIADM..............
A0A4R2KC04_9CLOT/1-132              ............................mik---TYTHNKLSSMYQYLIIAVVI.VWIG........DSI...YNK.QY.........LNVFVGVALIY..ISF....CEK.KVFITQEGILIR.T.KRMKRTK.ERIIKFSQIQ..RISVQKR-NGK--AMFYF...AREGAGQKAIV...DAENVEQIVAWAKKHNKKIDVY--yi............
R5SPA1_9FIRM/14-153                 ...............................IYVSRPPKPRKKWVTVGGWILVV.LLLL........FGL...MSK.RSnlp...lsvISFGLALLYTL..TLL....TKK.DAVVTTRGLEIF.Y.QMQITTQ.YDFFPWEQIN..SIVTEDR-KHPDLIRLHI...GYSSMEKALFF...TRSDAEAIIKLAKEKNPAIRVLD-y.............
E3CVG7_9BACT/1-130                  ............................mpl------------WMKVFIGAAGV.-LLL........GTA...MRG.YLtgsg.dslvAKLFVGAACLY..ALG....FDK.KMYVADEGIVKE.T.KTWLNRN.REVFPWEEVK..FVTLAFR--GGN-MMAFF...ERGVTGWKLLF...RRDQEEPMRALIRRRIPQVEVD--tv............
G7V6K5_THELD/7-135                  .......................sksgtpfp-----------SWMKWFALAVGI.FLVA........DGM...RVF.EF.........HKIFVGVVVAF..ISG....YQK.RLYVSSEGLVRE.N.GSWFRKY.KTVLPWEEIK..HVGLVKR---GNRMMAFF...ERDITGWKVLF...DAEDEPKLRAILAEYIPDVEIGE-v.............
A0A415E4I4_9FIRM/3-135              ...............................KIKAYDDKALRKSTRVAAVIAGI.ALIA........LSI...CSS.VK.........YSAIIGVVLLL..AVV....FGK.ETYATEEGISVE.Y.DFFVFKH.VIHWGFEEIT..DIHLEGKRGSYQ--GMHF...LKDVMTRRLLF...SRDEVDQVLQMAKSRNSAIHVEN-i.............
A0A1B2I321_9BACT/14-150             .......................sasgreag-----------KWKSISFVIIAV.YLFFtagwqfthGGM...TQK.AL.........LNLFLGCCSVM..VIK....YEK.RIYVSPLGFVKE.T.HTWISHH.RELLPWNEIK..YVTLTTK---GNRMMTLI...EKDAIGWKLFF...AKDDHAKLKEILKRYAPKVPVND-i.............
I0I351_CALAS/28-134                 srnmaigfamlaagiaafvadltdtffaeat-----------------------.----........---...---.AW.........VFIIWGLLFLYgdLLL....MTR.KFIVTEEGLEIY.I.PFRFWSR.RKVWAWKNIYrmDLVIDRRDTHPRDCK---...-----------...------------------------iqiyhqyp......
A0A1M6LW63_9CLOT/21-146             ............................kyi--KKLIIPTRKSYIQIIFVLISViILIS........ITY...FYGnKW.........IHYIVGVLASS..TYI....C--.--MWIKQGINSK.G.FVSMYRY.KETISWNEIE..KVIVTSS---KD-VKVKL...FGDFMEQTFYF...KNGDYEKVLTFLKENLP-------kea...........
A0A1G9DTV4_9CLOT/4-133              ..........................idisk------TNPNNRVYKVMSVILGG.ILII........TGI...VNL.SI.........INLLIGILLLF..YST....YNK.KVFLLPDGLVST.Y.TGFLFKQ.TDKYDLKSVK..EVDIIIH-GSKG--ILFF...MKDEFARKVEV...DNKQIDEINLFLKKHT-DIKV---kik...........
A0A1I0HEP4_9FIRM/22-158             ..............................v-YHAQEIKPRKESTKTLCWLMCG.FLIV........GGL...MTP.YK.........LIILFALLYML..VLL....MKK.DMVVTERGVETF.Y.QMRITTW.YEKLEWKDID..MVVREDR-DDPRLVALYFrerGNDDRVKRLFF...TREDAQSIMRMAKLQPDRIEVCEA..............
W2BWH1_9FIRM/1-53                   ..............................m-----------------------.----........---...---.--.........-----------..---....---.------------.-.-------.----------..AVHTDSIKSAPN-IELHI...NKGVINRRFIF...SKEDVNKVINLIESIKTNITVTEV..............
C6JLC7_FUSVA/2-134                  ...............................KCYGI-MPERKLWVKIGIIIFGI.YTIY........NSA...VNN.NF.........FYLPFGIIMIL..VTF....SER.KHIISQEGVDII.Y.TICGFQF.HNIWNWSEIN..TIHIDSISSKPN-VELHI...GKDITARRFIL...SKNDADKALTITSKMNSKIYIAE-l.............
I4BXX9_ACEMN/4-135                  .....................iiesqssysa----------SLKMKVVLFLFGV.YCIY........SAF...SAF.EI.........YKIIVAVVAFY..GIV....YKK.KIYVSSNGLVRE.V.RGVLGTS.VEVLPWEDVK..GVTIVYK---GDSMMAFF...EKGITGWKILF...KREDERLLRELLDKHAPDVEVT--vv............
E4KZ68_9FIRM/14-148                 ..............................a-IKYVYVNPRNKFSEKYAYMITS.LLII........LGI...FTK.YK.........LTVVLALLLLL..SLI....TKR.YVAASSKGLEMY.T.DMKITKT.YKVWEWSEID..AITYEKVPNQKGKILLYF...TKGDVTKRFFF...DENDQDRVFEVAKSHNKKIKIYDA..............
A0A1M4NEU1_9CLOT/46-174             ............................aik---RLIVPTRKNYVEIIALLVST.GILI........FIIc.fYAK.TW.........IHYLTGVLGIL..LLI....SSWfKSGITAEGFTSM.Y.-----KY.ENLLPWSEIN..KVILTFS---ED-IKVEV...FGSFMEQSFYF...KKKDYDKIISILKAYLP-------kkakvet.......
D7N8Q8_9FIRM/21-155                 ...............................IYTNREIKPRKDWVIAGGWIMTA.ILII........SGF...TTK.YK.........ISLVFGVLYAL..ALL....MIK.YVAVTNRGLEIF.Y.DMKIMKH.YELWEWKDIF..ALTHEKNIDYPEIIAIYF...SKGDRSKRLFF...DKRDKNAIIQMAKSLNPEIKIYDA..............
A0A415E106_9FIRM/2-134              ...............................IYKGI-LQSRSLYKRILILTACV.VLLY........LEF...VRG.QY.........LYIVLTVLLIL..AVF....HRK.EHIVSKEGVDIK.Y.SLFGMTT.TNRWTWDQIT..AVQPDYIKERPN-ARVLF...EKDAVLRSFLF...TPEDCQDVLKLAAKMNPEAFVDDY..............
R6E2N7_9FIRM/2-135                  ...............................KYHGI-IKQRELWLTITIFIIAA.YLLY........REY...AAG.QY.........IYIPLALMVML..ACF....FER.EHIISEEGVDIK.Y.NLFKVCIkHNYWAWDEIT..TLHPDYKRARPN-VMLHI...GKDVVTRTFTM...KPSDCKGAMELARRMNPHIYIDDI..............
A0A239LIY7_9BACT/25-158             .....nqlngimllfpcisglsffysllhge-----------------------.----........---...---.YR.........YAAVSAVAFVS..ALLglfpTKK.TLWVSGKGVETS.S.DLFDSAS.HRSFRWSEIC..ALKYSLGAEDDP-SGLYI...RTGRWSETCVLagvDEAQANEIIEAIFERFPNIELAD-e.............
A0A401UH83_9CLOT/22-150             ...........................ymke----LIMPTRKTYLEIITVLFCV.I-IF........IGIiyfYAN.AW.........VHYVIGVLAIV..MFV....---.-SIWIKQGINSK.G.FISMYRY.KEIILWNEIE..KVIVISS---KD-IKVKL...AGGFMEQTFHF...KKSDYDKVITILKENLPE------qaqiqk........
A0A010ZN57_9BACT/13-150             ........................vsasgre---------AGKWKSITFAMIAA.YLLL........TAV...WQF.SHeevt.qralLNLFLGCCSVV..VIK....YEK.LIYVSPLGFVKE.T.HTWVSHH.RELLPWNEVK..YVTLTTR--GSR-LMALI...EKDEIGWKLFF...KKDDLPELKEILKKHAPKVPVND-i.............
W2C0J7_9FIRM/2-141                  ...............................EYKALNLDTHKKEVKIGTVIVGL.LLVF........LGT..gLTG.YIkf.....niVAVIFGTLLVL..SAL....LRK.TVTVSSDGLLVH.Y.DMRIAKH.QELWGWKDMF..SLTWQKDENTPDLWRIYF...TKDDRTRKFLF...TEDDMENILKLGKEKNPSIKIYEA..............
A0A4Y8I221_9BACT/1-129              ..............................m-IKTYNPKEPKKWLEYSSLLVGI.IMII........WGV...ISY.QT.........ILLVLGFFFIL..VVS....NKT.EIIIDKKGILIT.TtTLFLMKR.KDRLNFKEMN..SMDIREG-TEK--SLVYF...MKGWKGRKILI...DTINLTKLIDYIKNENPD------li............
A0A1I1XQX1_9FIRM/2-134              ...............................EYYGI-LPERKPWVKIAVILLSM.YAIW........DTY...TNG.NW.........FYLPFGMILIL..ATF....SSR.KQVVSDIGVDIV.Y.TVLGQHF.HNMWEWDVIL..AVHTDKLKSAPN-VEMHF...NKGVINRRFIL...SKNDTRDVIELIGSVRPEISVTEV..............
A0A1H0VJG1_9CLOT/22-145             ............................yik---ELIIATRKSYVEIITVLFAV.-IIF........IGI...IYF.YAntw...mhyITGILGIFMFV..SMC....VK-.-QGISSKGF---.-.-ISMYRY.KELIVWNEIE..KVMVISS---KD-IKIEL...SGGFMEQTFHF...KKSDYDKVMIILKEKIP-------gk............
U2NL43_9CLOT/22-150                 .............................li--KTLIVPTRKNYIEISIIIIGIsVFIS........LMY..fFAK.NPl......hyIIGFLGIILII..VMW....LKR.--GINSKGFASM.Y.-----RY.KEFIYWDEID..RVVIVSS---KE-LKITL...FGNFMEQTFYF...DRESYNKVMSIFQENFP-------ketciei.......
A0A8H2R0P4_9FIRM/2-134              ...............................KYYGI-LPERKLWVKIAALILGV.LSSY........QAL...VHQ.NW.........FFMPFGLVVIL..ASF....SER.KQVVSDQGVDIE.Y.RVLGHCF.QNLWTYEEIQ..AIHKDSLKSAPR-VEVHF...NKGAINRRFIF...SPEDARGIEDLVREKLPKMKILE-v.............
A0A6G7WHD4_9LACT/45-170             ..........................kykkq----LILPTRKTYLEIITVLLSViILIF........ITY..fYAK.TW.........LHYVIGGLGVF..MFI....STR.I----KEGISSK.G.FISTYKY.KELILWNEIE..KVIVISS---ND-IKIKV...SGGFMQQTFNF...KKSDYDKVITILKEN---------lpika.........
R6E0D4_9FIRM/14-153                 ...............................IYTARANKPRKKWVKIGGWVLVV.VLLL........FGV...SSF.DRnlp...lavISMIFSILYSI..TMV....TVK.DAAITCRGLEIF.Y.NMQITTQ.YDFFAWEDIN..SIVIEDR-GDDEYVRLHI...GYSSLEKALFF...KRSEVNAICKYAKEQNPDIRVL--rh............
A0A1M6QLS6_9CLOT/1-126              ..............................m-ITGYKLRKELKWLNITFIVFAV.LIIL........LKG...ISN.LN.........I-LLFSIILFI..IGS....FRE.YIYVEPSGIVFKsY.LLFFIPL.LTQCPFHEAT..NISFENLDN--GFTVIKY...LKGNKLKRILI...EDKDVKQVKEWIKKQT--------k.............
A0A2Z4WG45_9CLOT/22-149             ..............................y-IKTLKIPTKKRYVELFTMLTSV.IVLG........WIMy.tYAQ.NW.........GHYIIGVLGIL..TFI....SS-.---CVKEGISSK.G.FVSMYKY.KQIILWNEIK..KVSVISS---KN-IKVKL...FGGFMEQSFYF...KKSDYDKVIAVIKENL--------pvtsele.......
D1VUJ8_9FIRM/14-148                 ...............................IYSYIDVKNRKNYVNYIAWFLTI.LFAL........IGI...FTV.YR.........IGIFIALVLFL..TLV....YKR.YVVVTSRGLEIF.Y.NIFISKS.YEIWDWEDIY..ALTYANDYDYKDLKIIYF...TKGDITKRFYF...KSEDLQGIILLAKSKSKKIKIFDA..............
A0A073J6U8_9BACT/14-150             .......................sasgreag-----------KWKSITFAAIAV.YLLC........TAA...WQF.WSgdfg.qkawLNLLLGCCSVL..VVK....YEK.RIYVSPLGFVKE.T.HTWHTHH.REILPWDEVR..CITLRAK--NGR-LMLLA...ERDVTGWKLFF...KTEDQAKLKEIFKRYAPKVKVNE-i.............
A0A1C7IFL5_9FIRM/15-148             ...............................IYYARDLKPRKPWVTYGCWILSA.ALII........GGI...ITP.YR.........VAAVFGVLYIL..TLL....MKK.DTVITERGLEIF.Y.QMRITTH.YDFWSWKEIV..SVIREDR-KHPELIALHF...GRGNRSKRLFF...TKADAKQIMVLARKKNSRAVVADA..............
F4XEL4_9FIRM/15-148                 ...............................HYAARELKPRKKWVTVGGWILVA.VLLL........GGL...ATR.YR.........VLLVFSALYAL..ALL....TKK.DVVVTSRGLEIN.Y.QMRITTQ.YDFWSWDKIV..SVTREDK-NNPEVVALYF...GMDNKAKRLYF...TRPVAEQVLKLAKEVKPGITIQEA..............
A0A095XIU3_9FIRM/2-134              ...............................RYYGI-LPKRKLWVKIAAIALGM.LAAY........DAY...VNG.NW.........FYVPFGLVLIV..ATF....SSR.TQVISESGVDIE.Y.RLLGHCF.HNNWSYDEIL..AVHKDSIKSAPN-IEIHI...NKGAINRRFIF...SPDDAENVLALIRKSKPGIVIKEV..............
A0A371IPA2_9FIRM/15-149             ...........................kivt----TIKSLSKPWVEKGAIVGGT.FLIF........GGI...FTP.YK.........IGIVLGLLIIL..ARL....MKK.YSAFTTRGMEIF.Y.DMLFTSS.HTVIEWKDID..AVTYEKAKTNPDLELIYV...TKGDITKKFYF...KHKQTKDIIDFAKKCHPSVKIYD-g.............
R6E2I9_9FIRM/2-136                  .............................vf--KGINMRERSKRKRILMFFGCL.GITA........LEI...WQK.NY.........FFAVVALILAF..FCI...gYNK.EHVISEEGVDIR.Y.VFLGIPY.NYRWTWDQIT..AMRPDYKKAKPN-IMMEI...AKDVSVRAFVF...TPEDAVKVMEFAQRMNPEAYVD--sr............
R6DRV5_9FIRM/3-136                  ...............................EYISVDTKQMRKSTRIAAIAAGL.FFIG........LGI...IRP.SI.........YAGLIGAVIIA..AML....LSK.ETVVCEEGIVVR.Y.DAILYQY.REVWPWEEIK..EIHKELSPDCKQ-YGLHF...MKDIMTKRLVF...PIPEAKEVLEFAKEMNPEIHIGN-v.............
A0A1Y4GLU7_9BACT/12-148             .....................kskssrtidg------------WRRFTFGALAA.YLLV........TGV...TEF.RAsgvn.qkvvINAFLCICGVL..VLK....FEK.KVYASPLGFVKD.T.HTWFSHH.REVLRWDEIR..HVTLVTK--GTG-LTAFL...EKDVIGWKLLF...ERNDMAALDGLFKKYAPKVKV---vi............
E7GKL2_CLOSY/17-150                 ...............................KYHARELKQRSKWVTAGSWFMSG.LLLA........AGV...ITP.YR.........VAFIFGLLYIL..ALK....MQK.DTVITKRGLEIF.Y.QMHITTQ.YDFWSWEQID..SVTLEDR-NHPELVALHI...SKGDRIRRLFF...TREDAADIMVLAKKQKPGILVGEA..............
A0A416RD26_9FIRM/14-147             ...............................IYTARPLKPRKKWVTTGGWILSV.VLIL........GGI...ATP.YR.........VLILFGVLYLL..TML....AVK.DTVVTSRGVEIF.Y.QMRITTH.YDFISWDQIE..SVVRKKE-DSPTMVSLYF...AHGDRVKRLFF...LKPDAENILALAKEQNPKVKLAE-d.............
#=GC seq_cons                       ..................................th.h..+cpahclhshlhul.hllh........huh...hsh.th.........lthllGllhll..shh....hp+.chhlopcGlphp.h.phhhhph.pchhsWc-Ip..slphppp.ttss.ltlah...t+sshs++hhF...pcpDhpplhplhKcptPpl.l.p...............
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