#=GF ID   fvmX1
#=GF AC   PF19998.3
#=GF DE   FtsH ternary system domain X1
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF SE   Aravind L
#=GF GA   27.00 27.00;
#=GF TC   108.70 108.50;
#=GF NC   20.60 19.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   32101166
#=GF RT   Highly regulated, diversifying NTP-dependent biological conflict
#=GF RT   systems with implications for the emergence of multicellularity.
#=GF RA   Kaur G, Burroughs AM, Iyer LM, Aravind L;
#=GF RL   Elife. 2020; [Epub ahead of print]
#=GF DR   INTERPRO; IPR045480;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Uncharacterized domain found in the FtsH ternary system, a class
#=GF CC   of NTP-dependent biological conflict systems.
#=GF SQ   24
#=GS A0A7W7PUL2_9ACTN/26-286  AC A0A7W7PUL2.1
#=GS A0A0N0SYI3_9ACTN/16-276  AC A0A0N0SYI3.1
#=GS A0A101P0U6_9ACTN/26-286  AC A0A101P0U6.1
#=GS A0A7W7MTH0_9ACTN/20-268  AC A0A7W7MTH0.1
#=GS F8B3Z2_9ACTN/34-381      AC F8B3Z2.1
#=GS A0A0F5VZE0_9ACTN/14-275  AC A0A0F5VZE0.1
#=GS A0A451CJG6_9GAMM/20-293  AC A0A451CJG6.1
#=GS A0A1S2PXM6_9ACTN/25-285  AC A0A1S2PXM6.1
#=GS A0A7K2FTJ7_9ACTN/27-291  AC A0A7K2FTJ7.1
#=GS A0A5N8XH83_9ACTN/20-322  AC A0A5N8XH83.1
#=GS A0A1G7X430_9ACTN/14-290  AC A0A1G7X430.1
#=GS A0A5M3XS70_9ACTN/20-279  AC A0A5M3XS70.1
#=GS A0A4R2J386_9PSEU/21-275  AC A0A4R2J386.1
#=GS A0A840P427_9ACTN/22-278  AC A0A840P427.1
#=GS A7BKG0_9GAMM/20-295      AC A7BKG0.1
#=GS A0A1V1NUZ1_9DELT/20-188  AC A0A1V1NUZ1.1
#=GS A0A8J3VM61_9ACTN/21-282  AC A0A8J3VM61.1
#=GS A0A4U1J759_9DELT/40-306  AC A0A4U1J759.1
#=GS K9V0S0_9CYAN/23-289      AC K9V0S0.1
#=GS A0A1H2AIK7_9ACTN/37-304  AC A0A1H2AIK7.1
#=GS A0A2U3A636_9ACTN/2-270   AC A0A2U3A636.1
#=GS A0A252E5K2_9NOSO/22-285  AC A0A252E5K2.1
#=GS A0A545AZJ1_9ACTN/43-318  AC A0A545AZJ1.1
#=GS D0LHH4_HALO1/31-321      AC D0LHH4.1
A0A7W7PUL2_9ACTN/26-286             .........APPEGELTDPQELAAPPPDVTAVLTGLAARTAARLRLDA...LA.AGE..RRP.VGAGALLLAAAVGGRA.RPHLAAETVRA...VPPA.........RSLWDVLTHHAVVTPAL...........................................................................-PHI....GD..AALAGRLRAASPLTALLDRPDPVGE.....tDAELLL.EDVLLTHPQGRRMITTVYCEAPA....SPAQALWRGRLLDQ.LRMS..ER....DLVIDVYEAALLRHAQAHLSLVRRARIGLTAP.P--------DLPAARPVAYWWAAL......ARLER.SHRQLLRARSGIGK..EYLEGVRL...YRQVERLEAS-e.............................................
A0A0N0SYI3_9ACTN/16-276             .........PPPEGELTDPQQLAVPPADVSAAVVRLAAQSAARLRLDA...LA.SGE..RRP.VGAGALLLAAAVGGRA.QALLAAETVRA...VPPA.........RSLWDVLAHHAVVAPAL...........................................................................-AHI....GD..RTLAGRLRAASPLTALLDRPDPVGE.....sDAELLL.EDVLLTHHQGRRLITTVYCEAPA....SPAQALWRGRLLDQ.LRMS..ER....ELVIDVYEAALLRHTAAHLALIRRARVGLTAP.P--------DLAAARPVASWWAAL......ARLER.SHRPLLRARSGIGK..EYLAGVRL...YRQVERLEA--rg............................................
A0A101P0U6_9ACTN/26-286             .........APPEGELTDPQHLAVPPPDVVTAVVRLAARSAARLRLDA...LV.SGE..RRP.VGAGALLLAAAVGGRA.QPHPAAETVRA...VPTA.........RSLWDVLAYHAVVAPAL...........................................................................-PHI....GD..PVLAGRLRAASPLTALLDRPDTVGE.....aAAELLL.EDVLLTHPQGRRLITTVYCEAPA....SPAQALWRGRLLDQ.LRMS..ER....ELVIDVYEAALLRHTEAHLSLIRRARVGLTVP.P--------DLATARPVAYWWAAL......ARLER.SHRRRLRARSGIGT..DYLAGVRL...YRQVEQLEAS-g.............................................
A0A7W7MTH0_9ACTN/20-268             .........PPPAGRLTRIGGLARPDAATADTLRWATATTAARIGAGR...PP.LGD..PGA.PGPAAVLLAAAIGGRR.QWEQSAKVLSL...VPRLrlt...rrdAGWAEGVARHAVVGPAV...........................................................................SAEPpaggAP..AEFVEALLAASPLTTVLHRPPDADR......ATAGGV.LSRLLRRPRGIAVLVAACAAPSA....DPLVLEWRWTVLDR.LRQE..RV....ADMLDVYIAARLWHGPAWDAHIEEARRGLT--.---GLPS----PRTVATLRFWLPL......AILDE.QEQR----------..--------...-----------esglayrv......................................
F8B3Z2_9ACTN/34-381                 .........PPPVGPLRDVGGLGRPGAATVTALRELIRGTAARLGTGS...PP.FAD..PVP.VGPGALLLAAAVGGRA.EPVPARALAEA...SPAVgl.....paGGWADALARHAVVAPALlacrtvhrtptpertatseqaaiseqaatagraaapertadsgpaaasgppgpagvpglatpatpvglatpvglaAERT....ID..AELADALLRASPLTAVLYRP-PLARlargatAMQAAA.AVGLLGRPRGCAVLTAALAAWSS....DPAVLAWRAELLTR.LSND..HP....DVVLDVYLLARLRHGADWDGRLGAAARALA--.-GTGPPDD----LPVATIRFWAPL......AVLDQ.RDPELIRSRMFLD-..GHRDALTLvrrYRLAVSAAGA-a.............................................
A0A0F5VZE0_9ACTN/14-275             .........APPEGDLRDLQDLAAPPPDVTDEVVRVAVYGAARLRLDR...--.LAEqeRRP.VGAGALLLAAAIGARA.QEELAAEAVRA...VPAA.........RSLWDVLAHHTVVAPAL...........................................................................PHCA....ST..PLLAERLRDASPLTAVLDRPNPPGE.....sAAELLL.EDVLLTHPQGRRLLTSVYCAAPA....SPGQALWRGRLLDQ.LRMQ..DR....ELVLDVYEAALLRHQAEHLVLIRQARLCLTVP.P--------DLPSARPVAQWWAAL......ARLER.SHPRLLRARTGITR..QYLAGVSL...YRQVERLEAI-t.............................................
A0A451CJG6_9GAMM/20-293             .........PPPGGDLAELDALLSPPVLVRATLAEVATVAAARLGLSPktiPP.ETT..AEP.LAPDGIWLAAAIGAGS.HPGFTTTAIELvrlCNAAtg.....wsGNWLGLAACHALVGPAL...........................................................................--AF....VP..EILAAELRLVSPLTSVLSLPAKGEE......DVALAL.AERLAGTPDGQRLIAHRFADPNA....HPEEIRWRARIMED.FRLTghHR....LLALDIYEAAVALHAEGWKRRIGEATAILAAR.E----PTPGQLETAMAIGSWWLPF......LGLYR.NDHEAIRERRYLNDfdLYLAGLRL...AQVV-------rais..........................................
A0A1S2PXM6_9ACTN/25-285             .........APPEGELTDPQDLVVPPPDVGAAVVGLAVRTAARLRLDA...--.LASreRRP.VGVGALLLAAAVGGRD.RARLAAETVRA...VPPA.........RSLWDVLAHHAVVAPAL...........................................................................-PHI....TD..PALAGRLRAASPLTALLDRPDPVGE.....sDAELLL.EDRLLTHPQGRRLITTVYCEAPA....SPAQALWRGRLLDQ.LRMS..ER....ELVIDVYEAALLRHTAAHLALIRRARIGLAVP.P--------DLDAARPVARWWAAL......ARLER.SHRHLLRARSGIGK..EYLAGVRL...YRQVERLEA--rg............................................
A0A7K2FTJ7_9ACTN/27-291             .grtagpts---------------PEQDPALLVERLAAVTAARMRLSD...PP.LGD..PGP.AGLPTLLLAAAVALR-.EGSLAERTLDS...VSAP.........GSARDLLARHGLVHPVLt.........................................................................aGSRS....VG..TSLGTALLRHSPLTGLFDAPAPGDD......EPCRQL.LDRLLDHPEGRRTVTAALSAPPR....TPDAMLWRSGLLSR.YRFD..PAe..rQWVYDVYETALLHHGPYYMRRTREAVAVLTGEtSGAPDTDRAAAAWADATSDWWRPL......DVLVT.RFPAELRARRMLR-..GHEGGLRL...SRLRARAEAL-r.............................................
A0A5N8XH83_9ACTN/20-322             ........q-PPHGPLWDVTGLRDPGEPVRSRLAETARTMAARLGAGN...PP.LGE..RNPtVGTGALLLAAAIGGRG.QPAAARALAEA...AGRRfpsrrsphtARWYDALARHAVVAPAVlalgpgngaarra.................................................tpapatgavhavdGPPT....DS..APIEETLLGLSPLTAVLHRPSHR-RlrggltAAERGT.AALLLTRARGREMLIGALSRWSP....DPAVLKWRTELVTQ.LDEQ..DP....ELILDVCTAARLRHADQWDTRLRTAAKSLM--.-LDGPADH----LALATARFWAPL......ATKRR.DGTDLARARPLLK-..GYEQAIRLvhqYGLSR------agta..........................................
A0A1G7X430_9ACTN/14-290             .........APGHGDLSGAADLADPPEELRVSLGRLAAVTAARLRLGP...PP.LGDgpGGA.VGPGAALLAAAVGARH.HLAASVDVLNAa.rLPTAadg..aaeaGGW-ELAVRHGVAEAAL...........................................................................AVPD....LD..PDLADLLRDCSPLTALLDHPTPEGE.....rEAELLL.TRRLLHHPDGWRLAALALAEPPA....GAAQAVWRSGLLSR.CRRV..NL....AFVLDVYEMGLSLFAAEHRRRLRAARRLLS--.-GAGRGRAVDPDAVAGTALWWRAL......AEIGK.TNPRAIGRRRWITA..EHAQGIEL...YRALRRWEAA-s.............................................
A0A5M3XS70_9ACTN/20-279             ........n-VPNGTLWKAARLADPPPDVVRRLAEITWRSNAVRGMGN...PP.FGE..AAR.VGLGGVLLAAVIGGRD.HPEPAMMIANS..lVRTR.........SRLPDATARHAVVLPALr........................................................................gvPSWQ....GV..EGLPDLLLRASPLTAVLHHP-PGDPds.seyRAVQER.VAELVTRPHGRAVVVGTLAECDS....DVRVLGWRAYLLNQwLRHG..EL....DLVRDVYATAWLRHGKAWARQIGQALRWEG--.------------------------......-----.--------------..--------...-----------kptpvmkatgaywaaaervdlgrtrpvargydsalrlvhryrtwrg
A0A4R2J386_9PSEU/21-275             ........a-MPEGDLADGEDLAAPDAESLRLVGRLASVTAARLRLEP...PV.LGD..KRP.PSAGAAVVAAAVGA-F.RHERARALLGV...LRPP.........TRVADLLAFHGVVAPAV...........................................................................---K....LL..PHLGDQLRDLSPLTGVLDRPGPRTT......ASCESL.LDRLRTDPTARAMIVLRFAMPSD....SPEQSQWRGECLAY.TRHE..DP....DFVVDVYETALLHYGREHEIRARIAWRHVL--.-GAG-PDD----PALPTAAWWRAL......AELEA.AEPDLIRGRTALE-..RRRVGTNL...FRRVQSREAA-..............................................
A0A840P427_9ACTN/22-278             .........PPPAGDLSDVGALAEPPPEVRQAAVGLAARTAARLRLSA...PP.LGD..GRP.VTCGVVLLAAAAGAWP.GGGAAADLLGA...VARS.........CSAYELLARHGLAEALL...........................................................................-AAG....CD..PALGGALRDFSPLTALLDEPGPGGP......ARCELV.LDELLADPEGRNLFTLAFAAPPA....TDGQSAWRGEVLAG.LLPA..EK....ELVLDVYETAMPQAGPAHLERVGAAARRLR-P.P-----S--DLAPAAATARWWQAL......ARLDR.TEGEGLRSRYGLS-..GHRPGLDL...YWQMF------rlgv..........................................
A7BKG0_9GAMM/20-295                 .........PPPQGDLYDAAALSHPSQALREAMQTLTVIEAAKLSFGS...APfLGD..KKP.LGVGGAILAAAIGVLH.WPESAQQVLKA...VPRA.........QPPAEWIIRHALVARVLpll.....................................................................aeyS---....GDavTHLRADLLLASPLTALVTVPVASQE......NEMMSL.VEQLLEQRASRRWLQLNLAEPTN....NQAIRDWRQRILAQ.LRQT..EEdsktSFVLAVYETLMIHHRSVAFDQVGAAIRVLRDP.IAT--ADEQRLQEALSIAQWWQPL......WALRR.TRLDELRQRLYLDY..QYLEGLEL...YSLAQRLRG--g.............................................
A0A1V1NUZ1_9DELT/20-188             .........PPPQGDLFDLDHLLTVDSNMSNLLSDFAGLSATRLGLI-...PP.VSD.tTDR.ISADILCLAAAIGGMTfQLEAAMKLLDA...IPSP.........DNHWQRIVCHGLIFPVI...........................................................................QSHF....LP..APQAEALLMQSPLTAVLFLPPKGGE......DAAINL.CKKLINIPQGRKLLIQHFADPES....HAGQLSWRGRLM--.----..--....--------------------------------.------------------------......-----.--------------..--------...-----------a.............................................
A0A8J3VM61_9ACTN/21-282             .......el--PEGDLSALAALGQPPDRLAATAVALSMVTQARLRLGP...AS.QGE..TMR.VAAGLVVAAAVLGARR.LP-GVVQLLDA...APAP.........RSLSDLTAYHGVVQPAVr........................................................................wiEANE....GA..SSLTDRLRALSPLTGVLDHPANSGR......EACLDL.LLERETIPGLHCAAAMAMAEPGD....DSAQWNWRAEVLGV.LRRR..GM....SFVLDVYESARRHHAARHDAQIRTAMGFLQ--.-GFT-----HRDPARDVADYWQPF......ADLIA.ARPDSVRARPDLL-..GYRDALNL...VRRYRLE----eaqt..........................................
A0A4U1J759_9DELT/40-306             ktpqgemgy----------PSLLAPPQRLRDAAAALAAIHAAKLGLRA...PP.LGD..GRP.LGPGGVVLAAAVGVVE.TKGVAEALAEA...CPEL.........SGAWDLVLRDAICSRAL...........................................................................-ATS....ID..ADFADMLRARSPLTAALGRPAPGGE......DETIAT.IAAIARHADGRRLVVQTFARPGA....PREVRRFRAAAMER.LRTG..ETs.llDLVIEVYEAALVFHRERVIEEITAARAVIL--.-GRGDPEA-KIEDALAVAAFYGPL......WRIRR.AHAELLRTRHGLDL.eGMLEGTRL...FQLGARLAG--ed............................................
K9V0S0_9CYAN/23-289                 .........VPPQGDLSGIEKLEHPSANLVAAIGQLTTVTAARLRWKM...PP.LGD..NRP.LGLDNTILAAALGT-P.NPQIARTLISA...VAEP.........SCFGDWVFRYGLITPAL...........................................................................--PF....LK..DDIADDCRQRSPLTAILNRPVPGQE......NQAVHF.VTQLLVYPSAKLSLTLYLAQPIS....DTKIRDWRTELLER.LRFG..KAe.iqSFVIDVYEAAMIYHQQEVINQTKDAYGVICNP.KAA--SDEERLRDALSVANWWKPL......WAIER.ADINQLRQRRYLSY..DYREGIKL...FNLSQKMLGS-i.............................................
A0A1H2AIK7_9ACTN/37-304             .........PPPLGTLRRVGDLVSVPA-VGERLRALTRVTAARSGAGN...PP.LGD..ASA.VGAGAVLLAASIGGRT.RPDLSTRLAAA...LPAPrld..qaaaTGWADALARHAVAGAAL..........................................................................sAPDH....GP..DDLAGAWLDASPLTAVLLAPHPSGR......QTAVRT.ALALARRPGGPGVLTHVLAGCHP....DVAVLQWRGDVLLR.LAAE..HP....GLVLDVYLAARNWHAAAWDARMASATRRIAAS.AAAGRPDA----DALRVVRFWAGLtarpvaALLARgRFPAALRDLYLLVR..RH------...-----------paagvs........................................
A0A2U3A636_9ACTN/2-270              .........PPPTTSARPDGTDDDP----VVLLERLARVTAARLHLSD...PP.LGD..RGP.AGLEPLMVAAALALRD.DPPTARQMAEG...VGGS.........GTVRDLMARHGLVGRAL...........................................................................SATP....LD..AGLRADLLRASPLTALFDHPPPGTE......ERCGQL.LDRFLEHTEGRRAAVAGLAAPPA....SPATARHRAALLRR.FRFT..PGe..rTVVYDVYETALLHHGGHYRERTDDVRRLARED.PARLLGDDAPGQWARATLDWWQPL......SVLAR.RHPEELRRRPLLS-..GYRTGTELhrvYGRVREFEAL-r.............................................
A0A252E5K2_9NOSO/22-285             .........VIPQGDLSGIEKLERPSAKLVQTLQQLSIVTAAKLRWSM...PP.LGD..HRP.ISLDNIIIAAALGT-A.NPQLARVLLKA...VPAP.........SCSGDWVVRHGLITPAL...........................................................................--SF....LK..DEIADDCRLLSPLTTVLNRPIPGQE......NQAVNV.GLQLLQNPEAKLSLTLHLAKPTV....DIKIRDWRTQLLDR.LRLG..KA....TFVLDVYETAMIYHQQEVINQVRTADSIISDR.QTA--ANEEELRDALSIANWWQPL......WAIER.ADVNQLRQRRYLGY..AYREGIKL...FNLSQRMLGS-v.............................................
A0A545AZJ1_9ACTN/43-318             .......sl--PVGPLTGTRRLGEPSASLQTSLRELAQQHAARLGAGV...PP.FGD..DGS.IGSETLLLAAALAGRG.QPVLAERLAGT...VTPF.........VGWADAVARHGLLDAVLaggrg.................................................................paargQQSR....VP..DPLIDLLRDGSGLTAVLDRPSLR-RlgseatGREAQL.AVDLLGRPRGPAVLVNAWSRWSA....DPEVLRWREELLTR.FALS..HA....DAVLDVYTAARARHGGDWTARLGWAATELG--.--SGNAD----PLALATVRYWAPL......ASIDR.RSPQALRSRRLLR-..DHRYALTLvhrFRLTRA-----vqs...........................................
D0LHH4_HALO1/31-321                 .algevtgd--------AIADLAEPDEPLCALTSHLAAIQAARLGWTA...PP.LGD..ARD.PGPAALWLAAAVAART.WPALCDRLLRV...IPAP.........ECAWDLLLRHAIAGPVLawshaqqag........................................................dtaasgagaaAGAS....GD..APWLEAVCEASPLTGVLAYPPRGQS......DRCLALaADTIIAHPQGASSLAAHFATPVSpgprALAVLTWRAHALDR.LRSG..DQa.qrEFVLDVYEHALSVHRGALFAALESARAALGSA.SGA------ALAHALATARWWQPL......WHLHR.SWPESLRERPYLDV.pGLLAGLDL...CRRAQILG---asa...........................................
#=GC seq_cons                       .........sPPpGcLpchtsLspPssslssslspLAshoAARLthss...PP.LGD..tpP.lGsGullLAAAlGuRs.psthAtpllcA...lPss.........sshhDhlARHulVsPAL............................................................................sph....ss..ssLustLptsSPLTAlLc+PsPssc......ssphtL.hspLLs+PpG+phlstshApssu....ssu.htWRucLLsp.LRhs..ct....phVlDVYEsAhlpHsstahsplcpAtthLs.........p..th..AhssApWWtsL......utLcR.sc.c.LRtR.hLs...tahtGlcL...ap.spth....t.............................................
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