#=GF ID fvmX2
#=GF AC PF20000.3
#=GF DE FtsH ternary system domain X2
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF SE Aravind L
#=GF GA 27.00 27.00;
#=GF TC 104.60 104.40;
#=GF NC 23.80 22.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 32101166
#=GF RT Highly regulated, diversifying NTP-dependent biological conflict
#=GF RT systems with implications for the emergence of multicellularity.
#=GF RA Kaur G, Burroughs AM, Iyer LM, Aravind L;
#=GF RL Elife. 2020; [Epub ahead of print]
#=GF DR INTERPRO; IPR045482;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Uncharacterized domain found in the FtsH ternary system, a class
#=GF CC of NTP-dependent biological conflict systems.
#=GF SQ 26
#=GS A0A4R2J8C2_9PSEU/1-260 AC A0A4R2J8C2.1
#=GS A0A5M3XW97_9ACTN/1-256 AC A0A5M3XW97.1
#=GS A0A8J3QHT0_9ACTN/1-261 AC A0A8J3QHT0.1
#=GS A0A101P0U9_9ACTN/1-261 AC A0A101P0U9.1
#=GS K9UZM4_9CYAN/1-255 AC K9UZM4.1
#=GS A0A1G7X4D6_9ACTN/1-260 AC A0A1G7X4D6.1
#=GS D0LHH1_HALO1/1-255 AC D0LHH1.1
#=GS A0A1V1NRW7_9DELT/1-254 AC A0A1V1NRW7.1
#=GS A0A840PEF4_9ACTN/1-261 AC A0A840PEF4.1
#=GS F8B3Y9_9ACTN/1-254 AC F8B3Y9.1
#=GS A0A7W7PUM9_9ACTN/1-261 AC A0A7W7PUM9.1
#=GS A0A1V1P6R4_9DELT/1-258 AC A0A1V1P6R4.1
#=GS A0A1S2PYK1_9ACTN/1-261 AC A0A1S2PYK1.1
#=GS A0A1I1NRW2_9ACTN/1-261 AC A0A1I1NRW2.1
#=GS A0A0F5VX00_9ACTN/1-229 AC A0A0F5VX00.1
#=GS A0A545AZL2_9ACTN/1-254 AC A0A545AZL2.1
#=GS A0A252E553_9NOSO/1-255 AC A0A252E553.1
#=GS A0A1H2AJ02_9ACTN/1-254 AC A0A1H2AJ02.1
#=GS A0A2A6RGE2_9CHLR/1-250 AC A0A2A6RGE2.1
#=GS A0A5N8XFX8_9ACTN/1-255 AC A0A5N8XFX8.1
#=GS A0A0M9ECC0_9DELT/1-261 AC A0A0M9ECC0.1
#=GS A0A0M8VB24_9ACTN/1-261 AC A0A0M8VB24.1
#=GS A0A2U3A5Z2_9ACTN/1-261 AC A0A2U3A5Z2.1
#=GS A0A7W7I3M4_9ACTN/1-254 AC A0A7W7I3M4.1
#=GS A0A7K2FTI9_9ACTN/1-261 AC A0A7K2FTI9.1
#=GS A0A1V1NWU3_9DELT/23-257 AC A0A1V1NWU3.1
A0A4R2J8C2_9PSEU/1-260 .....MCNPRRVRVQATRKIAEAWRTEIKQAATARGDV..SSEA..RMTQL..ISDYLPEPARRAFEQAMR....S....S.P.DWELT.D.GE.YRREVPGG.HVAYRPDTGELEIVVRLSVAIEAVGTAKLVAEGEVVDEVTAEGIGTYYADGFGGITEEHAKRQAEKAAD....AKLTELAEQRTASLKQKAEDKAKHELKKRQREATEQAKLSAEHKLTTQAQELQTGLDVRAGEQLEQVQAETLKGIFQLVAAGYSAALQEYAAQ-Y..GQNLQV.SEE.DGVIAIEFE.
A0A5M3XW97_9ACTN/1-256 .....MCNPRRIRVRATRLLAESWDHEVRRSVELTDQV..VGEA..RVRER..LSRSVGLPTLTALARVLG....R....T.E.GWEEG.E.DGvFRHPLDGG.VLSYDPDSRDLEIVARVSDRVRATGAASTTVRAEIRHTLAATGIGTYYDDEWGGVTEEDARREANRDAE....LALGEAAETARVKQREQAE-------KAHGDALTGQAHRNALDTLATLRGTRERELANEASRLLSDIGADARALFHRALAEAYRDAILAYARTRR..ATGISS.TEGpDGVLDIEFE.
A0A8J3QHT0_9ACTN/1-261 .....MCNPRRVKERASRRIARAWEESVSHVAQLVLQA..SGQA..SVRIP..FSETFSAAVRRAFERALS....N....D.S.RWRAT.D.VG.YETSVDDG.RVAYLSATGDLEILIELTDIVAVSEQRTGRVRAESTSDISSEGEGTY-DPEIRLRSEAEARQIALQNAN....RQLDAMEQAQANQLLQDARQEVLRRIGDEEARVREEAEAAAAATANELRARREQELTRRAQERLAIVRRQSTELAGAALGRAYQEVLVAAAVGRG..AQNLETfTDD.EGRIHIRFE.
A0A101P0U9_9ACTN/1-261 .....MCNPRRVRVRASSRLTRIWQEELRRTGRASAEV..AGEA..TLREA..FGSLLGAPARRAFEAALG....A....D.T.RWTWQ.D.GA.YRLDLDGG.TVVYHLDTGEIEMTARLSDIVTAEAEVVRTLEGTVEVDATAEHTEKYYDDNWAGLSKSVAERSARAQAQ....ERADRDAAEKGARQEEQERLAGRRRLAGQRDAIDAEAHAEAERRAATEAERRRGELERDAETRLLEARTGFLRPVHEVLAVAYRDAIVEYAREHG..VRDIQI.DES.DGTLNIQFE.
K9UZM4_9CYAN/1-255 .....MCNPRRIRVTATRQLNEAWQREVSRTVELQGQV..TGEA..RVRQP..LDSTLGVPALKALESALA....D...eN.S.GWTEV.G.EG.YRYDVEGG.YVLYLVDEQALEIVATLSDEIQVSAQAARTIEGSLNTAISTEAEGRYYDDGWGGRTEEVAQREAQTAAQ....RELDEIARSQIERMGNEAE-------AQAASDIEAAARTQAELELQQQAAQRQAALSAQARQHLDTVGVRCRQAFNQVLARAYRDAILAYARRNG..ADNIQC.SED.GNIIDIEF-n
A0A1G7X4D6_9ACTN/1-260 .....MCNPRRIRIRATRTIAERWSAEIRRTARVRGSV..TGTA..RMSQP..LASMLPDAPRRAFELVVA....R....H.P.EWRQV.G.DC.HLADVPGG.RIAYWPDTGELEISVELSTEIEAEGEGVVTIGGEVREDATAEAEAFYYSDGYSGRTRSAARRQARQAAE....AEADQRAAELAATRAAVAGELARAAGEGGEEAVEA-ARADAERRLDRQRARVADDLNRQAEEQLDDLHRRTLRVVFATVAEGYRAATIAYARANG..AENIRE.SDE.GGVIEIQFE.
D0LHH1_HALO1/1-255 .....MCNPRRIEITATRQVAEAWSREVERVAERSAQV..TGEA..RVRQR..LDDSVAAPALAALERALR....E...gV.P.GWRRE.G.EG.FRHEVEGG.YAVYLPEQRVLEIAAVLGAEVRGQGRANMRLHGHVEDEIAGSGASEYYEDGYRGRTQEVAEGEAAQEAE....HGIARAVAERVDEAARAAE-------AAAASELLARAEAQAGRDLEARTAAERARLEARAGERVELVGAHARQAFHRLLALAYRDALLALARARG..ADDIRC.DDD.GEVLEIEF-s
A0A1V1NRW7_9DELT/1-254 ..mih----------LAKSIEQAWRQTVEQSASASDEIseTGRI..NAEIR..LDAEMGDAALEMLERVMA....GdfgyE.D.PWERDsS.GC.YIKNVGDV.IVTYNPLTHRLNVETQLTESLTAEATATAEACGFTIGNVAVEALGQYYDDGWGGRTKEAALSEAQKKAE....EKLSQAIEELNRQQNPE-------TFLNAENKASKTAREKAELELEKMKENARIAMRERIMFILANSEENVNHMINRAVGEAYRQTLRKVVLDSG..GRVITD.DNT.GSIINMELE.
A0A840PEF4_9ACTN/1-261 .....MCNPRRVKVRASKRLSQAWQAELERTVALSATV..TGEA..RIIEP..VGAGLAPPVRARLAEILA....D....D.P.DWEKT.E.DG.LRRDVPGG.HLLYHPDTGELEIVATVAAEVSAEGQARRVIGGVAEAEAQVEVTVGYYEDGYRGRTKRVAEREGREQAEgeaeKQAVREAAERAGSEREAAER----RLREQEGALLAEARADAEQALAGARAARQDEVTAGAERRVRELHQGYLGYFNRPLTHAYRDVLLERAARAD..AHNLVY.VED.EGVIKIQFE.
F8B3Y9_9ACTN/1-254 .....MCNPRRVRVRAARDLSDAWEQEVRRQVTRRGQA..TGDA..RIREP..LTAGIGAPTLAALTGVLA....R....T.A.GWERD.G.ES.FRHALDGG.WLSYHPATRELEIVAEAVAEVTASGEASAVVRGQLAETVEAEGEGIYYDDNYGGRTQRYARREAARNAE....RAVDAQVEALLAAARQQAD-------SAEGTAVEAAAAARADAALAEAAAARAEALRREAAKRLVTVGIQGRNIFHQALAGAYRDAILAYARARH..AEGITW.SEN.NGVLDIEFE.
A0A7W7PUM9_9ACTN/1-261 .....MCNPRRVRVRASSRLTRMWQEELSRTGRASAEV..AGEA..TLRQE..FGTLLGAAARRAFETALG....A....D.T.RWTWQ.D.GA.YRLETDGG.TVVYHLDTGEIELTARLSDVVTAEAEVTRTLEGTVRVEATAERTAKYYDDSWAGLSRSVAERTARLEAQ....ERADRDAARQAAREEERARLAGQRSLASQRDEIDAEARAEAERRAAEDAERRREELERDAEVRLREARTDFLRPVHEVLAVAYRDAIVEYARTHG..AQDLRV.DET.DGTLNIQFE.
A0A1V1P6R4_9DELT/1-258 .....MCNPRRIQVTLTRQVQEAWEREVSRAVDISDTI..IGEA..RIRQS..LDDSLGGPAMMALQSLLA....N...gF.E.GWQAD.S.DGnFQHLVNDG.YVVYRPDDRQLEIVATAQQDICETGYSSERLTGSLSAEIETQGEGEYYDDGWRGQTREKAEQNAQEAAE....AGIQNIVRDRINAQADAAE-------QENEGILIQRAQADAQQRLNQRSETLIPELQQRARERLETVGVRGRQVFHRLLAHAYRDALTGLARRQGvaSSDITT.RET.DEYLEIDF-m
A0A1S2PYK1_9ACTN/1-261 .....MCNPRRVRVRASSRLTRMWQEEISRTASVSTEV..AAEA..TLRQE..FGTLLGVPARKAFESALG....A....D.T.RWTWQ.D.DA.YRLDTDHG.VIVYHLATGEIEMTARLTDVVTAEAEVTRTLQGTVEVNAVAEESARYYDDSWGGLSRSVAERTARMQAQ....ERADREAVEQIAREEEQQRLAGQRELADQRDDIDAEARAEAERRAAAGAGRRREELERDAAARLRDARTGLLRPVHEVLAVAYRDAIVTYAREHG..AQDLRV.DET.DGMLNIRFE.
A0A1I1NRW2_9ACTN/1-261 .....MCSARRIRVRASSRLARMWQEELTRTGEASALV..TGEA..TLREE..FGGLLGKAARNAFETALG....S....D.T.RWEWR.D.SA.YRMETDGG.RIAYFPESGELEMTLRLTDVVTARGAAVRTVRGTVDVETTAESSARYFEDGWADLTRESARREAECKAQ....AEADRDARRQLGRRLEEERRSGRRRLAAEAEQLAAEAARDAERRLAGPCRRRHQELSREAARRLADGRTGFLRPVHEVLAAAYRDTVVGYARANG..AEGLTV.AED.DGVISVRFE.
A0A0F5VX00_9ACTN/1-229 ....m---------------------------------..AGEA..TLRQE..FGTLLGAAARRAFEAALG....A....D.T.RWTWQ.D.GT.YRMELDGG.TVAYHLDTGEIEMTARLVDMVSAEAEVTRVVEGTVDVHTTAERTERYYDDNWGNLTKEVAERSARLEAQ....DRADRKAAEQAAREEEKARLAGQATLAAQRTELDAEAREEAERRVAATAEQRREELSRDAADRLADARTDFLRPVHEVLAVAYRDAIVEYARANG..AQALQV.DET.DGMLNIQFE.
A0A545AZL2_9ACTN/1-254 .....MCNPRRVRVRASRTIEDAWEQQVRRQVVRRGTA..TGEA..RVRES..LDATLGGPTLAALAGVLG....R....I.P.GWEQD.G.DS.FRHAVEGG.YVAYHPQTREMEIVAQASADVQVTGDASEVVRGTVSETAEVEGVGTYYDDGWGGRRESDARRDAELDAE....RGLAARARELLDEARRQAD-------LAEGARVEAEAGERADAALAEAARTRAEALSRAAEARLEAVGVQARSVFHRALAEAYRDAILAYARARR..AEGLRL.TEA.GGVIEIEFE.
A0A252E553_9NOSO/1-255 .....MCNPRRIRVTATRQLNEAWQREVSRTVELQEQV..IGEA..RVRQP..LDSTLGTPALRALESALA....A....E.DsGWREV.E.AG.YRYDVEGG.YAIYLVEERALEIVATLEDQIQISAQETRQITGAINTELAAEGEGRYYDDGWGGWTEELAQQQAQTAAQ....QKLDQIARAEIEQAQNQAE-------ATAAADIEAAARTQAQIQLQQLAAERQAALSSQARQHLDTIGLQCRQAFHRILARGYRDAILAYARRNG..AENIQF.SED.NNIIDIEF-t
A0A1H2AJ02_9ACTN/1-254 .....MCNPRRIRVQASRRLAESWNHEVRRQVTLHGEA..VGRA..ESRQE..LGSLLGRPVLAALERILS....A....H.D.GWREI.P.EG.FRYDVDGG.YVVYHLDSRSLQTVAEARTEVSAGREAAARVSGVVEEEVQVEGEGRYYDDGWGGLTEETARRDAGLDAD....RLLDRAAAARIDAARAAAE-------ANTQAEIEARAHAEAQAALAEATAAAEADLERTAGGQLAAVGARVQEAFNVVLASAYRDAILAYARSRR..AQGLRV.SEG.DGVVRIEFE.
A0A2A6RGE2_9CHLR/1-250 .....MCNPRRVIVTLAETVREEWQRTIEARVTAATEV..SAQAtlETQID..LGDELGPIALEELRLLLN....E....GfG.GWQAAdA.AS.YTLTLEHGiTLRYRPDAGHLEVQARLSETVEAAAVAQGAFQGTLDTEIAVEGEGRYYHDNWRGHSEARARYEAERAAQ....ARLAATREELISAAAH-A-------------QAEAQANQAAQARLREAAERQQAILDERLETLLHASEEQVQNAIGNLLGQTYRRAIIRLVQDNG..GQVIQD.QEQ.GAVIDL---v
A0A5N8XFX8_9ACTN/1-255 .....MCNPRRVRVRATRELAHAWEQEIRRRVTRTGEA..QGEA..RIREP..LGESVGAPALAALPAVLA....R....T.P.GWEQD.E.DGlFRHDLHGG.SVVYDPATRELEISARVTATVTASGEAATSVRAEVHDTVEAEGEGMYYDDNWGGRTEEDATRDAHEDLE....RAFAAARGRRMDEERRRAE-------DREGEALDQQAAARADRAYAAAADARTAELRAAAEDSLFAVGVEGRNLFHRALAEAYRDALLAYARQRG..AERLNV.SET.DGVLEIEFD.
A0A0M9ECC0_9DELT/1-261 .....MCNPRKVMIHLTRSIEEAWRRSVEETAQFEENI..CETG..RLSADifLDKEMGQQSLVMLERVLSgefdA....I.P.AWDRD.NsGN.FIQNLDDA.VIRYSPQSHVLQIEARLLENISAKASATQELCGFTVGEVATEVVKKYYDDGWGGRTKEKVEQEARQEAD....RRLDAAMEDLHREQNKDAF-------ADAEKKAQKTAEKKAGEKLAKRITEARAAMREQLQLVLHSAVSTARYEMNTVIGETYRQTFLALVENNH..GKVISD.VKT.GRVIEMELE.
A0A0M8VB24_9ACTN/1-261 .....MCNPRRVRVRASSRLTRMWQEELSRTAQASTEV..AAEA..TLRQE..FGSLLGAPARRAFESALG....T....D.T.RWAWQ.D.GG.YRLEMDGG.AIVYHLDSGEIEMTARLTDVVTAEAEVTRTLHGTVEVNATAEETAKYFDDNWAGLSRSVAERTAHAGAK....ERAEREAAEQIAREEERERLAGQRRLADQRDEIDAEAHAEAERRAVADAGRRREELERDAEARLRDARTAFLRPVHEILAVAYRDAIVAYAREHG..VQDLRV.DET.DGMLNIQFE.
A0A2U3A5Z2_9ACTN/1-261 .....MCNPRRVRVEATREVVEAWELALERRARASDSV..VSEL..EVRHP..FGGTLGQATRQVFERTLI....T....A.D.GWRTE.E.GG.HVLELTDG.RVRYDPATGELVVTARLEDQVTVEGHAAETLRGTVRDRATGSGEGRYYADGFAGRTREVAEREAQQVAE....ADAVRRAQELVGRLRTQASRESTAAAAAAEDRLQQAADDDARARLAEERERVRADLEARNHERITRLGQDGLRAVNGVLATAYQRALLDFARQHG..ATGIRQ.EES.DGGIDIEFE.
A0A7W7I3M4_9ACTN/1-254 .....MCNPRRVEVTATRQLDEAWEHEIRRLSLVSATA..VGEA..TVREA..LDDSIGEPTLEALVGVLE....R....T.E.GWERD.G.DA.FRYALPDG.HVTYHVEDQELEIVVRLSAEVEAEAEAVATAGGRISETLTVTGQGTYYDDGWGDITEDDAARAAQADAQ....RLLDGGRRERLQAEAAAAE-------REHDRALTAEAGERARALLDERLRQRSERLRTEALRRLSAAGILARTTFYQALAQALRDTLVAYARANN..AEGLTL.SES.DGVLNIQFE.
A0A7K2FTI9_9ACTN/1-261 .....MCNPRRVNITATREVVEAWQVEVERRVSRTDTV..VSEV..EVAYP..FGGTLGARTREAFEHALA....S....A.P.GWQEA.D.GV.FVLDLPDG.RVTYRPSTGELLVTARLEEEARAEGRASDVLSGTVSDTAQGAGEGRYYDDDYGGVTYASAEADARRQAE....HAAESQAMRLLEEVRRQARDASDAAAAAADERLRAAAGADAEARLASERERLQGELESRNRERLQQLASDGLGAVNEVLAASYRQAILAYAREHG..ATGIQV.EES.DHVIDIEFE.
A0A1V1NWU3_9DELT/23-257 ikscd----------------------------ISDTI..TGEA..RIRQS..LDDSLGGPALMALQSLLA....N....GfE.SWQED.S.DGnFRHLVDDG.YVVYRPDDRQLEIVATAQQDICETGCASERLTGSLTTEIETTGEGKYYDDGWGGHTKEKAEKDAQKNAE....AGVQHIVRDRLDRQADTAE-------EEHAENLIQRAEADARERLNQRAENLTPELQQRARERLETVGIRGRQVFHRLLAHAYRDALSGLARRQGvaSNDITT.RET.DEYLEIDF-m
#=GC seq_cons .....MCNPRRl+VpAoRplscuWppElcRssphsspl..sGEA..clRps..lustLGsPuhpAhEpsLu....s....s.s.sWcps.s.su.aRh-l-GG.hlsYcP-ot-LElsAcLsspVsApupAspslpGslpscssuEupGcYYDDuWuGhTccsAcRpAppsAc....cphsptAtcphsptpcpAc.......ssppsplpApAcscActcLsptstpcpt-LppcAppRLpsltspshpshaclLApAYRDAlluYARppG..Apslps.sEs.-GllcIcFE.
//
