#=GF ID ivWA
#=GF AC PF19997.3
#=GF DE vWA domain found in the FtsH ternary systems
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF SE Aravind L
#=GF GA 35.00 35.00;
#=GF TC 41.00 47.30;
#=GF NC 27.60 21.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0128
#=GF RN [1]
#=GF RM 32101166
#=GF RT Highly regulated, diversifying NTP-dependent biological conflict
#=GF RT systems with implications for the emergence of multicellularity.
#=GF RA Kaur G, Burroughs AM, Iyer LM, Aravind L;
#=GF RL Elife. 2020; [Epub ahead of print]
#=GF DR INTERPRO; IPR045477;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Highly-divergent vWA domain lacking metal-chelating aspartates
#=GF CC of typical vWA domains. Core component of the FtsH ternary
#=GF CC systems, a class of NTP-dependent biological conflict systems.
#=GF SQ 22
#=GS A0A6M5Z3X1_9BACT/253-477 AC A0A6M5Z3X1.1
#=GS A0A7V8VCM8_9BACT/255-445 AC A0A7V8VCM8.1
#=GS A0A142XFZ4_9BACT/253-496 AC A0A142XFZ4.1
#=GS S9QPG4_9DELT/253-441 AC S9QPG4.1
#=GS A6GJG8_9DELT/40-256 AC A6GJG8.1
#=GS A0A7Y5KSF4_9DELT/255-424 AC A0A7Y5KSF4.1
#=GS A0A518DRI1_9BACT/255-444 AC A0A518DRI1.1
#=GS A0A4V6M1T7_9BACT/253-478 AC A0A4V6M1T7.1
#=GS A0A5S9ISB1_9BACT/226-326 AC A0A5S9ISB1.1
#=GS A0A225E0S0_9BACT/299-524 AC A0A225E0S0.1
#=GS A0A6C2YJQ6_9BACT/258-438 AC A0A6C2YJQ6.1
#=GS A0A848LV13_9DELT/12-208 AC A0A848LV13.1
#=GS Q1D8B9_MYXXD/255-463 AC Q1D8B9.1
#=GS A0A5C1ADP9_9BACT/253-478 AC A0A5C1ADP9.1
#=GS E8R014_ISOPI/295-546 AC E8R014.1
#=GS A0A8E6B746_9BACT/154-317 AC A0A8E6B746.1
#=GS A0A5Q3L8M2_9BACT/271-455 AC A0A5Q3L8M2.1
#=GS A0A517XVN9_9BACT/253-484 AC A0A517XVN9.1
#=GS A0A1I1YB93_9DELT/260-472 AC A0A1I1YB93.1
#=GS A0A2S9XC36_9DELT/259-506 AC A0A2S9XC36.1
#=GS A0A850GL53_9DELT/253-476 AC A0A850GL53.1
#=GS A0A2Z3H199_9BACT/128-299 AC A0A2Z3H199.1
A0A6M5Z3X1_9BACT/253-477 PIGGYTSISTRGSIESLLHSQLAYM.EPE...---.--SPDLFDMKFVRDELFYYSRDENQFLRRRRA..FVFVLFPDLI.....AGRFKD..ADLPCQRIVLVQSAVLALVRKLTEWLSTDAIRFEV....L....FV.Q-........-DG..GKTPLAEEAALLKLLLREPIERGDGEV..TEV..PNRDAVAAHLNRLART.AQ.VHCLAVAT---------.------EPLG----MEMENVIVTELVVSGPRPEIGGGDGVVAELEGEDA--FDVWQETVLRVLQLW..................................................
A0A7V8VCM8_9BACT/255-445 PVGGFASIATRGSMESLLHSQLVYM.ER-...---.-EKPDLFDIKFLRNELLYYSRDENNFIINR-R..VYVFIIDYII.....NLRFKD..FELPYERIILLLSWIVTIIQWLNERLTDEAINFEI....R....FI.KHnsphkyikDTS..SSEERWEEQGWLELLLRDWIER-----..---..----------------.--.-----------------.------------------------------------------------------------------gaarvsvtdsldsvvgelkqwshradvyclymtskeqaekqkkee.....
A0A142XFZ4_9BACT/253-496 PVGGYTSISTKGSIESLLHSQLAYM.EDE...---.--SPDLFDMKFVRDELFYYSRDENQFLRRRRA..FVFVVFPDLI.....AARFKD..SELPYQRIVMLQSTILALVRKLTDWLSTDAIRFEV....L....FVqDG........GKA..---PLAEEAALLRLLLREPIERGDGLV..ATGdrTASGKNTPEQ-EAAER.GTeSREAVMTYLNRLSRNSQvHCLAIAT---EPFDMEMENVVVTELVVAGPRPEIGAGDGAVAALDG--EEPFDVWQESVMRVLQLW..................................................
S9QPG4_9DELT/253-441 PQGGFSSVSNVGSLENLVTSELVYM.EDD...---.-AGLDLFDMRYVEGELLYYTRDESLVVRRRRR..VTFALLPGLT.....EARVKD..AGLRWQRGVLVLGLVLSLVRRLSVWLGEEELRFRV....V....V-.-V........GEG..----LEAERGLCELLLREWLARGHAEV..TVA..DRMESVLTQAVVDAKR.AR.TDVLLLGGREVPP----.------------------------------------------------------------------apsqvglslldvsqpv..................................
A6GJG8_9DELT/40-256 PIGGYSSISTIGGMESLVSSELIYMgDAE...QRA.TGEVDLFEVRWAAGELLKYTRDESVHTRERRT..LSFALCPELD.....RARIKD..PSVPWQRLVVGLGAVVAMVRKLCAWLDAAELHLHLlfvaR....PP.GG........TLG..VPQPLAPESALLALVLREYIEAGTVEL..IDV..EGVQAAWTHAERATEL.GGsDLIWLLGG---------.------------------------------------------------------------------ptaeledaadadelrarvpvsmarssseaseda.................
A0A7Y5KSF4_9DELT/255-424 PMGGYAEMTQSSSLESVATSELALS.ETG...DI-.--AEDPFAVRWAMGELLSYTRDENVAHRRRIS..IWIAVSPDI-.....AARAKTlaRGTPWQRAVLALAAVCLFAERATRILHEEALSIHI....V....LP.QG........---..---WLDEERALLAIKLGA-LIRRGVVE..LHS..ESIDSVPERAA-----.--.-----------------.------------------------------------------------------------------aeeryadvaafeigvg..................................
A0A518DRI1_9BACT/255-444 PVGGFNSISNRGGIESLLHSQLAYM.ETD...--E.AERPDLFDIKFLRDELLYYSRDENQFLRRRQM..FFLVLSPDLV.....EARIKD..AGAPCQRIILLLAALLAAIHKLSDWLSTDALHFEV....V....L-.LT........ENG..-PSPLVEERQLLRTLLHDEIAAGTASVteRTP..RELQ---QTIQQQARR.SL.CHCL-LASTG-------.------------------------------------------------------------------prwldtaaastvalhc..................................
A0A4V6M1T7_9BACT/253-478 PVGGYTSISNRGSIESLLHSQLAYI.EPE...---.--SPDLFDVKFVRDELFYYSRDENQFLRRRRA..FVVVLFPDLV.....TARFKD..PELPHQRIVMLMSSVLALFRRLSDWLSTDAIRFEV....L....FV.QD........PSG..-KRPLAEEATLMELLLREPIERGDGLV..AWL..PDKDAAVAHLNRLSRL.SQ.--VHCLAAATE-PFEMD.----------------LDNVVVTEVVVDGPRPEVGTGDGVVAALEGEDA--LDVWQETVLRVLQLW..................................................
A0A5S9ISB1_9BACT/226-326 PLGGYDAITRKGDLASLVPSELAYI.EE-...---.EEAIDYFDYKYMQNELMYFKREEGIVFRIRRQghLFLVLDHEME.....HER---..-----------------------------------....-....--.--........---..---------------------------..---..----------------.--.-----------------.------------------------------------------------------------------nladlfafvlvfceklfhvfikdimtm.......................
A0A225E0S0_9BACT/299-524 PVGGYSSLSTKGSIESLLHSQLAYM.ESE...---.--SPDLFDMKFVRDELFYYSRDENQFLRRRRT..FAFALFPSLV.....AARFKD..PELDYQRIVMALATVLTLVRRLADWLSTDALRFEL....V....FV.QP........GGE..--KPLAQEAELLQLLLQELIERGAAQI..RAV..PDVAALAAVLTDQARL.SQ.VHCLTLAATP-VDLDPD.GAVV------------------SHLTVDGPRPTLTD------------------------------ghgvrvesdadlpapdhwaelmirvlelw.....................
A0A6C2YJQ6_9BACT/258-438 PVGGFSSISNRGSIESLLHSQLAFM.END...D--.--GPDLFDIKYVRDELYYYSRDENQFLRRRRT..FLFALLPELT.....QTRFKD..PELPCQRGVMMLATLLAAVEKLTEWLGDDALTFEF....L....LI.TE........SDS..-ASPLAHERELLERLLREQIENGTVVI..QTL..SR-DDLAKHCRNRAAR.SL.CHCLV------------.------------------------------------------------------------------tstepyqlhadl......................................
A0A848LV13_9DELT/12-208 PQGGFSSVSNVGSLENLVTSELVYM.E--...--D.EPTLDLFDVRYVEGELLYYTRDESLAVRRRRV..ITFALMPDLA.....DARVKD..AGVRWQRGVTALGLVLCLVRRLSAWLTAEDLRFRV....I....FV.QD........AKG..-LAPLEAERGLCELLLREWRARGTAEV..LTA..PDVDAVLSEASAATKR.AR.VDVLLLDAARQGAHDA-.------------------------------------------------------------------mkadprvglhlldlsg..................................
Q1D8B9_MYXXD/255-463 PQGGFSSVSNVGSLENLVTSELVYM.ED-...---.EPNLDLFDVRYVEGELLYYTRDESISVRRRRV..ITFVLPPDLV.....DARVKD..AGVRWQRVVVSMGLLLCLVRRLSLWLGSEELHFRA....V....FL.HA........HDG..-AVPLEAERGLCELLLREWRARGTAEV..LTA..STLDEVLTDAEARAKR.AR.VDLVLLDASSQVE----.------------------------------------------------------------------rmshpgasrverhvldlsgpsprvrtirdkr...................
A0A5C1ADP9_9BACT/253-478 PVGGYTSISNRGSVESLLHSQLAFM.EKD...E--.--SPDLFDMKFVRDELFYYSRDENQFLRRRRA..FAFVLTADLI.....AARFKD..AELPAQRIMLASATILALVRKLSEWLSTDALHFEL....L....F-.VG........DEG..-KQPLAEEAELFRILLRERIANKTAAV..EVV..ESLAAVGTHCSHLSRK.AQ.VQILQLTADVPM-----.------------------------------------------------------------------aepdgtvltalvidtarprlldgigravpleaedaaeawgrvvrkvlelw
E8R014_ISOPI/295-546 PVGGFASLSNRGSLESLLHSQLAFM.EPP...DSK.TPRPDLFDIKFVRDELLYYARDENAFYRRHRA..TFVLLRTDLT.....RARIKD..PGSPRQRIILLLAFLVATIRAALERLGEESLVFEV....I....PP.LT........EDG..-SDPLDQERLLLARLLRDQIANRTVIF..AAP..RPIPALVAHIDEAARR.SL.VTVWTLGCSDPTPNDPD.APIALGTPLGGSSSVTRDSVIRRRLIVSGPVPLRSQADGSLTTSESDDASVLEQWQHTLREWLNDW..................................................
A0A8E6B746_9BACT/154-317 PIGGYSSISNKGTFESLLHSQLAYM.SPD...RSE.--KPDTFDLKFLREELFYYSRDENIFLRQRRK..FIFVFAEDLK.....NARLKD..DGAPVQRLILALALVDAILQKLTERLAQDALHFHL....L....FL.RS........EEP..--LELQPERELLQILQRDGIQRGAVQL..---..----------------.--.-----------------.------------------------------------------------------------------eevapnllnekilnlrkei...............................
A0A5Q3L8M2_9BACT/271-455 PTGGYASLSTRGSIESLLYSQLAYM.E--...--K.EERPDLFDVYYLRNELLYYSRDENLFFRRRIR..FYWVFHPSLT.....ETRRKD..RELPTQRIILLCALLRAAWLLIQRELGKEALALDF....I....FL.EP........NNSihHTHPLSLEYQLIQQLFQSDLERGDVKL..QML..----------------.--.-----------------.------------------------------------------------------------------seeslrrnltatrksevchplwltcekiaeqesmr...............
A0A517XVN9_9BACT/253-484 PVGGYTSISPRGSIESLLHSQLAYM.EDG...RGR.D--PDLFDVKFARDELFYYSRDENQFLRRRRA..FVFVLLPDLVtspqhSARFKD..PELPVQRIVLILSLLQAVVWKLDEWLSTDAIRFEV....M....FV.--........QDA..GRKPMAEEATLCEFLLRPNIARGVAAV..RHV..ADRAEAGKALAELART.AQ.VHALVVGTRKTEL-VAD.AALVTGLVVGGPV-----------------------------------------------------ptlradpapvsleaatpfehwqealrrvlqlw..................
A0A1I1YB93_9DELT/260-472 PAGGFDALSTRGRFENLVRSEVAYV.DSG...REE.LGMIDLFDVRFAQGELLYYTRDESPLFDQRRR..VTVVIERPL-.....DQRHKH..PELDAQTLVLVDATTLRLQADMMQVFGPSGAELHL....R....WR.TG........GKA..DAEAAEEEARLMAMTLADDLAHRRVTL..ATM..TDWQEAPPRG------.--.--LVVFAAHQEDPRAGA.RAWV--------------RVGEPRWVLDGESFAVGEPGGLRALLDA--------------------lllrl.............................................
A0A2S9XC36_9DELT/259-506 PIGGYASLSTSGGIESLVSSELIYM.NPP...EERaAGHVDLFDVRWAAGELLKYTRDESVHTRERRT..VCFVLGPALD.....DARIKD..ADVPFQRIVVAFGGVVAGVRKLCAWLDEAELHLHL....LlvgePA.QG........GRP..TKQPLHAEAELARLLLREYIESGVVEL..VEL..ADVEAARTHAEAAAQTgSS.DIVWLLGARWQPPPPPA.KPAAKADSAVREHALSVDEARPRVWVDAG-------------------------------------sgteerslqvdgwdawlrafaellea........................
A0A850GL53_9DELT/253-476 PIGGYASISTIGGIESLVSSELIYM.DPPaapDTA.RSSVDLFDVRWAAGELLKYTRDESVHTRERRS..VLLVLGPDLD.....LARVKD..PQVPWQRLVVLLGGLVAGVRKLCAWLDEAELHLRF....LllpaPP.AP........GVA..PGSPLAPDAALCRLILREYIESGVVDF..IAL..DDADALQAAAEQAVEL.GG.C----------------.------------------------------------------------------------------dliwlsqgstpapsplpgarqhslslasveprlaldrgagpepqtl....
A0A2Z3H199_9BACT/128-299 PVGGYTSISTKGSIESLLHSQLAYM.EPE...---.--SPDLFDMKFVRDELFYYSRDENQFLRRRRA..FVFVLYPDLV.....TARFKD..ADLPYQRIVLVQATILALVRRLTEWLSTDAIRFEV....L....FV.QE........G-G..-KNPLTEEAALLKLLLREPIE------..---..----------------.--.-----------------.------------------------------------------------------------------rgdgevlelpnqeaiekhlgtlsrsaqvhclavaae..............
#=GC seq_cons PlGGYsSlSs+GSlESLlpSpLAYM.Est.........psDLFDl+alcsELhYYoRDEN.alRRRRs..hhaVLhP-Ls.....sARhKD..splPhQRlVlhhuhllAhl++LscWLus-uL+Fcl....l....hh.ps........spu....pPLstEttLhclLLR-.ItpGsstl..hth...shtth.tphtt.sph.u..s.hh.hs................................................................................t..............................................
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