#=GF ID   m04gp34like
#=GF AC   PF12216.12
#=GF DE   Immune evasion protein
#=GF AU   Assefa S;0000-0003-2178-533X
#=GF AU   Gavin OL;
#=GF SE   PFAM-B_2496 (release 23.0)
#=GF GA   25.00 25.00;
#=GF TC   25.30 31.40;
#=GF NC   23.10 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10644360
#=GF RT   The putative natural killer decoy early gene m04 (gp34) of
#=GF RT   murine cytomegalovirus encodes an antigenic peptide recognized
#=GF RT   by protective antiviral CD8 T cells.
#=GF RA   Holtappels R, Thomas D, Podlech J, Geginat G, Steffens HP,
#=GF RA   Reddehase MJ;
#=GF RL   J Virol. 2000;74:1871-1884.
#=GF DR   INTERPRO; IPR022022;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This protein is found in archaea and viruses. Proteins in this
#=GF CC   family are typically between 265 to 342 amino acids in length.
#=GF CC   The proteins in this family are or are related to the m04
#=GF CC   encoded protein gp34 of pathogenic microorganisms such as murine
#=GF CC   cytomegalovirus. m06 and m152 genes are expressed earlier in the
#=GF CC   intracellular replication phases of these microorganism' life
#=GF CC   cycles. They function to inhibit MHC-1 loading and export. gp34
#=GF CC   is theorized to prevent immune reactions from NK cells which
#=GF CC   would ordinarily recognise and attack cells lacking MHC.
#=GF SQ   12
#=GS H2A247_MUHV1/22-176  AC H2A247.1
#=GS H2A238_MUHV1/3-279   AC H2A238.1
#=GS H2A242_MUHV1/3-259   AC H2A242.1
#=GS H2A237_MUHV1/28-329  AC H2A237.1
#=GS H2A235_MUHV1/9-258   AC H2A235.1
#=GS H2A234_MUHV1/15-301  AC H2A234.1
#=GS H2A245_MUHV1/1-206   AC H2A245.1
#=GS H2A233_MUHV1/5-253   AC H2A233.1
#=GS H2A239_MUHV1/4-219   AC H2A239.1
#=GS H2A240_MUHV1/1-272   AC H2A240.1
#=GS A3R008_MUHV1/8-320   AC A3R008.1
#=GS H2A241_MUHV1/3-270   AC H2A241.1
H2A247_MUHV1/22-176             .......................rsdkmtvnimlffalflhrflclaakcrtyefdigfd-----------------------------..........................--........---------------..........-NC.TENDGG-.....TSRRQS.GS-ECIFSCNIDT.TICVYASWYATWVVsSSGTQY......VLGFVSYTSSSTSGATFTALWTNDTDTRPRL-....-----TTGNLRLDNKTGKVHLSPCTS-..-...-GGYSIECHMTVCR-....-------...---.........-------...-----------------........................------------------....................-----------------------------..........----------------vsatpf...............................................................
H2A238_MUHV1/3-279              ......................................................gytgdt-------MALMVLCVWLAYVFSVESRANG..........................CD.......pS----LAANYSNLTQ..........GQC.VTIKGV-.....---KND.TEG-RSYSCRTD-.AICIPASWEGTWLV.DGWPLP......--LGVYFKSSNSSPPLFSMTFNQTQPNTTP--....--PTINSTDYTLDPTSGRLIVSSNLTR..-...--SVSVTCKLTVCRQ....TDGYGPKpppRRP.........KKRTTTV...LPTTTSYTTLSVTHTSTirklittrqatesptvnhtspiptS----------------SrvnvsvdsntddettgsmerQKRSNMIAIVMLVCFSFGACVLLVGLAYY..........YGLFDDTQS-------hahgh................................................................
H2A242_MUHV1/3-259              ............................................................HRYLGRSLFILVIYFVALSISRVTPAAR-..........................APap....ktNNCTKFSYPGV--DP..........GYC.TERRDM-.....TKINTF.KNGTKVYSCPLQ-.TVCINARLSGIWCVnNSAVGS......----LFFTSTSTSPPKFQGLTGTPRP------....------RPGLRIDPGTGYLYVYPNAT-..K...RPEKEIYCTLTICITa..iTTRRPTT...TRS.........SRGVSTG...ISTTGLWTDETS-----........................---VVFPFGSADENFGVSa.................spQTASSGTIAAIVIVIAICVGLVVLAVLYYrgyighsrrlNLYRERLRARFLVSH-s....................................................................
H2A237_MUHV1/28-329             .....................................lvtvlasmtfqmgesliippiip--------EFSSFMMNPLPIPQIIPPSTNetkesyv...........kteepivgCNvs....rtEINRLKNQMKKIPNT..........FKC.FKKDGVR.....TSLDMQ.TTGEKRFACEIPN.NVYVNATWYVHWVV.GKIAAS......VSPIVYFTSTTSSPPTLDGNMHPFYQ------....RKIVTAANGFKVDEKTGDITVARSNA-..-...SLADSVRCRLIVCLW....TKNDSIS..dLPD.........DDPQMKN...MSGVIKLPDYSGPDTLL........................T--VPFDYAAWRQRMRTEmee..............psrRRRQLLLVISVIASLLWLAVGAMLFYTYGre......plAKLLKRYGKRLAAVR-i....................................................................
H2A235_MUHV1/9-258              ............................................................MSLASHLPLVALFFLPY-ILMIYASNDQ-..........................CK........ADDKVLKELLS-RHQ..........VGC.WYKRAD-.....TTISTS.GSE-TILSCTLP-.NVYVNATWFTEWIM.ERISAS......ANMRSYYVSSTSSRPTFKKTELLSVYKGNGRR....TKIVGPKEGFRVNDTNGNLHIYPNAS-..Y...SDTGSVICHLLICAW....TYNKDIC...---.........KEDIFKN...LSNVLSLPDYGVPSIE-........................RSRIDYDSTTKSPP-DVT....................-----VTALSVIVTLLYVAAFCVLAYVFG..........PSLCRRFFTNDCCSTF.....................................................................
H2A234_MUHV1/15-301             ...........................................................s-SPSVRVSLRSAWLFWSFVLCVVTSYVCEssan..................anqwCSglndtihkKLEEINYMN-----Mks.....svqLGC.LSPRRIT.....DVSLMI.HNNVTKAYFTLPStGIYVNATWLFEWIV.VPLLAL......VGETGCYTSTTSSIPRMLTKFTSPIFSSYNTSgtriIRTVGLNDGFKIDSSSGELHIFSNASVvaN...ITAKDILCILKLCTW....KLSDSMI...SVN.........DTTLNNN...LSTIISLPIYNESAALS........................DTQSRHNYGISQRHVT-Rr..................sNTAVLVAVLVFIIVTLFVAA--IFGYFYR..........STLVRHLS--------glttlq...............................................................
H2A245_MUHV1/1-206              .....................................................mrrlgiv------------IV-IASFLSAVESTETE..........................CD........T-------YNVTIKP..........ETCdFFDNLYEv...rVRVDEK.DTNRVHYSCQFKW.NICTQATWYGTWIR.MSFDEEmnpsprVLAHVQLMSTPTSPPTLVGFWNDSSSNKQYVL....SHN--SSAEIWQDPVTDNVYISSQVS-..-...SNQLGLICQLTGCLN....SKMDETY..pA--.........-------...-----------------........................------------------....................-----------------------------..........----------------farekietqtaiaiakpadkqselasqslakptss..................................
H2A233_MUHV1/5-253              .................................srwcasrprgvcrlrvlllvcaamfpv----------------------VSS----..........................--........-----------VPLP.........kIYC.YSKNATVarkpaRDRDYW.TPSVTVLGCRIPK.GVCIEGDWSIEWVI.HSMDAV......VIYQALFRSTAWLGPSMQRLILAMPK------....RRLVGCGQGFCVDRADGNLIITDNDTRkdEwarKPPRDAVCKLKACLT....ATSVPMS...SRL.........YEGCDGN...LTEYLNLPDYENWFGTQ........................NVVQDVPPVVGCD-----....................NPALNTAVIAVGVLTVVAFVSVV------..........AYLCRSAESRQLTW--ev...................................................................
H2A239_MUHV1/4-219              ..........................yldlsqflllavivtesvvlsmicdtnahsdlpq-----------------------------..........................--........---------------..........GKC.TILSKTP....vRNDSNL.GVDGWGYECPLG-.DICIPASWQVKWYI.GLYQM-......-DTGGFFRSSLTKPPTFQGLSMYVKD------....-KTNARPDGFAIKDEDGRLIVTVDANR..-...--PFTLGCKVTVCKR....E------...---.........-------...-----------------........................------------------....................-----------------------------..........----------------pdygpateepttaersttepvpipttqrittrsepqttarpttrptttvspttrptttvssttrptttv
H2A240_MUHV1/1-272              mklffsshlyflifaviaakslitsaapcdtardmafsstvtpghcrsivvtlkdlyglg-----------------------------..........................--........---------------..........---.-------.....------.SSSTWVYKCEFP-.IFCINATWRVEWLL.NKSP--......INVSVLYESTTSTPPRFKQLITNNATTR----....----PPPTGFEINRDNGYLYIYPDAG-..-...-NNFYLSCTGFVCVPpkpiTTTPSTT..rSRS.........STETRTT...RSGTKFIPHKITPSGSQ........................PVSPQVDDTTQLDI-DTAiiva............saemQTSNTPTAIAVSLVVIVVVTVIVLGLLYHygflgkwallDSYVDRFRVRF-----mgnt.................................................................
A3R008_MUHV1/8-320              ............................................................CTVMWRSVLVFLLFSSSWLTTSGDSPHRSrrpplqspksgittwiggssrtrfpsA-........----SFDNYKTTVSGkhpfspwksiSKC.FNSKDATp..flKKSVNQ.KTGDKTFTCMPAE.NVYANASWRIEWVL.GNGTTW......LTPAIRFVSTDRLPPTFNGTLSVAYSTRLLYTd.ekDNQNANNTGLYVDKSG--LHISSAVRAdlV...KDVHDVKCTLSVCLW....TDKISLY..nTSDgyvethvevDPIAVAN...LSIIATLDDFVYPLGYPm.....................eyTKKSAYSWPSETSQPQMS....................-MSVFFGILSVYIVLIIGEVYICLKCHYN..........---HKHESAADVAVEY.....................................................................
H2A241_MUHV1/3-270              ..................................................vspdrllqls--------------LVLAVFASPRVASRK..........................CD.......pVIS---KSYSSRTPP..........GTC.TGASVYL.....EIISKShSTQTWKYECQLP-.EACIEATWQVKWTV.NRIPMN......--ATALYNSTDSSLPKFDKILVINATT-----....---KPPPKGFTVNPHDGYLYLVSSPD-..E...TVSVHLQCEGFVCLP....NKTIHVT...TNP.........PTTISRTkrdTTKFISLSSRSQPVTRQ........................----ATDTTVSNTASSTDnaviv..........anaemQTSNTTVAIVVPLMVILVATVVVLGFLYHygflrkwallD---------------sylarvrghfttsd.......................................................
#=GC seq_cons                   ...........................................................s...................h..hts..p...........................s..................................htC.httpsh......pp.sp..ssstphasCpls..slClsAoW.scWll.sphst.......h.htshapSTsoSsPpFpthhssshsp.............ssssGaplDsssGpLalsssss........sshslhCpLplCh.....spp.shh...t............p.h.ts...hothh.hsph....h...............................hs.s........t......................t..hhhlsh.lhhhhshs.hhhhhha..............hcp...............................................................................
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