#=GF ID pEK499_p136
#=GF AC PF18736.5
#=GF DE HEPN pEK499 p136
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Burroughs AM;0000-0002-2229-8771
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF SE Iyer LM
#=GF GA 26.60 26.60;
#=GF TC 26.70 30.30;
#=GF NC 25.90 25.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0291
#=GF RN [1]
#=GF RM 23768067
#=GF RT Comprehensive analysis of the HEPN superfamily: identification
#=GF RT of novel roles in intra-genomic conflicts, defense,
#=GF RT pathogenesis and RNA processing.
#=GF RA Anantharaman V, Makarova KS, Burroughs AM, Koonin EV, Aravind L;
#=GF RL Biol Direct. 2013;8:15.
#=GF DR INTERPRO; IPR041318;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC pEK499_p136-like HEPN [1].
#=GF SQ 37
#=GS A0A1I2RA25_9GAMM/1-153 AC A0A1I2RA25.1
#=GS N6Z3F6_THAL4/1-145 AC N6Z3F6.1
#=GS A0A069CYH3_9BACE/1-65 AC A0A069CYH3.1
#=GS A0A4U8Z335_METTU/1-130 AC A0A4U8Z335.1
#=GS A0A1Y2R4H7_9BURK/14-155 AC A0A1Y2R4H7.1
#=GS A0A374AI62_9BACT/1-148 AC A0A374AI62.1
#=GS A0A4Q1ZYU8_9FIRM/1-73 AC A0A4Q1ZYU8.1
#=GS A0A848BVX9_9FUSO/4-151 AC A0A848BVX9.1
#=GS A0A086YJB8_9FIRM/1-162 AC A0A086YJB8.1
#=GS B8EIW9_METSB/10-154 AC B8EIW9.1
#=GS A0A328YDF3_9FLAO/3-181 AC A0A328YDF3.1
#=GS A0A2S8ST27_9BACT/2-153 AC A0A2S8ST27.1
#=GS A0A1X4G5T8_9CYAN/2-112 AC A0A1X4G5T8.1
#=GS A0A1D3RLG4_9BACT/20-175 AC A0A1D3RLG4.1
#=GS E4U0N6_SULKY/5-154 AC E4U0N6.1
#=GS A0A495RH88_9GAMM/5-145 AC A0A495RH88.1
#=GS A0A0Q0VJ72_9SPHI/1-66 AC A0A0Q0VJ72.1
#=GS A0A2C8F475_9DELT/1-157 AC A0A2C8F475.1
#=GS A0A1E2UTC2_9GAMM/1-154 AC A0A1E2UTC2.1
#=GS A0A083ZVV4_9GAMM/1-154 AC A0A083ZVV4.1
#=GS I4AJ14_BERLS/35-184 AC I4AJ14.1
#=GS A0A553DMT7_9FLAO/1-176 AC A0A553DMT7.1
#=GS A0A517SIK1_9PLAN/1-153 AC A0A517SIK1.1
#=GS A0A4R1N501_9FIRM/25-162 AC A0A4R1N501.1
#=GS C0GIJ4_9FIRM/1-136 AC C0GIJ4.1
#=GS F8X101_9BACT/3-178 AC F8X101.1
#=GS A0A071M259_9ENTR/1-154 AC A0A071M259.1
#=GS A0A4Q1CLS2_9BACT/1-176 AC A0A4Q1CLS2.1
#=GS A0A0D6TRN0_9FLAO/21-170 AC A0A0D6TRN0.1
#=GS K6U930_9CLOT/29-185 AC K6U930.1
#=GS H7EJG1_9SPIR/4-163 AC H7EJG1.1
#=GS A0A368JUB5_9BACT/1-155 AC A0A368JUB5.1
#=GS A0A2V1GVV4_9GAMM/33-171 AC A0A2V1GVV4.1
#=GS H8KXM8_SOLCM/2-154 AC H8KXM8.1
#=GS A0A7G1G6B7_9BACT/38-175 AC A0A7G1G6B7.1
#=GS A0A498DNF5_9PROT/1-154 AC A0A498DNF5.1
#=GS A0A7U6KEL2_9FIRM/3-181 AC A0A7U6KEL2.1
A0A1I2RA25_9GAMM/1-153 .............................md---YENVVRDFAKRTRKNLEYIEQGkk.......egnEVYEITHLINSCLGLLVLPHE...........NYI-NSIPTTSLDKLK..DQGWVVPQTI.NG..T---......................QPNDLKD.....LIRLLRNGVAHCNIA....FTADSESKL..DTLK......IWN.tQPRSGEK......TWETE......LGFEELRSILFKFSDLILEHSE--hd.....................
N6Z3F6_THAL4/1-145 ...............................MEYDPDFARSFMERTLTLATEYE--............GPLDATLLINCLLGLLVVPKE...........ALLIEKIPSTAFASIA..--DWGISPTS.IM..SFGKcdq................gheHQPNLKQ.....LVRRLRNAVAHFKID....-PVHRAGRV..TAFS......FRD..-----RN......GFYAV......IPLEELKEFVAFLSKYLHE-----na.....................
A0A069CYH3_9BACE/1-65 ...............................-------------------------............---------------------...........----------------..----------.--..----......................-------.....----MRNSIAHHNFT....ILKNENEEI..GSIE......FKDfpPRTKSTK......TFELT......IEIKPLKKFLLKFSEEMIRIM---eaa....................
A0A4U8Z335_METTU/1-130 .............................md---YESLLYDFADRTRHNLEVIQQAke.......kgeCVYEVTQLINSLLGLLVLPNE...........RFT-DIIPKTPLSELV..--EQGWPVPS.VS..GEFR......................EATDLRE.....LVRYLRNAISHFNID....FHTDSKSAL..SGIT......VWN.cETKTKK-......-----......------------------------rygklv.................
A0A1Y2R4H7_9BURK/14-155 ..............................m-SFNSNFDRAFIDRSLQLVQEYT--............GPHDATLLLNCLLGLLIVPKE...........SCL-ASIPKKPIEDLA..--SWGISPSA.IT..AFGRadr................edeDPHNLRG.....LVWRLRNSVAHFRFR....-PEPEDGEV..VAFH......FHD..-----KS......GFKAT......VQLSELRIFVERLAKH--------vre....................
A0A374AI62_9BACT/1-148 ...............................MEYKNIFEIEFIQRTQEIVNGYQ--............IPFENTLFINACVGLLIIPQQ...........SLF-NHLPTEVVSADK..---WGIADTD.IS..CIKE......................PNKSVKN.....VARHIRNAIAHDGIR....FGSDNGKDI..THIKi....tDWK..DERHKTE......TFKAV......IEVTKFKTFVWAFAQFALTQQS--lf.....................
A0A4Q1ZYU8_9FIRM/1-73 ..............................m--EYKHFGYDFIERTTELIKSTASI...........yEKYDVTYLLNCCFGLITIPRE...........TMI-KQIPKIDLKTAQ..FGE-------.--..----......................-------.....---------------....---------..----......---..-------......-----......------------------------invekisks..............
A0A848BVX9_9FUSO/4-151 ..........................pitkv-------EQEFFKRTFKLAERYK-E............FDYDVTFLINCLYGIIIVAQS...........NFY-SSLAFKFGKNIE..---GVNYKKN.GE..EVEL......................RNVKLRH.....LLTIFRNSLAHFGDM...rEGENYGRDN..IKFEstplneIGK.iKFKNKSG......KAEIE......FNS---------------------skslflfieeleklfk.......
A0A086YJB8_9FIRM/1-162 ..............................m--EYETLERDFITRTLKIICQYEKNip........kfEQFEVTLLINCLVGLLILPKE...........RFY-KKIPNTPINQLK..--DWGLRADH.II..KPGMekrsl............keltiEKLTLKE.....VVRRMRNSVSHFKLEvrgdGNEITHLVFsdQHIV......FSD.qHKLKKKD......VFEAV......IPVECLKTFVTKLAQS--------v......................
B8EIW9_METSB/10-154 ...........................vimr-------------RSMANLAFVETHag........paGPYEVTQLINTFLGALAHPFE...........AMR-DDLMALPLADAA..VLGWPTINKE.RP..SDR-......................EPASLGD.....LIRLMRNGMAHGNLD....YLSDGKGQI..HALR......VWN.tHPRTGAR......TWGTV......VPIADVRRFLGLFVDLIE------rrhsd..................
A0A328YDF3_9FLAO/3-181 ............................ypt---IDKFDIKFIERTKQNVKEFD--............KTNKFTHLINSLVGLIFIPNEfhk.....kgrRTYKVDFLNSFISNYP.eLEKIFTGEVT.IE..N--ElgnqiiqnkffyrdnkgnqrtiYNTELGE.....LVRLFRNGIAHSNII....-PVSEGNYW..KGIIv...knFENktKEKNNDF......NFETF......LNQKELRVFATLIADEYLKNI---q......................
A0A2S8ST27_9BACT/2-153 ...........................nydh----EKLLADFADRTLHNLQLMREIqkt.....qpeaKAFEVTQLINSLLGLLVFPKE...........RYL-DGIPEKTWEQLK..AEGWLIPNVR.SG..C--E......................PPPNLKE.....FLRLMRNAIAHFNIE....FLPDQNNEI..AGIR......VWN..-KNRGVK......NWEAE......LNLEQLEDIALRFVNIL-------ketk...................
A0A1X4G5T8_9CYAN/2-112 ..............................i-------------------------............-----------LYGLFVLPKE...........-FWENHLDKSNFFSES..--GFVFNSKG.TF..TMYR......................PNNDIDNv...qFLRKLRNSIAHSNVN....--IDK--DT..GYIR......FKN..FNKNRDC......DFEVT......NNIPGLAKFVEEISGFFID-----enni...................
A0A1D3RLG4_9BACT/20-175 ..........................sdars-------KKEFIESSKNVVKKLKIVppkdt..nnnvwPFFNSSWDAYHLYCLIVVPKEl.........yGLRNDDPFYQKLKAKK..---IFRNFNI.IK..SEKS......................PIDNLEY.....HFRSLRNSISH--VN....FSIGNDSSY..TMWD......HLP..-HKKELE......HWRVK......ISKPNMIIFFEEMADSLF------diyner.................
E4U0N6_SULKY/5-154 ..............................p-EEKSEFIREFFKRTLHNLHIYLEDqqn.....skfrYPYDVTQTINSFLGLIVFLQD...........SDI---VFTQELEDFV..-EAHLPIQWT.CF..DGNNg....................lEEHNFRN.....YLKRLRNAVSHRKIK....SIPDQNNEI..MALE......FRD..--GKNGG......CFCAK......LSVESVNLL---------------itllsrnilg.............
A0A495RH88_9GAMM/5-145 ...........................vtey----SNGNLDFIQRTLDILERNK-D............EKYNVTLLINCCIGLLVVPKE...........AFF-DNIKTMALSQFN..-----IDTAH.LT..-AKN......................KDKNLQS.....IVRRMRNGITHFHLD....-FESRDNEI..NKIT......IKD.rPSPDREF......DFEIT......FEIKELKDFLLSLTSYLI------khh....................
A0A0Q0VJ72_9SPHI/1-66 ..............................m-------------------------............---------------------...........----------------..----------.--..----......................-------.....----FRNSIAHQNIT....-PVAEGDEW..QGII......IKN..-YRNKTDtangffNFEAF......LNQKEVRLFATLIADEYLKNA---q......................
A0A2C8F475_9DELT/1-157 ...............................MGMYEGLLRDFAVRTKANLEYIDEAwelqeregledrRVFNVTQLINSCLGMVVFMSE...........NGIAPNIPIQEFCPEM..--KFITRLDV.RN..----......................SNRNLNA.....FLKRFRNAISHCHIE....-AYGTETDI..EGFN......LWD..GPPNGAI......NWRIE......MNTASIRALALALVGLVEDNYPP-n......................
A0A1E2UTC2_9GAMM/1-154 ...............................MGNYKDFEQDFVMRTMMLIDQYNEEiipk....kpfhEQFNYTLLLNCLLGLIVMPKE...........KAL-TAIPTDRLTKKF..KQSMGLENST.LP..G---......................AETSLRQ.....LLIKMRNSVAHFDFE...vVSTDENMLF..DIVK......FKD..---TESK......DVFAS......FKANEIYPFLQFYTDCLHRNIP--ni.....................
A0A083ZVV4_9GAMM/1-154 ...............................MGNYSDFETDFIERTLALIDQYNAMieg.....kpfpEQYNYTLTLNCLLGLIVMPKE...........RAV-SYLPSDRLTLKL..KAEIGLNQSQ.LP..G---......................EEMNLRE.....LIHKMRNSVAHFCVQ...vESISDARLV..DQIV......FKE..--THGAG......RAYAI......FSAPELLPFLKYYAALLLANMRS-h......................
I4AJ14_BERLS/35-184 ndydnrnmryylqeiadiqkeeeytehllhs-------------------------............-----CVILPKLLAWTLLREQ...........DAWKNIIPNKNDTVYS..-KDWKINESCsIN..FANE......................KNKNLVE.....LFSRIRNSIVHYRFK....----LDSEV..ENIT......FED..YRTDGSN......KIIMK......LN----------------------llyfnnemlfphimkvekwiien
A0A553DMT7_9FLAO/1-176 ...............................MSSIKNYQIDFVNRTKKLLSENFEDf.........knRDLESTLLLNCLLGLIVVVSEnek.....ngnKSLKGKIDESFLNFIPqkIGFLIKSQHK.K-..---Dlteieltni...qtevghrndlTKFEKLW.....FVNKIRNGIAHQNIE....-GINENDLW..IGIK......LWN..TNNEKTK......DFEVI......FTMEELKKLALKIAEDYI------isitk..................
A0A517SIK1_9PLAN/1-153 ..............................m--YYEDLVKDFAKRTQRNLAVIRERra.......agdEVYDVTQLINSMLGLLVLPKE...........HYY-DRIPQTPLDELR..--DAGWPAPV.VT..GEMP......................EPKDLRK.....LMALLRNSIAHCNMT....-FTERGGRI..TGVEv...wnTKN..GKKDGER......NWTAL......LSLQDLESITDRFTEVIL------slps...................
A0A4R1N501_9FIRM/25-162 ....................qhknnkdikls----------------EILEKINKDe.........hhYFWNQYQMLTSLTAFIVIPKE...........TFW-NDVSDIELSKLS..-ERWGLRNVS.SK..---Y......................ADMKLKF.....FLRKIRNSISHGNIE....----IDKTV..FIFK......DKN..-PDTSKY......DFIVN......LTYDELSKFVQAFARYIM------tsdi...................
C0GIJ4_9FIRM/1-136 ............................mer----QVVEKDFVARTMHILENYD--............GPYGVTLLINCLLGLIVLPRE...........RGF-NRVCHQEGIGFS..--DLGIDPQE.ICwgRIAE......................QEQTASR.....FLQCMRNSVAHIKIE....-SISEQGEI..ESLR......FKD..-----QS......GFEVV......MKIEKVKELATKLAQY--------vq.....................
F8X101_9BACT/3-178 .............................sp--SIQYFDISFIERTLENLKKYE--............GKYDFTMLLNSLLGLLVVPNEyni.....akkRRFKYPFLNEKISKFS.sIKEIFKNKSY.SF..LDKDkkeinqykfr.wlddnknvltiNNITLES.....FLRRIRNGIAHFGIT....-PVKEDSLW..IGII......IRN..-YKNREM......NMEVY......FEEDELRTFALFIAEKYLETVVK-k......................
A0A071M259_9ENTR/1-154 ...............................MGNYYDFETEFVQRTLALIDQYNIMieg.....wpfpEQYNYTLTLNCLLGLIVLPKE...........RAF-TFIPSTRLTQEL..KAEMGLHQSQ.LP..G---......................PEMNLRE.....LIHKMRNSVAHFCVQ...iESVTDEHLV..NRIV......FKE..--ARGER......DGYAT......FSAPELLPFLKYYASLLLNNMGH-r......................
A0A4Q1CLS2_9BACT/1-176 ...............................MSEIKNYKIDFVTRTKELLNDNFADf.........ksKDKEVTFLLNCLLGLIVNVSEnek.....kskLTFNGKIDHAFISLLP.dKVGFIIKKRH.SE..DLTDervek...........ietkigHKSDLKSqdkfwFINKLRNGIAHQNIE....-GINEANKW..VGVK......LWN..-TYNEER......DFEII......FTVDQLKSLALKIADDYLTKH---kpt....................
A0A0D6TRN0_9FLAO/21-170 ..qfqeeleknpsktiseffndfcnepfpgs-------------------NKCNFY............QTKNQGTIIILLYGLMVIPKEi.........wE--------KTNTNFP..--FKTKEKFT.FN..PPTD......................TNISTLE.....FLRLFRNSIAHA---....-NFSLDTNT..EKWT......FWN..INRSNIK......NFEVS......VKHFDLGLFTAEIGKYYLNDVRP-k......................
K6U930_9CLOT/29-185 ..............................t-EEGEVYIRHFYDEHIKHACEVESD............TSKSLSVILGYIYCSILYTKE...........SLF-NLLPDICLNSEE..-NEWGIRVAE.SS..KSNY......................PNLSLKY.....VVKKIRNSFACRSFKinihENITRDKVF..KNIKm....vFYD.iNPNDRSD......MFEIE......LSIDELVDFVKKFNSEICKNYEI-s......................
H7EJG1_9SPIR/4-163 ..............................e-KLSENYAKEFISRTETILSQYNEIvatkleaehresEFYDVSLFINCLYGLLMMPSK...........--LNKSVLEKYENATD.fLSEHGFSDAI.FF..TTEP.....................kREINLEE.....FVRSIRNGMGH---W...kEDEIEKLKN..QGFD......YEP..--KTEGA......LIEKI......IIHGSFGYKSKTILTTTVLNIAS-e......................
A0A368JUB5_9BACT/1-155 ...............................MGNYKNIETEFIERTLELISQYDEKmqs.....ldfeKQFNHTLLINCLLGIIVLPKE...........KTI-SYLPTDRITEDL..KREMGIGNST.IN..K---......................DITDMRS.....LIVGLRHSISHFDIQ...fNSNDDDFLI..DKIV......FLD..-NKRSSN......YIVAT......FLSEELLNFIRYYGGWVVHSIN--kn.....................
A0A2V1GVV4_9GAMM/33-171 .............klreildqlyapyekves------------------------Dyr.......nnhSFYNQYQFISSLYTYIVLPKE...........SFF-DSIPDDIETNSL..KTQWGINKLQ.PS..----......................--YKLKY.....FLRRLRNAVSHGEIE....-----FTET..IDFI......FTD.kNPRNKSD......VFQVK......LSVDELMNFTQALAY---------wcmtkdie...............
H8KXM8_SOLCM/2-154 .............................gi--ENGRYDIELIKRTKKLIETYD--............GVFNLTLLMNSVLSLIVLPQQh........nsRIRKLAFMNQNLDEIP.eINFVINSPHF.QF..DPRN......................FNYDLKN.....LLNRIRNGISHQRIE....-AISEDNKW..KGIV......IED..YDRNNNL......GLHLE......LTTSQVRNLAFYIAEKYLEEVGE-l......................
A0A7G1G6B7_9BACT/38-175 .....................dlkfkdrfvh-------------------EQIKSI............GIMNNGMIPVILYMMLIIPKE...........-LFDNTKYSENFKEINkqISNLKNIEII.KS..TYKS......................DEKNINY.....-IRHFRNAVAHMNIK....----CEK--..TVVV......FED..--KNKKE......NFKIE......VSYKALGEIVGFFYKFYAEL----ieeykek................
A0A498DNF5_9PROT/1-154 ...............................MGNYHDLESEFIERTMRLISQYYETldr.....yvfeEQYNYTLTINCLLGLIVMPKE...........RVM-PYIPTIRLTTEF..RKEIGMEHSE.IG..T---......................GIVTLRD.....LVKGLRHSVAHFAIN...vISEDDRNLI..DWIE......FKD..--TQNND......LLIAR......FKSSELQAFLKYYSGCLLENLER-n......................
A0A7U6KEL2_9FIRM/3-181 ...........................efsv----EHFISNICLRTKKNLNYIDETnq.......kdkSVYELTQLINSLFALLIMPVEkyksindgyepN---AKKYKEYKDIES.iINECKKNKFY.RS..T--Yt...................edYKYPVTW.....FIRHIRNALAHSGDQgihfIPLQEKKDI..KYII......FYD..TQKKNLK......GQEIEcffcvkLSIIQIHNLAIKISELYA------nieneskn...............
#=GC seq_cons ...................................p.h.hcFhpRThp.lpphp..............t.ashThllNsLlGLlVlPpE...........phh.stlspp.lsph.....thhhpptp.h...t.........................tphsLcp.....hl+phRNulAHhslp.....s.spspph..ptlp......hts....ppppp......sacsh......hshppltthhhhhuphhh......p......................
//
