#=GF ID   ptaRNA1_toxin
#=GF AC   PF12703.11
#=GF DE   Toxin of toxin-antitoxin type 1 system
#=GF PI   plasmid_Toxin; PtaRNA1-toxin;
#=GF AU   Gardner P;0000-0002-7808-1213
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Gardner P [1])
#=GF GA   27.00 27.00;
#=GF TC   35.90 47.60;
#=GF NC   23.50 19.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   PtaRNA1
#=GF RN   [1]
#=GF RM   20220307
#=GF RT   A novel family of plasmid-transferred anti-sense ncRNAs.
#=GF RA   Findeiss S, Schmidtke C, Stadler PF, Bonas U;
#=GF RL   RNA Biol. 2010;7:120-124.
#=GF DR   INTERPRO; IPR024640;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family is the toxin of a type 1 toxin-antitoxin system
#=GF CC   which is found in a relatively widespread range of bacterial
#=GF CC   species. The species distribution suggests frequent horizontal
#=GF CC   gene transfer.  In a type 1 system, as characterised for the
#=GF CC   plasmid-encoded E coli hok/sok system, the toxin-encoding stable
#=GF CC   mRNA encodes a protein which rapidly leads to cell death unless
#=GF CC   the translation is suppressed by a short-lived small RNA. The
#=GF CC   plasmid-encoded module prevents the growth of plasmid-free
#=GF CC   offspring, thus ensuring the persistence of the plasmid in the
#=GF CC   population. Plasmid-free cells arising after cell-division will
#=GF CC   be killed because the stable mRNA toxin is present while the
#=GF CC   comparably unstable anti-toxin is rapidly degraded. Where the
#=GF CC   system is transcribed chromosomally, the mechanism is poorly
#=GF CC   understood [1].
#=GF SQ   23
#=GS A0A1G6CCN9_9GAMM/1-73  AC A0A1G6CCN9.1
#=GS A0A2V1JX02_9BURK/1-73  AC A0A2V1JX02.1
#=GS A0A4V1A752_9GAMM/1-73  AC A0A4V1A752.1
#=GS A0A2T4DWT5_9GAMM/1-54  AC A0A2T4DWT5.1
#=GS D2UDH0_XANAP/1-73      AC D2UDH0.1
#=GS A0A6G8IFL4_9BURK/1-73  AC A0A6G8IFL4.1
#=GS A0A2Z7C5N2_9LAMI/1-36  AC A0A2Z7C5N2.1
#=GS A0A556ACS9_9BURK/1-73  AC A0A556ACS9.1
#=GS A0A2I6S7K8_9RHOO/1-73  AC A0A2I6S7K8.1
#=GS A0A261TM66_9BORD/1-73  AC A0A261TM66.1
#=GS A0A231HKU6_9BURK/1-73  AC A0A231HKU6.1
#=GS A0A366HEQ6_9BURK/1-50  AC A0A366HEQ6.1
#=GS A0A220ST46_9GAMM/1-73  AC A0A220ST46.1
#=GS A0A7H0GK52_9BURK/1-75  AC A0A7H0GK52.1
#=GS A0A7U7END8_9PSED/1-73  AC A0A7U7END8.1
#=GS W8WY27_CASDE/1-75      AC W8WY27.1
#=GS Q63PW1_BURPS/1-73      AC Q63PW1.1
#=GS A0A845H3R5_9BURK/1-73  AC A0A845H3R5.1
#=GS A0A4U0H2D5_9GAMM/1-73  AC A0A4U0H2D5.1
#=GS A0A553H3V2_9PSED/1-73  AC A0A553H3V2.1
#=GS A0A103EHI8_9BURK/1-73  AC A0A103EHI8.1
#=GS U1ZUI8_9BURK/1-73      AC U1ZUI8.1
#=GS A0A0K1XD00_9GAMM/1-73  AC A0A0K1XD00.1
A0A1G6CCN9_9GAMM/1-73             MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPLAEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c........
A0A2V1JX02_9BURK/1-73             MATMNSNEA..VEAVHHAAALLGDLKWLDQDTARQISPMAEAVANMFVVLFYQAETGQATQDDFREALAAIQQTL.........
A0A4V1A752_9GAMM/1-73             MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPLAEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c........
A0A2T4DWT5_9GAMM/1-54             ---------..----------MAALEFIDQETARQFSPVAEAVANMFTILYYQAETGRATSEDFELALDTIRQ--vt.......
D2UDH0_XANAP/1-73                 MATTHDIEA..RQVIHHAATQLADLDFMDQRTAQELSTMAEAVANLFMVVFYQAETGRATHGDFSEAMAAVRQTL.........
A0A6G8IFL4_9BURK/1-73             MATLNPTNA..TQAVHHAAVQLAALDWLDQDAARQLGPLAEAVANAFMVVFYQAETGQATPADFREALDAVRQSL.........
A0A2Z7C5N2_9LAMI/1-36             ---------..---------------------------MAEAVANLFMVVFYQAETGRATRLDFK----------rynmqragr
A0A556ACS9_9BURK/1-73             MATVYPNEF..SQVVHHAAAELNAIDWLDQAAARELGPLAEATANMFMVLFYQAETGLATRDDFLKARTQI----qnvl.....
A0A2I6S7K8_9RHOO/1-73             MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPLAEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c........
A0A261TM66_9BORD/1-73             MATIHPNEF..SQAVQHAATELNAIGWLGQDAARELGPLAEATANLFMVLFYQAETGLATRGDFSQARAQIQ---hvl......
A0A231HKU6_9BURK/1-73             MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPLAEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c........
A0A366HEQ6_9BURK/1-50             MTTQHLIEP..GQVVQQAAAILASLEYIDQSAAQRLGPLAEAVANTFMVVYY-----------------------.........
A0A220ST46_9GAMM/1-73             MTTQHLIEP..GQVVHQAAAIIASLEYIDQGAAQRLGPLAEVVTNAFMVVYYQAETGRATRNDFCEALEAIRRSL.........
A0A7H0GK52_9BURK/1-75             MATLNPTNAiaTQAVHHAAAQLAALDWIDQEAARQLSPMAEAVANMFMMLYYQAETGQATRDDFRQALDAVRQSL.........
A0A7U7END8_9PSED/1-73             MATLNPTNA..TQAVHHAAVQLAALDWLDQDAARQLGPLAEAVANAFMVVFYQAETGQATPADFREALDAVRQSL.........
W8WY27_CASDE/1-75                 MATLNPTNAtaTQAVHHAAAQLAALDWIDQEAARQLSPMAEAVANMFMVLYYQAETGLASRDDFREALDAVRQSL.........
Q63PW1_BURPS/1-73                 MATMHDTEA..REVIHHTAMQLAALEFIDPHAAKDLSEMTEAMVNLFVVVFYQAETGRATRSDFREAMTAVRQAL.........
A0A845H3R5_9BURK/1-73             MTTQHLIEP..GQVVHQAAAILASLEYIDQGAAQRLGPLAEAVANAFMVVYYQAETGRATRNDFCEALEAIRLSL.........
A0A4U0H2D5_9GAMM/1-73             MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPLAEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c........
A0A553H3V2_9PSED/1-73             MATSNPTNV..TQAIHHAAVQLAAMDWIDQEEARELGPLAEAVANAFIVVFYQAETGQATAADFREVVDTVRRTL.........
A0A103EHI8_9BURK/1-73             MATMHDTEA..REVIHLTAMKLAALEFIDPLTAKDLSEMAEAVANLFVVVFYQAETGRATRSDFREARTAVRQAL.........
U1ZUI8_9BURK/1-73                 MTTQHLIEP..DQVVHQAAAILASLEYIDQGAAQRLGPLAEAVTNAFMVVYYQAETGRATRNDFCEALEAIRRSL.........
A0A0K1XD00_9GAMM/1-73             MTTQHIIEP..GQAVHQAAAILSSLEYINQAEARSLGPLAEAVANAFMVVYYQAETGRATQADFQEAMNALRQA-c........
#=GC seq_cons                     MsT.H.hEs..sQsVHpAAA.LuuL-aIDQssARpLGPLAEAVANhFMVVaYQAETGRATpsDFpEAhsAlRQu..........
//