#=GF ID zf-ANAPC11
#=GF AC PF12861.11
#=GF DE Anaphase-promoting complex subunit 11 RING-H2 finger
#=GF PI zf-Apc11;
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE manual
#=GF GA 21.40 21.40;
#=GF TC 21.40 21.40;
#=GF NC 21.30 21.30;
#=GF BM hmmbuild --amino HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF CL CL0229
#=GF RN [1]
#=GF RM 16896351
#=GF RT The anaphase promoting complex/cyclosome: a machine designed to
#=GF RT destroy.
#=GF RA Peters JM;
#=GF RL Nat Rev Mol Cell Biol. 2006;7:644-656.
#=GF RN [2]
#=GF RM 10230407
#=GF RT ROC1, a homolog of APC11, represents a family of cullin partners
#=GF RT with an associated ubiquitin ligase activity.
#=GF RA Ohta T, Michel JJ, Schottelius AJ, Xiong Y;
#=GF RL Mol Cell. 1999;3:535-541.
#=GF RN [3]
#=GF RM 10888670
#=GF RT The APC11 RING-H2 finger mediates E2-dependent ubiquitination.
#=GF RA Leverson JD, Joazeiro CA, Page AM, Huang H, Hieter P, Hunter T;
#=GF RL Mol Biol Cell. 2000;11:2315-2325.
#=GF DR INTERPRO; IPR024991;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Apc11 is one of the subunits of the anaphase-promoting complex
#=GF CC or cyclosome [1]. The APC subunits are cullin family proteins
#=GF CC with ubiquitin ligase activity [2]. Polyubiquitination marks
#=GF CC proteins for degradation by the 26S proteasome and is carried
#=GF CC out by a cascade of enzymes that includes ubiquitin-activating
#=GF CC enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and
#=GF CC ubiquitin ligases (E3s). Apc11 acts as an E3 enzyme and is
#=GF CC responsible for recruiting E2s to the APC and for mediating the
#=GF CC subsequent transfer of ubiquitin to APC substrates in vivo. In
#=GF CC Saccharomyces cerevisiae this RING-H2 finger protein defines the
#=GF CC minimal ubiquitin ligase activity of the APC, and the integrity
#=GF CC of the RING-H2 finger is essential for budding yeast cell
#=GF CC viability [3].
#=GF SQ 2112
#=GS A0A8H7Q5N8_MORIS/1-85 AC A0A8H7Q5N8.1
#=GS A0A2G5DI03_AQUCA/29-86 AC A0A2G5DI03.1
#=GS A0A1S3R1R1_SALSA/28-61 AC A0A1S3R1R1.1
#=GS Q2MGS9_CARAU/1-84 AC Q2MGS9.1
#=GS G3B6Z6_CANTC/1-92 AC G3B6Z6.1
#=GS A0A0K9Q6G6_ZOSMR/1-86 AC A0A0K9Q6G6.1
#=GS A0A850VAX1_9CORV/1-84 AC A0A850VAX1.1
#=GS Q6VFS1_9POXV/1-76 AC Q6VFS1.1
#=GS A0A4W3I6R2_CALMI/1463-1536 AC A0A4W3I6R2.1
#=GS Q7RGA3_PLAYO/2-85 AC Q7RGA3.1
#=GS A0A3E2GXF2_SCYLI/245-324 AC A0A3E2GXF2.1
#=GS A0A437BQN1_CHISP/1-83 AC A0A437BQN1.1
#=GS A0A8C0QY76_CANLU/1-84 AC A0A8C0QY76.1
#=GS A0A3Q2CLA2_CYPVA/1-84 AC A0A3Q2CLA2.1
#=GS A0A8H6WZ53_9AGAR/1-83 AC A0A8H6WZ53.1
#=GS A0A8C5YZ52_MARMA/1-84 AC A0A8C5YZ52.1
#=GS A0A3B3BJY6_ORYME/1-84 AC A0A3B3BJY6.1
#=GS A0A0P1BMR8_9BASI/1-90 AC A0A0P1BMR8.1
#=GS A0A7M7L8Q9_APIME/1-84 AC A0A7M7L8Q9.1
#=GS A0A8B8Q5V7_9MYRT/29-110 AC A0A8B8Q5V7.1
#=GS G7JEI7_MEDTR/7-88 AC G7JEI7.2
#=GS A0A427A2M4_ENSVE/1-84 AC A0A427A2M4.1
#=GS A0A068RPT4_9FUNG/1-85 AC A0A068RPT4.1
#=GS C4JFP2_UNCRE/3-35 AC C4JFP2.1
#=GS A0A238BYY9_9BILA/296-380 AC A0A238BYY9.1
#=GS A0A0V1P7H0_9BILA/82-165 AC A0A0V1P7H0.1
#=GS A0A4T0WJI8_9PEZI/1-85 AC A0A4T0WJI8.1
#=GS A0A6P4DXC0_DRORH/23-55 AC A0A6P4DXC0.1
#=GS A0A814EBH3_9BILA/1-85 AC A0A814EBH3.1
#=GS G4LX01_SCHMA/19-102 AC G4LX01.1
#=GS R0JZL3_SETT2/5-48 AC R0JZL3.1
#=GS A0A1B8F440_9PEZI/1-85 AC A0A1B8F440.1
#=GS A0A8R1YG26_PRIPA/91-171 AC A0A8R1YG26.1
#=GS D5GCN7_TUBMM/1-85 AC D5GCN7.1
#=GS I7LU22_TETTS/18-72 AC I7LU22.2
#=GS A0A1J5WJS8_9MICR/10-92 AC A0A1J5WJS8.1
#=GS A0A420IXZ8_9PEZI/69-98 AC A0A420IXZ8.1
#=GS A0A8H7UE83_9FUNG/1-85 AC A0A8H7UE83.1
#=GS A0A7K6SJ97_CALNI/1-84 AC A0A7K6SJ97.1
#=GS A0A4Z2CUT2_SCHJA/30-113 AC A0A4Z2CUT2.1
#=GS R7SU29_DICSQ/1-93 AC R7SU29.1
#=GS A0A5F4VXV4_CALJA/6-83 AC A0A5F4VXV4.2
#=GS A0A8H6XC22_9AGAR/1-88 AC A0A8H6XC22.1
#=GS N1QJJ5_SPHMS/1-87 AC N1QJJ5.1
#=GS A0A7K6H8T4_9PASS/1-84 AC A0A7K6H8T4.1
#=GS A0A0L6UCG9_9BASI/26-104 AC A0A0L6UCG9.1
#=GS A0A4P9XF46_9FUNG/1-86 AC A0A4P9XF46.1
#=GS E3QIY9_COLGM/1-85 AC E3QIY9.1
#=GS A0A8J2JZ95_9HEXA/1-83 AC A0A8J2JZ95.1
#=GS A0A2U9B5X6_SCOMX/74-111 AC A0A2U9B5X6.1
#=GS A0A7N4NVL9_SARHA/37-120 AC A0A7N4NVL9.1
#=GS A0A3P9N5W5_POERE/1-84 AC A0A3P9N5W5.1
#=GS A0A2G2XYI6_CAPAN/11-58 AC A0A2G2XYI6.1
#=GS A0A672YKW2_9TELE/1-84 AC A0A672YKW2.1
#=GS A0A0H1BCZ4_9EURO/32-53 AC A0A0H1BCZ4.1
#=GS A0A0C9XVY9_9AGAM/1-97 AC A0A0C9XVY9.1
#=GS A0A671TKF9_SPAAU/73-156 AC A0A671TKF9.1
#=GS A0A0L7K3L0_OPEBR/1-74 AC A0A0L7K3L0.1
#=GS B2AMU6_PODAN/1-85 AC B2AMU6.1
#=GS A0A1A8Z222_9APIC/10-93 AC A0A1A8Z222.1
#=GS I4YFK0_WALMC/1-85 AC I4YFK0.1
#=GS A0A074VRH0_9PEZI/1-85 AC A0A074VRH0.1
#=GS APC11_SCHPO/1-85 AC Q9UT86.1
#=GS A0A7C8IBM0_9PLEO/322-398 AC A0A7C8IBM0.1
#=GS A0A023B9M4_GRENI/7-92 AC A0A023B9M4.1
#=GS A0A1V8TBE2_9PEZI/1-87 AC A0A1V8TBE2.1
#=GS A0A7L3EFA8_9PASS/1-84 AC A0A7L3EFA8.1
#=GS A0A4P9XV69_9FUNG/1-78 AC A0A4P9XV69.1
#=GS A0A7K7ICD5_LOXCU/1-84 AC A0A7K7ICD5.1
#=GS A0A0N4TRQ5_BRUPA/46-130 AC A0A0N4TRQ5.1
#=GS A0A401S4B6_CHIPU/1-84 AC A0A401S4B6.1
#=GS A0A0D2I9K4_9EURO/1-85 AC A0A0D2I9K4.1
#=GS A0A7K7PGP2_ACRAR/1-84 AC A0A7K7PGP2.1
#=GS A0A8E2DQV2_9APHY/1-93 AC A0A8E2DQV2.1
#=GS A0A6J5XPB5_PRUAR/21-103 AC A0A6J5XPB5.1
#=GS A0A8H3W6Y3_9PEZI/1-85 AC A0A8H3W6Y3.1
#=GS A0A5N5P3H1_9ROSI/22-87 AC A0A5N5P3H1.1
#=GS A0A8H7MFR3_9PLEO/1-64 AC A0A8H7MFR3.1
#=GS A0A2V1E8M4_9PLEO/334-410 AC A0A2V1E8M4.1
#=GS A0A8B8MF44_ABRPR/1-83 AC A0A8B8MF44.1
#=GS A0A0N4YY56_NIPBR/31-87 AC A0A0N4YY56.1
#=GS A0A0B1TPL1_OESDE/1-58 AC A0A0B1TPL1.1
#=GS F7VM69_SORMK/67-116 AC F7VM69.1
#=GS A0A7K7M9M3_9PASS/1-84 AC A0A7K7M9M3.1
#=GS A0A1Y3NI21_PIRSE/1-76 AC A0A1Y3NI21.1
#=GS A0A0V1MUZ7_9BILA/1695-1778 AC A0A0V1MUZ7.1
#=GS A0A4Q9LSV8_9MICR/2-81 AC A0A4Q9LSV8.1
#=GS A0A1S3CFQ1_CUCME/2-84 AC A0A1S3CFQ1.1
#=GS A0A0C3S5G0_PHLGI/1-91 AC A0A0C3S5G0.1
#=GS A0A7N1A3P9_KALFE/1-57 AC A0A7N1A3P9.1
#=GS A0A318ZU71_9EURO/1-85 AC A0A318ZU71.1
#=GS A0A7N9AK25_9TELE/1-84 AC A0A7N9AK25.1
#=GS A0A199VQD4_ANACO/1-84 AC A0A199VQD4.1
#=GS A0A0C3H227_9PEZI/1-79 AC A0A0C3H227.1
#=GS A0A015MT31_RHIIW/198-278 AC A0A015MT31.1
#=GS A0A328E8X1_9ASTE/31-113 AC A0A328E8X1.1
#=GS A0A1E4T8D3_9ASCO/1-85 AC A0A1E4T8D3.1
#=GS A0A2K6RGV5_RHIRO/1-58 AC A0A2K6RGV5.1
#=GS A0A8H4RDW6_9HELO/279-356 AC A0A8H4RDW6.1
#=GS A0A167J6I5_CALVF/1-98 AC A0A167J6I5.1
#=GS A0A498JSC4_MALDO/42-94 AC A0A498JSC4.1
#=GS A0A2A9MMS1_9APIC/24-113 AC A0A2A9MMS1.1
#=GS A0A6I9Y8G2_9SAUR/1-84 AC A0A6I9Y8G2.1
#=GS X0CR56_FUSOX/1-35 AC X0CR56.1
#=GS A0A5B8MNM4_9CHLO/23-105 AC A0A5B8MNM4.1
#=GS A0A0N4U995_DRAME/31-113 AC A0A0N4U995.1
#=GS A0BJU5_PARTE/1-81 AC A0BJU5.1
#=GS S3CWB0_GLAL2/36-94 AC S3CWB0.1
#=GS A0A7L0QMV2_SETKR/1-84 AC A0A7L0QMV2.1
#=GS G0VK26_NAUCC/1-107 AC G0VK26.1
#=GS A0A183DN50_9BILA/184-260 AC A0A183DN50.1
#=GS A0A226NBK4_CALSU/29-71 AC A0A226NBK4.1
#=GS A0A7J8G3N6_ROUAE/1-84 AC A0A7J8G3N6.1
#=GS A0A1Y1JK44_PLAGO/2-85 AC A0A1Y1JK44.1
#=GS A0A261XWP4_9FUNG/1-85 AC A0A261XWP4.1
#=GS A0A8K0N1R3_COCNU/31-65 AC A0A8K0N1R3.1
#=GS A0A5N5H4Z1_9ROSA/1-57 AC A0A5N5H4Z1.1
#=GS A0A2S4UKK9_9BASI/1-97 AC A0A2S4UKK9.1
#=GS A0A2P6S8X3_ROSCH/1-86 AC A0A2P6S8X3.1
#=GS C1N9D7_MICPC/190-245 AC C1N9D7.1
#=GS A0A507BSV0_9FUNG/1-76 AC A0A507BSV0.1
#=GS A0A340YHX4_LIPVE/1-84 AC A0A340YHX4.1
#=GS A0A146I967_MYCCL/1-93 AC A0A146I967.1
#=GS A0A2K6B5N7_MACNE/28-60 AC A0A2K6B5N7.1
#=GS A0A074X870_9PEZI/1-85 AC A0A074X870.1
#=GS A0A0M9WHZ0_9EURO/17-101 AC A0A0M9WHZ0.1
#=GS A0A8B7BC62_ORYAF/1-84 AC A0A8B7BC62.1
#=GS A0A232FI52_9HYME/21-57 AC A0A232FI52.1
#=GS A0A7K5WAB0_9SYLV/1-54 AC A0A7K5WAB0.1
#=GS A0A2T3AAM2_9PEZI/1-85 AC A0A2T3AAM2.1
#=GS A0A545W6V6_9HYPO/1-85 AC A0A545W6V6.1
#=GS A0A8C5WYU4_LATLA/1-84 AC A0A8C5WYU4.1
#=GS A0A2S4WIH0_9BASI/1-131 AC A0A2S4WIH0.1
#=GS W6YHS6_COCCA/1-85 AC W6YHS6.1
#=GS A0A2A4ITC0_HELVI/319-401 AC A0A2A4ITC0.1
#=GS A0A1U8B5H0_NELNU/1-92 AC A0A1U8B5H0.1
#=GS A0A109FEI9_9BASI/1-106 AC A0A109FEI9.1
#=GS A0A6J1ZKA9_ACIJB/28-85 AC A0A6J1ZKA9.1
#=GS M1CKZ5_SOLTU/1-57 AC M1CKZ5.1
#=GS A0A1S3WVE0_ERIEU/1-84 AC A0A1S3WVE0.1
#=GS A0A3P9BMU1_9CICH/25-63 AC A0A3P9BMU1.1
#=GS A0A7J8G473_ROUAE/1-50 AC A0A7J8G473.1
#=GS A0A286UHJ5_9AGAM/1-96 AC A0A286UHJ5.1
#=GS C6HH07_AJECH/1-85 AC C6HH07.1
#=GS E1ZKB0_CHLVA/3-85 AC E1ZKB0.1
#=GS A0A4W5N6Z9_9TELE/82-165 AC A0A4W5N6Z9.1
#=GS A0A8J8W284_9EURO/1-85 AC A0A8J8W284.1
#=GS A0A5A9NWN8_9TELE/1-84 AC A0A5A9NWN8.1
#=GS A0A8C6XRH8_NAJNA/1-84 AC A0A8C6XRH8.1
#=GS A0A093Y4A3_9PEZI/1-85 AC A0A093Y4A3.1
#=GS A0A399HRX5_9PLEO/1-85 AC A0A399HRX5.1
#=GS A0A7K8CKJ2_9CORV/1-84 AC A0A7K8CKJ2.1
#=GS A0A251K9C5_MANES/6-72 AC A0A251K9C5.1
#=GS A0A5E4FP32_PRUDU/114-197 AC A0A5E4FP32.1
#=GS A0A4Q9PWU8_9APHY/1-93 AC A0A4Q9PWU8.1
#=GS B4N7R6_DROWI/1-84 AC B4N7R6.1
#=GS A0A835J5P0_9ROSI/1-57 AC A0A835J5P0.1
#=GS A0A803KN74_CHEQI/177-224 AC A0A803KN74.1
#=GS A0A2J6QDS1_9HELO/47-131 AC A0A2J6QDS1.1
#=GS A0A812STI6_9DINO/215-302 AC A0A812STI6.1
#=GS A0A091DUE5_FUKDA/1-84 AC A0A091DUE5.1
#=GS A0A1B7TI19_9ASCO/1-123 AC A0A1B7TI19.1
#=GS A0A6J0N2Q8_RAPSA/1-57 AC A0A6J0N2Q8.1
#=GS A0A368FE00_ANCCA/87-172 AC A0A368FE00.1
#=GS V5EUK3_KALBG/1-83 AC V5EUK3.1
#=GS A0A565B693_9BRAS/16-97 AC A0A565B693.1
#=GS A0A443SFE8_9ACAR/1-84 AC A0A443SFE8.1
#=GS A0A0D0AWN7_9AGAM/1-93 AC A0A0D0AWN7.1
#=GS A0A0K9RR38_SPIOL/1-84 AC A0A0K9RR38.1
#=GS A0A8W7S8I5_ANOGA/3-73 AC A0A8W7S8I5.1
#=GS A0A2Y9P7X4_DELLE/28-67 AC A0A2Y9P7X4.2
#=GS I0YWM4_COCSC/3-85 AC I0YWM4.1
#=GS A0A8J6DGB8_GALPY/51-99 AC A0A8J6DGB8.1
#=GS A0A821RT67_9NEOP/1-83 AC A0A821RT67.1
#=GS V4BUC7_LOTGI/1-85 AC V4BUC7.1
#=GS G2R786_THETT/1-85 AC G2R786.1
#=GS F4X344_ACREC/1-84 AC F4X344.1
#=GS A0A5C6MX80_9TELE/1-84 AC A0A5C6MX80.1
#=GS A0A498SAE5_ACAVI/187-271 AC A0A498SAE5.1
#=GS A0A329SZS8_9STRA/1-85 AC A0A329SZS8.1
#=GS A0A8H6S386_9AGAR/1-93 AC A0A8H6S386.1
#=GS A0A812XRE5_SYMPI/1-55 AC A0A812XRE5.1
#=GS S7NEA6_MYOBR/28-78 AC S7NEA6.1
#=GS A0A3P7E2Q6_WUCBA/58-142 AC A0A3P7E2Q6.1
#=GS A0A7J9KD58_9ROSI/27-108 AC A0A7J9KD58.1
#=GS A0A1Q8RR93_9PEZI/1-63 AC A0A1Q8RR93.1
#=GS A0A094K5T6_9PEZI/1-26 AC A0A094K5T6.1
#=GS A0A8C4L8M6_EQUAS/1-84 AC A0A8C4L8M6.1
#=GS A0A8C5X8U6_9PASS/23-100 AC A0A8C5X8U6.1
#=GS A0A7L1YQF5_9PASS/1-84 AC A0A7L1YQF5.1
#=GS A0A2I0KEB2_PUNGR/17-61 AC A0A2I0KEB2.1
#=GS A0A4D8XP04_9ALVE/1-84 AC A0A4D8XP04.1
#=GS Q5KP48_CRYNJ/1-108 AC Q5KP48.2
#=GS A0A2S4VZ56_9BASI/2-72 AC A0A2S4VZ56.1
#=GS A0A8B9P9A4_APTOW/246-330 AC A0A8B9P9A4.1
#=GS A0A7K7VN43_EUDEL/1-84 AC A0A7K7VN43.1
#=GS A0A1V6XHQ7_PENNA/1-61 AC A0A1V6XHQ7.1
#=GS S8BWY0_DACHA/1-55 AC S8BWY0.1
#=GS A0A3G2S3G7_9BASI/20-98 AC A0A3G2S3G7.1
#=GS A0A0D0TP90_CRYGA/1-77 AC A0A0D0TP90.1
#=GS A0A2J6R624_9HELO/1-85 AC A0A2J6R624.1
#=GS A0A6J2M632_9CHIR/28-75 AC A0A6J2M632.1
#=GS A0A0R3QRV9_9BILA/40-124 AC A0A0R3QRV9.1
#=GS A0A8C9YTC9_SANLU/9-77 AC A0A8C9YTC9.1
#=GS A0A397HTX6_9GLOM/1-85 AC A0A397HTX6.1
#=GS D3Z392_MOUSE/28-76 AC D3Z392.1
#=GS A0A8I6ST67_CIMLE/1-84 AC A0A8I6ST67.1
#=GS B6H8Y3_PENRW/305-358 AC B6H8Y3.1
#=GS A0A072Q2V2_9EURO/1-79 AC A0A072Q2V2.1
#=GS A0A024UM87_9STRA/1-86 AC A0A024UM87.1
#=GS A0A080WHP9_TRIRC/1-59 AC A0A080WHP9.1
#=GS A0A8H4V157_9HYPO/1-68 AC A0A8H4V157.1
#=GS A0A851UKZ5_9PASS/1-84 AC A0A851UKZ5.1
#=GS A0A397Z3W1_BRACM/28-110 AC A0A397Z3W1.1
#=GS A0A4Y7Q672_9AGAM/1-97 AC A0A4Y7Q672.1
#=GS A0A3P7UHN7_HAEPC/24-109 AC A0A3P7UHN7.1
#=GS A0A0C2DBK8_9BILA/139-224 AC A0A0C2DBK8.1
#=GS A0A1Y1WAA4_9FUNG/25-109 AC A0A1Y1WAA4.1
#=GS D7MN37_ARALL/1-87 AC D7MN37.1
#=GS A0A317SH44_9PEZI/1-85 AC A0A317SH44.1
#=GS A0A367L919_9HYPO/30-76 AC A0A367L919.1
#=GS A0A835G771_SPOEX/25-111 AC A0A835G771.1
#=GS A0A0N0RTA7_9HYPO/1-68 AC A0A0N0RTA7.1
#=GS A0A319FFS8_ASPSB/1-85 AC A0A319FFS8.1
#=GS A0A139HUI3_9PEZI/31-117 AC A0A139HUI3.1
#=GS A0A1B7MYS4_9AGAM/1-93 AC A0A1B7MYS4.1
#=GS S8E8F9_FOMPI/1-93 AC S8E8F9.1
#=GS A0A5M9K293_MONFR/1-91 AC A0A5M9K293.1
#=GS A0A340Y2H0_LIPVE/1-84 AC A0A340Y2H0.1
#=GS A0A0R3WK33_HYDTA/1-82 AC A0A0R3WK33.1
#=GS I1LAY8_SOYBN/1-57 AC I1LAY8.1
#=GS Q0ULE3_PHANO/322-395 AC Q0ULE3.1
#=GS A0A673FVZ3_9TELE/10-93 AC A0A673FVZ3.1
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#=GC seq_cons ................................................................................M+lp.l+....p.....Wp.u.....V..A.sW.p..W....h.s..p...........................................................D.-.....s..C.G..I...C......R.......h.........s.....F.........s.......G.......s..........C.......P.................s.......C..............K..........h.......P........G..........D.............D.............C...........P..........L..............l........h..............G............p........C..................s..............H......s..F........Hh.....H..C.Ih...c.........W....l.....p.....p.......p.........p........s.......p.........t..........p......CP.MCR.ppaph.....................................................
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