#=GF ID zf_C2H2_13
#=GF AC PF18508.5
#=GF DE Zinc finger domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF02228
#=GF GA 26.50 26.50;
#=GF TC 26.50 26.60;
#=GF NC 26.40 26.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0361
#=GF RN [1]
#=GF RM 20434206
#=GF RT Structural basis for assembly and activation of the
#=GF RT heterotetrameric SAGA histone H2B deubiquitinase module.
#=GF RA Kohler A, Zimmerman E, Schneider M, Hurt E, Zheng N;
#=GF RL Cell. 2010;141:606-617.
#=GF RN [2]
#=GF RM 20395473
#=GF RT Structural insights into the assembly and function of the SAGA
#=GF RT deubiquitinating module.
#=GF RA Samara NL, Datta AB, Berndsen CE, Zhang X, Yao T, Cohen RE,
#=GF RA Wolberger C;
#=GF RL Science. 2010;328:1025-1029.
#=GF RN [3]
#=GF RM 22771212
#=GF RT A role for intersubunit interactions in maintaining SAGA
#=GF RT deubiquitinating module structure and activity.
#=GF RA Samara NL, Ringel AE, Wolberger C;
#=GF RL Structure. 2012;20:1414-1424.
#=GF RN [4]
#=GF RM 25526805
#=GF RT Uncovering the role of Sgf73 in maintaining SAGA
#=GF RT deubiquitinating module structure and activity.
#=GF RA Yan M, Wolberger C;
#=GF RL J Mol Biol. 2015;427:1765-1778.
#=GF DR INTERPRO; IPR041251;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The SAGA (Spt-Ada-Gcn5-acetyltransferase) complex performs
#=GF CC multiple functions in transcription activation including
#=GF CC deubiquitinating histone H2B, which is mediated by a subcomplex
#=GF CC called the deubiquitinating module (DUBm). The yeast DUBm
#=GF CC comprises a catalytic subunit, Ubp8, and three additional
#=GF CC subunits, Sgf11, Sus1 and Sgf73, all of which are required for
#=GF CC DUBm activity. A portion of the non-globular Sgf73 subunit lies
#=GF CC between the Ubp8 catalytic domain and the zinc finger (ZnF)-UBP
#=GF CC domain and has been proposed to contribute to deubiquitinating
#=GF CC activity by maintaining the catalytic domain in an active
#=GF CC conformation. Sgf73 contributes to maintaining both the
#=GF CC organization and ubiquitin-binding conformation of Ubp8, thereby
#=GF CC contributing to overall DUBm activity. This domain is a Sgf73
#=GF CC fragment in the DUB module. It is a zinc finger (ZnF) domain
#=GF CC whose integrity is essential for the incorporation of this
#=GF CC subunit into DUBm as well as for the catalytic activity of Ubp8,
#=GF CC as either a short deletion or point mutations in Sgf73
#=GF CC zinc-coordinating residues disrupt the association of Sgf73 with
#=GF CC the rest of the DUBm [1 -4].
#=GF SQ 36
#=GS A0A1G4K355_9SACH/55-96 AC A0A1G4K355.1
#=GS J7RMR6_KAZNA/55-94 AC J7RMR6.1
#=GS A0A1X7R004_9SACH/51-91 AC A0A1X7R004.1
#=GS A0A7H9HW89_9SACH/63-104 AC A0A7H9HW89.1
#=GS M5G5Y7_DACPD/67-101 AC M5G5Y7.1
#=GS A0A1D2VH95_9ASCO/149-190 AC A0A1D2VH95.1
#=GS A0A1E5RDM2_9ASCO/68-108 AC A0A1E5RDM2.1
#=GS I2GZ14_TETBL/70-112 AC I2GZ14.1
#=GS H2B1T6_KAZAF/51-94 AC H2B1T6.1
#=GS A0A1S7HDQ3_9SACH/63-106 AC A0A1S7HDQ3.1
#=GS A0A4T0X7H6_9ASCO/68-106 AC A0A4T0X7H6.1
#=GS A0A1E3NT41_9ASCO/88-121 AC A0A1E3NT41.1
#=GS G0WFT5_NAUDC/53-94 AC G0WFT5.1
#=GS G8ZVX5_TORDC/61-103 AC G8ZVX5.1
#=GS A0A1G4M9A6_LACFM/54-95 AC A0A1G4M9A6.1
#=GS G8BYW8_TETPH/70-113 AC G8BYW8.1
#=GS Q6FJK0_CANGA/52-93 AC Q6FJK0.1
#=GS A0A1G4KAL7_9SACH/56-97 AC A0A1G4KAL7.1
#=GS J8Q556_SACAR/59-100 AC J8Q556.1
#=GS SGF73_YEAST/59-100 AC P53165.1
#=GS A0A1E4U3E1_PACTA/89-122 AC A0A1E4U3E1.1
#=GS A0A167S6B2_CALVF/19-52 AC A0A167S6B2.1
#=GS C5E2D7_LACTC/55-96 AC C5E2D7.1
#=GS A0A4C2EBR8_9SACH/63-106 AC A0A4C2EBR8.1
#=GS Q755C0_ASHGO/70-105 AC Q755C0.1
#=GS A0A7H9AXB0_ZYGMR/62-103 AC A0A7H9AXB0.1
#=GS A0A1S7HU39_9SACH/63-106 AC A0A1S7HU39.1
#=GS G0VEK5_NAUCC/54-95 AC G0VEK5.1
#=GS Q6CWP9_KLULA/56-95 AC Q6CWP9.1
#=GS K0KX27_WICCF/73-110 AC K0KX27.1
#=GS A0A376B4A2_9ASCO/74-114 AC A0A376B4A2.1
#=GS A0A0C7NAE6_9SACH/55-96 AC A0A0C7NAE6.1
#=GS I2K335_DEKBR/84-119 AC I2K335.2
#=GS G8JP42_ERECY/69-107 AC G8JP42.1
#=GS A0A1E3QYW2_9ASCO/62-99 AC A0A1E3QYW2.1
#=GS A7TE81_VANPO/66-109 AC A7TE81.1
A0A1G4K355_9SACH/55-96 ...........NESA.SILEN.PLGQP..LEYRVCEGCGKPVNLGAIVDHLQVHCKG....
J7RMR6_KAZNA/55-94 ...gvaedsyf----.-----.-VDTD..FNFRVCRGCGRPIALRALEAHLASGCA-a...
A0A1X7R004_9SACH/51-91 ...........NPNA.NII--.PTENA.fAGYRICKSCGKPILLNSIIDHIQNHCP-g...
A0A7H9HW89_9SACH/63-104 ..........s-ANG.RILED.PLESS..FQYRVCNNCGVPLALNSIMDHLENHCKG....
M5G5Y7_DACPD/67-101 ........gaa----.-----.PMHDE..LDVRVCKDCGKPVLASAVAAHLEN-CK-k...
A0A1D2VH95_9ASCO/149-190 ..........k--NP.NLITNnPLSKP..FKYRICNICQRPILESVLIDHLNNC---ikn.
A0A1E5RDM2_9ASCO/68-108 ...........SSNV.EILPN.PIQNR..INLRVCNNCNKPLTPTAIQKHVA-FCN-n...
I2GZ14_TETBL/70-112 ...........NPNV.RLLEDsPLDLN..LKYRICNKCGKPLSSDSIIDHLEKFCKG....
H2B1T6_KAZAF/51-94 ...........NPNTkRLLVD.NLDFN.sLTFKVCNNCKIPISANAIDDHLRSCCT-s...
A0A1S7HDQ3_9SACH/63-106 ...........NSNT.HIIEN.PLEPSasFQYRVCNSCGKPLALNAIMEHLEDHCKG....
A0A4T0X7H6_9ASCO/68-106 .......yelg----.---KD.PLQQP..VNYRICNSCGTAILIENIIEHLQTC---gke.
A0A1E3NT41_9ASCO/88-121 .........sr----.-----.PLTQP..INYRICNSCGTAILEKNMADHIS-HCS-t...
G0WFT5_NAUDC/53-94 ...........SENA.TIIED.SLDTL..SEYRVCNQCGKPIKLYALIAHLENGCKS....
G8ZVX5_TORDC/61-103 ...........NSNA.KIIED.PLEES.aFNYRICNSCGAPLALNSIMDHLENHCKG....
A0A1G4M9A6_LACFM/54-95 .........nt--SG.TIIDN.PLGQP..LEYRVCNSCGKPISLSVIVEHLKSHCKG....
G8BYW8_TETPH/70-113 ...........NSNT.HFIDN.GLATNnyTNYRLCNACGKPISIEVIMDHLKTYCSK....
Q6FJK0_CANGA/52-93 ...........EPNT.RIIID.ALDKQ..TNFRVCKGCGKPILLEAIVDHIENHCSN....
A0A1G4KAL7_9SACH/56-97 ...........NQNG.RLIRD.PIGEP..LNYRLCNNCDRPVSVSAIVQHLESDC--pa..
J8Q556_SACAR/59-100 ..........k-PNA.QLIEN.PLDTP..IQFRVCEKCGKPLALTAIVDHLENHCA-g...
SGF73_YEAST/59-100 ...........NPNA.QLIED.PLDKP..IQYRVCEKCGKPLALTAIVDHLENHCA-g...
A0A1E4U3E1_PACTA/89-122 .........cg----.----N.PLGAP..INYRICNHCDRPILETFLADHIKS----cv..
A0A167S6B2_CALVF/19-52 ........aap----.-----.-MHDD..LDLRVCKDCGKPVLASAAAAHLEN-CK-k...
C5E2D7_LACTC/55-96 .........rd--SA.SIIKN.PLDKP..LDYRICDGCGKPVSLSAIVEHLQTYCKG....
A0A4C2EBR8_9SACH/63-106 ...........NSNT.RIIEN.PLETSasFQYRVCNDCGKPLALNAIVDHLENHCKG....
Q755C0_ASHGO/70-105 ........tva----.-----.PLEPP..VDYRVCNDCGRPIAYSALLVHLQEHCR-r...
A0A7H9AXB0_ZYGMR/62-103 ...........NSKA.RIIEN.PVETA..FQYRICVSCGKPIALNAIMDHLENHCQG....
A0A1S7HU39_9SACH/63-106 ...........NSNT.HIIEN.PLEPSasFQYRVCNSCGKPLALNAIMEHLEDHCKG....
G0VEK5_NAUCC/54-95 .........rr--DA.HIIEA.PLESL..SEFRVCKKCGKPIKLTALVDHLENNCS-i...
Q6CWP9_KLULA/56-95 .psevlsgvsk----.-----.----E.dIRYRNCTACHQPVLVSAIIDHLENHC--id..
K0KX27_WICCF/73-110 ......knnln----.--LKN.PLNQI..VNYRVCNLCDRPILIDHLTKHIKT----c...
A0A376B4A2_9ASCO/74-114 ...........NPNT.TILDN.PIENG..LEYRVCNKCGKPISLNVIAQHIENNC--g...
A0A0C7NAE6_9SACH/55-96 ...........NDPS.SILED.PLGSA..LEYRVCEKCGKPVSLSALVDHLQIHCKG....
I2K335_DEKBR/84-119 ........nsr----.----D.PLEKP..VSYRICNICDNPILESSMADHIV-----qcqe
G8JP42_ERECY/69-107 lsntvpvinlp----.-----.-----..IEYRTCNDCGRPIAYSALIDHLQNHCRG....
A0A1E3QYW2_9ASCO/62-99 .....pqdelg----.---TN.PLAAP..LNYRVCNHCNRPILASHIAKHIT-----dc..
A7TE81_VANPO/66-109 ...........NANT.HLLEN.TVESNssSNYRICNSCGRPISLETIVDHLNNHCNS....
#=GC seq_cons .............ss.pllps.PLcps..lpYRlCNsCG+PlslsuIh-HLcsaCp.....
//
