ENTRY           A920058 - Synthetic(fragment)           1819672
AUTHORS         Ikezu T., Okamoto T., Ogata E. & Nishimoto I.
JOURNAL         FEBS Lett. (1992) 311(1), 29-32
TITLE           Amino acids 356-372 constitute a Gi-activator sequence of the
                  alpha-2-adrenergic receptor and have a Phe substitute in the
                  G protein-activator sequence motif.
CROSS-REFERENCE
PROTEIN         alpha-2-Adrenergic receptor, (Lys--Phe 356-372 fragment)
SOURCE          Human
N-TERMINAL
CHANGE          Phe 372 Arg
FUNCTION        Gi-activating activity [=] 
CHANGE          Phe 372 Tyr
FUNCTION        Gi-activating activity [=] 
CHANGE          Phe 372 Trp
FUNCTION        Gi-activating activity [=] 
CHANGE          Phe 372 Asp
FUNCTION        Gi-activating activity [-] 
CHANGE          Phe 372 Ala
FUNCTION        Gi-activating activity [0] 
COMMENT         Synthetic polypeptide KASRWRGRQNREKRFTF (356-372) was found to
                  activate Gi and Go strongly.
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