KEGG   Pan paniscus (bonobo): 100967895
Entry
100967895         CDS       T02283                                 
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase isoform X2
  KO
K00501  tyrosine 3-monooxygenase [EC:1.14.16.2]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00350  Tyrosine metabolism
pps00790  Folate biosynthesis
pps01100  Metabolic pathways
pps04728  Dopaminergic synapse
pps04917  Prolactin signaling pathway
pps05012  Parkinson disease
pps05030  Cocaine addiction
pps05031  Amphetamine addiction
pps05034  Alcoholism
Module
pps_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    100967895 (TH)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    100967895 (TH)
 09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    100967895 (TH)
  09156 Nervous system
   04728 Dopaminergic synapse
    100967895 (TH)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    100967895 (TH)
  09165 Substance dependence
   05030 Cocaine addiction
    100967895 (TH)
   05031 Amphetamine addiction
    100967895 (TH)
   05034 Alcoholism
    100967895 (TH)
Enzymes [BR:pps01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     100967895 (TH)
SSDB
Motif
Pfam: Biopterin_H TH_ACT TOH_N LTP_2
Other DBs
NCBI-GeneID: 100967895
NCBI-ProteinID: XP_003816109
Ensembl: ENSPPAG00000037007
UniProt: A0A2R9BE28
Position
11:complement(2204820..2212750)
AA seq 497 aa
MPTPDATTPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIEDARKEREAAVAAAAAAV
PSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETRPAQR
PRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCHHLV
TKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLK
GLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFL
ASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASD
EEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQ
PYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLE
GVQDELDTLAHALSAIG
NT seq 1494 nt   +upstreamnt  +downstreamnt
atgcccacccccgacgccaccacgccacaggccaagggcttccgcagggccgtgtctgag
ctggatgccaagcaggcagaggccatcatgtccccgcggttcattgggcgcaggcagagc
ctcatcgaggacgcccgcaaggagcgggaggcggcggtggcagcagcggccgctgcagtc
ccctcggagcccggggaccccctggaggccgtggcctttgaggagaaggaggggaaggcc
gtgctaaacctgctcttctccccgagggccaccaagccctccgcgctgtcccgagctgtg
aaggtgtttgagacgtttgaagccaaaatccaccatctagagacccggcccgcccagagg
ccgcgagctgggggcccccacctggagtacttcgtgcgcctcgaggtgcgccgaggggac
ctggccgccctgctcagtggtgtgcgccaggtgtcagaggacgtgcgcagccccgcgggg
cccaaggtcccctggttcccaagaaaagtgtcagagctggacaagtgtcatcacctggtc
accaagttcgaccctgacctggacttggaccacccgggcttctcggaccaggtgtaccgc
cagcgcaggaagctgattgctgagatcgccttccagtacaggcacggcgacccgattccc
cgtgtggagtacaccgccgaggagattgccacctggaaggaggtctacaccacgctgaag
ggcctctacgccacgcacgcctgcggggagcacctggaggcctttgctttgctggagcgc
ttcagcggctaccgggaagacaatatcccccagctggaggacgtctcccgcttcctgaag
gagcgcacgggcttccagctgcggcctgtggccggcctgctgtccgcccgggacttcctg
gccagcctggccttccgcgtgttccagtgcacccagtatatccgccacgcgtcctcgccc
atgcactcccctgagccggactgctgccacgagctgctggggcacgtgcccatgctggcc
gaccgcaccttcgcgcagttctcgcaggacattggcctggcatccctgggggcctcggat
gaggaaattgagaagctgtccacgctgtactggttcacggtggagttcgggctgtgtaag
cagaatggggaggtgaaggcctatggtgccgggctgctgtcctcctacggggagctcctg
cactgcctgtctgaggagcccgagattcgggccttcgaccctgaagctgcagccgtgcag
ccctaccaagaccagacgtaccagtcagtctacttcgtgtctgagagcttcagtgacgcc
aaggacaagctcaggagctatgcctcacgcatccagcgccccttctccgtgaagttcgac
ccgtacacgctggccatcgacgtgctggacagcccccaggccgtgcggcgctccctggag
ggtgtccaggatgagctggacacccttgcccatgcgctgagtgccattggctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (9)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (4)   
   Pfam (4)   
All databases (37)   

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