KEGG   Pan paniscus (bonobo): 100983152
Entry
100983152         CDS       T02283                                 
Symbol
PTEN
Name
(RefSeq) phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  KO
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00562  Inositol phosphate metabolism
pps01100  Metabolic pathways
pps01521  EGFR tyrosine kinase inhibitor resistance
pps04068  FoxO signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04115  p53 signaling pathway
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04218  Cellular senescence
pps04510  Focal adhesion
pps04931  Insulin resistance
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05200  Pathways in cancer
pps05206  MicroRNAs in cancer
pps05208  Chemical carcinogenesis - reactive oxygen species
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05222  Small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05230  Central carbon metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100983152 (PTEN)
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100983152 (PTEN)
   04070 Phosphatidylinositol signaling system
    100983152 (PTEN)
   04071 Sphingolipid signaling pathway
    100983152 (PTEN)
   04151 PI3K-Akt signaling pathway
    100983152 (PTEN)
   04150 mTOR signaling pathway
    100983152 (PTEN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100983152 (PTEN)
  09143 Cell growth and death
   04115 p53 signaling pathway
    100983152 (PTEN)
   04218 Cellular senescence
    100983152 (PTEN)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100983152 (PTEN)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100983152 (PTEN)
   05206 MicroRNAs in cancer
    100983152 (PTEN)
   05208 Chemical carcinogenesis - reactive oxygen species
    100983152 (PTEN)
   05230 Central carbon metabolism in cancer
    100983152 (PTEN)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100983152 (PTEN)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    100983152 (PTEN)
   05214 Glioma
    100983152 (PTEN)
   05218 Melanoma
    100983152 (PTEN)
   05215 Prostate cancer
    100983152 (PTEN)
   05213 Endometrial cancer
    100983152 (PTEN)
   05224 Breast cancer
    100983152 (PTEN)
   05222 Small cell lung cancer
    100983152 (PTEN)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100983152 (PTEN)
   05165 Human papillomavirus infection
    100983152 (PTEN)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    100983152 (PTEN)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    100983152 (PTEN)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100983152 (PTEN)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:pps01009]
    100983152 (PTEN)
Enzymes [BR:pps01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     100983152 (PTEN)
    3.1.3.48  protein-tyrosine-phosphatase
     100983152 (PTEN)
    3.1.3.67  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
     100983152 (PTEN)
Protein phosphatases and associated proteins [BR:pps01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Dual specificity phosphatases)
   Phosphatase and Tensin homologs (PTEN)
    100983152 (PTEN)
SSDB
Motif
Pfam: PTEN_C2 DSPc Y_phosphatase PTPlike_phytase Y_phosphatase3 DUF3256
Other DBs
NCBI-GeneID: 100983152
NCBI-ProteinID: NP_001288689
Ensembl: ENSPPAG00000029313
UniProt: A0A024QYR5
Position
10:84587841..84689043
AA seq 403 aa
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
NT seq 1212 nt   +upstreamnt  +downstreamnt
atgacagccatcatcaaagagatcgttagcagaaacaaaaggagatatcaagaggatgga
ttcgacttagacttgacctatatttatccaaacattattgctatgggatttcctgcagaa
agacttgaaggcgtatacaggaacaatattgatgatgtagtaaggtttttggattcaaag
cataaaaaccattacaagatatacaatctttgtgctgaaagacattatgacactgccaaa
tttaattgcagagttgcacaatatccttttgaagaccataacccaccacagctagaactt
atcaagcccttttgtgaagatcttgaccaatggctaagtgaagatgacaatcatgttgca
gcaattcactgtaaagctggaaagggacgaactggtgtaatgatttgtgcatatttatta
catcggggcaaatttttaaaggcacaagaggccctagatttctatggggaagtaaggacc
agagacaaaaagggagtaactattcccagtcagaggcgctatgtgtattattatagctac
ctgttaaagaatcatctggattatagaccagtggcactgttgtttcacaagatgatgttt
gaaactattccaatgttcagtggcggaacttgcaatcctcagtttgtggtctgccagcta
aaggtgaagatatattcctccaattcaggacccacacgacgggaagacaagttcatgtac
tttgagttccctcagccgttacctgtgtgtggtgatatcaaagtagagttcttccacaaa
cagaacaagatgctaaaaaaggacaaaatgtttcacttttgggtaaatacattcttcata
ccaggaccagaggaaacctcagaaaaagtagaaaatggaagtctatgtgatcaagaaatc
gatagcatttgcagtatagagcgtgcagataatgacaaggaatatctagtacttacttta
acaaaaaatgatcttgacaaagcaaataaagacaaagccaaccgatacttttctccaaat
tttaaggtgaagctgtacttcacaaaaacagtagaggagccgtcaaatccagaggctagc
agttcaacttctgtaacaccagatgttagtgacaatgaacctgatcattatagatattct
gacaccactgactctgatccagagaatgaaccttttgatgaagatcagcatacacaaatt
acaaaagtctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (28)   
   KEGG PATHWAY (28)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (5)   
   KEGG ENZYME (3)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (5)   
   RefSeq(nuc) (3)   
   GenBank (1)   
   EMBL (1)   
Protein domain (6)   
   Pfam (6)   
All databases (63)   

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