KEGG   Pan paniscus (bonobo): 100990108
Entry
100990108         CDS       T02283                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps00562  Inositol phosphate metabolism
pps01100  Metabolic pathways
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps01524  Platinum drug resistance
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04140  Autophagy - animal
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04152  AMPK signaling pathway
pps04210  Apoptosis
pps04211  Longevity regulating pathway
pps04213  Longevity regulating pathway - multiple species
pps04218  Cellular senescence
pps04360  Axon guidance
pps04370  VEGF signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04611  Platelet activation
pps04613  Neutrophil extracellular trap formation
pps04620  Toll-like receptor signaling pathway
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagocytosis
pps04668  TNF signaling pathway
pps04670  Leukocyte transendothelial migration
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04750  Inflammatory mediator regulation of TRP channels
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04923  Regulation of lipolysis in adipocytes
pps04926  Relaxin signaling pathway
pps04929  GnRH secretion
pps04930  Type II diabetes mellitus
pps04931  Insulin resistance
pps04932  Non-alcoholic fatty liver disease
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04935  Growth hormone synthesis, secretion and action
pps04960  Aldosterone-regulated sodium reabsorption
pps04973  Carbohydrate digestion and absorption
pps05010  Alzheimer disease
pps05017  Spinocerebellar ataxia
pps05020  Prion disease
pps05100  Bacterial invasion of epithelial cells
pps05132  Salmonella infection
pps05135  Yersinia infection
pps05142  Chagas disease
pps05146  Amoebiasis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05171  Coronavirus disease - COVID-19
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05207  Chemical carcinogenesis - receptor activation
pps05208  Chemical carcinogenesis - reactive oxygen species
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pps05415  Diabetic cardiomyopathy
pps05417  Lipid and atherosclerosis
pps05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100990108 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100990108 (PIK3CB)
   04014 Ras signaling pathway
    100990108 (PIK3CB)
   04015 Rap1 signaling pathway
    100990108 (PIK3CB)
   04370 VEGF signaling pathway
    100990108 (PIK3CB)
   04630 JAK-STAT signaling pathway
    100990108 (PIK3CB)
   04668 TNF signaling pathway
    100990108 (PIK3CB)
   04066 HIF-1 signaling pathway
    100990108 (PIK3CB)
   04068 FoxO signaling pathway
    100990108 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    100990108 (PIK3CB)
   04072 Phospholipase D signaling pathway
    100990108 (PIK3CB)
   04071 Sphingolipid signaling pathway
    100990108 (PIK3CB)
   04024 cAMP signaling pathway
    100990108 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    100990108 (PIK3CB)
   04152 AMPK signaling pathway
    100990108 (PIK3CB)
   04150 mTOR signaling pathway
    100990108 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100990108 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    100990108 (PIK3CB)
   04218 Cellular senescence
    100990108 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100990108 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    100990108 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100990108 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100990108 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    100990108 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    100990108 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    100990108 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    100990108 (PIK3CB)
   04660 T cell receptor signaling pathway
    100990108 (PIK3CB)
   04662 B cell receptor signaling pathway
    100990108 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    100990108 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    100990108 (PIK3CB)
   04670 Leukocyte transendothelial migration
    100990108 (PIK3CB)
   04062 Chemokine signaling pathway
    100990108 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100990108 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    100990108 (PIK3CB)
   04929 GnRH secretion
    100990108 (PIK3CB)
   04915 Estrogen signaling pathway
    100990108 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    100990108 (PIK3CB)
   04917 Prolactin signaling pathway
    100990108 (PIK3CB)
   04926 Relaxin signaling pathway
    100990108 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    100990108 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    100990108 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100990108 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100990108 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    100990108 (PIK3CB)
   04722 Neurotrophin signaling pathway
    100990108 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100990108 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    100990108 (PIK3CB)
   04380 Osteoclast differentiation
    100990108 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    100990108 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    100990108 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100990108 (PIK3CB)
   05206 MicroRNAs in cancer
    100990108 (PIK3CB)
   05205 Proteoglycans in cancer
    100990108 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    100990108 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    100990108 (PIK3CB)
   05203 Viral carcinogenesis
    100990108 (PIK3CB)
   05230 Central carbon metabolism in cancer
    100990108 (PIK3CB)
   05231 Choline metabolism in cancer
    100990108 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100990108 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100990108 (PIK3CB)
   05212 Pancreatic cancer
    100990108 (PIK3CB)
   05225 Hepatocellular carcinoma
    100990108 (PIK3CB)
   05226 Gastric cancer
    100990108 (PIK3CB)
   05214 Glioma
    100990108 (PIK3CB)
   05221 Acute myeloid leukemia
    100990108 (PIK3CB)
   05220 Chronic myeloid leukemia
    100990108 (PIK3CB)
   05218 Melanoma
    100990108 (PIK3CB)
   05211 Renal cell carcinoma
    100990108 (PIK3CB)
   05215 Prostate cancer
    100990108 (PIK3CB)
   05213 Endometrial cancer
    100990108 (PIK3CB)
   05224 Breast cancer
    100990108 (PIK3CB)
   05222 Small cell lung cancer
    100990108 (PIK3CB)
   05223 Non-small cell lung cancer
    100990108 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100990108 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    100990108 (PIK3CB)
   05161 Hepatitis B
    100990108 (PIK3CB)
   05160 Hepatitis C
    100990108 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    100990108 (PIK3CB)
   05164 Influenza A
    100990108 (PIK3CB)
   05162 Measles
    100990108 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    100990108 (PIK3CB)
   05163 Human cytomegalovirus infection
    100990108 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100990108 (PIK3CB)
   05169 Epstein-Barr virus infection
    100990108 (PIK3CB)
   05165 Human papillomavirus infection
    100990108 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100990108 (PIK3CB)
   05135 Yersinia infection
    100990108 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    100990108 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100990108 (PIK3CB)
   05142 Chagas disease
    100990108 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100990108 (PIK3CB)
   05017 Spinocerebellar ataxia
    100990108 (PIK3CB)
   05020 Prion disease
    100990108 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100990108 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    100990108 (PIK3CB)
   05415 Diabetic cardiomyopathy
    100990108 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100990108 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    100990108 (PIK3CB)
   04931 Insulin resistance
    100990108 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100990108 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100990108 (PIK3CB)
   01524 Platinum drug resistance
    100990108 (PIK3CB)
   01522 Endocrine resistance
    100990108 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pps04131]
    100990108 (PIK3CB)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100990108 (PIK3CB)
Membrane trafficking [BR:pps04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100990108 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 100990108
NCBI-ProteinID: XP_034813386
Ensembl: ENSPPAG00000031755
Position
3:complement(135685120..135867096)
AA seq 1070 aa
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKE
ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaacctccttatggatattgactcctatatgttt
gcatgtgtgaatcagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagcgaggaaaaaatc
ctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccagagcat
gaaccatccatccctgaaaacttagaagataaactttatgggggaaagctcatcgtagct
gttcattttgaaaactgccaggacgtgtttagctttcaagtgtctcctaatatgaatcct
atcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gttagcccctatgattatgtgttgcaagtcagcgggagagtagaatatgtttttggtgat
catccactaattcagttccagtatatccggaactgtgtgatgaacagggccctgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaattcatctaatcttcctcttccattaccaccaaagaaaaca
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgagctcctgtgtaaaaccatcgtaagctcagaggtatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggctcgatta
tgttttgctgtttatgcagttttggataaagtaaaaacgaagaaatcaacgaaaactatt
aatccctctaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcgtgg
gtaaatacgatggtttttgactttaaaggacaattgagaactggagacataatattacac
agctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatgttaaatttccagagaataaaaaa
caaccttattattaccctcccttcgataagattattgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattgaaagaa
atcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatttggact
ttgcgacaagactgccgagagattttcccacaatcactgccaaaattactgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttggcctaaa
ctgcccccccgggaggccctagagcttctggatttcaactatccagaccagtacgttcga
gaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttctcaatatctttta
caactggtgcaagtgttaaaatatgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttggtaatcggaggatagggcagtttctattttggcatcttaggtca
gaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatactgccgg
ggaagtgtggggcacatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgccgtgaagttaaacagagccaaagggaaggag
gccatgcatacctgtttaaaacagagtgcttaccgggaagccctctctgacctgcagtca
cccctgaacccatgtgttatcctctcagaactctatgttgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccaaatgttg
cgcttgatggatttactctggaaagaagctggtttggatcttcggatgttgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggaa
tttacactgtcctgtgctggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttattctt
acctatgatttcatccatgtcattcaacaaggaaaaacaggaaatacagaaaagtttgga
cggttccgccagtgttgtgaggatgcatatctgattttacgacggcacgggaatctcttc
atcactctctttgcgctgatgttgactgcagggcttcctgaactcacatcagtcaaagat
atacagtatcttaaggactctcttgcattagggaagagtgaagaagaagcactcaaacag
tttaagcaaaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (105)   
   KEGG PATHWAY (105)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   RefSeq(pep) (6)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
Protein domain (7)   
   Pfam (7)   
All databases (139)   

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