PMID:
     3838366
Authors:
     Jacobs K, Shoemaker C, Rudersdorf R, Neill SD, Kaufman RJ, Mufson A,
     Seehra J, Jones SS, Hewick R, Fritsch EF, et al..
Title:
     Isolation and characterization of genomic and cDNA clones of human 
     erythropoietin.
Journal:
     Nature. 1985 Feb 28-Mar 6;313(6005):806-10. doi: 10.1038/313806a0.
Abstract:
     The glycoprotein hormone erythropoietin regulates the level of oxygen in the 
     blood by modulating the number of circulating erythrocytes, and is produced in 
     the kidney or liver of adult and the liver of fetal or neonatal mammals. Neither 
     the precise cell types that produce erythropoietin nor the mechanisms by which 
     the same or different cells measure the circulating oxygen concentration and 
     consequently regulate erythropoietin production are known. Cells responsive to 
     erythropoietin have been identified in the adult bone marrow, fetal liver or 
     adult spleen. In cultures of erythropoietic progenitors, erythropoietin 
     stimulates proliferation and differentiation to more mature red blood cells. 
     Detailed molecular studies have been hampered, however, by the impurity and 
     heterogeneity of target cell populations and the difficulty of obtaining 
     significant quantities of the purified hormone. Highly purified erythropoietin 
     may be useful in the treatment of various forms of anaemia, particularly in 
     chronic renal failure. Here we describe the cloning of the human erythropoietin 
     gene and the expression of an erythropoietin cDNA clone in a transient mammalian 
     expression system to yield a secreted product with biological activity.

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