KEGG   Rattus norvegicus (rat): 114212
Entry
114212            CDS       T01003                                 
Symbol
Chek2
Name
(RefSeq) serine/threonine-protein kinase Chk2
  KO
K06641  serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04110  Cell cycle
rno04115  p53 signaling pathway
rno04218  Cellular senescence
rno05166  Human T-cell leukemia virus 1 infection
Brite
KEGG Orthology (KO) [BR:rno00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    114212 (Chek2)
   04115 p53 signaling pathway
    114212 (Chek2)
   04218 Cellular senescence
    114212 (Chek2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114212 (Chek2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    114212 (Chek2)
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:rno03400]
    114212 (Chek2)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     114212 (Chek2)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: CAMK group
  RAD53 family
   114212 (Chek2)
DNA repair and recombination proteins [BR:rno03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    114212 (Chek2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr FHA Kinase-like RIO1 Kdo ABC1 YrbL-PhoP_reg Pkinase_fungal APH
Other DBs
NCBI-GeneID: 114212
NCBI-ProteinID: NP_446129
RGD: 621543
Ensembl: ENSRNOG00000037509
UniProt: A6J285 A0A0G2K8L3
Position
12:complement(51448838..51481159)
AA seq 545 aa
MKSHQSHGSTSSKAHDSASCSQSQGGFSQSQGTPSQLHDLSQYQGASSSSTSTVPSSSQS
SHSSSGTLSSLETVSTQELCSIPEDQEPEEPGPTPWARLWALQDGFSNLDCVNDNYWFGR
DKSCEYCFDGPLLKRTDKYRTYSKKHFRIFREMGPKNCYIVYLEDHSGNGTFVNTELIGK
GKRCPLSNNSEIALSLCRNKVFVFFDLTVDDQSVYPKELRDEYIMSKTLGSGACGEVKMA
FERKTCKKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVFDVEDY
YIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSS
QEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLISNGTAGYSRAVDCWSLGVIL
FICLSGYPPFSEHKTQVSLKDQITSGKYNLIPEVWTDVSEKALDLVKKLLVVDPKARLTT
EEALSHPWLQDEHMKKKFQDLLVQEKNLVPLPLAPAQTSGQKRPLELEAEDAESSKRLAV
CKAVL
NT seq 1638 nt   +upstreamnt  +downstreamnt
atgaagagtcatcagtcccacggcagcacctcctcgaaggctcatgacagtgcttcctgt
tcacagtctcaaggcggcttcagccagtcccaaggcaccccctctcagttgcacgacctc
tcacagtatcagggtgcatccagttcctccaccagcacagtgccatcctccagccagtcc
tcccactccagctctgggaccctgagctctttagagacagtgtctactcaggaactctgt
tctattcctgaggaccaagaaccggaagagcctggacctactccttgggctcggctatgg
gctcttcaggatggattctcgaatctagactgtgttaatgacaactactggttcgggagg
gataaaagctgtgaatattgcttcgatggaccactgttgaaaaggacggataagtaccgg
acttacagcaagaagcactttcgcatcttcagggaaatgggccctaagaattgttacatt
gtatacctagaagaccacagtggaaatggaacctttgtaaatacagagcttatcgggaaa
ggaaaacgctgtcctttgagtaacaactctgaaatcgcactttcactgtgtagaaataaa
gtttttgtattttttgatctgactgtagatgaccagtcagtttatcctaaggaattaaga
gacgaatacatcatgtcaaaaactcttggaagcggtgcctgtggggaggtaaagatggcc
tttgagaggaaaacgtgtaagaaagtggccataaagatcatcagcaagcggaggttcgcc
cttggctcgtccagagaagctgacacagctcccagtgtggaaactgaaatagaaattttg
aagaagctgaatcatccgtgcatcatcaagattaaagatgtctttgatgtggaagattat
tacattgttctggaactgatggaaggaggagaattgtttgaccgtgtggtggggaacaaa
cgcctgaaggaagccacctgcaagctctatttctaccaaatgcttttagctgtacagtac
cttcatgaaaatgggatcatacatcgggacctaaagccagagaatgttcttctgtcatct
caggaagaggactgtcttatcaagatcactgattttggacagtccaagatcttgggggag
acctccctgatgaggactctatgtggtacgcccacttatctggctcctgaggtccttatc
tccaacgggactgctgggtacagccgggccgtcgactgctggagcctaggagtcattctt
ttcatctgcctaagtgggtatccacctttctctgagcataagacccaagtgtcactgaag
gatcagatcaccagtggaaagtacaaccttattccggaagtctggacagatgtctcagag
aaggctctggaccttgtcaagaaactactggttgtggatccaaaggccaggcttaccaca
gaggaagccttaagtcatccttggcttcaggatgagcacatgaagaagaagtttcaggat
ctgctggtgcaggaaaagaacttggtgcccctccctctggctcctgcccagacttccggt
caaaagcggcccctggaactggaggcggaggacgcggagagctcgaagcgcctggccgtg
tgtaaggctgtgttgtga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (8)   
   UniProt (2)   
   RefSeq(pep) (6)   
DNA sequence (8)   
   RefSeq(nuc) (6)   
   GenBank (1)   
   EMBL (1)   
Protein domain (10)   
   Pfam (10)   
All databases (42)   

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