KEGG   Rattus norvegicus (rat): 116554
Entry
116554            CDS       T01003                                 
Symbol
Mapk8
Name
(RefSeq) mitogen-activated protein kinase 8
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01522  Endocrine resistance
rno04010  MAPK signaling pathway
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04024  cAMP signaling pathway
rno04068  FoxO signaling pathway
rno04071  Sphingolipid signaling pathway
rno04137  Mitophagy - animal
rno04140  Autophagy - animal
rno04141  Protein processing in endoplasmic reticulum
rno04210  Apoptosis
rno04215  Apoptosis - multiple species
rno04217  Necroptosis
rno04310  Wnt signaling pathway
rno04380  Osteoclast differentiation
rno04510  Focal adhesion
rno04530  Tight junction
rno04620  Toll-like receptor signaling pathway
rno04621  NOD-like receptor signaling pathway
rno04622  RIG-I-like receptor signaling pathway
rno04625  C-type lectin receptor signaling pathway
rno04657  IL-17 signaling pathway
rno04658  Th1 and Th2 cell differentiation
rno04659  Th17 cell differentiation
rno04660  T cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04668  TNF signaling pathway
rno04722  Neurotrophin signaling pathway
rno04723  Retrograde endocannabinoid signaling
rno04728  Dopaminergic synapse
rno04750  Inflammatory mediator regulation of TRP channels
rno04910  Insulin signaling pathway
rno04912  GnRH signaling pathway
rno04914  Progesterone-mediated oocyte maturation
rno04917  Prolactin signaling pathway
rno04920  Adipocytokine signaling pathway
rno04926  Relaxin signaling pathway
rno04930  Type II diabetes mellitus
rno04931  Insulin resistance
rno04932  Non-alcoholic fatty liver disease
rno04933  AGE-RAGE signaling pathway in diabetic complications
rno04935  Growth hormone synthesis, secretion and action
rno04936  Alcoholic liver disease
rno05010  Alzheimer disease
rno05012  Parkinson disease
rno05016  Huntington disease
rno05017  Spinocerebellar ataxia
rno05020  Prion disease
rno05022  Pathways of neurodegeneration - multiple diseases
rno05132  Salmonella infection
rno05133  Pertussis
rno05135  Yersinia infection
rno05142  Chagas disease
rno05145  Toxoplasmosis
rno05152  Tuberculosis
rno05161  Hepatitis B
rno05162  Measles
rno05166  Human T-cell leukemia virus 1 infection
rno05167  Kaposi sarcoma-associated herpesvirus infection
rno05169  Epstein-Barr virus infection
rno05170  Human immunodeficiency virus 1 infection
rno05171  Coronavirus disease - COVID-19
rno05200  Pathways in cancer
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05210  Colorectal cancer
rno05212  Pancreatic cancer
rno05231  Choline metabolism in cancer
rno05415  Diabetic cardiomyopathy
rno05417  Lipid and atherosclerosis
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    116554 (Mapk8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    116554 (Mapk8)
   04012 ErbB signaling pathway
    116554 (Mapk8)
   04014 Ras signaling pathway
    116554 (Mapk8)
   04310 Wnt signaling pathway
    116554 (Mapk8)
   04668 TNF signaling pathway
    116554 (Mapk8)
   04068 FoxO signaling pathway
    116554 (Mapk8)
   04071 Sphingolipid signaling pathway
    116554 (Mapk8)
   04024 cAMP signaling pathway
    116554 (Mapk8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    116554 (Mapk8)
   04137 Mitophagy - animal
    116554 (Mapk8)
  09143 Cell growth and death
   04210 Apoptosis
    116554 (Mapk8)
   04215 Apoptosis - multiple species
    116554 (Mapk8)
   04217 Necroptosis
    116554 (Mapk8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    116554 (Mapk8)
   04530 Tight junction
    116554 (Mapk8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    116554 (Mapk8)
   04621 NOD-like receptor signaling pathway
    116554 (Mapk8)
   04622 RIG-I-like receptor signaling pathway
    116554 (Mapk8)
   04625 C-type lectin receptor signaling pathway
    116554 (Mapk8)
   04660 T cell receptor signaling pathway
    116554 (Mapk8)
   04658 Th1 and Th2 cell differentiation
    116554 (Mapk8)
   04659 Th17 cell differentiation
    116554 (Mapk8)
   04657 IL-17 signaling pathway
    116554 (Mapk8)
   04664 Fc epsilon RI signaling pathway
    116554 (Mapk8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    116554 (Mapk8)
   04920 Adipocytokine signaling pathway
    116554 (Mapk8)
   04912 GnRH signaling pathway
    116554 (Mapk8)
   04914 Progesterone-mediated oocyte maturation
    116554 (Mapk8)
   04917 Prolactin signaling pathway
    116554 (Mapk8)
   04926 Relaxin signaling pathway
    116554 (Mapk8)
   04935 Growth hormone synthesis, secretion and action
    116554 (Mapk8)
  09156 Nervous system
   04728 Dopaminergic synapse
    116554 (Mapk8)
   04723 Retrograde endocannabinoid signaling
    116554 (Mapk8)
   04722 Neurotrophin signaling pathway
    116554 (Mapk8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    116554 (Mapk8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    116554 (Mapk8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116554 (Mapk8)
   05208 Chemical carcinogenesis - reactive oxygen species
    116554 (Mapk8)
   05231 Choline metabolism in cancer
    116554 (Mapk8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    116554 (Mapk8)
   05212 Pancreatic cancer
    116554 (Mapk8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    116554 (Mapk8)
   05170 Human immunodeficiency virus 1 infection
    116554 (Mapk8)
   05161 Hepatitis B
    116554 (Mapk8)
   05171 Coronavirus disease - COVID-19
    116554 (Mapk8)
   05162 Measles
    116554 (Mapk8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    116554 (Mapk8)
   05169 Epstein-Barr virus infection
    116554 (Mapk8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    116554 (Mapk8)
   05135 Yersinia infection
    116554 (Mapk8)
   05133 Pertussis
    116554 (Mapk8)
   05152 Tuberculosis
    116554 (Mapk8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    116554 (Mapk8)
   05142 Chagas disease
    116554 (Mapk8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116554 (Mapk8)
   05012 Parkinson disease
    116554 (Mapk8)
   05016 Huntington disease
    116554 (Mapk8)
   05017 Spinocerebellar ataxia
    116554 (Mapk8)
   05020 Prion disease
    116554 (Mapk8)
   05022 Pathways of neurodegeneration - multiple diseases
    116554 (Mapk8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    116554 (Mapk8)
   05418 Fluid shear stress and atherosclerosis
    116554 (Mapk8)
   05415 Diabetic cardiomyopathy
    116554 (Mapk8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    116554 (Mapk8)
   04936 Alcoholic liver disease
    116554 (Mapk8)
   04932 Non-alcoholic fatty liver disease
    116554 (Mapk8)
   04931 Insulin resistance
    116554 (Mapk8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    116554 (Mapk8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    116554 (Mapk8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    116554 (Mapk8)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     116554 (Mapk8)
Protein kinases [BR:rno01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   116554 (Mapk8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 Kinase-like RIO1 FTA2 APH DUF530
Other DBs
NCBI-GeneID: 116554
NCBI-ProteinID: NP_446281
RGD: 621506
Ensembl: ENSRNOG00000020155
UniProt: P49185
Position
16:complement(8645171..8728225)
AA seq 427 aa
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagtaaacgtgacaacaatttttatagtgtagagatcggagattctacattc
acagtcctaaaacgataccagaacttaaagcctataggctcaggagctcaaggaatagtg
tgtgcagcttatgatgctattcttgaaagaaatgttgcaatcaagaagctcagccggcca
tttcagaatcagacccatgctaagcgagcctaccgagaactagttcttatgaagtgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggagttagatcatgaaagaatgtcctaccttctctatcaaatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcctagtaatatagtagtcaaa
tcagactgcactttgaagattcttgattttggactggcaaggactgcaggaacgagtttt
atgatgacgccttacgtggtaactcgttactacagagcaccagaggtcattctcggcatg
ggctacaaggagaacgtggatttatggtctgtggggtgcattatgggagaaatggtttgc
ctcaaaatcctctttccaggaagggactatattgatcagtggaataaagttattgaacag
ctcggaacaccttgtcctgaattcatgaagaaactacaaccaacagtaaggacttacgtt
gaaaacagacctaagtacgctggctatagctttgagaaactgtttcctgatgtgcttttc
ccagctgactcagaacataacaaacttaaagccagtcaggcgagagatttgttatctaaa
atgctggtgatagatgcgtccaaaaggatctccgtagacgaagctctccagcacccgtac
atcaacgtctggtatgatccttcagaagcagaggccccaccaccaaagatccctgacaag
cagttagatgaaagggagcacacaatagaggagtggaaagaactgatatacaaggaggtc
atggatttggaggagcgaactaagaatggcgtcataagagggcagccgtctcctttaggt
gcagcagtgatcaatggctctcagcatccggtctcttcgccgtctgtcaatgacatgtct
tcaatgtccacagatccgactctggcctcggatacagacagcagtctagaagcatcagct
ggacctctgggctgctgtagatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (70)   
   KEGG PATHWAY (70)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
Protein domain (9)   
   Pfam (9)   
All databases (108)   

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