KEGG   Rattus norvegicus (rat): 116719
Entry
116719            CDS       T01003                                 
Symbol
Acacb
Name
(RefSeq) acetyl-CoA carboxylase 2 precursor
  KO
K01946  acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00061  Fatty acid biosynthesis
rno00620  Pyruvate metabolism
rno00640  Propanoate metabolism
rno01100  Metabolic pathways
rno04152  AMPK signaling pathway
rno04910  Insulin signaling pathway
rno04920  Adipocytokine signaling pathway
rno04922  Glucagon signaling pathway
rno04931  Insulin resistance
rno04936  Alcoholic liver disease
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    116719 (Acacb)
   00640 Propanoate metabolism
    116719 (Acacb)
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    116719 (Acacb)
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    116719 (Acacb)
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    116719 (Acacb)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    116719 (Acacb)
   04922 Glucagon signaling pathway
    116719 (Acacb)
   04920 Adipocytokine signaling pathway
    116719 (Acacb)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    116719 (Acacb)
   04931 Insulin resistance
    116719 (Acacb)
Enzymes [BR:rno01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.15  acetyl-CoA carboxytransferase
     116719 (Acacb)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.14  biotin carboxylase
     116719 (Acacb)
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.2  acetyl-CoA carboxylase
     116719 (Acacb)
SSDB
Motif
Pfam: ACC_central Carboxyl_trans CPSase_L_D2 ACCA_BT Biotin_carb_N Biotin_carb_C Biotin_lipoyl ATP-grasp Dala_Dala_lig_C
Other DBs
NCBI-GeneID: 116719
NCBI-ProteinID: NP_446374
RGD: 620500
Ensembl: ENSRNOG00000000658
UniProt: O70151
Position
12:complement(48026394..48138214)
AA seq 2455 aa
MVLLLFLTCLVFSCLTISWLKIWGKMTDSKPLSNSKVDASLLSSKEESFSASDQSEEHGD
CSCPLTTPDQEELASHGGPVDASQQRNSVPSSHQKPPRNPLSSNDTCSSPELQTNRVAAP
GSEVPEANGLPFPARPQTQRTGSPTREDKKQAHIKRQLMTSFILGSLDDNSSDEDPSASS
FQTSSRKGSRASLGTLSQEAALNTADPESHTPTMRPSMSGLHLVKRGREHKKLDLHRDFT
VASPAEFVTRFGGNRVIETVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPED
LKANAEYIKMADQYVPVPGGPNNNNYANVELIIDIAKRIPVQAVWAGWGHASENPKLPEL
LCKHEIAFLGPPSEAMWALGDKISSTIVAQTLQIPTLPWSGSGLTVEWTEDSQHQGKCIS
VPEDVYEQGCVRDVDEGLQAAEKVGFPLMIKASEGGGGKGIRRAESAEDFPMLFRQVQSE
IPGSPIFLMKLAQNARHLEVQVLADQYGNAVSLFGRDCSIQRRHQKIIEEAPATIAAPAV
FEFMEQCAVLLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAA
QLQIAMGVPLHRLKDIRLLYGESPWGVTPVSFETPLSPPIARGHVIAARITSENPDEGFK
PSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKE
LSIRGDFRTTVEYLVNLLETESFQNNDIDTGWLDHLIAQRVQAEKPDIMLGVVCGALNVA
DAMFRTCMTEFLHSLERGQVLPADSLLNIVDVELIYGGIKYVLKVARQSLTMFVLIMNGC
HIEIDAHRLNDGGLLLSYNGSSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAG
KLMQYTVEDGQHVEVGSSYAEMEVMKMIMTLNVQESGRVKYIKRPGAVLEAGCVVAKLEL
DDPSKVHAAQPFTGELPAQQTLPILGERLHQVFHSVLENLTNVMNGYCLPEPFFSMKLKD
WVEKLMMTLRHPSLPLLELQEIMTSVAGRIPVPVEKAVRRVMAQYASNITSVLCQFPSQQ
IATILDCHAATLQRKVDREAFFMNTQSIVQLIQRYRSGTRGYMKAVVLDLLRRYLNVEHH
FQQAHYDKCVINLREQFKPDMTRVLDCIFSHSQVAKKNQLVTMLIDELCGPDPTLSEELT
SILKELTQLSRSEHCKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCPENL
KKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRELPDGTCVVEF
QFMLPSSHPNRMAMPINVSDPDLLRHSKELFMDSGFSPLCQRMGAMVAFRRFEEFTRNFD
EVISCFANVPTDTPLFSKACTSLYSEEDSKSLQEEPIHILNVAIQCADHMEDERLVPVFR
AFVQSKKHILVDYGLRRITFLIAQEREFPKFFTFRARDEFAEDRIYRHLEPALAFQLELS
RMRNFDLTAVPCANHKMHLYLGAAKVKEGLEVTDHRFFIRAIIRHSDLITKEASFEYLQN
EGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPTVIMDPLKIEESVRAMVMRYGSRLW
KLRVLQAEVKINIRQTTSDCAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSFGNK
QGSLHGMLINTPYVTKDLLQAKRFQAQSLGTTYVYDFPEMFRQALFKLWGSPEKYPKDIL
TYTELVLDSQGQLVEMNRLPGCNEVGMVVFKMRFKTPEYPEGRDTIVIGNDITFQIGSFG
IGEDFLYLRASEMARTEGIPQIYLAANSGARMGLSEEIKQIFQVAWVDPEDPYKGFRYLY
LTPQDYTQISSQNSVHCKHIEDEGESRYVIVDVIGKDSSLGVENLRGSGMIAGEASLAYE
KNVTISMVTCRAIGIGAYLVRLGQRVIQVENSHIILTGAGALNKVLGREVYTSNNQLGGV
QIMHTNGVSHVTVPDDFEGVCTILEWLSYIPKDNQSPVPIITPSDPIDREIEFTPTKAPY
DPRWLLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRS
VEVAVPADPANLDSEAKIIQQAGQVWFPDSAFKTAQVIRDFNQEHLPLMIFANWRGFSGG
MKDMYEQMLKFGAYIVDSLRLFKQPVLIYIPPGAELRGGAWVVLDSSINPLCIEMYADKE
SRGGVLEPEGTVEIKFRKKDLVKTIRRIDPVCKKLLGQLGTAQLPDKDRKELESQLKARE
DLLLPIYHQVAVQFADLHDTPGHMLEKGIISDVLEWKTTRTYFYWRLRRLLLEAQVKQEI
LRASPELSHEHTQSMLRRWFVETEGAVKAYLWDSNQVVVQWLEQHWSARDNLRSTIRENI
NYLKRDSVLKTIQSLVQEHPEATMDCVAYLSQHLTPAEQMQVVQLLSTTESPASH
NT seq 7368 nt   +upstreamnt  +downstreamnt
atggtcttgcttctctttctgacttgcctggttttctcctgcctgaccatttcctggtta
aaaatctgggggaagatgacagactcgaagccgctcagcaacagtaaggtggatgcaagc
ctcctttcgagcaaggaggagtccttttcagcctcggaccagtcagaggagcatggcgac
tgcagctgtccgttgacaactcctgaccaggaggagctggcctcccacggaggtcctgta
gatgccagtcagcagaggaactctgtgccaagctcacaccagaagcctccgaggaaccca
ctatcttccaatgacacctgttcctccccagaactccaaaccaacagggtagcagcccct
ggctcagaggttccagaagccaacgggttgcctttcccagccaggcctcagacccagaga
acgggatcccccactagggaggacaagaagcaggcacacatcaagaggcagctgatgacc
agctttatcctgggctccctcgatgacaactcctctgacgaggaccctagtgctagctcc
ttccagacctcctctcggaagggcagcagggctagcctgggcaccctgtcccaggaggct
gcattgaacacagctgatcctgagtctcacacacctactatgaggcccagcatgtctgga
ctccatctggtgaagagaggccgtgaacacaagaaactggacctgcacagagatttcact
gtagcttccccagccgaatttgtcacccgctttggaggcaacagggtcatcgagacggtg
ctcatcgccaataatggtatcgctgcggtcaagtgtatgcgctccatccgccgctgggcc
tatgagatgttccgtaatgaacgcgccatccggtttgtggttatggtgacacccgaggat
cttaaggccaacgcagagtacatcaagatggcggaccagtacgttccggtcccaggagga
cccaataataacaactacgccaacgttgagctgatcatagacattgccaagagaatccct
gtgcaggccgtgtgggctggctggggccacgcttcggaaaaccccaaacttccagagcta
ctgtgcaagcacgagattgctttcctaggtcccccgagtgaggccatgtgggccctggga
gacaagatctcctccaccattgtagcccagacattgcagatcccaactctaccctggagc
ggaagcggtctcacagtggagtggacggaggacagccagcatcagggcaaatgcatcagc
gtcccggaagacgtttatgaacaaggctgtgtgagagatgtggacgaaggcttgcaggca
gcagaaaaagtaggatttcctctgatgatcaaagcctctgaaggtggaggagggaaagga
atccgcagggctgagagtgcagaggacttcccgatgcttttcagacaggtgcagagtgag
atcccgggctcgcccatctttctcatgaagctggcccagaatgctcggcacttggaggtc
caggtcttggcagatcagtatgggaacgcagtgtccctgtttggacgagactgctccatc
cagaggcggcaccagaagatcattgaggaggctccggccaccatcgctgctccggctgtg
tttgagttcatggaacagtgtgccgtcctcctggccaagactgtgggttatgtgagcgcg
ggaaccgtggagtacctatacagccaggatggcagctttcacttcttggagctgaaccca
cgcctgcaggtggaacatccctgcactgaaatgatcgcagatgtcaacctgcccgctgca
cagttacagatcgccatgggcgtgcccctgcaccggctgaaggacatacggcttctgtac
ggagagtccccctggggagtgacccccgtttcttttgagacccctttgagccctcccatt
gcccgaggccatgtcattgcagccaggatcaccagcgaaaacccagacgagggctttaag
ccaagctcagggacagtgcaggagctgaacttccgcagcaacaagaacgtgtggggttac
ttcagcgtggccgctgctgggggcttgcacgagtttgccgattcccagtttgggcactgc
ttctcctggggcgagaaccgtgaagaggctatttcgaacatggtggtggctttgaaagaa
ctgtctatccggggtgacttccggaccaccgtggaatatctcgtcaaccttctggagacg
gagagcttccagaacaatgatatcgacacagggtggctggaccacctcatcgctcagcgg
gtgcaggcagagaagccggacatcatgctcggggtggtgtgtggggccttgaacgtggca
gacgcgatgttcagaacctgtatgacggaattcctgcattccttggaaaggggtcaggtc
ctcccggctgattctctgctgaacatcgtggacgttgagttgatttacggaggcatcaaa
tatgttctcaaggtggcccggcagtccctgaccatgtttgtcctcatcatgaatggttgc
cacatcgagatcgatgcccaccggctgaacgatgggggcctgctcctgtcctacaatggt
agcagttacactacatacatgaaggaagaggtggacagttaccggatcactatcggcaat
aagacatgcgtgtttgaaaaggaaaacgaccccaccgtcctgagatccccctcggctggg
aagctgatgcagtacacggtggaggatggccagcacgtggaagtcgggagcagctatgct
gagatggaggtgatgaagatgatcatgaccctgaacgtgcaagagagcggccgggtgaag
tacatcaagcgaccaggggcggtattggaggctggctgcgtggtggcaaagctagaactc
gatgacccttcaaaagtgcacgcggcacagccgttcacaggggagctccccgcccagcag
actctgcccatcctcggggagaggctgcatcaggtgttccacagcgtcttggaaaatctg
accaatgtcatgaatggctactgcctgcccgagcccttcttcagcatgaagctgaaggac
tgggtggagaagctcatgatgactctccggcatccctccctacctctgctggagctgcag
gagatcatgaccagcgtggcaggccgcatcccggttccggtggagaaggcagtccgcagg
gtgatggcgcagtacgccagcaacatcacttcggtgctctgccagttccccagccagcag
atagccaccatcctggactgccacgccgccaccctgcagcgtaaggtggaccgagaggcc
ttcttcatgaacacacagagcatcgtgcagctgatccagagataccgcagtgggacccgt
ggctacatgaaggctgtggtgctagacctcctgaggagatatctgaacgtggagcatcat
ttccagcaagcccactatgacaagtgtgtgatcaacctgagggagcagttcaagccggac
atgactcgggtgctggactgcatcttctcacactcacaagtggccaagaagaaccagctg
gtgaccatgttgatagatgagctgtgtggcccagaccccaccctgtcagaagagctgacc
tccatcctcaaggaactcacgcagttgagcaggagtgagcactgcaaggtggccctcaga
gccaggcaggtcctgattgcctctcacctcccctcctacgagctgcggcacaaccaggtg
gagtccatcttcctgtcagccattgacatgtatggccaccagttctgcccggaaaacctc
aagaaactaatactttcggaaacgaccatattcgatgtcctgcccactttcttctatcac
gctaacaaggtcgtctgtatggcgtccctggaggtttatgtgaggagaggttacatcgcc
tacgagttaaacagcctacagcaccgggagctccctgacggcacctgcgtggtggagttc
cagttcatgctgccgtcttcccaccccaaccggatggccatgcccatcaatgtctctgac
cctgacctgctgagacacagtaaggaactcttcatggacagtggcttctccccactgtgc
cagcggatgggggccatggtggccttcaggagatttgaggagttcaccaggaacttcgat
gaagtcatctcctgctttgccaacgtgcctacagacactcctctcttcagtaaggcgtgc
acttccctctactcagaggaggacagcaagagccttcaagaggagcccatccacatcctg
aatgtggccatccagtgcgccgaccacatggaggacgagagactggtgccggttttccgt
gcctttgtacagtccaagaaacacatccttgtggattacggactgcgaagaatcacattc
cttatcgcccaagagagagaatttcccaagttcttcacgttcagagcgagagatgagttt
gcagaagaccggatttaccgccacttggagccggccctggccttccagctggagctgagc
cggatgcgcaactttgacctgacggccgtgccctgtgccaaccataagatgcatctttac
ctgggagccgccaaggtgaaggaagggctggaggtgactgaccacaggttcttcatccga
gccatcataaggcactcagacctgatcaccaaggaagcctccttcgagtacctgcagaat
gaaggggagcggctgctgctggaagccatggacgagctggaggtggcgttcaacaacacc
agcgtgcgcactgactgcaaccacatcttcctcaacttcgtgcccacggtcatcatggac
ccactcaagatcgaggagtcggtgcgtgccatggtcatgcgttacggcagtcggctgtgg
aagctccgtgtgctgcaggcagaagttaagatcaacatccgtcagacgacctcggactgc
gccgtccccattcgcctcttcatcaccaacgagtccggctactacctggacatcagcctc
tacaaagaagtgaccgactccagatccggaaacatcatgtttcattccttcggcaacaaa
caagggagcctgcacgggatgctgatcaacacgccctacgtcaccaaggatctgctccaa
gccaagcgattccaggcgcagtccctggggaccacctatgtgtacgacttcccagagatg
ttcaggcaggctctctttaaattgtggggctccccagagaagtaccccaaagatatcctg
acatacacagagctggtgttggactcccagggccagctggtggagatgaaccggcttcct
ggttgtaacgaggtgggcatggtggttttcaaaatgaggttcaagaccccggagtatcca
gaaggccgggacactatcgtcatcggcaacgacattaccttccaaatcggctctttcggc
ataggagaggacttcctgtatctacgggcatcggagatggcccggacagagggcatcccc
caaatctatctggcagccaacagcggggcccgtatgggcctgtccgaggagatcaagcag
atattccaagtggcatgggtggaccctgaggatccctacaaaggatttagatacctgtac
ctgacgccccaagactacacccagatcagctcccagaactccgtgcactgcaaacacatc
gaggacgaaggcgagtccaggtatgtcatcgttgatgtcatcgggaaggacagcagcctg
ggtgtggagaacctgcggggctcgggcatgattgcaggagaggcttctctggcttacgaa
aaaaatgtcaccatcagcatggtgacctgccgcgccatcggaatcggggcttacctggtg
aggctgggccagcgggtgatccaggtggaaaactcccacatcatcctcacgggagccggt
gctctcaacaaggtcctgggaagagaggtctacacatccaacaaccaactgggcggtgtg
cagatcatgcacaccaacggggtctcccacgtcacggtgccagatgacttcgagggggtc
tgcaccattctggaatggctgtcatatataccaaaggacaatcaaagcccagtccccatc
atcactccttctgaccccatcgacagggaaattgaattcaccccaaccaaagctccctat
gaccccaggtggctgctggcagggaggcctcacccaactctgaaggggacctggcagagt
ggattcttcgaccatggcagtttcaaggaaatcatggcaccctgggcccagactgtggtg
actggacgagcaaggctggggggcatccctgtaggggtgattgccgtggagactcggtct
gtggaggtggctgtccctgctgaccctgccaacttggattctgaggccaagatcatccag
caggcaggccaggtgtggttcccggactctgccttcaagacggctcaggtcatcagggac
ttcaaccaggagcatctgcctctcatgatctttgctaactggagaggcttctcgggcggc
atgaaagacatgtacgagcagatgctgaagtttggcgcctacatcgtggacagtctccgt
ctgttcaagcagccagttctcatctatatccctcccggtgccgaactccgagggggcgcc
tgggttgtcctcgactccagcatcaaccccctgtgcatagagatgtacgcagacaaagag
agcagggggggtgtcctggagcccgagggcactgtggagattaagttccggaagaaagat
ttggtgaagaccataaggaggattgacccagtgtgcaagaaactcctggggcagctgggg
acagcccagctccctgacaaggaccggaaagagctggagagccagctgaaggcccgggag
gacctgctgctccccatctaccaccaggtggcagtgcagttcgccgacctgcatgacacg
ccgggccacatgctggagaagggaatcatttctgatgtgctggagtggaagaccacacgt
acctacttctactggaggctgcgccggctgctgctggaggcacaggtgaagcaggagatt
ctgcgagccagccctgagctgagccatgagcacacgcagtccatgctgcgacgctggttt
gtggagaccgagggcgccgtcaaggcctacctgtgggacagcaaccaggtggtagtccag
tggctggaacagcactggtcagccagggacaacctgcgttccactatccgagagaacatc
aattatctgaagcgggactctgtcctcaagaccatccaaagcctagttcaagaacaccca
gaggcgaccatggactgtgtggcatacctgagccagcacctcacgcccgctgagcagatg
caggtggttcagctgctgtctaccacggagagcccagcttcccactga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (10)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (3)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (15)   
   UniProt (1)   
   RefSeq(pep) (14)   
DNA sequence (20)   
   RefSeq(nuc) (14)   
   GenBank (3)   
   EMBL (3)   
Protein domain (9)   
   Pfam (9)   
All databases (73)   

Download RDF
DBGET integrated database retrieval system