KEGG   Rattus norvegicus (rat): 24211
Entry
24211             CDS       T01003                                 
Symbol
Atp1a1
Name
(RefSeq) sodium/potassium-transporting ATPase subunit alpha-1 precursor
  KO
K01539  sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04022  cGMP-PKG signaling pathway
rno04024  cAMP signaling pathway
rno04260  Cardiac muscle contraction
rno04261  Adrenergic signaling in cardiomyocytes
rno04820  Cytoskeleton in muscle cells
rno04911  Insulin secretion
rno04918  Thyroid hormone synthesis
rno04919  Thyroid hormone signaling pathway
rno04925  Aldosterone synthesis and secretion
rno04960  Aldosterone-regulated sodium reabsorption
rno04961  Endocrine and other factor-regulated calcium reabsorption
rno04964  Proximal tubule bicarbonate reclamation
rno04970  Salivary secretion
rno04971  Gastric acid secretion
rno04972  Pancreatic secretion
rno04973  Carbohydrate digestion and absorption
rno04974  Protein digestion and absorption
rno04976  Bile secretion
rno04978  Mineral absorption
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    24211 (Atp1a1)
   04022 cGMP-PKG signaling pathway
    24211 (Atp1a1)
 09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    24211 (Atp1a1)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    24211 (Atp1a1)
   04918 Thyroid hormone synthesis
    24211 (Atp1a1)
   04919 Thyroid hormone signaling pathway
    24211 (Atp1a1)
   04925 Aldosterone synthesis and secretion
    24211 (Atp1a1)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    24211 (Atp1a1)
   04261 Adrenergic signaling in cardiomyocytes
    24211 (Atp1a1)
  09154 Digestive system
   04970 Salivary secretion
    24211 (Atp1a1)
   04971 Gastric acid secretion
    24211 (Atp1a1)
   04972 Pancreatic secretion
    24211 (Atp1a1)
   04976 Bile secretion
    24211 (Atp1a1)
   04973 Carbohydrate digestion and absorption
    24211 (Atp1a1)
   04974 Protein digestion and absorption
    24211 (Atp1a1)
   04978 Mineral absorption
    24211 (Atp1a1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    24211 (Atp1a1)
   04961 Endocrine and other factor-regulated calcium reabsorption
    24211 (Atp1a1)
   04964 Proximal tubule bicarbonate reclamation
    24211 (Atp1a1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:rno04147]
    24211 (Atp1a1)
Enzymes [BR:rno01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.2.2.13  Na+/K+-exchanging ATPase
     24211 (Atp1a1)
Exosome [BR:rno04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   24211 (Atp1a1)
  Exosomal proteins of other body fluids (saliva and urine)
   24211 (Atp1a1)
  Exosomal proteins of colorectal cancer cells
   24211 (Atp1a1)
  Exosomal proteins of bladder cancer cells
   24211 (Atp1a1)
SSDB
Motif
Pfam: E1-E2_ATPase Cation_ATPase_C Cation_ATPase Cation_ATPase_N Hydrolase Hydrolase_3 HAD
Other DBs
NCBI-GeneID: 24211
NCBI-ProteinID: NP_036636
RGD: 2167
Ensembl: ENSRNOG00000030019
UniProt: P06685
Structure
Position
2:complement(191709311..191737414)
AA seq 1023 aa
MGKGVGRDKYEPAAVSEHGDKKSKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLS
RGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIRSA
TEEEPPNDDLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSI
NAEDVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETR
NIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAEEIEHFIHLITGVAV
FLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKN
LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWFA
LSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIEVCCGSVMEMREKYTKIVEI
PFNSTNKYQLSIHKNPNASEPKHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQN
AYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDEVNFPVDNLCFVGLISMIDPPRAAVP
DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQVNPRDA
KACVVHGSDLKDMTSEELDDILRYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVN
DSPALKKADIGVAMGIVGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL
TSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPK
TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPFHLLGIRETWDDRWINDVED
SYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFE
ETALAAFLSYCPGMGAALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKE
TYY
NT seq 3072 nt   +upstreamnt  +downstreamnt
atggggaagggggttggacgagacaagtatgagcccgcagctgtatcagaacatggggac
aagaagagcaagaaggcgaagaaggaaagggacatggacgaactcaagaaggaagtgtct
atggacgaccataaactcagcctggatgaactccatcgtaaatacggaacagatttgagc
cgaggcctaacacccgcaagggccgctgagatcctggctcgggatggccccaacgccctc
acgccccctcccactactcccgagtgggtcaaattctgtcggcagctgttcggtggcttc
tccatgttactgtggattggagccattctttgtttcttggcttatggcatccgaagtgct
acagaagaggaaccaccaaatgatgatctgtacctcggggtcgtgctgtctgctgtcgtc
atcataactggctgtttctcctattatcaagaagcaaaaagctccaagatcatggaatcc
ttcaagaacatggtccctcagcaagccctcgtgattcgaaatggagagaagatgagcatc
aacgcagaggatgtcgtcgttggtgatctggtggaggtgaagggcggagaccgaatccct
gctgatctcagaatcatatctgcaaatggctgcaaggtggataactcctcactcactggt
gaatcagaaccccagactcggtccccggatttcacaaacgagaaccccttggagacaagg
aacattgccttcttctcaaccaactgtgttgaaggaactgcacgtggcatcgttgtgtac
actggggatcgcaccgtgatgggcaggatcgccacccttgcttctgggctggaaggcggc
cagacccccattgctgaagaaatcgagcacttcatccacctcatcacgggtgtggccgtg
ttcctgggggtgtctttcttcattctctctctgatccttgagtacacctggctcgaggct
gtcatcttcctcattggtatcatcgtagccaacgtgccggaaggtttgctggccaccgtc
acggtatgtctgacgctcactgccaagcgcatggcgaggaagaactgcctggtgaagaac
ctggaagctgtggagaccttggggtccacatccaccatctgctccgacaagactggaact
ctgactcagaaccggatgacagtggctcacatgtggtttgacaatcaaatccatgaagct
gacaccacagagaatcagagtggggtctcctttgacaagacgtcagccacctggttcgct
ctgtccagaattgctggtctctgtaacagggcagtgtttcaggctaaccaagaaaacctg
cctatccttaagcgtgcagtagcgggagatgcttccgagtcggcgctcttaaagtgcatc
gaggtctgctgtggctccgtgatggagatgagggagaagtacaccaagatagtggagatt
cctttcaactccaccaacaagtaccagctctccattcacaagaacccaaacgcatcggag
cctaagcacctgctagtgatgaagggcgccccagaaaggatcctggaccgatgcagttct
atcctcctccacggcaaggagcagcccctggacgaagagctgaaggacgcctttcagaat
gcctacctagagctggggggccttggagagcgtgtgctaggtttctgccacctccttctg
cctgacgaacagtttcccgaaggcttccagtttgacactgatgaagtcaatttccccgtg
gataacctctgcttcgtgggtcttatctccatgattgaccctcctcgagctgctgtcccc
gatgctgtgggcaaatgccgcagcgctgggattaaggtcatcatggtcacaggagaccat
ccaatcacagccaaagccattgctaagggggtgggcattatctcagaaggtaacgagacc
gtggaagacattgctgcccgcctcaacattccagtgaaccaggtgaaccccagagatgcc
aaggcctgtgtagtacatggcagtgacttgaaggacatgacctctgaggagctggatgac
attttgcggtaccacacggagattgtctttgctaggacctctcctcaacagaagctcatc
attgtggagggctgccagcggcagggtgccatcgtggctgtcacaggggatggtgtcaat
gactctccagctttgaaaaaggcagatattggggttgccatggggattgttggctcggat
gtgtccaagcaagctgctgacatgattcttctggatgacaactttgcctccatcgtgact
ggagtagaagaaggtcgtctgatatttgataacttgaagaaatccattgcttacacccta
acaagtaacattccggaaatcacccccttcttgatatttattattgcaaacattccactg
cccctgggcaccgtgaccatcctctgcattgacttgggcactgacatggttcccgccatc
tctctggcctatgaacaggctgaaagtgacatcatgaagaggcagcccagaaatcccaaa
acggacaaacttgtgaacgagcgtctgatcagcatggcctatggacagatcggtatgatc
caggccctgggaggcttcttcacttattttgtgattctggctgagaacggtttcctgccc
tttcacctgttgggcatccgagagacctgggatgaccgctggatcaatgatgtggaggac
agctacgggcagcagtggacctacgagcagaggaagattgtggagttcacctgccacacg
gccttctttgtcagtatcgtggtagtgcagtgggctgacttggtcatctgcaagaccaga
aggaattctgtcttccagcagggaatgaagaacaagatcttaatatttggcctctttgaa
gagacagctcttgctgctttcctgtcctactgccctgggatgggtgcagcccttaggatg
tatcccctcaaacctacttggtggttctgtgccttcccctactcccttctcatcttcgtg
tatgacgaggtgcggaagctcatcatcaggcgacgccctggcggctgggtggagaaggaa
acctactactag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (19)   
   KEGG PATHWAY (19)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (19)   
   RefSeq(nuc) (1)   
   GenBank (9)   
   EMBL (9)   
3D Structure (2)   
   PDB (2)   
Protein domain (7)   
   Pfam (7)   
All databases (61)   

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