KEGG   Rattus norvegicus (rat): 24298
Entry
24298             CDS       T01003                                 
Symbol
Cyp21a1
Name
(RefSeq) steroid 21-hydroxylase
  KO
K00513  steroid 21-monooxygenase [EC:1.14.14.16]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00140  Steroid hormone biosynthesis
rno01100  Metabolic pathways
rno04925  Aldosterone synthesis and secretion
rno04927  Cortisol synthesis and secretion
rno04934  Cushing syndrome
Module
rno_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    24298 (Cyp21a1)
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    24298 (Cyp21a1)
   04927 Cortisol synthesis and secretion
    24298 (Cyp21a1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    24298 (Cyp21a1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:rno00199]
    24298 (Cyp21a1)
Enzymes [BR:rno01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     24298 (Cyp21a1)
Cytochrome P450 [BR:rno00199]
 Cytochrome P450, animal type
  CYP21 family
   24298 (Cyp21a1)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 24298
NCBI-ProteinID: NP_476442
RGD: 2461
Ensembl: ENSRNOG00000000428
Vega: OTTRNOG00000001692
UniProt: F1LRG0
Position
20:4028323..4031549
AA seq 493 aa
MLLPGLLLLLLLLLLAGTRWLWGQWKLWKLRLPPLAPGFLHFLQPNLPVYLFGLAQKLGP
IYRIRLGLQDVVVLNSNKTIEEALIQKWVDFAGRPQILDGKMNFDLSMGDYSLTWKAHKK
LSRSALVLGMRDSMEPLVEQLTQEFCERMRAQAGASVAIHKEFSLLTCSIISCLTFGDKQ
DSTLLNATHSCVRDLLKAWNHWSVQILDIIPFLRFFPNPGLWKLKQFQESRDHIVMQELK
RHKDSLVAGQWKDMIDYMLQGVEKQRDARDPGQLHERHVHMSVVDLFVGGTETTAATLSW
AVAFLLHHPEIQKRLQEELDLKLAPSSQLLYKNRMQLPLLMATIAEVLRLRPVVPMALPH
RATKASSISGYDIPKDTIIIPNIQGANLDEMVWELPSKFWPDRFLESGKSPRIPTFGCGA
RVCLGEPLARLELFVVLARLLQTFTLLPPPDGTLPSLQPLPYTGINLLIPPFQVRLQPRN
LAPQDQGQKSSTG
NT seq 1482 nt   +upstreamnt  +downstreamnt
atgctgctacctgggctgctgttgctgctgctgctgctgctgctagctggcacccgctgg
ctgtggggtcagtggaagctctggaaactccgcctcccgcctctggccccggggtttctg
cactttctacagcccaaccttccggtctacctgtttggcctggctcagaaacttgggccc
atctacaggatccgcttggggctacaagatgtggtggtgttgaactctaacaaaaccatt
gaggaggccttgatccaaaagtgggtggactttgctggccgaccccagatactagatgga
aagatgaactttgacctctccatgggggattattctctaacatggaaagcccacaagaaa
ctctctcgttcggccctggtgctgggcatgagagactccatggaacctctggtagagcag
ctgacccaggaattctgtgagcgcatgagagcccaggccggtgcctctgtggccatccat
aaggaattctccttactcacctgcagtatcatcagctgtctcactttcggagacaagcag
gacagcactttgctgaatgccactcacagctgtgtccgggacttgctgaaagcctggaat
cactggtccgtccaaatcttggatataattccctttctcaggttcttccccaatccaggc
ctctggaaactgaagcagttccaggagagtagggaccatatcgtaatgcaggagctgaag
aggcacaaggacagcctggtggcagggcagtggaaagacatgattgactacatgctccag
ggtgtggagaagcaaagagatgccagagacccagggcagctccacgagcggcacgtgcat
atgtcggtggtggacctttttgtcggtggcacggagaccacggctgccacgctctcctgg
gctgtggctttcctgcttcaccaccctgagatccagaagcggctgcaggaagaattagac
ctcaagctggcccccagctcccagctcctgtacaagaaccgaatgcagctacctctgctc
atggccaccattgctgaagtgctgcgtttgcggcccgtggtgcccatggccttgccccat
cgtgcaactaaggctagcagcatctctggctatgatatccccaaggatacgatcatcatc
cccaacatccaaggcgccaacctggatgagatggtttgggaactgcccagcaagttctgg
cctgatcgcttcctggaatccggcaagagtcccagaataccgacctttggctgtggggca
cgcgtgtgcctgggcgagcctctggcgcggctggagctcttcgtggtgctggctcgcctg
ctccagaccttcacgctgctgccgccaccagatggtaccctgccctccctgcagcccctg
ccgtatactggcatcaatctcttaattcctcccttccaggtgcggctgcagcccaggaac
ctggcaccccaagaccagggccagaaatcctcgacaggatag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (5)   
   KEGG MODULE (2)   
Chemical substance (16)   
   KEGG COMPOUND (16)   
Chemical reaction (7)   
   KEGG ENZYME (1)   
   KEGG REACTION (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
   VEGA (1)   
Protein sequence (5)   
   UniProt (1)   
   RefSeq(pep) (4)   
DNA sequence (8)   
   RefSeq(nuc) (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (1)   
   Pfam (1)   
All databases (55)   

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