KEGG   Rattus norvegicus (rat): 24422
Entry
24422             CDS       T01003                                 
Symbol
Gsta2
Name
(RefSeq) glutathione S-transferase alpha-1
  KO
K00799  glutathione S-transferase [EC:2.5.1.18]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00480  Glutathione metabolism
rno00980  Metabolism of xenobiotics by cytochrome P450
rno00982  Drug metabolism - cytochrome P450
rno00983  Drug metabolism - other enzymes
rno01100  Metabolic pathways
rno01524  Platinum drug resistance
rno05200  Pathways in cancer
rno05204  Chemical carcinogenesis - DNA adducts
rno05207  Chemical carcinogenesis - receptor activation
rno05208  Chemical carcinogenesis - reactive oxygen species
rno05225  Hepatocellular carcinoma
rno05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    24422 (Gsta2)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    24422 (Gsta2)
   00982 Drug metabolism - cytochrome P450
    24422 (Gsta2)
   00983 Drug metabolism - other enzymes
    24422 (Gsta2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    24422 (Gsta2)
   05204 Chemical carcinogenesis - DNA adducts
    24422 (Gsta2)
   05207 Chemical carcinogenesis - receptor activation
    24422 (Gsta2)
   05208 Chemical carcinogenesis - reactive oxygen species
    24422 (Gsta2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    24422 (Gsta2)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    24422 (Gsta2)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    24422 (Gsta2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:rno02000]
    24422 (Gsta2)
Enzymes [BR:rno01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     24422 (Gsta2)
Transporters [BR:rno02000]
 Other transporters
  Pores ion channels [TC:1]
   24422 (Gsta2)
SSDB
Motif
Pfam: GST_C GST_C_3 GST_N GST_N_2 GST_N_3 Ank_4
Other DBs
NCBI-GeneID: 24422
NCBI-ProteinID: NP_058709
RGD: 2754
Ensembl: ENSRNOG00000029861
UniProt: P00502 B6DYP7
Structure
Position
8:complement(88064829..88077168)
AA seq 222 aa
MSGKPVLHYFNARGRMECIRWLLAAAGVEFDEKFIQSPEDLEKLKKDGNLMFDQVPMVEI
DGMKLAQTRAILNYIATKYDLYGKDMKERALIDMYTEGILDLTEMIMQLVICPPDQKEAK
TALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDIHLLELLLYVEEFDASLLTSFPL
LKAFKSRISSLPNVKKFLQPGSQRKLPVDAKQIEEARKIFKF
NT seq 669 nt   +upstreamnt  +downstreamnt
atgtctgggaagccagtgcttcactacttcaatgcccggggcagaatggagtgcatccgg
tggctcctggctgcagcaggagtggagtttgatgagaagtttatacagagtccagaagac
ttggaaaagctaaagaaagacgggaatttgatgtttgaccaagtgcccatggtggagatt
gacgggatgaagctggcacagaccagagccattctcaactacatcgccaccaaatatgac
ctctatgggaaggacatgaaggagagagccctgattgacatgtacaccgaaggcatttta
gatctgactgaaatgattatgcaattggtaatatgtcccccagaccaaaaagaagccaag
accgccttggcaaaagacaggaccaaaaaccggtacttgcctgcctttgaaaaggtgttg
aagagccatggccaagactaccttgtaggtaacaggctgacccgggtagacatccacctg
ctggaacttctcctctatgttgaagagtttgatgccagccttctgacctctttccctctg
ctgaaggccttcaagagcagaatcagcagcctccccaatgtgaagaagttcctgcagcct
ggcagtcagagaaagcttcccgtggatgcaaaacaaatcgaagaagcaaggaagattttc
aagttttag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Chemical substance (45)   
   KEGG COMPOUND (45)   
Chemical reaction (23)   
   KEGG ENZYME (1)   
   KEGG REACTION (22)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (14)   
   RefSeq(nuc) (2)   
   GenBank (6)   
   EMBL (6)   
3D Structure (2)   
   PDB (2)   
Protein domain (6)   
   Pfam (6)   
All databases (117)   

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