KEGG   Rattus norvegicus (rat): 24592
Entry
24592             CDS       T01003                                 
Symbol
Nf1
Name
(RefSeq) neurofibromin
  KO
K08052  neurofibromin 1
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01521  EGFR tyrosine kinase inhibitor resistance
rno04010  MAPK signaling pathway
rno04014  Ras signaling pathway
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    24592 (Nf1)
   04014 Ras signaling pathway
    24592 (Nf1)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    24592 (Nf1)
SSDB
Motif
Pfam: RasGAP CRAL_TRIO_2 CRAL_TRIO MOR2-PAG1_C MIF4G_like_2
Other DBs
NCBI-GeneID: 24592
NCBI-ProteinID: NP_036741
RGD: 3168
Ensembl: ENSRNOG00000013780
UniProt: P97526
Position
10:64803986..65037086
AA seq 2820 aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT
ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF
LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT
DMAECAGKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISRDVVDENNTNKKLFL
DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP
SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN
SAWDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPALRMAPSLTFKEKVTSLKFKEK
PTDLEARSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE
VAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL
REILICRNKFLLKNKQADRSSCHSLYLYGVGCDLPASGNVTQMSVDHEESLRTCAPGASL
RKGRGNSSMDSTAGCSGTPPICRQAQTKLEVALYMFLWSPDTEVVLVAMSCFRHLCEEAD
IRCGVDEVSVHNFLPNYNTFMEFASVSNMLSTGRAALQKRVMALLRRIEHPTAGNTEAWE
DTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWI
NMTGFLCALGGVCLQQRSSSGLATYSPPMGPVSERKGSMISVMSSEGNVDSPVSRFMDRL
LSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKSAISKFFDSQGQVLLTDSNT
QFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQL
VEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVS
LLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRL
ASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAE
TVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLW
NMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIIITSSDWQHVS
FEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPSQLRSVCHCLYQVVSQRFPQ
NSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKVLQSIANHVLFTKEE
HMRPFNDFVKSNFDLARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIG
QYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTHWSSLNLTSSKFEEFMTRHQVH
EKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLKPYYAKPY
EIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLLTG
LKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGS
TAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEA
IVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCA
LTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSI
ELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGS
LGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIID
KTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLR
ASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFR
SSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQ
YNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALT
KLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEV
FMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLTL
VNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIH
HGDPSSRTLKETQPWSSPRGSEGYLAATYPAVGQTSPRARKSMSLDMGQPSQANTKKLLG
TRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVS
ESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPLVHN
LLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFS
KQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLS
NSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAGSFKRNSIKKIV
NT seq 8463 nt   +upstreamnt  +downstreamnt
atggccgcacacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag
cttccaataaaaacaggacagcagaacacacataccaaagtcagcacggagcacaacaag
gagtgtctgatcaacatttccaagtacaagttttctttggtcatcagtggactcaccacc
attctaaagaatgttaacaatatgaggatatttggagaagctgctgaaaaaaatttgtat
ctctctcagttgatcatattggatacactggaaaaatgtcttgctgggcaaccaaaggac
acaatgagattagatgaaacaatgctggtcaaacagttgctaccagaaatctgccatttt
cttcacacctgccgtgaaggaaaccaacatgcagccgaacttcggaattctgcttctggg
gttttattttctctcagctgcaacaacttcaatgcagtctttagtcgaatttctacaagg
ttacaggagttgactgtctgttcagaagacaatgttgatgttcatgatatagaattgtta
cagtatatcaatgtggattgtgcaaaattaaaacgactcctgaaggaaacagcatttaaa
tttaaagccctgaagaaggtggcacaattggcagttataaatagcctagaaaaggctttt
tggaactgggtggaaaattatccagatgaatttacaaagctataccaaattccacagaca
gatatggctgagtgtgcaggaaagctgtttgacttggtggatggttttgcagaaagcacc
aaacgtaaagcagcagtttggccactacagatcattctcctcattctgtgtccagaaata
atccaggacatatccagggatgtggtcgatgagaacaacacaaacaagaaactgtttctg
gacagtttacggaaagcacttgctggccatggcggaagcagacagctgactgaaagtgct
gccatcgcttgtgtcaagttgtgtaaagcaagtacttacatcaactgggaagacaactct
gtcattttcctactggttcagtccatggtggttgatctgaagaacctgctttttaatcca
agtaaaccattctctagaggcagtcagcctgcagatgtggacctcatgattgactgtctt
gtctcttgctttcggatcagccctcacaacaaccaacactttaagatctgtctggctcag
aattcaccttctacatttcactatgtgttggtaaactcactccaccgcattatcaccaat
tctgcatgggattggtggcctaagattgacgctgtatattgtcactcagttgaacttcga
aatatgtttggtgaaacccttcataaagcagtgcaaggctgtggagcacacccagcatta
cggatggcaccaagtcttacctttaaggaaaaggtaacaagccttaagtttaaagaaaag
cctacggacctagaggcaaggagctacaagtatcttcttttgtctatggtgaaactgatt
catgcagacccaaagcttttgctttgtaatccaagaaaacagggccctgaaactcaaggt
agtacagcagaactgattacagggctcgtacagctggttcctcagtcacacatgccagag
gtcgctcaggaggctatggaggctttgttggttcttcatcagttagacagcattgatctg
tggaatcctgatgctcctgtagaaacgttttgggaaattagttcacaaatgcttttttac
atctgcaagaaattaactagtcatcaaatgcttagtagcacagaaattctcaagtggtta
cgggaaattctgatctgcaggaataaatttcttcttaaaaataagcaggcagatagaagt
tcctgtcattctctctacctttatggagtaggatgtgacctgcctgctagtggaaatgtc
actcagatgtcagttgatcatgaggagtcactacgtacctgtgctcctggagcctctctg
cggaaaggaagagggaattcctccatggatagcacagcagggtgcagtggaaccccacct
atatgccgacaagcccagaccaagctagaagtggccttgtacatgtttctgtggagtcct
gacacggaagttgttctggttgctatgtcctgtttccgccacctctgtgaagaagcagac
atccgatgtggtgtggatgaagtgtcagtacacaacttcttgcccaactacaacacattc
atggaatttgcctcagtcagcaatatgttgtcaacaggaagagcggcacttcagaaaaga
gtgatggccctgctaaggcgcattgagcaccctactgcaggaaacactgaggcctgggaa
gatacacatgcaaagtgggaacaggctacaaaactaatccttaactacccaaaggccaaa
atggaagatggccaggctgcagaaagtcttcataagaccattgttaagagacggatgtcc
catgtcagtggaggaggatccatagacttgtctgacacagactccctgcaggaatggatc
aacatgactggcttcctctgtgcccttggtggggtgtgcctgcaacagagaagcagctct
ggcctagcaacatacagcccacctatgggccctgtcagtgaacgcaaagggtctatgatt
tctgtaatgtcttctgaagggaatgttgattcacctgtcagcagatttatggaccggctt
ctgtccttgatggtgtgtaaccatgagaaagtggggcttcagatacggaccaatgttaag
gacctggtgggtctggagctgagtcctgctctgtatccaatgctgttcaacaaactgaag
agtgccatcagcaagttttttgactctcaaggacaggtattattaactgacagcaatact
cagtttgtagagcaaaccatagctataatgaagaacctactggataatcatactgaaggc
agctctgagcatctgggacaagctagcattgagacaatgatgctaaatctggtcagatat
gttcgtgttcttgggaatatggttcatgcaattcaaataaaaacgaaattgtgtcagtta
gttgaagtcatgatggcaagaagagacgacctctcgttttgtcaagagatgaaatttcgg
aataagatggtggagtacctaacagactgggttatgggcacttcaaaccaagccgcagat
gatgatgtaaagtgtctcacaagagatctagaccaagcaagcatggaggcagtagtctcg
ctcctcgctggtcttccactgcagcctgaagaaggagacggagtggagctgatggaggcc
aagtcacagctattccttaagtacttcacattatttatgaaccttttgaatgactgtagt
gaagttgaagatgaaaatgcacaaacaggtggcaggaaacgtggcatgtctcggaggctg
gcatccctgaggcactgtacagtgcttgcaatgtcaaacttactcaatgctaatgtggac
agtggactcatgcactccataggcttaggttatcataaagatcttcagacaagagctaca
tttatggaagttctgacaaaaatccttcaacaaggaacagaatttgatacacttgctgaa
accgtgttggcagatcggttcgagagacttgtggaactggtcacaatgatgggagaccag
ggagagctccctatagctatggctctggccaatgtggtcccttgttctcagtgggatgag
ctggctcgagttctggtcacgctgtttgattctcggcatttgctctaccagctgctctgg
aacatgttttctaaggaggtagagttggcagactccatgcagactctctttcgaggcaac
agcttggccagtaagataatgacgttctgcttcaaggtgtacggtgctacttacctacaa
aagctcttggaccccttgttacgaatcattatcacatcctccgattggcagcatgttagc
tttgaagtggatcctaccaggttagagccctctgagagccttgaggagaaccagaggaac
ctccttcagatgacagagaagttcttccatgccatcatcagttcttcctcagagttcccc
tcgcagcttcgaagtgtctgccattgtttgtaccaggtggttagccagcgcttccctcag
aacagcatcggtgccgtcggaagtgccatgttcctgaggttcatcaaccctgccattgtc
tcaccgtatgaagcagggattttagataaaaagccaccacctagaattgaaaggggcttg
aagttaatgtcaaaggtccttcagagcattgccaatcatgtactgttcacaaaggaagag
cacatgaggccttttaatgattttgtgaaaagcaacttcgacttggcacggaggtttttc
ttagatatagcatcagattgtcccacaagtgacgcagtaaaccatagtctttccttcatc
agtgatggcaatgtgctcgctttacatcggctgctttggaataatcaggagaaaattggc
cagtatctttccagcaacagggatcataaagctgttggaagacgacctttcgataagatg
gccacacttcttgcatatctgggtcctccggagcacaagcctgtggcagatacacactgg
tccagccttaaccttaccagttcaaagtttgaggaatttatgaccaggcatcaggttcat
gagaaggaagagttcaaggccttgaaaacattaagcatcttctaccaagctggcacatcc
aaagctgggaatcctattttctattatgttgcacggaggttcaaaactggccaaatcaat
ggggatttgctgatataccatgtcttgctgactttaaagccatattatgcaaagccatat
gaaattgtagtggaccttacccatactgggcctagcaatcgctttaaaacagacttcctc
tctaagtggtttgttgtttttcctggctttgcttatgacaacgtgtctgcagtctatatc
tataactgtaactcctgggtcagggagtacaccaaataccatgagcggctgctgactggc
ctcaagggcagcaaaaggctcattttcatcgactgtcctgggaagctggctgagcacata
gagcacgagcaacagaagctccctgctgctaccttggcactggaagaggatctaaaggtt
ttccacaatgcgctcaagctagctcacaaggacaccaaagtttctattaaggttggttct
actgctgttcaggtaacctcagcagaaagaacaaaagtattggggcaatccgtctttcta
aatgatatctactatgcttctgaaatcgaagagatctgcctagttgatgagaaccagttc
actttaaccattgcaaaccaaggcacaccgctgacctttatgcaccaagagtgtgaagcc
attgttcagtctatcattcatatcaggacccgatgggaactgtcacagcctgactccatc
cctcagcataccaagattcgaccaaaagatgtccctggaacactgcttaatatcgcatta
ctgaatttgggcagttcagaccctagtttacggtctgctgcctataacctcctgtgtgcc
ttaacttgtacctttaatttaaagatcgaaggtcagttactagagacatcagggttatgc
atccctgccaacaacaccctcttcattgtctctatcagtaaaacgcttgcagccaacgag
ccacacctcaccttagagtttttggaagagtgtatttctggatttagcaaatctagtatt
gaattgaaacacctttgtttggaatatatgaccccatggctgtcaaacctagtccgtttt
tgtaagcataacgatgacgccaaacgacaaagggttactgccatccttgataaactcata
acaatgaccataaatgaaaagcagatgtacccttctattcaagcaaaaatatgggggagc
cttgggcagatcacagacctgctagatgttgtgcttgacagtttcatcaaaaccagtgct
accggagggttggggtctatcaaagctgaggtgatggcagacacagctgtggctttagct
tctggaaatgtgaaactggtgtcaagtaaggttattggaaggatgtgtaaaataattgac
aagacttgcttatctccaactccaactttagaacagcatcttatgtgggacgacattgcc
attttagcccgctatatgctgatgctgtccttcaacaactccctggatgtggccgctcat
ctcccctatctcttccatgttgtcaccttcttagtagccacaggtcctttgtcccttcgc
gcttccacccacggattggtcattaatatcattcactctctgtgcacttgctcacagctt
cattttagtgaagagaccaagcaagttttgaggctcagtctgacagagttctcgttaccc
aaattttacttactgtttggcatcagcaaagtcaagtcagctgctgtcattgccttccgt
tccagctaccgggaccggtcgttctctcctggctcctatgaaagggagacttttgctttg
acgtccctggaaacagtcacagaagctttgttggagatcatggaggcatgtatgagagat
attccaacatgcaagtggctggatcagtggacggaactggctcaaagatttgcatttcag
tacaacccatccctgcagccaagagctcttgtggtgtttggctgtattagcaaacgtgtg
tctcacgggcagataaagcagattatccgaatccttagcaaggcacttgaaagttgttta
aagggacctgacacttacaacagtcaagttctgatagaagccacagtgattgcactgacc
aaactacagccacttcttaataaggactcaccactgcacaaagccctcttctgggttgct
gtggctgtgctgcagctagatgaagtcaacttgtactcagctggcactgcacttctggaa
cagaatctgcataccttggatagtctccggatattcaatgacaagagtccggaagaggta
tttatggcaatccggaatcctctggaatggcactgcaagcaaatggatcactttgttgga
ctcaatttcaactctaattttaactttgcactagttggacacctcttaaaagggtacaga
catccttcacctgccattgttgcaagaacagtcagaattttgcatacactactaactctt
gttaacaaacatagaaattgtgacaaatttgaggtgaatacacagagtgtggcttactta
gcagctctactcacagtgtctgaagaggttcgaagtcgctgtagcctcaagcataggaag
tcccttcttcttactgatatctcaatggaaaatgttcctatggatacatatcccattcat
cacggtgatcccagctctaggacactaaaggagactcagccatggtcctctcccagaggt
tcagaaggataccttgcagccacctacccagctgtaggccaaactagtccccgagccagg
aaatccatgagcttggacatgggacagccttctcaggccaacacaaaaaaattgcttgga
acaaggaaaagttttgatcacttgatatcagacacaaaggctcctaaaagacaagaaatg
gaatcagggattacaacacccccaaaaatgagaagagtggcagagaccgactatgaaatg
gaaacccaaaggatttcctcctcgcagcagcacccacatttacggaaagtctcagtgtct
gaatctaatgttctattggacgaagaagtacttactgacccaaagatccaagcactgctt
cttactgttctggctacactggtaaaatataccacagatgaatttgatcagcgaattctt
tatgaatatctagcagaggccagtgttgtgtttcccaaagtgtttcctcttgtgcacaat
ttgttggactctaagatcaataccctcttgtctttgtgccaagatccaaatttgttaaat
ccgatccatggaatcgtgcagagtgtggtgtaccatgaggaatcccctccacagtaccaa
acatcatacctgcaaagtttcggttttaatggcttatggcggtttgcaggacccttttca
aagcaaacacaaatcccagactatgctgagctcattgttaaatttcttgatgccttgatt
gacacgtacttgcctggaattgatgaagaaaccagtgaggagtccctcctgacacccaca
tctccttaccctcctgcactgcagagccagcttagtatcactgccaaccttaacctctct
aattctatgacctcacttgcaacttcccagcattccccaggaatcgacaaggagaacgtt
gaactctcccccaccactggccactgtaacagtggacggactcgccatggatccgcaagc
caagtgcagaagcaaaggagtgctggcagtttcaaacgtaatagcattaagaagatcgtg
tga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (3)   
   KEGG PATHWAY (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (6)   
   RefSeq(nuc) (4)   
   GenBank (1)   
   EMBL (1)   
Protein domain (5)   
   Pfam (5)   
All databases (28)   

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