Entry |
|
Symbol |
Plcb1
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
|
KO |
|
Organism |
rno Rattus norvegicus (rat)
|
Pathway |
rno04070 | Phosphatidylinositol signaling system |
rno04072 | Phospholipase D signaling pathway |
rno04261 | Adrenergic signaling in cardiomyocytes |
rno04270 | Vascular smooth muscle contraction |
rno04613 | Neutrophil extracellular trap formation |
rno04621 | NOD-like receptor signaling pathway |
rno04723 | Retrograde endocannabinoid signaling |
rno04750 | Inflammatory mediator regulation of TRP channels |
rno04919 | Thyroid hormone signaling pathway |
rno04925 | Aldosterone synthesis and secretion |
rno04927 | Cortisol synthesis and secretion |
rno04928 | Parathyroid hormone synthesis, secretion and action |
rno04933 | AGE-RAGE signaling pathway in diabetic complications |
rno04935 | Growth hormone synthesis, secretion and action |
rno04961 | Endocrine and other factor-regulated calcium reabsorption |
rno04973 | Carbohydrate digestion and absorption |
rno05022 | Pathways of neurodegeneration - multiple diseases |
rno05163 | Human cytomegalovirus infection |
|
Module |
rno_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:rno00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
24654 (Plcb1)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
24654 (Plcb1)
04310 Wnt signaling pathway
24654 (Plcb1)
04371 Apelin signaling pathway
24654 (Plcb1)
04020 Calcium signaling pathway
24654 (Plcb1)
04070 Phosphatidylinositol signaling system
24654 (Plcb1)
04072 Phospholipase D signaling pathway
24654 (Plcb1)
04071 Sphingolipid signaling pathway
24654 (Plcb1)
04022 cGMP-PKG signaling pathway
24654 (Plcb1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
24654 (Plcb1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
24654 (Plcb1)
04613 Neutrophil extracellular trap formation
24654 (Plcb1)
04621 NOD-like receptor signaling pathway
24654 (Plcb1)
04062 Chemokine signaling pathway
24654 (Plcb1)
09152 Endocrine system
04911 Insulin secretion
24654 (Plcb1)
04922 Glucagon signaling pathway
24654 (Plcb1)
04929 GnRH secretion
24654 (Plcb1)
04912 GnRH signaling pathway
24654 (Plcb1)
04915 Estrogen signaling pathway
24654 (Plcb1)
04921 Oxytocin signaling pathway
24654 (Plcb1)
04926 Relaxin signaling pathway
24654 (Plcb1)
04935 Growth hormone synthesis, secretion and action
24654 (Plcb1)
04918 Thyroid hormone synthesis
24654 (Plcb1)
04919 Thyroid hormone signaling pathway
24654 (Plcb1)
04928 Parathyroid hormone synthesis, secretion and action
24654 (Plcb1)
04916 Melanogenesis
24654 (Plcb1)
04924 Renin secretion
24654 (Plcb1)
04925 Aldosterone synthesis and secretion
24654 (Plcb1)
04927 Cortisol synthesis and secretion
24654 (Plcb1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
24654 (Plcb1)
04270 Vascular smooth muscle contraction
24654 (Plcb1)
09154 Digestive system
04970 Salivary secretion
24654 (Plcb1)
04971 Gastric acid secretion
24654 (Plcb1)
04972 Pancreatic secretion
24654 (Plcb1)
04973 Carbohydrate digestion and absorption
24654 (Plcb1)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
24654 (Plcb1)
09156 Nervous system
04724 Glutamatergic synapse
24654 (Plcb1)
04725 Cholinergic synapse
24654 (Plcb1)
04728 Dopaminergic synapse
24654 (Plcb1)
04726 Serotonergic synapse
24654 (Plcb1)
04720 Long-term potentiation
24654 (Plcb1)
04730 Long-term depression
24654 (Plcb1)
04723 Retrograde endocannabinoid signaling
24654 (Plcb1)
09157 Sensory system
04742 Taste transduction
24654 (Plcb1)
04750 Inflammatory mediator regulation of TRP channels
24654 (Plcb1)
09159 Environmental adaptation
04713 Circadian entrainment
24654 (Plcb1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
24654 (Plcb1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
24654 (Plcb1)
09174 Infectious disease: parasitic
05146 Amoebiasis
24654 (Plcb1)
05142 Chagas disease
24654 (Plcb1)
05143 African trypanosomiasis
24654 (Plcb1)
09164 Neurodegenerative disease
05010 Alzheimer disease
24654 (Plcb1)
05016 Huntington disease
24654 (Plcb1)
05017 Spinocerebellar ataxia
24654 (Plcb1)
05022 Pathways of neurodegeneration - multiple diseases
24654 (Plcb1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
24654 (Plcb1)
05415 Diabetic cardiomyopathy
24654 (Plcb1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
24654 (Plcb1)
04934 Cushing syndrome
24654 (Plcb1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:rno04131]
24654 (Plcb1)
Enzymes [BR:rno01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
24654 (Plcb1)
Membrane trafficking [BR:rno04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
24654 (Plcb1)
Endocytosis
Macropinocytosis
Phospholipase C
24654 (Plcb1)
|
SSDB |
|
Motif |
|
Other DBs |
|
Position |
3:142512765..143224042
|
AA seq |
1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETSSEAPSETRTTPAENGVNHTATLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQMELEQEYQDKFKRLPLEILEFVQEAMKGKVSEDSNHGSAPPSLASDPAKVNLKSPSS
EEVQGENAGREFDTPL |
NT seq |
3651 nt +upstreamnt +downstreamnt
atggctggggctcagcccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactatagttactcca
attattttgaggaccgatcctcagggatttttcttttactggacagatcagaataaggag
acggagctgttagatctcagcctcgtcaaggatgccaggtgtgggaagcacgccaaagct
cccaaggaccccaagttacgtgaacttctggatgttgggaacatcggacacttggaacag
cgcatgataactgtggtgtatgggccagacctggtgaatatctcccacctgaatcttgtg
gcttttcaagaggaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaac
ctgctggctcagaacatgtccagggacgcatttctggagaaagcatatactaagctcaag
cttcaggtgaccccagaagggcgcattcctcttaaaaacatctatcgactgttttcggca
gaccggaagcgagtggaaactgcgctagaggcctgtagtcttccatcgtcaaggaacgat
tccatccctcaagaggactttactccagatgtatacagagttttcctgaacaatctttgt
ccccgacctgaaattgataacatcttctctgaatttggtgccaaaagcaaaccgtacctt
actgttgatcagatgatggattttatcaaccttaagcagagagatccccggctgaatgaa
atactttacccacctctgaagcaagagcaggtccaagtgttgattgagaagtacgagccc
aacagcagcctcgccaagaaagggcagatgtcagtggatggattcatgcgctacctgagc
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaacgaagacatgtctcag
cccctgtctcactatttcatcaattcctcacacaacacctacctcacagctggccagttg
gctgggaactcgtctgtagagatgtatcgccaggtgcttctgtctggatgtcgctgtgtg
gagctggactgctggaagggcaggaccgctgaggaagagcctgtcatcacccatggattc
accatgacaacagaaatatccttcaaggaagtcatagaagccatcgcagagtgtgcgttc
aagacttctccttttcccatcctcctttcctttgagaaccatgtggattccccgaagcaa
caagccaagatggccgagtattgccgattaatctttggtgatgccctccttatggagcca
ctggaaaaatacccactggaatctggggtacctcttccaagccctatggatttaatgtat
aaaatcttggtgaaaaacaagaagaagtcacacaagtcgtcagagggaagtggtaaaaag
aagctctctgagcaagcttccaacacgtacagcgactcttccagcgtgttcgagccttcg
tctccgggagctggggaagcagatacggagagtgatgacgatgacgacgatgatgactgt
aaaaagtcttccatggatgaggggactgctggcagcgaggccatggccacagaagagatg
tctaacctggtgaactatattcagcctgtcaagtttgagtcctttgaaacttcaaaaaaa
agaaataaaagctttgaaatgtcttccttcgtggaaaccaaaggactcgaacaactcacg
aagtctccagttgaatttgtcgaatacaacaagatgcagcttagcaggatatatcccaaa
ggaacacgcgtggactcatccaactacatgcctcagctcttctggaatgctggctgtcag
atggtggcgctcaacttccagacagtggatctagctatgcagataaacatgggcatgtac
gaatacaatgggaagagtggctacaggctgaagccagagttcatgaggaggccagacaag
cattttgatccatttactgaaggaatcgtagatgggatagtggccaacactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagttgggacttatgtggaagtggat
atgtttggtttgcctgtggacacaagaaggaaggcatttaaaaccaagacatcccaagga
aatgctgtaaatcctgtctgggaagaagagccaattgtattcaaaaaggtagttctgcct
tctctggcctgtttaaggatagcagcatatgaggaaggaggcaaatttattggccaccgg
atcttgcctgtgcaagcaattcggccaggctatcactacatctgcctgcggaatgagagg
aaccagcccctgatgctgccagctgtctttgtctacatagaagtcaaagactatgtccca
gacacgtatgcagatgtaattgaagcattatcaaacccaatccgatatgtcaatctgatg
gaacagagagctaagcagttggctgcattgacactggaggatgaagaggaagtcaagaag
gaggctgaccccggggaaacgtcatccgaggctccaagtgaaaccaggacaactccagca
gagaatggggtgaatcacaccgcaacccttgcacccaagccaccttcccaggctccacac
agccagcctgctccagggtctgtgaaggcacccgccaaaacagaggatctgattcagagc
gtgttaacagaagtagaggcgcagaccattgaagagctcaagcaacagaaatcgttcgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggtcaagagacaccacaagaaa
accaccgagctcatcaaggagcataccaccaagtacaatgagattcagaatgactacttg
agaaggagggcagccttggaaaagtccgccaaaaaggatagcaagaagaaatctgaaccc
agcagcccagatcatggctcatccgccattgagcaagacctcgcggccctggatgcagaa
atgactcagaagttgatagacttgaaagacaagcaacaacagcagctgcttaatcttcgg
caagagcagtattacagtgagaagtaccagaagcgggagcacattaaattgctcattcag
aagttgacagatgttgctgaagagtgtcagaacaatcagttgaagaagctgaaggaaatc
tgcgagaaagagaagaaggaattaaagaagaaaatggataagaagaggcaggagaagata
acagaagccaagtccaaagacaaaagccagatggaagaggagaagacagagatgatccga
tcatacatccaggaggtggtgcagtacatcaagaggttagaggaagcacaaagtaaaaga
caagaaaaacttgtggaaaaacacaaggagatccgccagcagatcctggatgagaagccc
aagctgcagatggagctggagcaagaataccaagacaagttcaaaagactgcccctggag
attctggagtttgtacaggaagccatgaaagggaaggttagtgaggacagcaatcacggc
tctgcccctccctcgctggcctcagaccctgctaaggtgaacctcaagtctccctccagt
gaggaggtacaaggagagaacgcgggaagagagtttgatactcctctgtga |