KEGG   Rattus norvegicus (rat): 24716
Entry
24716             CDS       T01003                                 
Symbol
Ret
Name
(RefSeq) proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor
  KO
K05126  proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno04010  MAPK signaling pathway
rno04020  Calcium signaling pathway
rno04151  PI3K-Akt signaling pathway
rno05200  Pathways in cancer
rno05216  Thyroid cancer
rno05223  Non-small cell lung cancer
rno05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    24716 (Ret)
   04020 Calcium signaling pathway
    24716 (Ret)
   04151 PI3K-Akt signaling pathway
    24716 (Ret)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    24716 (Ret)
   05230 Central carbon metabolism in cancer
    24716 (Ret)
  09162 Cancer: specific types
   05216 Thyroid cancer
    24716 (Ret)
   05223 Non-small cell lung cancer
    24716 (Ret)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:rno01001]
    24716 (Ret)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     24716 (Ret)
Protein kinases [BR:rno01001]
 Receptor tyrosine kinases (RTK)
  RET family
   24716 (Ret)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr RET_CLD4 RET_CLD1 RET_CLD3 Pkinase Cadherin RIO1 Pkinase_fungal Haspin_kinase ABC1
Other DBs
NCBI-GeneID: 24716
NCBI-ProteinID: NP_036775
RGD: 3556
Ensembl: ENSRNOG00000014751
UniProt: G3V9H8
Position
4:complement(152998344..153040556)
AA seq 1115 aa
MAKARSGAAGLGLKLFLLLPLLGEAPLGLYFSRDAYWERLYVDQPAGTPLLYVHALRDAP
GEVPSFRLGQYLYGVYRTRLHENDWIHIDSGTGLLYLNQSLDHSSWEQLSIRNGGFPLLT
VFLQVFLGSTAQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVSFRIRENR
PPGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVSTRWALDRELQEKYVLE
AECAVAGPGANKEKVAVSFPVTVYDEDDSPPTFSGGVGTASAVVEFKRKEGTVVATLQVF
DADVVPASGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSVRATMHNYKLVLN
RSLSISESRVLQLVVLVNDSDFQGPGSGVLFLHFNVSVLPVTLNLPMAYSFPVNRRARRY
AQIGKVCVENCQEFSGVSIQYKLQPSSTNCSALGVVTSTEDTSGTLYVNDTEALRRPECT
ELQYTVVATDRQTRRQTQASLVVTVEGTYIAEEVGCPKSCAVNKRRPECEECGGLGSPTG
RCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINICPQDCLRGPIVGGHERGER
QGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDELCRTVITAAVLFSFIISVLLSTFCIHR
YHKHAHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPKWEF
PRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLL
KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLD
HPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV
YEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPER
LFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLA
ASTPSDSLLYDDGLSEEETPLVDCNSAPLPRSLPSTWIENKLYGMSDPNWPGESPVPLTR
ADGTSTGFPRYANDSVYANWMVSPSAAKLMDTFDS
NT seq 3348 nt   +upstreamnt  +downstreamnt
atggcgaaagcgaggtccggcgccgcagggctggggctgaagctgtttttgctgctgccg
ctactgggagaagccccgctgggtctctacttctcaagggatgcttactgggagaggctg
tatgtggaccagccagctggcacacctctgctctatgtccatgccctacgggatgcccct
ggagaagtgcccagcttccgcctgggccagtatctctatggcgtctaccgcacgcgtctg
catgagaatgactggatccacatcgattcgggcactggcctcctctacctcaatcagagc
ctggaccatagttcctgggagcagctcagcatccgcaatggcggcttccccttgctcacc
gtcttcctccaggtcttcctggggtccacagcccagagagagggagagtgtcattggcca
ggctgtgcccgtgtgtacttctccttcatcaacgacaccttcccaaattgtagctccttc
aaagcccgggatctctgcaccccggagacgggtgtgtccttccgcatcagggagaacagg
ccccctggcaccttctaccagttccgcatgctacctgtgcagttcctttgtcctaacatc
agtgtgaagtacaaactcttagaaggggacggtctgcccttccgttgtgaccccgactgt
ctggaggtgagcacgcggtgggcgctggatcgggagcttcaggagaagtatgtgctggag
gctgagtgcgcagtggcaggccctggagccaacaaggagaaggtggccgtgtccttcccg
gtgacggtgtatgatgaagacgactccccgcccaccttctccggaggtgtgggcaccgcc
agtgctgtggtggagtttaagcggaaggagggcactgtggtagccactctgcaggtgttt
gatgcagatgtggtgccagcatctggggagctggtgaggcggtacacaagcacactactc
tcaggggattcctgggcccagcagaccttccgggtggagcacacacccaacgagaccttg
gtccagtccaacaacaactccgtgcgggcaaccatgcacaattacaagctggttctcaac
aggagcctgtccatctcagagagccgagtcctgcagctagtagtcctggtcaatgactca
gacttccaggggcctgggtcaggtgttctcttcctccatttcaacgtgtctgtgctgcct
gtcaccctgaacctacccatggcctactccttcccagtgaataggagagcccgccgttat
gcccagattgggaaagtttgcgtggagaactgccaggagttcagcggtgtctccatccag
tacaagctgcagccctccagcaccaactgcagtgccctaggtgtggtcacctcaacagaa
gacacctcagggaccctatatgtaaatgacacggaggccctgcggcgacctgagtgtacc
gagcttcagtacacagtggtagccactgaccggcagacccgcaggcagacccaggcttcg
ttagtcgtcacagtggaggggacatacattgcagaagaagtgggctgccccaagtcctgt
gcagtaaacaagaggcgacctgagtgtgaggagtgtggtggcctgggttctccaactggc
agatgtgagtggcgtcagggagatggtaaagggatcaccaggaacttctccacctgttct
cctagcaccaggacctgtcctgatggccactgtgatgctctggagagccgggatatcaac
atttgcccccaggactgtctccgtggccccattgttggcgggcatgagcgaggggagcgc
caggggattaaagccggctatggcatctgcaactgtttccctgatgagaagaagtgcttc
tgcgagccagaggacagccagggcccattgtgcgatgagctgtgccgtacggtcatcaca
gccgctgtcctcttctccttcataatctctgtcctgctgtccaccttctgcatccaccgc
taccacaagcatgcgcacaagccacccatcgcgtcagccgaaatgaccttctgccggccg
gcccagggcttcccaatcagctattcttcctcgggcacccgccggccctcactggactcc
atggagaaccaggtctctgtggactctttcaagatcccggaggatccgaagtgggaattt
cctcggaagaacttagttcttgggaaaaccctgggagaaggcgagtttggaaaagtagtc
aaggccacagccttccgtctgaaaggccgggcaggatacaccacagtggctgtgaaaatg
ctgaaagaaaacgcctcccagagtgaactacgagacctgctctctgagttcaaccttctg
aaacaagtcaaccatccacatgtcatcaagttgtacggggcttgcagccaggatgggcca
cttcttctcattgtggagtatgcaaagtatggatccctgcgggggttcctgcgggacagc
cgcaagatcgggcctgcctatgtgagcagtggaggcagccgcaattccagctccctggac
cacccagacgaaagggtgctgaccatgggcgacctcatctccttcgcctggcagatctcg
aggggtatgcagtacttggctgaaatgaagctcgtacatcgagacttagctgccagaaac
atcttggtggcagagggacggaagatgaagatctctgactttgggctgtcccgagatgtt
tatgaagaagattcctatgtgaagaaaagcaagggccggattcccgtcaaatggatggca
atcgagtctctcttcgatcacatctataccactcaaagtgatgtgtggtcctttggagtg
ctgctatgggagattgtgaccctgggaggcaacccctaccctggaattcctcctgaacga
ctcttcaaccttctgaagacaggccacaggatggagaggccagacaactgcagcgaggaa
atgtaccgcctgatgctgcagtgctggaagcaggagccggacaagaggccagtatttgct
gacatcagcaaggatctggagaagatgatggtcaaaagcagagactacttggacctggct
gcatccaccccttcggactcactgctctatgacgatgggctctcggaagaggagacgccc
ctggtggactgtaacagtgctcccctcccgcgctccctcccttccacatggattgaaaac
aaactctatggcatgtcagacccgaactggcctggagagagtcctgtaccactcacgaga
gccgatggcactagcactgggttcccaagatatgcaaatgatagtgtatatgctaactgg
atggtttcaccctcagcggcaaaattaatggacacatttgatagttaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (7)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (2)   
Protein domain (10)   
   Pfam (10)   
All databases (40)   

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